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| 1 | Liquid biopsy in patients with hepatocellular carcinoma: Circulating tumor cells and cell-free nucleic acids显示文摘Hepatocellular carcinoma(HCC), with its high incidence and mortality rate, is one of the most common malignant tumors. Despite recent development of a diagnostic and treatment method, the prognosis of HCC remains poor. Therefore, to provide optimal treatment for each patient with HCC, more precise and effective biomarkers are urgently needed which could facilitate a more detailed individualized decision-making during HCC treatment, including the following; risk assessment, early cancer detection, prediction of treatment or prognostic outcome. In the blood of cancer patients, accumulating evidence about circulating tumor cells and cell-free nucleic acids has suggested their potent clinical utilities as novel biomarker. This concept, so-called 'liquid biopsy' is widely known as an alternative approach to cancer tissue biopsy. This method might facilitate a more sensitive diagnosis and better decision-making by obtaining genetic and epigenetic aberrations that are closely associated with cancer initiation and progression. In this article, we review recent developments based on the available literature on both circulating tumor cells and cell-free nucleic acids in cancer patients, especially focusing on Hepatocellular carcinoma. | wataru okajima shuhei komatsu daisuke ichikawa mahito miyamae takuma ohashi taisuke imamura jun kiuchi keiji nishibeppu tomohiro arita hirotaka konishi atsushi shiozaki ryo morimura hisashi ikoma kazuma okamoto eigo otsuji | 2017 | World Journal of Gastroenterology2017，23，31： | 22 |
| 2 | 'Extended' radical cholecystectomy for gallbladder cancer:Long-term outcomes, indications and limitations显示文摘AIM:To delineate indications and limitations for 'ex tended' radical cholecystectomy for gallbladder cancer:a procedure which was instituted in our department in 1982. METHODS:Of 145 patients who underwent a radi cal resection for gallbladder cancer from 1982 through 2006, 52 (36%) had an extended radical cholecystec tomy, which involved en bloc resection of the gallblad der, gallbladder fossa, extrahepatic bile duct, and the regional lymph nodes (first-and second-echelon node groups). A retrospective analysis of the 52 patients was conducted including at least 5 years of follow up. Residual tumor status was judged as no residual tumor (R0) or microscopic/macroscopic residual tumor (R1 2). athological findings were documented according tothe American Joint Committee on Cancer Cancer Stag ing anual (7th edition). RESULTS:he primary t mor as classified as patho-logical T1 (pT1) in 3 patients, pT2 in 36, pT3 in 12, and pT4 in 1. Twenty three patients had lymph node metastases; 11 had a single positive node, 4 had two positive nodes, and 8 had three or more positive nodes. None of the three patients with pT1 tumors had nodal disease, whereas 23 of 49 (47%) with pT2 or more advanced tumors had nodal disease. One patient died during the hospital stay for definitive resection, giv ing an in hospital mortality rate of 2%. Overall survival (OS) after extended radical cholecystectomy was 65% at 5 years and 53% at 10 years in all 52 patients. OS differed according to the p classification ( < 0.001) and the nodal status ( = 0.010). All of 3 patients with pT1 tumors and most (29 of 36) patients with pT2 tu mors survived for more than 5 years. Of 12 patients with pT3 tumors, 8 who had an R1 2 resection, distant metastasis, or extensive extrahepatic organ involve ment died soon after resection. Of the remaining four pT3 patients who had localized hepatic spread through the gallbladder fossa and underwent an R0 resection, 2 survived for more than 5 years and another survived for 4 years and 2 mo. The only patient with pT4 tumor died of disease soon after resection. Among 23 node positive patients, 11 survived for more than 5 years, and of these, 10 had a modest degree of nodal disease (one or two positive nodes). CONCLUSION:Extended radical cholecystectomy is indicated for pT2 tumors and some pT3 tumors with localized hepatic invasion, provided that the regional nodal disease is limited to a modest degree (up to two positive nodes). Extensive pT3 disease, pT4 disease, or marked nodal disease appears to be beyond the scope of this radical procedure. | Yoshio Shirai Jun Sakata Toshifumi Wakai Taku Ohashi Katsuyoshi Hatakeyama | 2012 | World Journal of Gastroenterology2012，18，34： | 11 |
| 3 | 云南汉族HLA-DRB1多态性分析及与9个汉族群体的比较显示文摘应用聚合酶链反应—微孔板杂交 (PolymeraseChainReactionandMicrotitrePlateHybridization ,PCR MPH)的方法对云南 12 9个无亲缘关系的汉族样品进行了HLA DRB1的遗传多态性分析 ,对MPH初分出的DRB1 15组的样品进行了单链构象多态 (Single StrandConformationPolymorphism ,SSCP)检测。共发现 36种等位基因 ,其中等位基因频率大于 0 0 5的有DRB1 15 0 1(0 12 4 0 ) ,DRB1 0 90 12 (0 0 96 9) ,DRB1 0 80 32 (0 0 930 ) ,DRB1 12 0 2(0 0 891) ,DRB1 12 0 1(0 0 814 ) ,DRB1 14 0 1(0 0 775 ) ,DRB1 0 70 1(0 0 6 2 0 )。云南汉族HLA DRB1等位基因频率与中国其他 9个汉族群体进行 χ2 检验 ,结果显示与云南汉族比较 χ2 >10的有西安汉族 (DR8,χ2 =13 9712 )、上海汉族 (DR4 ,χ2 =10 16 32 )、广东汉族 (DR9,χ2 =12 6 12 1)和南京汉族 (DR4 ,χ2 =10 5 796 )。从遗传距离分析发现 ,在 9个国内汉族群体中云南汉族与辽宁汉族有最近的距离 (0 0 5 4 1) ,而与广东汉族最远 (0 185 1)。云南汉族在构成上可能与辽宁汉族更为接近 ,尽管地处南方 ,但已不属典型的南方汉族。这也可能因云南汉族与当地的少数民族存在基因交流 。 | 许绍斌 陶玉芬 黄小琴 初正韬 班贵宏 钱亚屏 OHASHI Jun TOKUNAGA Katsushi 褚嘉祐 | 2004 | 遗传2004，26，6： | 9 |
| 4 | The G/G Genotype of a Resistin Single-Nucleotide Polymorphism at ?420 Increases Type 2 Diabetes Mellitus Susceptibility by Inducing Promoter Activity through Specific Binding of Sp1/3显示文摘 | Haruhiko Osawa Kazuya Yamada Hiroshi Onuma Akiko Murakami Masaaki Ochi Hiroko Kawata Tatsuya Nishimiya Toshiyuki Niiya Ikki Shimizu Wataru Nishida Mitsuru Hashiramoto Azuma Kanatsuka Yasuhisa Fujii Jun Ohashi Hideichi Makino | 2004 | The American Journal of Human Genetics2004，，4： | 1 |
| 5 | Prospective and randomized clinical trial for the treatment of hepatocellular carcinoma—a comparison between L-TAE with Farmorubicin and L-TAE with Adriamycin: preliminary results (second cooperative study)显示文摘 | Saburo Kawai Masayoshi Tani Jun Okamura Makoto Ogawa Yasuo Ohashi Morito Monden Shigeki Hayashi Jushiro Inoue Yoshifumi Kawarada Mitsuo Kusano Yasuhiko Kubo Chikazumi Kuroda Yu Sakata Yoshiyuki Shimamura Kenji Jinno Akira Takahashi Kenichi Takayasu Kazuo | 1994 | Cancer Chemotherapy and Pharmacology1994，，1： | 1 |
| 6 | A Polymorphism in the AMPKα2 subunit gene is associated with insulin resistance and Type 2 diabetes in the Japanese population 显示文摘 | Momoko Horikoshi kazuo Hara Jun Ohashi | 2006 | Diabetes2006，55，5： | 1 |
| 7 | Association between epicardial adipose tissue volume and characteristics of non-calcified plaques assessed by coronary computed tomographic angiography显示文摘 | Toshiharu Oka Hideya Yamamoto Norihiko Ohashi Toshiro Kitagawa Eiji Kunita Hiroto Utsunomiya Ryo Yamazato Yoji Urabe Jun Horiguchi Kazuo Awai Yasuki Kihara | 2011 | International Journal of Cardiology2011，，1： | 1 |
| 8 | A replication study confirmed the EDAR gene to be a major contributor to population differentiation regarding head hair thickness in Asia显示文摘 | Akihiro Fujimoto Jun Ohashi Nao Nishida Taku Miyagawa Yasuyuki Morishita Tatsuhiko Tsunoda Ryosuke Kimura Katsushi Tokunaga | 2008 | Human Genetics2008，，2： | 1 |
| 9 | Comparison of Corneal and Aqueous Humor Penetration of Moxifloxacin, Gatifloxacin and Levofloxacin during Keratoplasty显示文摘 | Masahiko Fukuda Masakazu Yamada Shigeru Kinoshita Tsutomu Inatomi Yuichi Ohashi Toshihiko Uno Jun Shimazaki Yoshiyuki Satake Naoyuki Maeda Yuichi Hori Kohji Nishida Akira Kubota Toru Nakazawa Yoshikazu Shimomura | 2012 | Advances in Therapy2012，，4： | 1 |
| 10 | Prospective and randomized clinical trial for the treatment of hepatocellular carcinoma — a comparison of lipiodol-transcatheter arterial embolization with and without Adriamycin (first cooperative study)显示文摘 | Saburo Kawai Jun Okamura Makoto Ogawa Yasuo Ohashi Masayoshi Tani Jushiro Inoue Yoshifumi Kawarada Mitsuo Kusano Yasuhiko Kubo Chikazumi Kuroda Yu Sakata Yoshiyuki Shimamura Kenji Jinno Akira Takahashi Kenichi Takayasu Kazuo Tamura Naofumi Nagasue Yoshimi | 1992 | Cancer Chemotherapy and Pharmacology1992，，1： | 1 |
| 11 | Solar power sail mission of OKEANOS显示文摘The solar power sail is an original Japanese concept in which electric power is generated by thin-film solar cells attached on the solar sail membrane.Japan Aerospace Exploration Agency(JAXA)successfully demonstrated the world’s first solar power sail technology through IKAROS(Interplanetary Kite-craft Accelerated by Radiation of the Sun)mission in 2010.IKAROS demonstrated photon propulsion and power generation using thin-film solar cells during its interplanetary cruise.Scaled up,solar power sails can generate enough power to drive high specific impulse ion thrusters in the outer planetary region.With this concept,we propose a landing or sample return mission to directly explore a Jupiter Trojan asteroid using solar power sail-craft OKEANOS(Oversize Kite-craft for Exploration and AstroNautics in the Outer Solar System).After rendezvousing with a Trojan asteroid,a lander separates from OKEANOS to collect samples,and perform in-situ analyses in three proposed mission sequences,including sending samples back to Earth.This paper proposes a system design for OKEANOS and includes analyses of the latest mission. | Osamu Mori Jun Matsumoto Toshihiro Chujo Masanori Matsushita Hideki Kato Takanao Saiki Yuichi Tsuda Jun'ichiro Kawaguchi Fuyuto Terui Yuya Mimasu Go Ono Naoko Ogawa Yuki Takao Yuki Kubo Kaoru Ohashi Ahmed Kiyoshi Sugihara Tatsuaki Okada Takahiro Iwata Hajime Yano | 2020 | Astrodynamics2020，4，3： | 0 |
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