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| 1 | MiR-122 in hepatic function and liver diseases显示文摘As the most abundant liver-specific microRNA,mi-croRNA-122(miR-122)is involved in various physio-logical processes in hepatic function as well as in liver pathology.There is now compelling evidence that miR-122,as a regulator of gene networks and pathways in hepatocytes,plays a central role in diverse aspects of hepatic function and in the progress of liver diseases.This liver-enriched transcription factors-regulated miRNA promotes differentiation of hepatocytes and regulates lipid metabolism.With regard to liver diseases,miR-122 was shown to stimulate hepatitis C virus(HCV)replication through a unique and unusual interaction with two binding sites in the 5′-UTR of HCV genome to mediate the stability of the viral RNA,whereas inhibit the expression and replication of hepatitis B virus(HBV)by a miR-122-cylin G1/p53-HBV enhancer regulatory pathway.In addition,miR-122 acts as a suppressor of cell prolif-eration and malignant transformation of hepatocytes with remarkable tumor inhibition activity.Notably,a clinical trial targeting miR-122 with the anti-miR-122 oli-gonucleotides miravirsen,the first miRNA targeted drug,has been initiated for treatment of HCV infection.With further understanding of the comprehensive roles of miR-122 in hepatic functions and the mechanisms in-volved in miR-122 down-regulation in chronic hepatitis or hepatocellular carcinoma,miR-122 appears to be a promising candidate for effective therapeutic ap-proaches against tumor and infectious diseases. | Jun Hu Yaxing Xu Junli Hao Saifeng Wang Changfei Li Songdong Meng | 2012 | Protein & Cell2012，3，5： | 22 |
| 2 | Characteristics and Source Identification of Polycyclic Aromatic Hydrocarbons (PAHs) in Urban Soils: A Review显示文摘Polycyclic aromatic hydrocarbons(PAHs) are mainly produced by combustion processes and consist of a number of toxic compounds.They are always emitted as a mixture and have become a major type of pollutants in urban areas.The degree of soil contamination by PAHs is of special concern in areas immediately in proximity to cities with heavy traffic,factories,older buildings,and infrastructure.The accumulation of soil PAHs is also affected by non-anthropogenic factors,such as climate,vegetation,and soil property.This paper reviews three typical source identification techniques,including diagnostic ratios,positive matrix factorization,and principle components analysis.The advantages or disadvantages of these techniques are analyzed.It is recommended that multiple identification techniques be used to determine the sources in order to minimize the weaknesses inherent in each method and thereby to strengthen the conclusions for PAH source identification. | WANG Chunhui WU Shaohua ZHOU Shenglu SHI Yaxing SONG Jing | 2017 | Pedosphere2017，27，1： | 18 |
| 3 | Spatial and temporal variations of vegetation in Qinghai Province based on satellite data显示文摘这篇论文使用了五年(2001 ¨ C 2006 ) 有 1-km 的 MODIS NDVI 图象的时间系列在中国生产 Qinghai 省的一张陆地盖子地图的空间分辨率。为有植被上的特殊强调的不同陆地盖子类型的一条分类途径, | WANG Liwen WEI Yaxing NIU Zheng | 2008 | Journal of Geographical Sciences2008，18，1： | 9 |
| 4 | Spatial scaling of net primary productivity model based on remote sensing显示文摘Spatial scaling for net primary productivity (NPP) refers to the transferring process of establishing quantitative correlation between simulated NPP derived from data at different spatial resolutions. How to transfer NPP at one scale by the algorithm with smaller error to at another is the urgent problem. Nonlinearity and effects from land cover type are two main problems in NPP scaling. In this paper, the contextural approach based on mixed pixels and support vector machine (SVM) algorithm are used to make the scaling model from the fine resolution (TM) to the coarse resolution (MODIS). Spatial scaling from NPP retrieved from fine resolution data to NPP derived from coarse resolution images is performed, and the correction of scale effect to NPP retrieved from coarse resolution data of MODIS is accomplished. The result shows that the correlation between Rj_coereted of the correction factor for scale effect and 1-Fmiddle dessity grassland estimated by SVM regression model is higher (R2=0.81). Before the correction for scale effect, the correlation between NPPMODIS and NPPTM is lower (R2=0.69; RMSE=3.47), while the correlation between NPPTM and corrected NPPMODIS_corrected is higher (R2=0.84; RMSE= 1.87). Therefore, NPP corrected for scale effect has been greatly improved in both correlation and error. | WANG Liwen WEI Yaxing NIU Zheng | 2010 | 遥感学报2010，14，6： | 5 |
| 5 | The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection显示文摘Epigenetic modifications to histones dictate the differentiation of naïve CD4^(+) T cells into different subsets of effector T helper(TH)cells.The histone methyltransferase enhancer of zeste homolog 2(EZH2)has been implicated in the mechanism regulating the differentiation of TH1,TH2 and regulatory T(Treg)cells.However,whether and how EZH2 regulates follicular helper T(TFH)cell differentiation remain unknown.Using a mouse model of acute lymphocytic choriomeningitis virus(LCMV)infection,we observed abundant EZH2 expression and associated H3K27me3 modifications preferentially in the early committed virus-specific TFH cells compared to those in TH1 cells.Ablation of EZH2 in LCMV-specific CD4^(+) T cells leads to a selective impairment of early TFH cell fate commitment,but not late TFH differentiation or memory TFH maintenance.Mechanistically,EZH2 specifically stabilizes the chromatin accessibility of a cluster of genes that are important for TFH fate commitment,particularly B cell lymphoma 6(Bcl6),and thus directs TFH cell commitment.Therefore,we identified the chromatin-modifying enzyme EZH2 as a novel regulator of early TFH differentiation during acute viral infection. | Xiangyu Chen Guoshuai Cao Jialin Wu Xinxin Wang Zhiwei Pan Jianbao Gao Qin Tian Lifan Xu Zhirong Li Yaxing Hao Qizhao Huang Pengcheng Wang Minglu Xiao Luoyingzi Xie Shupei Tang Zhenyu Liu Li Hu Jianfang Tang Ran He Li Wang Xinyuan Zhou Yuzhang Wu Mengjie Chen Beicheng Sun Bo Zhu Jun Huang Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，3： | 4 |
| 6 | A critical survey of technologies of large offshore wind farm integration: summary, advances, and perspectives显示文摘Offshore wind farms(OWFs)have received widespread attention for their abundant unexploited wind energy poten-tial and convenient locations conditions.They are rapidly developing towards having large capacity and being located further away from shore.It is thus necessary to explore effective power transmission technologies to connect large OWFs to onshore grids.At present,three types of power transmission technologies have been proposed for large OWF integration.They are:high voltage alternating current(HVAC)transmission,high voltage direct current(HVDC)transmission,and low-frequency alternating current(LFAC)or fractional frequency alternating current transmission.This work undertakes a comprehensive review of grid connection technologies for large OWF integration.Compared with previous reviews,a more exhaustive summary is provided to elaborate HVAC,LFAC,and five HVDC topologies,consisting of line-commutated converter HVDC,voltage source converter HVDC,hybrid-HVDC,diode rectifier-based HVDC,and all DC transmission systems.The fault ride-through technologies of the grid connection schemes are also presented in detail to provide research references and guidelines for researchers.In addition,a comprehensive evalu-ation of the seven grid connection technologies for large OWFs is proposed based on eight specific indicators.Finally,eight conclusions and six perspectives are outlined for future research in integrating large OWFs. | Bo Yang Bingqiang Liu Hongyu Zhou Jingbo Wang Wei Yao Shaocong Wu Hongchun Shu Yaxing Ren | 2022 | Protection and Control of Modern Power Systems2022，7，1： | 4 |
| 7 | EXPERIMENTAL STUDY OF FRETTING WEAR OF TITANIUM ALLOY BEFORE AND AFTER LASER BEAM QUENCHING显示文摘EXPERIMENTALSTUDYOFFRETTINGWEAROFTITANIUMALLOYBEFOREANDAFTERLASERBEAMQUENCHINGDaiZhendong,TangYaxing,ZhangHong,WangMin(Depart... | Dai Zhendong, Tang Yaxing, Zhang Hong, Wang Min (Department of Mechanical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, 210016, China) Yang Shenrong, Zhang Xueshou (Laboratory of Solid Lubrication, Lanzhou Institu | 1997 | Chinese Journal of Aeronautics1997，10，3： | 4 |
| 8 | Progress on major genes for high fecundity in ewes显示文摘The existence of major genes affecting fecundity in sheep flocks throughout the world has been demonstrated.Three major genes whose mutations can increase ovulation rate have been discovered,and all related to the transforming growth factorβ(TGF-β)superfamily.The mutant FecB of bone morphogenetic protein receptor 1B(BMPR1B)has an additive effect on ovulation rate.Six mutations(Fec^(XI),Fec^(XH),Fec^(XG),Fec^(XB),Fec^(XL),Fec^(XR))of bone morphogenetic protein 15(BMP15)related with fertility have been identified that share the same mechanism.All the mutants can increase ovulation rate in heterozygotes and cause complete sterility in homozygotes.Homozygous ewes with two new mutations(FecX^(Gr),FecX^(O))of BMP15 had increased ovulation rate without causing sterility.There are five mutations in growth differentiation factor 9(GDF9)associated with sheep prolificacy where FecG^(E) and FecG^(F) have additive an effect on ovulation rate and litter size.The newly identifiedβ-1,4-N-acetylgalactosaminyltransferase 2(B4GALNT2)gene of FecL is proposed as a new mechanism of ovulation rate regulation in sheep.Woodlands is an X-linked maternally imprinted gene which increases ovulation rate.In addition,several putative major genes need to be verified.This review is focused on the identification of the mutations and mechanisms whereby the major genes affecting ovulation rate. | Qiuyue LIU Zhangyuan PAN Xiangyu WANG Wenping HU Ran DI Yaxing YAO Mingxing CHU | 2014 | Frontiers of Agricultural Science and Engineering2014，1，4： | 3 |
| 9 | Application of intraoperative O-arm-assisted real-time navigation technique for spinal fixation显示文摘This study explored the combined use of the O-arm and real-time navigation during spinal fixation. The clinical data for 60 patients undergoing spinal fixation, at Beijing Tsinghua Chang Gung Hospital between May 5, 2015 and May 1, 2017, were retrospectively analyzed. Pre-, intra-, and postoperative imaging findings were assessed. The patients were classified into the occipitocervical fusion(32 cases) and thoracic/lumbar/sacral spine fixation(28 cases, including 6 cases of percutaneous pedicle screw) groups. Lesion resections were performed microscopically. An O-arm, combined with real-time navigation, was used to assess spinal fixation. Efficacy was evaluated using operative times, X-ray times, screw positioning, and complications. Within the occipitocervical fusion group, 182 screws were placed in the cervical spine and 96 in the occipital bone. However, 6 screws penetrated the bone cortex and were adjacent to the vertebral arteries, based on O-arm three-dimensional imaging; therefore, the precision rate was 96.7%. Within the thoracic/lumbar/sacral spine fixation group, 148 pedicle screws were implanted, with 4 initially outside the vertebral body,yielding a precision rate of 97.3%. Ten percutaneous pedicle screws were implanted and well positioned. O-arm scans were performed 3 times/patient, with an average of 20–30 min/time. Screw implantation times were 5–7 min(cervical spine), 8–10 min(thoracic spine), and 6–8 min(lumbar spine). Intraoperative O-arm scans, combined with real-time navigation technology, allow real-time observation of screw angles and depths, improving the accuracy and safety of posterior screw fixations and reducing the radiation dose and frequency experienced by patients and surgeons. | Zhenxing Sun Dan Yuan Yaxing Sun Zhanquan Zhang Guihuai Wang Yi Guo Guoqin Wang Dongkang Liu Peng Chen Linkai Jing Feng Yang Peihai Zhang Huifang Zhang Youtu Wu Wei Shi James Wang | 2017 | Translational Neuroscience and Clinics2017，3，3： | 2 |
| 10 | Ophthalmology: potential future developments in China and worldwide显示文摘 | Jost B. Jonas Songhomitra Panda-Jonas Wang Yaxing Wei Wenbin | 2014 | Chinese Medical Journal2014，，8： | 2 |
| 11 | Configurations and Control of Traction Motors for Electric Vehicles:A Review显示文摘In recent decades,worldwide global warming and reduction in petroleum resources have accelerated researcher’s attention to produce alternative sustainable and environmentally clean transportation systems.Electrification of vehicular technology is capable of curbing the environmental pollution problem in an efficient and effective way,due to high efficiency electric motors,development and advancement in the field of power electronic devices,digital signal processing and advanced control techniques.This article presents a comprehensive review on different configurations/architecture of electric vehicles(EVs)and hybrid electric vehicles(HEVs),traction motors for electric propulsion system and high performance speed sensorless control of traction drive.The basic architecture key components of hybrid vehicle and different power train configurations with respect to applications and limitations are discussed.The integral part of electric propulsion system,traction motor classes for desired operational characteristics and limitations are summarized from a system perspective with the latest improvements.High performance traction motor control techniques are discussed with respect to automotive applications.Finally,speed sensorless control techniques research trends as well as an extensive review on rotor speed estimation techniques for robust and efficient sensorless traction drive control are highlighted.This article provides state of the art key global trends and tradeoff of various technologies with future trends and potential areas of research. | Saqib Jamshed Rind Yaxing Ren Yihua Hu Jibing Wang Lin Jiang | 2017 | Chinese Journal of Electrical Engineering2017，3，3： | 2 |
| 12 | Efficient separation between trivalent americium and lanthanides enabled by a phenanthroline-based polymeric organic framework显示文摘Separation of the minor actinides(Am and Cm)from lanthanides in high-level liquid wastes(HLLW)is one of the most challenging chemical separation tasks known owing to their chemical similarities and is highly significant in nuclear fuel reprocessing plants because it could practically lead to sustainable nuclear energy by closing the nuclear fuel cycle.The solid phase extraction is proposed to be a possible strategy but all reported sorbent materials severely suffer from limited stability and/or efficiency caused by the harsh conditions of high acidity coupled with intense irradiation.Herein,a phenanthroline-based polymeric organic framework(PhenTAPB-POF)was designed and tested for the separation of trivalent americium from lanthanides for the first time.Due to its fully conjugated structure,PhenTAPB-POF exhibits previously unachieved stability under the combined extreme conditions of strong acids and high irradiation field.The americium partitioning experiment indicates that PhenTAPB-POF possesses an ultrahigh adsorption selectivity towards Am(Ⅲ)over lanthanides(e.g.,SFAm(Ⅲ)/Eu(Ⅲ)=3326)in highly acidic simulated HLLW and relatively fast adsorption kinetics in both static and dynamic experiments.Am(Ⅲ)can be almost quantitatively eluted from the PhenTAPB-POF packed-column using a concentrated nitric acid elution.The high stability and superior separation performance endow PhenTAPB-POF with the promising alternative for separating minor actinides over lanthanides from highly acidic HLLW streams. | Afshin Khayambashi Long Chen Xue Dong Kai Li Zhipeng Wang Linwei He Suresh Annam Lixi Chen Yaxing Wang Matthew V.Sheridan Chao Xu Shuao Wang | 2022 | Chinese Chemical Letters2022，33，7： | 1 |
| 13 | Correction to:Efficient derivation of extended pluripotent stem cells from NOD-scid II2rg^-/-mice显示文摘Figure 1.Generation of NOD-scid II2rg^-1-extended pluripotent stem cells.(A)Schematic of two approaches used for generating NOD-scid II2rg^-1-extended pluripotent stem cells:de novo derivation from blastocysts(upper panels)and chemical reprogramming from embryonic fibroblasts(lower panels).(B)Phase-contrast images of de novo derived outgrowth and EPS colonies for 17 passages in LCDM medium.Scale bars,100 pm.(C)qRT-PCR analysis of XEN marker genes expression during the chemical induction process(day 16).Error bars indicate SEM(n=2).(D)Co-immunostaining of XEN marker genes during the chemical induction process(day 16).Upper panels:GATA6 and SALL4;lower panels:SOX17 and SALL4.Scale bars,100 pm. | Yaqin Du Ting Wang Jun Xu Chaoran Zhao Haibo Li Yao Fu Yaxing Xu Liangfu Xie Jingru Zhao Weifeng Yang Ming Yin Jinhua Wen Hongkui Deng | 2019 | Protein & Cell2019，10，2： | 1 |
| 14 | Rapid generation of gene-targeted EPS-derived mouse models through tetraploid complementation显示文摘One major strategy to generate genetically modified mouse models is gene targeting in mouse embryonic stem(ES)cells,which is used to produce gene-targeted mice for wide applications in biomedicine.However,a major bottleneck in this approach is that the robustness of germiine transmission of gene-targeted ES cells can be significantly reduced by their genetic and epigenetic instability after long-term culturing,which impairs the efficiency and robustness of mouse model generation.Recently,we have established a new type of pluripotent cells termed extended pluripotent stem(EPS)cells,which have superior developmental potency and robust germline competence compared to conventional mouse ES cells.In this study,we demonstrate that mouse EPS cells well maintain developmental potency and genetic stability after long-term passage.Based on gene targeting in mouse EPS cells,we established a new approach to directly and rapidly generate gene-targeted mouse models through tetraploid complementation,Haibo Li and Chaoran Zhao contributed equally to this work.Electronic supplementary material The online version of this article(https://doi.org/10.1007/s13238-018-0556-1)contains supplementary material,which is available to authorized users.which could be accomplished in approximately 2 months.Importantly,using this approach,we successfully constructed mouse models in which the human interleukin 3(IL3)or interleukin 6(IL6)gene was knocked into its corresponding locus in the mouse genome.Our study demonstrates the feasibility of using mouse EPS cells to rapidly generate mouse models by gene targeting,which have great application potential in biomedical research. | Haibo Li Chaoran Zhao Jun Xu Yaxing Xu Chunmei Cheng Yinan Liu Ting Wang Yaqin Du Liangfu Xie Jingru Zhao Yanchuang Han Xiaobao Wang Yun Bai Hongkui Deng | 2019 | Protein & Cell2019，10，1： | 1 |
| 15 | Causes of blindness and visual impairment in urban and rural areas in Beijing显示文摘 | Liang Xu Yaxing Wang Yibin Li | 2006 | Ophthalmology2006，113，7： | 1 |
| 16 | Competing Crystallization between Lanthanide and Actinide in Acidic Solution Leading to Their Efficient Separation显示文摘Summary of main observation and conclusion We present a new method for generating europium oxalate compounds by decomposing of N-methyl 2-pyrrolidone in HNO3 media.The reaction exhibits high selectivity towards Eu^3+ over UO2^2+,which suggests that these conditions could be applied to a selective crystallization based separation system for trivalent lanthanides and hexavalent actinides. | Xuemiao Yin Yaxing Wang Xiaoyan Li Jian Xie Mark A.Silver Lanhua Chen Daopeng Sheng Guoxun Ji Zhifang Chai Shuao Wang | 2019 | Chinese Journal of Chemistry2019，37，1： | 1 |
| 17 | UranyI Phosphonates with Multiple UranyI Coordination Geometries and Low Temperature Phase Transition显示文摘Main observation and conclusion Two new uranium(VI)phosphonate compounds,namely K_(8)[N(C_(2)H_(5))_(4)]_(2)(UO_(2))_(17)(H_(2)O)_(4)[CH_(2)(PO_(3))_(2)]_(8)[CH_(2)(PO_(3))(PO_(3)H)]_(4)·16(H_(2)O)(1)and[N(C_(2)H_(5))_(4)]_(4)(H_(3)O)_(2)(UO_(2))_(10)[CH_(2)(PO_(3))_(2)]_(5)[CH_(2)(PO_(3))(PO_(3)H)]_(2)·10H_(2)O(2),have been synthesized under mild hydro/solvothermal condition.The structural analysis of the two compounds reveals that they both contain all three typical coordination geometries of the U(VI)ions,including UO;tetragonal,UO,pentagonal,and UOg hexagonal bipyramids.Moreover,compound 1 displays a tempera-ture-induced single crystal to single crystal phase transformation as confirmed by the Single-crystal X-ray diffraction data collected at different temperatures.Temperature-dependent fluorescence spectra presented herein illustrate the perturbation of the electronic structure of uranyl centers. | Lanhua Chen Yugang Zhang Zhehui Weng Zhiyong Liu Jiarong Zhang Yaxing Wang Shuao Wang | 2021 | Chinese Journal of Chemistry2021，39，3： | 1 |
| 18 | Derivation of totipotent-like stem cells with blastocyst-like structure forming potential显示文摘It is challenging to derive totipotent stem cells in vitro that functionally and molecularly resemble cells from totipotent embryos.Here,we report that a chemical cocktail enables the derivation of totipotent-like stem cells,designated as totipotent potential stem(TPS)cells,from 2-cell mouse embryos and extended pluripotent stem cells,and that these TPS cells can be stably maintained long term in vitro.TPS cells shared features with 2-cell mouse embryos in terms of totipotency markers,transcriptome,chromatin accessibility and DNA methylation patterns.In vivo chimera formation assays show that these cells have embryonic and extraembryonic developmental potentials at the single-cell level.Moreover,TPS cells can be induced into blastocyst-like structures resembling preimplantation mouse blastocysts.Mechanistically,inhibition of HDAC1/2 and DOT1L activity and activation of RARγsignaling are important for inducing and maintaining totipotent features of TPS cells.Our study opens up a new path toward fully capturing totipotent stem cells in vitro. | Yaxing Xu Jingru Zhao Yixuan Ren Xuyang Wang Yulin Lyu Bingqing Xie Yiming Sun Xiandun Yuan Haiyin Liu Weifeng Yang Yenan Fu Yu Yu Yinan Liu Rong Mu Cheng Li Jun Xu Hongkui Deng | 2022 | Cell Research2022，32，6： | 1 |
| 19 | Stabilization of Plutonium(V)Within a Crown Ether Inclusion Complex显示文摘Crystalline coordination complexes of actinides,especially in atypical oxidation states,are not only fundamentally important for expanding the notably limited knowledge on the bonding nature of actinides but could also provide critical information toward the development of nuclear fuel cycle,waste management,and national security.Plutonium(Pu)is the only element in the periodic table that could exist in four oxidation states in aqueous solutions simultaneously. | Yaxing Wang Shu-Xian Hu Liwei Cheng Chengyu Liang Xuemiao Yin Hailong Zhang Ao Li Daopeng Sheng Juan Diwu Xiaolin Wang Jun Li Zhifang Chai Shuao Wang | 2020 | CCS Chemistry2020，2，4： | 1 |
| 20 | Causes of Blindness and Visual Impairment in Urban and Rural Areas in Beijing显示文摘 | Liang Xu Yaxing Wang Yibin Li Yun Wang Tongtong Cui Jianjun Li Jost B. Jonas | 2006 | Ophthalmology2006，，7： | 1 |
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