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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV显示文摘 | Juang Y T Wang Y Solomou E E | 2005 | J Clin Invest2005，115，4： | 1 |
| 3 | Adsorption of tannic acid, humic acid, and dyes from water using the composite of chitosan and activated clay显示文摘 | Chang M Y Juang R S | 2004 | Journal of Colloid and Interface Science2004，278，1： | 1 |
| 4 | An experimental investigation of the failure mechanism of simulated transversely isotropic rocks显示文摘 | Tien Y M Kuo M C Juang C H | 2006 | Int J Rock Mech Min Sci2006，43，8： | 1 |
| 5 | Protein phos- phatase 2A is a negative regulator of IL-2 production in patients with systemic lupus erythematosus 显示文摘 | Katsiari C G Kyttaris V C Juang Y T | 2005 | J Clin Invest2005，115，11： | 1 |
| 6 | Single-layered graphene oxide nanosheet/polyaniline hybrids fabricated through direct molecular ex{oliation显示文摘 | Chen G L Shau S M Juang T Y | 2011 | Langmuir2011，27，14： | 1 |
| 7 | Adsorption of tannic acid, humic acid, and dyes from water using the composite of chitosan and activated clay 显示文摘 | Chang M Y Juang R S | 2004 | Journal of Colloid and Interface Science2004，278，1： | 1 |
| 8 | Increased levels of NF-ATc2 differentially regulate CD154 and IL-2 genes in T cells from patients with systemic lupus erythematosus 显示文摘 | Kyttaxis V C Wang Y Juang Y T | 2007 | J Immunol2007，178，3： | 1 |
| 9 | Equilibrium sorption of copper( II )-ethylenedi- aminetetraacetic acid chelates onto cross-linked, polyaminated chi- tosan beads 显示文摘 | Juang R S Ju C Y | 1997 | Industrial and Engineering Chemistry Research1997，36，12： | 1 |
| 10 | Amino acid separation with D2 EHPA by solvent extraction and liquid surfactant membranes显示文摘 | R S Juang Y Y Wang | 2002 | Journal of Membrane Science2002，207，： | 1 |
| 11 | Stability analysis of existing slopes considering uncertainty显示文摘 | Jhi Y Y Lee D H | 1998 | Engineering Geology1998，49，2： | 1 |
| 12 | Adaptive fuzzy particle swarm optimization for global optimization of multimodal functions显示文摘 | Juang Y T Tung S L Chiu H C | 2011 | Information Sciences2011，181，20： | 1 |
| 13 | Direct transfer of p65 into T lymphocytes from systemic lupus erythematosus patients leads to increased levels of inter- leukin-2 promoter activity 显示文摘 | Herndon T M Juang Y T Solomou E E | 2002 | Clin Immunol2002，103，2： | 1 |
| 14 | Energy-efficient computing for wildlife tracking: design tradeoffs and early experiences with ZebraNet 显示文摘 | JUANG P OKI H WANG Y | 2002 | ACM Operating Systems Review2002，36，5： | 1 |
| 15 | Aggressive characteris tics of cervical cancer in young women in Taiwan显示文摘 | Lau HY Juang CM Chen Y J | 2009 | Int J Gynaecol Obstet2009，107，3： | 1 |
| 16 | Developing a semiquantitative occupational risk prediction model for chemical exposures and its application to a national chemical exposure databank显示文摘 | WANG S M WU T N JUANG Y J | 2013 | Int J Environ Res Public Health2013，10，8： | 1 |
| 17 | Preparation of protein-silicate hybrids from polyamine intercalation of layered montmorillonite显示文摘 | LIN J J WEI J C JUANG T Y | 2007 | Langmuir2007，23，4： | 1 |
| 18 | 显示文摘 | Chang M Y Juang R S | 2005 | Enzyme Microb Teehnol2005，36，： | 1 |
| 19 | Metal rejection by nanofiltration from diluted solutions in the presence of complexing agents显示文摘 | Lin S H Wang T Y Juang R S | | 0，，02： | 1 |
| 20 | Reliability analysis of rock wedge stability:Knowledge-based clustered partitioning approach显示文摘 | LEE Y F CHI Y Y JUANG C H | 2012 | Journal of Geotechnical and Geoenvironmental Engineering2012，138，6： | 1 |
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