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| 1 | Is rectal indomethacin effective in preventing of post-endoscopic retrograde cholangiopancreatography pancreatitis?显示文摘AIM:To investigate the effectiveness of rectally administered indomethacin in the prophylaxis of post-endoscopic retrograde cholangiopancreatography(ERCP)pancreatitis and hyperamylasaemia in a multicentre study.METHODS:A prospective,randomised,placebocontrolled multicentre study in five endoscopic units was conducted on 686 patients randomised to receive a suppository containing 100 mg indomethacin,or an inert placebo,10-15 min before ERCP.Post-ERCP pancreatitis and hyperamylasaemia were evaluated 24 h following the procedure on the basis of clinical signs and laboratory parameters,and computed tomography/magnetic resonance imaging findings if required.RESULTS:Twenty-one patients were excluded because of incompleteness of their data or because of protocol violation.The results of 665 investigations were evaluated:347 in the indomethacin group and 318 in the placebo group.The distributions of the risk factors in the two groups did not differ significantly.Pancreatitis developed in 42 patients(6.3%):it was mild in34(5.1%)and severe in eight(1.2%)cases.Hyperamylaesemia occurred in 160 patients(24.1%).There was no significant difference between the indomethacin and placebo groups in the incidence of either postERCP pancreatitis(5.8%vs 6.9%)or hyperamylasaemia(23.3%vs 24.8%).Similarly,subgroup analysis did not reveal any significant differences between the two groups.CONCLUSION:100 mg rectal indomethacin administered before ERCP did not prove effective in preventing post-ERCP pancreatitis. | Zoltán Dbrnte Zoltán Szepes Ferenc Izbéki Judit Gervain László Lakatos Gyula Pécsi Miklós Ihász Lilla Lakner Erzsébet Toldy László Czakó | 2014 | World Journal of Gastroenterology2014，20，29： | 16 |
| 2 | Restoration of energy level in the early phase of acute pediatric pancreatitis显示文摘Acute pancreatitis (AP) is a serious inflammatory disease with rising incidence both in the adult and pediatric populations. It has been shown that mitochondrial injury and energy depletion are the earliest intracellular events in the early phase of AP. Moreover, it has been revealed that restoration of intracellular ATP level restores cellular functions and defends the cells from death. We have recently shown in a systematic review and meta-analysis that early enteral feeding is beneficial in adults; however, no reviews are available concerning the effect of early enteral feeding in pediatric AP. In this minireview, our aim was to systematically analyse the literature on the treatmentof acute pediatric pancreatitis. The preferred reporting items for systematic review(PRISMA-P) were followed, and the question was drafted based on participants, intervention, comparison and outcomes: P: patients under the age of twenty-one suffering from acute pancreatitis; I: early enteral nutrition (per os and nasogastric- or nasojejunal tube started within 48 h); C: nil per os therapy; O: length of hospitalization, need for treatment at an intensive care unit, development of severe AP, lung injury (including lung oedema and pleural effusion), white blood cell count and pain score on admission. Altogether, 632 articles (Pub Med: 131; EMBASE: 501) were found. After detailed screening of eligible papers, five of them met inclusion criteria. Only retrospective clinical trials were available. Due to insufficient information from the authors, it was only possible to address length of hospitalization as an outcome of the study. Our mini-meta-analysis showed that early enteral nutrition significantly(SD = 0.806, P = 0.034) decreases length of hospitalization compared with nil per os diet in acute pediatric pancreatitis. In this minireview, we clearly show that early enteral nutrition, started within 24-48 h, is beneficial in acute pediatric pancreatitis. Prospective studies and better presentation of research are crucially needed to achieve a higher level of evidence. | Dóra Mosztbacher Nelli Farkas Margit Solymár Gabriella Pár Judit Bajor ákos Szucs József Czimmer Katalin Márta Alexandra Mikó Zoltán Rumbus Péter Varjú Péter Hegyi Andrea Párniczky | 2017 | World Journal of Gastroenterology2017，23，6： | 8 |
| 3 | Increased duodenal expression of mi R-146a and-155 in pediatric Crohn's disease显示文摘AIM: To evaluate the role of micro RNA(mi R)-146 a,-155 and-122 in the duodenal mucosa of pediatric patients with Crohn's disease(CD) and the effect of transforming growth factor-β(TGF-β) on these mi Rs in duodenal epithelial and fibroblast cells.METHODS: Formalin-fixed, paraffin-embedded biopsies derived from the macroscopically inflamed(CD inflamed: n = 10) and intact(CD intact: n = 10) duodenal mucosa of pediatric CD patients and control children(C: n = 10) were examined. Expression of mi R-146 a,-155 and-122 was determined by realtime polymerase-chain reaction(PCR). The expression of the above mi Rs was investigated in recombinant human TGF-β(1 nmol/L, 24 h) or vehicle treated small intestinal epithelial cells(CCL-241) and primary duodenal fibroblast cells derived from healthy children as well.RESULTS: Expression of mi R-146 a was significantly higher in the inflamed duodenal mucosa compared to the intact duodenal mucosa of children with CD(CD inflamed: 3.21 ± 0.50 vs CD intact: 0.62 ± 0.26, p ≤ 0.01) and to the control group(CD inflamed: 3.21 ± 0.50 vs C: 1.00 ± 0.33, p ≤ 0.05). The expression of mi R-155 was significantly increased in the inflamed region of the duodenum compared to the control group(CD inflamed: 4.87 ± 1.02 vs Control: 1.00 ± 0.40, p ≤ 0.001). The expression of mi R-122 was unchanged in the inflamed or intact mucosa of CD patients compared to controls. TGF-β treatment significantly decreased the expression of mi R-155 in small intestinal epithelial cells(TGF-β: 0.7 ± 0.083 vs Control: 1 ± 0.09, p ≤ 0.05) and also the expression of mi R-146a(TGF-β: 0.67 ± 0.04 vs Control: 1 ± 0.15, p ≤ 0.01) and mi R-155(TGF-β: 0.72 ± 0.09 vs Control: 1 ± 0.06, p ≤ 0.05) in primary duodenal fibroblasts compared to corresponding vehicle treated controls. TGF-β treatment did not influence the expression of mi R-122.CONCLUSION: The elevated expression of mi R-146 a and-155 in the inflamed duodenal mucosa of CD patients suggests the role of these mi Rs in the pathomechanism of inflammatory bowel disease. Antiinflammatory TGF-β plays an important role in the regulation of the expression of these mi Rs. | Dániel Szucs Nóra Judit Béres Réka Rokonay Kriszta Boros Katalin Borka Zoltán Kiss András Arató Attila J Szabó ádám Vannay Erna Sziksz Csaba Bereczki Gábor Veres | 2016 | World Journal of Gastroenterology2016，22，26： | 2 |
| 4 | Exploring measures and perceptions of fluency in the speech of second language learners显示文摘 | Judit Kormos Mariann Dénes | 2004 | System2004，，2： | 2 |
| 5 | An attempt to trace eutrophication in a shallow lake (Balaton, Hungary) using chironomids显示文摘 | Gy?rgy Dévai Judit Moldován | 1983 | Hydrobiologia1983，，1： | 1 |
| 6 | Enzymatic reso- lution of bicyclie 1,3-anno alcohols in organic media 显示文摘 | Judit K Johan V D E Antal P eta/ | 2001 | Tetrahedron :Asymmetry2001，12，4： | 1 |
| 7 | Purification and some properties of β-fructofuranosidase from Aspergillus niger IMI303386显示文摘 | QUANG D Nguyen JUDIT M REZESSY-Szab O | 2005 | Process Biochemistry2005，40，7： | 1 |
| 8 | Prevalence and risk factors of human papilloma virus infection in asymptomatic women in southeastern Hungary显示文摘 | Tibor A N La szlo K Judit D | 2004 | European Journal of Obstetrics & Gynecology and Reproductive Biology2004，115，1： | 1 |
| 9 | Clinical relations of methotrexate pharmacokinetics in the treatment for pediatric osteosarcoma显示文摘 | Marta Hegyi ágnes Gulácsi Edit Cságoly Katalin Csordás Olivér Eipel Dániel Erdélyi Judit Müller Karolina Nemes Orsolya Lautner-Csorba Gábor Kovács | 2012 | Journal of Cancer Research and Clinical Oncology2012，，10： | 1 |
| 10 | NF-κB in development and progression of human cancer显示文摘 | Xavier D David L Judit P | 2005 | Virchows Arch2005，446，5： | 1 |
| 11 | Multicentric plasmocytic Castleman’s disease with polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes syndrome and coexistent human herpes virus-6 infection – a possible relationship显示文摘 | á dá m Fazakas Má rta Csire Gy? rgy Berencsi á gota Szepesi Andrá s Matolcsy Lajos Jakab Istvá n kará di Judit Vá rkonyi | 2009 | Leukemia & Lymphoma2009，，： | 1 |
| 12 | Evaluation of mathematical models describing durg release fromlipophilic matrices显示文摘 | Judit D Istvan A | 1996 | Int J Pharm1996，145，1： | 1 |
| 13 | Changes of microbialpopulation and some components in carrot juice during fermentationwith selected Bifidobacterium strains显示文摘 | SZILARD K JUDIT M R QUANG D N | 2008 | Process Biochemistry2008，43，： | 1 |
| 14 | Changes of Microbial Population and some Components In Carrot Juice During Fermentation with Selected Bifidobacterium Strains 显示文摘 | SZILARD K JUDIT M R QUANG D N | 2008 | Process Biochemistry2008，43，： | 1 |
| 15 | Analysis of land-use/land-cover change in the Carpathian region based on remote sensing techniques 显示文摘 | Zsuzsanna D Judit Rita P | 2005 | Physics and Chemistry of the Earth2005，，30： | 1 |
| 16 | Ahered electrophysiological characteristics of developing rat cortical neurones after chronic methylmereury chloride treatment 显示文摘 | Ildiko V Judit D Ilona BP | 2000 | International Journal of Developmental Neuroscience2000，18，： | 1 |
| 17 | Micropropagation of apple:a review显示文摘 | Judit D Jaime A | 2010 | Biotechnological Advances2010，28，： | 1 |
| 18 | Evaluation of mathematical models describing durg release from lipophilic matrices 显示文摘 | Judit D Istvan A | 1996 | Int J Pharm1996，145，1： | 1 |
| 19 | Purification and some properties of β-fructofuranosidase from Aspergillus niger IMI303386显示文摘 | Quang D Nguyen Judit M Rezessy-Szab Mahalingeshwara K Bhat | 2005 | Process Biochemistry2005，40，： | 1 |
| 20 | Incidence, Paris Classification, and Follow-up in a Nationwide Incident Cohort of Pediatric Patients With Inflammatory Bowel Disease显示文摘 | Katalin E. Müller Péter L. Lakatos András Arató Judit B. Kovács ágnes Várkonyi Dániel Sz?cs Erzsébet Szakos Enik? Sólyom Márta Kovács Marianne Polgár éva Nemes Ildikó Guthy István Tokodi Gergely Tóth ágnes Horváth András Tárnok Noémi Csoszánszki Márta Bal | 2013 | Journal of Pediatric Gastroenterology and Nutrition2013，，5： | 1 |
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