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| 1 | Restoration of energy level in the early phase of acute pediatric pancreatitis显示文摘Acute pancreatitis (AP) is a serious inflammatory disease with rising incidence both in the adult and pediatric populations. It has been shown that mitochondrial injury and energy depletion are the earliest intracellular events in the early phase of AP. Moreover, it has been revealed that restoration of intracellular ATP level restores cellular functions and defends the cells from death. We have recently shown in a systematic review and meta-analysis that early enteral feeding is beneficial in adults; however, no reviews are available concerning the effect of early enteral feeding in pediatric AP. In this minireview, our aim was to systematically analyse the literature on the treatmentof acute pediatric pancreatitis. The preferred reporting items for systematic review(PRISMA-P) were followed, and the question was drafted based on participants, intervention, comparison and outcomes: P: patients under the age of twenty-one suffering from acute pancreatitis; I: early enteral nutrition (per os and nasogastric- or nasojejunal tube started within 48 h); C: nil per os therapy; O: length of hospitalization, need for treatment at an intensive care unit, development of severe AP, lung injury (including lung oedema and pleural effusion), white blood cell count and pain score on admission. Altogether, 632 articles (Pub Med: 131; EMBASE: 501) were found. After detailed screening of eligible papers, five of them met inclusion criteria. Only retrospective clinical trials were available. Due to insufficient information from the authors, it was only possible to address length of hospitalization as an outcome of the study. Our mini-meta-analysis showed that early enteral nutrition significantly(SD = 0.806, P = 0.034) decreases length of hospitalization compared with nil per os diet in acute pediatric pancreatitis. In this minireview, we clearly show that early enteral nutrition, started within 24-48 h, is beneficial in acute pediatric pancreatitis. Prospective studies and better presentation of research are crucially needed to achieve a higher level of evidence. | Dóra Mosztbacher Nelli Farkas Margit Solymár Gabriella Pár Judit Bajor ákos Szucs József Czimmer Katalin Márta Alexandra Mikó Zoltán Rumbus Péter Varjú Péter Hegyi Andrea Párniczky | 2017 | World Journal of Gastroenterology2017，23，6： | 8 |
| 2 | Medication adherence in schizophrenia显示文摘Non-adherence is a major problem in the treatment of schizophrenia. Its high prevalence, potentially severe consequences and associated costs make the study of this phenomenon a priority issue. In this article, basic non-adherence concepts of prevalence, consequences, evaluation methods, methodological restrictions of available studies, risk factors and intervention strategies, are reviewed. Studying non-adherence risk factors is a necessary step toward designing adequately oriented intervention strategies. An operative definition of adherence and good knowledge of its evaluation methods are essential to study this phenomenon. Unfortunately, most available studies contain methodological restrictions, especially concerning the evaluation methods, and an agreed operative definition of adherence has only very recently been reached. Knowing non-adherence risk factors, intervention strategies and available evidence on their effectiveness is essential in making treatment decisions in daily clinical practice. | Francisco Javier Acosta José Luis Hernández José Pereira Judit Herrera Carlos J Rodríguez | 2012 | World Journal of Psychiatry2012，2，5： | 5 |
| 3 | Increased duodenal expression of mi R-146a and-155 in pediatric Crohn's disease显示文摘AIM: To evaluate the role of micro RNA(mi R)-146 a,-155 and-122 in the duodenal mucosa of pediatric patients with Crohn's disease(CD) and the effect of transforming growth factor-β(TGF-β) on these mi Rs in duodenal epithelial and fibroblast cells.METHODS: Formalin-fixed, paraffin-embedded biopsies derived from the macroscopically inflamed(CD inflamed: n = 10) and intact(CD intact: n = 10) duodenal mucosa of pediatric CD patients and control children(C: n = 10) were examined. Expression of mi R-146 a,-155 and-122 was determined by realtime polymerase-chain reaction(PCR). The expression of the above mi Rs was investigated in recombinant human TGF-β(1 nmol/L, 24 h) or vehicle treated small intestinal epithelial cells(CCL-241) and primary duodenal fibroblast cells derived from healthy children as well.RESULTS: Expression of mi R-146 a was significantly higher in the inflamed duodenal mucosa compared to the intact duodenal mucosa of children with CD(CD inflamed: 3.21 ± 0.50 vs CD intact: 0.62 ± 0.26, p ≤ 0.01) and to the control group(CD inflamed: 3.21 ± 0.50 vs C: 1.00 ± 0.33, p ≤ 0.05). The expression of mi R-155 was significantly increased in the inflamed region of the duodenum compared to the control group(CD inflamed: 4.87 ± 1.02 vs Control: 1.00 ± 0.40, p ≤ 0.001). The expression of mi R-122 was unchanged in the inflamed or intact mucosa of CD patients compared to controls. TGF-β treatment significantly decreased the expression of mi R-155 in small intestinal epithelial cells(TGF-β: 0.7 ± 0.083 vs Control: 1 ± 0.09, p ≤ 0.05) and also the expression of mi R-146a(TGF-β: 0.67 ± 0.04 vs Control: 1 ± 0.15, p ≤ 0.01) and mi R-155(TGF-β: 0.72 ± 0.09 vs Control: 1 ± 0.06, p ≤ 0.05) in primary duodenal fibroblasts compared to corresponding vehicle treated controls. TGF-β treatment did not influence the expression of mi R-122.CONCLUSION: The elevated expression of mi R-146 a and-155 in the inflamed duodenal mucosa of CD patients suggests the role of these mi Rs in the pathomechanism of inflammatory bowel disease. Antiinflammatory TGF-β plays an important role in the regulation of the expression of these mi Rs. | Dániel Szucs Nóra Judit Béres Réka Rokonay Kriszta Boros Katalin Borka Zoltán Kiss András Arató Attila J Szabó ádám Vannay Erna Sziksz Csaba Bereczki Gábor Veres | 2016 | World Journal of Gastroenterology2016，22，26： | 2 |
| 4 | Drying of suspensions and solutions on inert particle surface in mechanically spouted bed dryer显示文摘To eliminate some disadvantages of the conventional spouted bed dryers the mechanically spouted bed (MSB) system was developed. This dryer type is convenient to use inert particles providing an increased surface area for drying of materials of high-moisture content and heat sensitive materials. On three different drying tasks are demonstrated the experimental optimization of process parameters to obtain products of demanded quality. The main object was at drying of AlO(OH) suspension to preserve the particle size under 2.5 m and to obtain product with a moisture content of about 0.05 kg/kg (d.b.). For this reason a very thin particle coating and intensive abrasion had to be assured. At drying of tomato concentrates the thermoplasticity makes the process very difficult. To jump over the deliquescent and sticky state developed at the critical temperature-moisture content values a very short drying time (8-10 s) must be provided. The third task was to form powder-like product from bovine serum albumin (BSA) solution having very low solid content (2-4%). The selected process parameters given in this paper resulted in a mean particle size of less than 20 m while the soluble preserved protein content was higher than 90%. | Elisabeth Pallai-Varsányi Judit Tóth János Gyenis | 2007 | China Particuology2007，5，5： | 2 |
| 5 | Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn’s disease patients显示文摘AIM:To investigate the interaction of interleukin-23 receptor(IL23R)(rs1004819 and rs2201841),autophagy-related 16-like 1(ATG16L1)(rs2241880), caspase recruitment domain-containing protein 15 (CARD15)genes,and IBD5 locus in Crohn's disease(CD) patients. METHODS:A total of 315 unrelated subjects with CD and 314 healthy controls were genotyped.Interactions and specific genotype combinations of a total of eight variants were tested.The variants of IBD5locus(IGR2198a_1 rs11739135 and IGR2096a_1 rs12521868),CARD15(R702W rs2066845 and L1007fs rs2066847),ATG16L1(rs2241880)and IL23R (rs1004819,rs2201841)genes were genotyped by PCR-RFLP,the G908R(rs2066844)in CARD15 was determined by direct sequencing. RESULTS:The association of ATG16L1 T300A with CD was confirmed[P=0.004,odds ratio(OR)=1.69, 95%CI:1.19-2.41],and both IL23R variants were found to represent significant risk for the disease(P= 0.008,OR=2.05,95%CI:1.20-3.50 for rs1004819 AA;P<0.001,OR=2.97,95%CI:1.65-5.33 for rs2201841 CC).Logistic regression analysis of pairwise interaction of the inflammatory bowel disease (IBD)loci indicated that IL23R,ATG16L1,CARD15 and IBD5(IGR2198a_1)contribute independently to disease risk.We also analysed the specific combina- tions by pair of individual ATG16L1,IL23R rs1004819, rs2201841,IGR2198a_1,IGR2096a_1 and CARD15 genotypes for disease risk influence.In almost all cases,the combined risk of susceptibility pairs was higher in patients carrying two different risk-associated gene variants together than individuals with just one polymorphism.The highest OR was found for IL23R rs2201841 homozygous genotype with combination of positive CARD15 status(P<0.001,OR=9.15,95% CI:2.05-40.74). CONCLUSION:The present study suggests a cumulative effect of individual IBD susceptibility loci. | Veronika Csngei Luca Járomi EnikSáfrány Csilla Sipeky Lili Magyari Bernadett Faragó Judit Bene Noémi Polgár Lilla Lakner Patrícia Sarlós Márta Varga Béla Melegh | 2010 | World Journal of Gastroenterology2010，16，2： | 2 |
| 6 | Elevated Levels of Anti- Helicobacter pylori Antibodies in Henoch–Sch?nlein Purpura显示文摘 | János Novák Zoltán Szekanecz Judit Sebesi Alajos Takáts Pál Demeter László Bene Sándor Sipka Zoltán Csiki | 2003 | Autoimmunity2003，，5： | 1 |
| 7 | Physico chemical modeling of the role of free radicals in photodynamic therapy 显示文摘 | ANDRAS N JUDIT J | 1999 | Biochemical and Biophysical Research Communications1999，255，： | 1 |
| 8 | Impact of Positive Intraabdominal Lavage Cytology on the Long-term Prognosis of Colorectal Cancer Patients显示文摘 | Rita Temesi László Sikorszki János Bezsilla ákos Botos Judit Kovács Tibor Tihanyi | 2012 | World Journal of Surgery2012，，11： | 1 |
| 9 | Solvent-free reduction of aromatic nitro compounds with alumina-supported hydrazine under microwave irradiation显示文摘 | József Dudás Judit Tóth | 2001 | Tetrahedron Letters2001，42，32： | 1 |
| 10 | Physicochemical modeling of the role of free radicals in hotodynamic therapy显示文摘 | ANDRAS N JUDIT J | 1999 | Biochemical and Biophysical Research Communications1999，255，： | 1 |
| 11 | Physicochemical modeling of the role of free radicals in photodynamic therapy显示文摘 | Andras N Judit J Tamas K | 1999 | Biochem Blophys Res Commun1999，255，： | 1 |
| 12 | Elevated Levels of Anti- Helicobacter pylori Antibodies in Henoch–Sch?nlein Purpura显示文摘 | János Novák Zoltán Szekanecz Judit Sebesi Alajos Takáts Pál Demeter László Bene Sándor Sipka Zoltán Csiki | 2003 | Autoimmunity2003，，5： | 1 |
| 13 | Clinico-Pathological Particularities of the Shock-Related Pancreatitis显示文摘 | Judit K Simona G Janos J | 2012 | Pathol Oncol Res2012，18，4： | 1 |
| 14 | Genetics of Rheumatoid Arthritis — A Comprehensive Review显示文摘 | Júlia Kurkó Timea Besenyei Judit Laki Tibor T. Glant Katalin Mikecz Zoltán Szekanecz | 2013 | Clinical Reviews in Allergy & Immunology2013，，2： | 1 |
| 15 | Detection of four lymphotropic herpesviruses in Hungarian Patients with multiple myeloma and lymphoma显示文摘 | Márta Csire Gábor Mikala Mónika Pet? Judit Jánosi Attila Juhász Attila Tordai János Jákó Gyula Domján János Dolgos Gy?rgy Berencsi István Vályi‐Nagy | 2007 | FEMS Immunology & Medical Microbiology2007，，： | 1 |
| 16 | Physico chemical modeling of the role of free radicals in photodynamic therapy显示文摘 | Andras N Judit J Tamas K | 1999 | Biochem Bioph Res Co1999，255，： | 1 |
| 17 | Overcoming resistance to bisphosphonates through the administration of alfacalcidol: results of a 1-year, open follow-up study显示文摘 | János Gaál Tamás Bender József Varga Irén Horváth Judit Kiss Péter Somogyi Péter Surányi | 2009 | Rheumatology International2009，，1： | 1 |
| 18 | C alleles on IBD5 locus of chromosome 5q31 region confer risk for Crohn’s disease in Hungarian patients显示文摘 | Lilla Lakner Veronika Cs?ngei Patrícia Sarlós Luca Járomi Enik? Sáfrány Márta Varga Péter Orosz Lili Magyari Judit Bene Pál Miheller Zsolt Tulassay Béla Melegh | 2009 | International Journal of Colorectal Disease2009，，5： | 1 |
| 19 | Prevalence of SLC22A4 1672T and SLC22A5 ?207C combination defined TC haplotype in Hungarian ulcerative colitis patients显示文摘 | Lili Magyari Judit Bene Katalin Komlósi Gábor Talián Bernadett Faragó Veronika Cs?ngei Luca Járomi Enik? Sáfrány Csilla Sipeky Lilla Lakner Márta Varga Beáta Gasztonyi Béla Melegh | 2007 | Pathology & Oncology Research2007，，1： | 1 |
| 20 | Toxicity and immune system effects of dietary deltamethrin exposure in tiger salamanders (Ambystoma tigerinum)显示文摘 | Jennifer M W F Judit E G S Douglas J F | 2009 | Journal of Toxicology and Environmental Health Part A2009，72，8： | 1 |
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