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| 1 | Climate change over the Yarlung Zangbo River Basin during 1961-2005显示文摘The Yarlung Zangbo River (YR) is the highest great river in the world, and its basin is one of the centers of human economic activity in Tibet. Using 10 meteorological stations over the YR basin in 1961–2005, the spatial and temporal characteristics of temperature and precipitation as well as potential evapotranspiration are analyzed. The results are as follows. (1) The annual and four seasonal mean air temperature shows statistically significant increasing trend, the tendency is more significant in winter and fall. The warming in Lhasa river basin is most significant. (2) The precipitation is decreasing from the 1960s to the 1980s and increasing since the 1980s. From 1961 to 2005, the annual and four seasonal mean precipitation is increasing but not statistically significant, especially in fall and spring. The increasing precipitation rates are more pronounced in Niyangqu and Palong Zangbo river basins, the closer to the upper YR is, the less precipitation increasing rate would be. (3) The annual and four seasonal mean potential evapotranspiration has decreased, especially after the 1980s, and most of it happens in winter and spring. The decreasing trend is most significant in the middle YR and Nianchu river basin. (4) Compared with the Mt. Qomolangma region, Tibetan Plateau, China and global average, the magnitudes of warming trend over the YR basin since the 1970s exceed those areas in the same period, and compared with the Tibetan Plateau, the magnitudes of precipitation increasing and potential evapotranspiration decreasing are larger, suggesting that the YR basin is one of the most sensitive areas to global warming. | YOU Qinglong KANG Shichang WU Yanhong YAN Yuping | 2007 | Journal of Geographical Sciences2007，17，4： | 25 |
| 2 | Genetically encoded X-ray cellular imaging for nanoscale protein localization显示文摘Spatial resolution defines the physical limit of microscopes for probing biomolecular localization and interactions in cells.Whereas synchrotron-based X-ray microscopy(XRM)represents a unique approach for imaging a whole cell with nanoscale resolution due to its intrinsic nanoscale resolution and great penetration ability,existing approaches to label biomolecules rely on the use of exogenous tags that are multi-step and error-prone.Here,we repurpose engineered peroxidases as genetically encoded X-ray-sensitive tags(GXET)for site-specific labeling of protein-of-interest in mammalian cells.We find that 3,3-diaminobenzidine(DAB)polymers that are in-situ catalytically formed by fusion-expressed peroxidases are visible under XRM.Using this new tag,we imaged the protein location associated with the alteration of a DNA-methylation pathway with an ultra-high resolution of 30 nanometers.Importantly,the excellent energy resolution of XRM enables multicolor imaging using different peroxidase tags.The development of GXET enlightens the way to nanoscopic imaging for biological studies. | Huating Kong Jichao Zhang Jiang Li Jian Wang Hyun-Joon Shin Renzhong Tai Qinglong Yan Kai Xia Jun Hu Lihua Wang Ying Zhu Chunhai Fan | 2020 | National Science Review2020，7，7： | 3 |
| 3 | 96-Week Treatment of Tenofovir Amibufenamide and Tenofovir Disoproxil Fumarate in Chronic Hepatitis B Patients显示文摘Background and Aims:Tenofovir amibufenamide(TMF)is a novel phosphoramidated prodrug of tenofovir with nonin-ferior efficacy and better bone and renal safety to tenofovir disoproxil fumarate(TDF)in 48 weeks of treatment.Here,we update 96-week comparison results.Methods:Patients with chronic hepatitis B were assigned(2:1)to receive either 25 mg TMF or 300 mg TDF with matching placebo for 96 weeks.The virological suppression was defined as HBV DNA levels<20 IU/mL at week 96.Safety was evaluated thoroughly with focusing on bone,renal,and metabolic pa-rameters.Results:Virological suppression rates at week 96 were similar between TMF and TDF group in both HBeAg-positive and HBeAg-negative populations.Noninferior efficacy was maintained in the pooled population,while it was first achieved in patients with HBV DNA≥7 or 8 log10 IU/mL at baseline.Non-indexed estimated glomerular filtration rate for renal safety assessment was adopted,while a smaller decline of which was seen in the TMF group than in the TDF group(p=0.01).For bone mineral density,patients receiv-ing TMF displayed significantly lower reduction levels in the densities of spine,hip,and femur neck at week 96 than those receiving TDF.In addition,the lipid parameters were stable after week 48 in all groups while weight change still showed the opposite trend.Conclusions:TMF maintained similar efficacy at week 96 compared with TDF with continued superior bone and renal safety profiles(NCT03903796). | Zhihong Liu Qinglong Jin Yuexin Zhang Guozhong Gong Guicheng Wu Lvfeng Yao Xiaofeng Wen Zhiliang Gao Yan Huang Daokun Yang Enqiang Chen Qing Mao Shide Lin Jia Shang Huanyu Gong Lihua Zhong Huafa Yin Fengmei Wang Peng Hu Qiong Wu Chao Pan Wen Jia Chuan Li Chang’an Sun Junqi Niu Jinlin Hou TMF Study Group | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 3 |
| 4 | Enzyme-Triggered Fluorescence Turn-on: A Probe for Specifically Imaging Ovarian-Cancer-Related γ-Glutamyltranspeptidase显示文摘 | Jie Tian Qinglong Yan Ying Zhu Jichao Zhang Jiao Li Ben Shi Ge Xu Chunhai Fan Chunchang Zhao | 2017 | Chinese Journal of Chemistry2017，35，11： | 2 |
| 5 | Introducing Degree Days to Building Thermal Climatic Zoning in China显示文摘Building thermal climatic zoning is a key issue in building energy efficiency.Heating degree days(HDD) and cooling degree days(CDD) are often employed as indexes to represent the heating and cooling energy demand in climatic zoning.However,only using degree days may oversimplify the climatic zoning in regions with complex climatic conditions.In the present study,the application of degree days to current building thermal climatic zoning in China was assessed based on performance simulations.To investigate the key indexes for thermal climatic zoning,the climate characteristics of typical cities were analyzed and the relationships between the climate indexes and heating/cooling demand were obtained.The results reveal that the annual cumulative heating load had a linear correlation with HDD 18 only in regions with small differences in altitude.Therefore,HDD is unsuitable for representing the heating demand in regions with large differences in altitude.A comprehensive index(winter climatic severity index) should be employed instead of HDD,or complementary indexes(daily global solar radiation or altitude) could be used to further divide climate zones.In the current official climatic zoning,the base temperature of 26℃ for CDD is excessively high.The appropriate base temperature range is 18℃ to 22℃.This study provides a reference for selecting indexes to improve thermal climatic zoning in regions with similar climates. | LIU Yan WEN Zeqiu LYU Kailin YANG Liu LIU Jiaping DONG Hong GAO Qinglong | 2023 | Journal of Thermal Science2023，32，3： | 1 |
| 6 | GC-MS Analysis of Liposoluble Constituents from Buds,Flowers and Fruits of Millettia speciosa Champ.显示文摘[Objectives] To study the material foundation of liposoluble constituents from buds,flowers and fruits of Millettia speciosa Champ.and provide a reference for the development of flowers and fruits of Millettia speciosa Champ.[Methods]The liposoluble constituents were extracted from buds,flowers and fruits of Millettia speciosa by Soxhlet extraction and solvent extraction method,and analyzed by GC-MS.[Results]24 compounds were identified from the liposoluble constituents of buds,accounting for 88. 31 % of the total liposoluble constituents,mainly comprising alkanes and olefins compounds( 52. 00%) and alcohols compounds( 17. 46%); 29 compounds were identified from the liposoluble constituents of flowers,accounting for 91. 38 % of the total liposoluble constituents,mainly comprising alkanes and olefins compounds( 60. 64%) and alcohols compounds( 17. 17%); 32 compounds were identified from the liposoluble constituents of fruits,accounting for 80. 01 % of the total liposoluble constituents,mainly comprising alkanes and olefins compounds( 32. 56%),phenyl and its derivatives compounds( 22. 46%) and fatty acids compounds( 12. 54%). 6 compounds were common in buds,flowers and fruits. [Conclusions] Although there were some differences in liposoluble constituents from flowers,fruits,leaves and roots of Millettia speciosa Champ.,the different parts of Millettia speciosa Champ. had development value. | Maoyuan WANG Qing YANG Qinglong WANG Xiaoxia YAN Jianrong WANG Zhunian WANG | 2017 | Medicinal Plant2017，8，4： | 1 |
| 7 | From brightening to dimming in sunshine duration over the eastern and central Tibetan Plateau (1961–2005)显示文摘 | Qinglong You Shichang Kang Wolfgang-Albert Flügel Arturo Sanchez-Lorenzo Yuping Yan Jie Huang Javier Martin-Vide | 2010 | Theoretical and Applied Climatology (-)2010，，3： | 1 |
| 8 | Relationship between temperature trend magnitude, elevation and mean temperature in the Tibetan Plateau from homogenized surface stations and reanalysis data显示文摘 | Qinglong You Shichang Kang Nick Pepin Wolfgang-Albert Flügel Yuping Yan Houshang Behrawan Jie Huang | 2010 | Global and Planetary Change2010，，1： | 1 |
| 9 | A Design Method of the Rotor Auxiliary Slot for the Water-filled Submersible Induction Motors显示文摘Aiming at the problem of electromagnetic vibration of the water-filled submersible induction motor(WSIM),a method of opening auxiliary slots on the rotor side is proposed to weaken the air-gap field harmonics caused by the rotor slot permeance harmonics.By analyzing the research status of electromagnetic vibration of the WSIM and the composition of the air-gap magnetic field of the motor,the idea that the auxiliary slots mainly affect the air-gap field harmonics by changing the air-gap permeance of the motor is put forward.The mathematical model of air-gap permeance of WSIM is established to simulate the influence of auxiliary slots on the air-gap permeance.Through the parametric analysis of the mathematical model,the change of auxiliary slot size is simulated.The air-gap permeance waveform is decomposed by the two-dimensional Fourier transform,and then the variation of the air-gap permeance harmonics with the size of the auxiliary slot is analyzed.Finally,the finite element simulation model of the WSIM with the auxiliary slots is established,and the waveform of the air-gap flux density of the motor is analyzed to verify the effectiveness of the mathematical model.Meanwhile,the results show that after opening the auxiliary slot,the radial electromagnetic force of the motor was reduced by 28.4%. | Jiaxin Li Jingwen Yan Chong Di Xiaohua Bao Qinglong Zhu | 2022 | CES Transactions on Electrical Machines and Systems2022，6，1： | 1 |
| 10 | Antiviral Treatment Alters the Frequency of Activating and Inhibitory Receptor-Expressing Natural Killer Cells in Chronic Hepatitis B Virus Infected Patients显示文摘 | Juan Lv Qinglong Jin Haibo Sun Xiumei Chi Xiaoli Hu Hongqing Yan Yu Pan Weihua Xiao Zhigang Tian Jinlin Hou Damo Xu Zhengkun Tu Junqi Niu Alex Kleinjan | 2012 | Mediators of Inflammation2012，，： | 1 |
| 11 | Diversity of culturable root-associated/endophytic bacteria and their chitinolytic and aflatoxin inhibition activity of peanut plant in China显示文摘 | WANG Kai YAN Peisheng DING Qinglong | 2013 | World Journal of Microbiology and Biotechnology2013，29，1： | 1 |
| 12 | Development and Processing of Millettia speciosa Instant Tea显示文摘This paper analyzed the effect of raw material crushing fineness,cooking time,ethanol content during ethanol precipitation and other factors on the preparation of raw material extract from Millettia speciosa Champ. instant tea. The raw materials of Millettia speciosa Champ.,Philippine flemingia root and radix fici simplicissimae were crushed into 10 mesh or finer powder,and cooked for 60 min. During ethanol precipitation,the ethanol content was about 50% to 70%,standing 12 h. The ophiopogon root was cooked in 1∶ 15 boiling water for 45 min,and chrysanthemum was leached for 45 min with 1∶ 20 demineralized water at 80 ℃. After concentration,preparation and spray drying,the finished Millettia speciosa Champ. instant tea was created. The detection of each product index indicated that Millettia speciosa Champ. instant tea had good taste and flavor,and there were no heavy metals,harmful substances and excessive microbes,thereby showing that the raw material of Millettia speciosa Champ. instant tea was selected reasonably,the mixture ratio was rational,and the processing technology was of some security,stability and maturity,which provided a theoretical basis for its development and application. | Maoyuan WANG Qing YANG Qinglong WANG Xiaoxia YAN Jianrong WANG Zhunian WANG | 2017 | Asian Agricultural Research2017，9，3： | 1 |
| 13 | Susceptibility Test of Culter mongolicus to Several Kinds of Common Drugs显示文摘[Objective] This study aimed to provide references for reasonable drug administration in Culter mongolicus and promote the development of its breeding industry.[Method] C. mongolicus was administrated with cypermethrin,mebendazole,trichlorfon,cupric sulfate,trichloroisocyanuric acid,povidone iodine and phoxim,respectively,to analyze its susceptibility to different drugs.[Result]C. mongolicus was very sensitive to cypermethrin; the median tolerance limit( TLM)at 48 h was 0. 072 mg / L,minimum lethal concentration was 0. 063- 0. 069 mg / L,safe concentration was 0. 021 6 mg / L. C. mongolicus was insensitive to mebendazole,trichlorfon,cupric sulfate,trichloroisocyanuric acid and povidone iodine. According to safe concentration of various drugs,C. mongolicus exhibited higher susceptibility to cypermethrin than to phoxim.[Conclusion] This study laid a solid foundation for better protection and development of C. mongolicus resources. | Qinglong JIANG Baohua YAN | 2015 | Agricultural Biotechnology2015，4，1： | 1 |
| 14 | Restructuring Tilth Layers Can Change the Microbial Community Structure and Affect the Occurrence of Verticillium Wilt in Cotton Field显示文摘Restructuring tilth layers(RTL)is a tillage method that exchanges the 0–20 and 20–40 cm soil layers that can be applied during cotton cultivation to increase cotton yield,eliminate weeds and alleviate severe disease,including Verticillium wilt.However,the mechanism by which RTL inhibits Verticillium wilt is unclear.Therefore,we investigated the distribution of microbial communities after rotary tillage(CK)and RTL treatments to identify the reasons for the reduction of Verticillium wilt in cotton fields subjected to RTL.Illumina high-throughput sequencing was used to sequence the bacterial and fungal genes.The disease incidence and severity of Verticillium wilt decreased by 28.57%and 42.64%,respectively,after RTL.Moreover,RTL significantly enhanced bacterial richness and evenness at 20–40 cm and-reduced the differences in fungal evenness and richness between soil depths of 0–20 and 20–40 cm.The number of Verticillium dahliae decreased,while the relative abundance of biocontrol bacteria such as Bacillus and Pseudoxanthomonas increased significantly following RTL.Overall RTL improved bacterial diversity,decreased the number of Verticillium dahliae and increased the relative abundance of biocontrol bacteria,which may have suppressed the occurrence of Verticillium wilt in cotton fields. | Ming Dong Yan Wang Shulin Wang Guoyi Feng Qian Zhang Yongzeng Lin Qinglong Liang Yongqiang Wang Hong Qi | 2023 | Phyton-International Journal of Experimental Botany2023，92，10： | 0 |
| 15 | Transmissibility of tuberculosis among students and non-students:an occupational-specific mathematical modelling显示文摘Background: Recently, despite the steady decline in the tuberculosis (TB) epidemic globally, school TB outbreaks have been frequently reported in China. This study aimed to quantify the transmissibility ofMycobacterium tuberculosis (MTB) among students and non-students using a mathematical model to determine characteristics of TB transmission.Methods: We constructed a dataset of reported TB cases from four regions (Jilin Province, Xiamen City, Chuxiong Prefecture, and Wuhan City) in China from 2005 to 2019. We classified the population and the reported cases under student and non-student groups, and developed two mathematical models [nonseasonal model (Model A) and seasonal model (Model B)] based on the natural history and transmission features of TB. The effective reproduction number (R(eff)) of TB between groups were calculated using the collected data.Results: During the study period, data on 456,423 TB cases were collected from four regions: students accounted for 6.1% of cases. The goodness-of-fit analysis showed that Model A had a better fitting effect (P < 0.001). The average R_(eff) of TB estimated from Model A was 1.68 [interquartile range (IQR): 1.20–1.96] in Chuxiong Prefecture, 1.67 (IQR: 1.40–1.93) in Xiamen City, 1.75 (IQR: 1.37–2.02) in Jilin Province, and 1.79 (IQR: 1.56–2.02) in Wuhan City. The average R_(eff) of TB in the non-student population was 23.30 times (1.65/0.07) higher than that in the student population.Conclusions: The transmissibility of MTB remains high in the non-student population of the areas studied, which is still dominant in the spread of TB. TB transmissibility from the non-student-to-student-population had a strong influence on students. Specific interventions, such as TB screening, should be applied rigorously to control and to prevent TB transmission among students. | Qiuping Chen Shanshan Yu Jia Rui Yichao Guo Shiting Yang Guzainuer Abudurusuli Zimei Yang Chan Liu Li Luo Mingzhai Wang Zhao Lei Qinglong Zhao Laurent Gavotte Yan Niu Roger Frutos Tianmu Chen | 2022 | Infectious Diseases of Poverty2022，11，6： | 0 |
| 16 | Geochemical evidence of paleogeography and paleoclimate during deposition of the 2nd Member of Kongdian Formation in Kongnan area显示文摘The 2nd Member of Kongdian Formation has been made up of a large number of oil shale and mudstone in the Kongnan aera of Huanghua depression around the Bohai Bay.In the Kongnan area,the lake basins were very large and deep during the deposition of the 2nd Member of Kongdian Formation.During that period,the lakes were sealed,uncommunicated with the sea water and the paleoclimate was very warm and wet in Kongnan area.Analyzing the content of the trace element and the rare earth element,carbon and oxygen isotope in the disquisition,The authors prove the two views correct. | Qinghua YAN Jing SUN Xudong ZHANG Qinglong MENG Man WANG | 2007 | Global Geology2007，10，1： | 0 |
| 17 | Rapid screening of SARS-CoV-2 inhibitors via ratiometric fluorescence of RBD–ACE2 complexes in living cells by competitive binding显示文摘To the Editor:The current coronavirus disease-19(COVID-19)pandemic spurs the development of antiviral drugs for SARS-CoV-2,as the number of patients with viral infections continues to rise globally in the context of widespread vaccination.Targeting the interaction between the receptor binding domain(RBD)of SARS-CoV-2 spike protein and the host cell ACE2 is a promising therapeutic strategy to effectively inhibit viral entry. | Lu Miao Wei Zhou Chunyu Yan Yuebin Zhang Qinglong Qiao Xuelian Zhou Yingzhu Chen Guangying Wang Zhendong Guo Jun Liu Hailong Piao Xia Pan Mengxue Yan Weijie Zhao Guohui Li Yueqing Li Zhaochao Xu | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 0 |
| 18 | GC-MS Analysis of Liposoluble Constituents from Calotropis gigantea Roots显示文摘[Objectives] To effectively develop Calotropis gigantea resources and find the biological active constituents with medicinal value.[Methods]The liposoluble constituents from C. gigantea roots were studied by GC-MS for the first time. [Results] 62 constituents were separated and identified from C. gigantea roots,amounting to 60. 43% of the total constituents,α-amyrin( 4. 18%),ethyl palmitate( 3. 49%),1,7-dimethyl-naphthalene( 3. 06%) were the main liposoluble constituents. [Conclusions] Cardiac glycoside was mainly found in methanol extracts and not detected in liposoluble constituents by extraction of petroleum ether. However,the present study found another component of low toxicity—naphthalene and its derivatives. | Maoyuan WANG Qing Yang Qinglong Wang Xiaoxia YAN Jianrong WANG Zhunian WANG | 2017 | Medicinal Plant2017，8，6： | 0 |
| 19 | Spatiotemporal characteristics of sea ice transport in the Baffin Bay and its association with atmospheric variability显示文摘Sea ice export through the Baffin Bay plays a vital role in modulating the sea ice cover variability in the Labrador Sea.In this study,satellite-derived sea ice products are used to obtain the sea ice area flux(SIAF)through the three passages in the Baffin Bay(referred to as A,B,and C for the north,middle,and south passages,respectively).The spatial variability of the monthly sea ice drift in the Baffin Bay is presented.The interannual variability and trends in SIAF via the three passages are outlined.The connection to several large-scale atmospheric circulation modes is assessed.Over the period of 1988-2015,the average annual(October to the following September)SIAF amounts to 555×10^(3) km^(2),642×10^(3) km^(2),and 551×10^(3) km^(2) through Passages A,B,and C,respectively.These quantities are less than that observed through the Fram Strait(FS,707×10^(3) km^(2))of the corresponding period.The positive trends in annual SIAF,on the order of 53.1×10^(3) km^(2)/(10 a)and 43.2×10^(3) km^(2)/(10 a)(significant at the 95%confidence level),are identified at Passages A and B,respectively.The trend of the south passage(C),however,is slightly negative(-13.3×10^(3) km^(2)/(10 a),not statistically significant).The positive trends in annual SIAF through the Passages A and B are primarily attributable to the significant increases after 2000.The connection between the Baffin Bay sea ice export and the North Atlantic Oscillation is not significant over the studied period.By contrast,the association with the cross-gate sea level pressure difference is robust in the Baffin Bay(R equals 0.69 to 0.71,depending on the passages considered),but relatively weaker than that over FS(R=0.74). | Weifu Sun Haibo Bi Min Fu Xi Liang Yunhe Wang Yu Liang Jue Huang Haijun Huang Liwen Yan Qinglong Yu Shuang Liang | 2021 | Acta Oceanologica Sinica2021，40，3： | 0 |
| 20 | ssDNA functionalized nanodiamonds for uranium decorporation显示文摘The hunt for agents that are suitable for actinide decorporation to reduce the whole-body load of actinide in accidental internal exposure is the ever-lasting goal in radiation protection and medical treatment in nuclear emergency.All current decorporation agents can be categorized as two groups,one is the molecular ligands,and the other is the nanoparticles decorated with molecular ligands.Here in this work,functional nanodiamonds(fN Ds)with ss DNA(the endogenous biomacromolecule rich in phosphate groups)loaded on the NDs is reported,which poses good uranyl adsorption selectivity,high cellular uptake,fast excretion,and effective decorporation of uranyl from rat renal proximal tubular epithelial cells(NRK-52E).All those results corroborate that f NDs can potentially serve as a brand new family of chelators for actinide decorporation. | Qinglong Yan Yu Miao Xiaomei Wang Jifei Ma Juan Diwu Ying Zhu Shuao Wang Chunhai Fan | 2022 | Chinese Chemical Letters2022，33，7： | 0 |
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