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| 1 | Characterization of Hand,Foot,and Mouth Disease in China between 2008 and 2009显示文摘Objective To investigate the epidemiological and clinical features of hand,foot and mouth disease (HFMD) since several outbreaks of HFMD caused by enteroviruses were documented in China between 2007 and 2008.Methods HFMD cases reported to the National Infectious Disease Information Management System database between May 2008 and April 2009 were assessed.Clinical features in some of the severe and fatal cases were analyzed the etiology of the outbreaks was investigated.Results 89.1% of reported HFMD cases were found in children<5 year‐old with an age‐specific incidence rate of 834.1/100 000 in the first year as the notifiable disease in China from May 2008 to April 2009.The incidence,mortality and percentage of severe cases were studied for three regions of China and found to be highest in the central region.The incidence of severe cases and mortality in rural population were significantly higher than those in urban population.Among the laboratory confirmed EV17 positive cases there were 52.6% mild,83.5% severe,and 96.1% fatal cases.More myoclonic jerks were found in the severe case group than in group that died.Tachypnea,lip purpling,pink foaming and low limb temperature occurred more frequently in the fatal cases than in the severe cases.Conclusion The epidemic of HFMD in China was characterized predominantly by EV71 infections,had relatively high mortality rates especially in the central region,and was most prevalent in young,rural populations. | ZHANG Jing SUN JunLing CHANG ZhaoRui ZHANG WeiDong WANG ZiJun FENG ZiJian | 2011 | Biomedical and Environmental Sciences2011，24，3： | 74 |
| 2 | Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known liver-restorative herb Polygonum multiflorum显示文摘草药的药最近在美国作为导致药的肝损害(DILI ) 的第二个很普通的原因被认出了。然而,识别一些植物的 DILI 诱发性的可靠方法例如 Heshouwu (蓼 multiflorum 的弄干的根) ,留下缺乏。在这研究,有肝机能障碍和 Heshouwu DILI 的 147 个报导文学的案例的 12 307 个住院病人的一个总数被屏蔽。一个一般算法仅仅显示了那 22.5%(9/40 ) 并且(45/147 ) 分别地, 30.6% 所有住院和文学案例报告表明 Heshouwu 的 DILI 诱发性的高概率。由对比,(19/20 )95% 生药学,植物化学,和 metabolomic 有希望地调查的所有情况测试展出高度可能的诱发性,包括不正确地以前被归因的一个病人和从由 pharmacognostic 证据的 Heshouwu 诱发性被排除的一个案例。污染也是的毒素(重金属,杀虫剂,和 mycotoxins ) 从 Heshouwu DILI 诱发性排除了。为 Heshouwu DILI 诊断地址安全的这些屏蔽方法的客观性担心考虑包含芪的草药的药和饮食的补充。 | Jiabo Wang Zhijie Ma Ming Niu Yun Zhu Qingsheng Liang Yanling Zhao Jingyuan Song Zhaofang Bai Yaming Zhang Ping Zhang Na Li Yakun Meng Qi Li Lushan Qin Guangju Teng Junling Cao Baosen Li Shilin Chen Yonggang Li Zhengsheng Zou Honghao Zhou Xiaohe Xiao | 2015 | Frontiers of Medicine2015，9，4： | 47 |
| 3 | Chemical characterization of size-resolved aerosols in four seasons and hazy days in the megacity Beijing of China显示文摘Size-resolved aerosol samples were collected by MOUDI in four seasons in 2007 in Beijing. The PM10 and PM1.8mass concentrations were 166.0 ± 120.5 and 91.6 ± 69.7 μg/m^3, respectively,throughout the measurement, with seasonal variation: nearly two times higher in autumn than in summer and spring. Serious fine particle pollution occurred in winter with the PM1.8/PM10 ratio of 0.63, which was higher than other seasons. The size distribution of PM showed obvious seasonal and diurnal variation, with a smaller fine mode peak in spring and in the daytime. OM(organic matter = 1.6 × OC(organic carbon)) and SIA(secondary inorganic aerosol) were major components of fine particles, while OM, SIA and Ca_2+were major components in coarse particles. Moreover, secondary components, mainly SOA(secondary organic aerosol) and SIA,accounted for 46%–96% of each size bin in fine particles, which meant that secondary pollution existed all year. Sulfates and nitrates, primarily in the form of(NH_4)_2SO_4, NH_4NO_3, Ca SO_4, Na_2SO_4 and K_2SO_4, calculated by the model ISORROPIA II, were major components of the solid phase in fine particles. The PM concentration and size distribution were similar in the four seasons on non-haze days, while large differences occurred on haze days, which indicated seasonal variation of PM concentration and size distribution were dominated by haze days. The SIA concentrations and fractions of nearly all size bins were higher on haze days than on non-haze days, which was attributed to heterogeneous aqueous reactions on haze days in the four seasons. | Kang Sun Xingang Liu Jianwei Gu Yunpeng Li Yu Qu Junling An Jingli Wang Yuanhang Zhang Min Hu Fang Zhang | 2015 | Journal of Environmental Sciences2015，27，6： | 19 |
| 4 | Enhancing both selectivity and coking-resistance of a single-atom Pd1/C3N4 catalyst for acetylene hydrogenation显示文摘选择加氢是在化学升级的一个重要工业催化过程,在因为他们的高加氢活动,基于 Pd 的催化剂广泛地被使用的地方。然而,因为重焦炭形成,差的选择和短催化剂一生是主要担心。在这个工作,原子地驱散 Pd 原子成功地在 graphitic 碳氮化物上被综合(g-C 3 用原子层免职的 N 4) 。没有 Pd nanoparticle (NP ) ,改正错误的高角度的环形的黑暗地的扫描传播电子显微镜学(HAADF 茎) 证实了孤立的 Pd 原子的主导的存在形成。在在过量乙烯的乙炔的选择加氢期间, g-C 3 N 4-supported Pd NP 催化剂比常规 Pd/Al 2 O 3 和 Pd/SiO 2 催化剂。在原处, X 光检查光致核裂变光谱学表明可观的费用从 Pd NP 转到 g-C 3 N 4 多半在催化表演改进起一个重要作用。更给人深刻印象地,单个原子的 Pd 1/C3 N 4 催化剂展出了两种更高的乙烯选择和更高的 coking 抵抗。我们的工作证明单个原子的 Pd 催化剂是在加氢反应改进选择和焦炭抵抗的一个有希望的候选人。 | Xiaohui Huang Yujia Xia Yuanjie Cao Xusheng Zheng Haibin Pan Junfa Zhu Chao Ma Hengwei Wang Junjie Li Rui You Shiqiang Wei Weixin Huang Junling Lu | 2017 | Nano Research2017，10，4： | 16 |
| 5 | Environmental magnetism and paleoclimatic interpretation of the Sanmenxia loess-paleosol sequence in the southeastern extremity of the Chinese Loess Plateau显示文摘这是多参数矿物质的一份报告在在间隔 ofL1 上的中国黄土高原(CLP ) 的 SE 极限的 Sanmenxialoess-paleosol 两行诗的磁性的结果 - 跨越最后 1 个妈的 L13。这些结果显示出那团特定的磁性的危险性(x) , Xarm 和 SIRM,他们的比率展出平行 stratigraphic 变化。Sincesuperparamagnetic (SP ) 粒子有重要贡献到到顽磁的 X 而是没有贡献,例如,手臂和 SIRM,在 x 之间的强壮的线性关联一(i 顽磁(例如, ARMand SIRM ) 建议生产成土作用的磁性的谷物是主要在里面小单个领域范围。因而,到想在以前的研究的体积 x 的 SP 粒子的重要贡献显然被过高估计。在 Sanmenxia 和中部的谷物尺寸的 2arm/X 数据从 CLP 显示的内地典型黄土节记录强壮的相似,暗示 Jarm/X 可以为监视变化 offerrimagnetic 谷物被认为是可靠指示物缩放。S 比率和 HIRM 的结果((SIRM+IRM_(.3T ))/2 ) 大小显示在与成土作用联系的 paleosols 有软磁铁矿 / 磁赤铁矿和 hardhematite/goethite 的重要改进。 | WANG Xisheng YANG Zhenyu Reidar Levlie SUN Zhiming PEI Junling | 2006 | Chinese Science Bulletin2006，51，22： | 15 |
| 6 | Initial study of biexponential model of intravoxel incoherent motion magnetic resonance imaging in evaluation of the liver fibrosis显示文摘 | Chen Cuiyun Wang Bin Shi Dapeng Fu Fangfang Zhang Jiliang Wen Zejun Zhu Shaocheng Xu Junling Lin Qing Li Jing Dou Shewei | 2014 | Chinese Medical Journal2014，，17： | 15 |
| 7 | Insight of the stability and activity of platinum single atoms on ceria显示文摘Single-atom catalysts (SACs) have recently attracted broad attention in the catalysis field due to their maximized atom efficiency and unique catalytic properties.An atomic-level understanding of the interaction between the metal atoms and support is vital for developing stable and high-performance SACs.In this work,Pt1 single atoms with Ioadings up to 4 wt.% were fabricated on ceria nanorods using the atomic layer deposition technique.To understand the Pt-O-Ce bond interfacial interactions,the stability of Pt1 single atoms in the hydrogen reducing environment was extensively investigated by using in situ diffuse reflectance infrared Fourier transform spectroscopy CO chemisorption measurements.It was found that ceria defect sites,metal Ioadings and high-temperature calcination are effective ways to tune the stability of Pt1 single atoms in the hydrogen environment.X-ray photoemission spectroscopy further showed that Pt1 single atoms on ceria are dominantly at a +2 valence state at the defect and step edge sites,while those on terrace sites are at a +4 state.The above tailored stability and electronic properties of Pt1 single atoms are found to be strongly correlated with the catalytic activity in the dry and water-mediated CO oxidation reactions. | Xuxu Ye Hengwei Wang Yue Lin Xinyu Liu Lina Cao Jian Gu Junling Lu | 2019 | Nano Research2019，12，6： | 13 |
| 8 | Adaptive immune-genetic algorithm for global optimization to multivariable function显示文摘An adaptive immune- genetic algorithm (ALGA) is proposed to avoid premature convergence and guarantee the diversity of the population.Rapid immune response (secondary response),adaptive mutation and density operators in the AIGA are emphatically designed to improve the searching ability,greatly increase the converging speed,and decrease locating the local maxima due to the premature convergence.The simulation results obtained from the global optimization to four multivariable and multi-extreme functions show that AIGA converges rapidly,guarantees the diversity,stability and good searching ability. | Dai Yongshou Li Yuanyuan Wei Lei Wang Junling Zheng Deling | 2007 | Journal of Systems Engineering and Electronics2007，18，3： | 9 |
| 9 | Anlotinib suppresses lymphangiogenesis and lymphatic metastasis in lung adenocarcinoma through a process potentially involving VEGFR-3 signaling显示文摘Objective:Lymphatic metastasis is one of the leading causes of malignancy dispersion in various types of cancer.However,few anti-lymphangiogenic drugs have been approved for clinical use to date.Therefore,new therapies to block lymphangiogenesis are urgently required.Methods:Immunohistochemistry,immunofluorescence,Western blot,migration assays,and lymphangiogenesis and lymphatic metastasis assays were used.Results:Anlotinib,a receptor tyrosine kinase inhibitor,suppressed the rate of new metastatic lesions(31.82%in the placebo arm and 18.18%in the anlotinib arm)in patients with advanced lung adenocarcinoma who were enrolled in our ALTER-0303 study.D2-40+-lymphatic vessel density was strongly correlated with disease stage,metastasis,and poor prognosis in 144 Chinese patients with lung adenocarcinoma.In mice bearing A549EGFP tumors,tumor lymphatic vessel density,tumor cell migration to lymph nodes,and the number of distant metastatic lesions were lower in the anlotinib group than in the controls.Anlotinib inhibited the growth and migration of human lymphatic endothelial cells(hLECs)and lymphangiogenesisin vitro andin vivo.Treatment of hLECs with anlotinib downregulated phosphorylated vascular endothelial growth factor receptor 3(VEGFR-3).Conclusions:Anlotinib inhibits lymphangiogenesis and lymphatic metastasis,probably through inactivating VEGFR-3 phosphorylation.The results indicate that anlotinib may be beneficial for treatment in avoiding lymphangiogenesis and distant lymphatic metastasis in lung adenocarcinoma.(Trial registration:ALTER0303;NCT02388919;March 17,2015.) | Tingting Qin Zhujun Liu Jing Wang Junling Xia Shaochuan Liu Yanan Jia Hailin Liu Kai Li | 2020 | Cancer Biology & Medicine2020，17，3： | 9 |
| 10 | Detection of ALK translocation in non-small cell lung carcinoma(NSCLC) and its clinicopathological significance using the Ventana immunohistochemical staining method: a single-center large-scale investigation of 1,504 Chinese Han patients显示文摘Objective: The novel fully automated immunohistochemistry(IHC) assay-Ventana anaplastic lymphoma kinase(ALK)-D5F3 for screening ALK rearrangements has been approved by China's Food and Drug Administration in 2013, our previous study disclosed a highly specificity and sensitivity nearly 100%, and its efficacy needs to be evaluated in a large cohort of primary lung adenocarcinoma patients, and to compare clinicopathological features with ALK(+) and ALK(-) lung adenocarcinoma.Methods: A total of 1,504 consecutive surgical lung adenocarcinoma cases of Chinese Han population were collected and re-diagnosed according to the 2011 multidisciplinary classification of lung adenocarcinoma.Fully automated Ventana ALK-D5F3 IHC staining with a binary scoring was adopted to evaluate staining and correlated with clinicopathological characters, including age, sex, differentiation degree, histological subtype, lymph node metastasis, and clinical staging.ALK(+) patients were followed-up, and targeted therapy of ALKinhibitors was adopted and observed in patients with stage Ⅳ according to the NCCN guideline.Results: ALK positive adenocarcinomas were identified in 6.6% of the surgically resected 1,504 NSCLCs, and significantly younger than the negative group(P<0.05).Mucinous adenocarcinoma(28.2%) was determined to be predominant in ALK(+) cases, followed by the solid type(11.7%), specific type(6.8%), papillary type(5.6%), acinar type(5.5%), and lepidic type(3.1%), and the differences were statistically significant(χ~2=42.011, P<0.05).ALK(+) adenocarcinoma with lymph node metastasis(10.8%) were significantly higher than that without lymph node metastasis(4.5%)(χ~2=19.809, P<0.05); and ALK(+) in phase Ⅳ(20%) was significantly higher than phase Ⅲ(12.9%), phase Ⅱ(4.2%), phase Ⅰ(4.5%), and phase 0(0)(χ~2=36.068, P<0.05).Multivariate logistic regression disclosed that patient age, AJCC staging, and histological mucinous subtype were correlated with ALK positive staining(OR=0.959, 1.578, 5.036, respectively).Sixty eight patients had followed-up results, five patients out of which primarily diagnosed or progressed into Stage Ⅳ benefited well from targeted therapy with Crizotinib.Conclusions: The ALK fusion protein was seen in 6.6% Chinese NSCLC patients, and mostly seen in younger, clinically higher staging, mucinous and solid predominant adenocarcinoma.Clinical trials in patients of Stage Ⅳ confirmed that ALK-D5F3 Ventana IHC is serviceable in screening ALK-positive candidates for molecular targeted therapy. | Lin Yang Yun Ling Lei Guo Di Ma Xuemin Xue Bingning Wang Junling Li Jianming Ying | 2016 | Chinese Journal of Cancer Research2016，28，5： | 8 |
| 11 | Velvet antler polypeptide is able to induce differentiation of neural stem cells towards neurons in vitro显示文摘OBJECTIVE: To investigate the neural differentiation capacity of water extraction of velvet antler.METHODS: Velvet antler(Cervus Nippon Temminck) polypeptide(VAP) was used to differentiate neural stem cells(NSCs) towards neurons in the study. Firstly, we obtain the polypeptides of VAP by water extraction. Secondly, we observed the morphology, assayed the factors in the media by enzyme-linked immunosorbent assay, and detected the special neural molecules by immuno fl uorescence staining. NSCs were cultured on the cell climbing film. After neuronal differentiation, differentiated NSCs were mounted for immunocytochemistry with immunofluorescence technique.RESULTS: The differentiating cells look like neuron,some special factors, such as Glial cell line-derived neurotrophic factor, nerve growth factor, in the media can be detected while differentiated neuron-like cells can express the special neural molecules.CONCLUSION: Differentiation of NSCs towards neurons can be induced by velvet antler polypeptide. | Zhang Lihong Zhuang Zhihong Sun Yanan Ma Shuhua Yang Weifeng Lei Hongtao Zuo Junling Ouyang Jingfeng Wang Yi | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 8 |
| 12 | Bamboo Leaf and Pollen Fossils from the Late Miocene of Eastern Zhejiang,China and their Phytogeological Significance显示文摘Fossil bamboo leaves and pollen from Upper Miocene deposits of the Shengxian Formation in Tiantai and Ninghai counties,eastern Zhejiang,China represent a rare record in Asia.The distinctive pseudopetiole and parallel venation of the leaf blades and the clearly thickened annulus of the pollen aperture place them in the subfamily Bambusoideae.Morphological analysis supports the determination of these fossil leaves as belonging to the genus Bambusium and two new species are described.Bambusium latipseudopetiolus Q.J.Wang et B.N.Sun sp.nov.has a distinctly wide pseudopetiole of 0.23 cm in width and 0.40 cm in length,several vascular bundles on parallel veins,and 5–8 lateral veins on both sides of the midrib.Bambusium longipseudopetiolus Q.J.Wang et B.N.Sun sp.nov.has a distinctly long pseudopetiole of 0.60 cm in length and 0.10 cm in width,several vascular bundles on the pseudopetiole,and 6 lateral veins on both sides of the midrib.Pollen grains from the same layer provide additional evidence of bamboos.They are characterized by 32.0–51.0 μm in diameter,a round pore 3.0–4.0 μm in diameter with a broad thickened annulus 2.5–3.5 μm around,and several conspicuous secondary folds on the exine surface.The morphological analysis leads to their assignment to Graminidites bambusoides Stuchlik.These fossils are important for the study of bamboo phytogeography in China.They demonstrate that there were bamboos growing in southeastern China during the Late Miocene and that bamboos in Zhejiang begin to diversify no later than the Late Miocene.In combination with bamboo fossils from other places,it seems that bamboos had a wide distribution across southern China during the Miocene,ranging from southwestern Yun'nan to southeastern Zhejiang. | WANG Qiujun MA Fujun YANG Yi DONG Junling WANG Haofei LI Ruiyun XU Xiaohui SUN Bainian | 2014 | Acta Geologica Sinica(English Edition)2014，88，4： | 7 |
| 13 | A method for satellite time series anomaly detection based on fast-DTW and improved-KNN显示文摘In satellite anomaly detection,there are some problems such as unbalanced sample distribution,fewer fault samples,and unobvious anomaly characteristics.These problems cause the extisted anomaly detection methods are difficult to train accurate classification model,and the accuracy of anomaly detection is hard to improve.At the same time,the monitoring data of satellite has high dimension and is difficult to extract effective features.Based on the DTW over-sampling method,this paper realizes the over-sampling of fault samples in satellite time series,and constructs a distributed and balanced time series data set.The Fast-DTW method is applied to calculate the distance between different time series,which can improve the speed of similarity calculation.KNN(K-Nearest Neighbor)method is applied for classification and the best classification result is obtained by search the optimal hyper-parameters k.The results show that the proposed method has high anomaly detection accuracy and consumes short calculation time. | Langfu CUI Qingzhen ZHANG Yan SHI Liman YANG Yixuan WANG Junle WANG Chenggang BAI | 2023 | Chinese Journal of Aeronautics2023，36，2： | 7 |
| 14 | Correlation between the cumulative analgesic effect of electroacupuncture intervention and synaptic plasticity of hypothalamic paraventricular nucleus neurons in rats with sciatica显示文摘In the present study, a rat model of chronic neuropathic pain was established by ligation of the sciatic nerve and a model of learning and memory impairment was established by ovariectomy to investigate the analgesic effect of repeated electroacupuncture stimulation at bilateral Zusanli (ST36) and Yanglingquan (GB34). In addition, associated synaptic changes in neurons in the paraventricular nucleus of the hypothalamus were examined. Results indicate that the thermal pain threshold (paw withdrawal latency) was significantly increased in rats subjected to 2-week electroacupuncture intervention compared with 2-day electroacupuncture, but the analgesic effect was weakened remarkably in ovariectomized rats with chronic constrictive injury. 2-week electroacupuncture intervention substantially reversed the chronic constrictive injury-induced increase in the synaptic cleft width and thinning of the postsynaptic density. These findings indicate that repeated electroacupuncture at bilateral Zusanli and Yanglingquan has a cumulative analgesic effect and can effectively relieve chronic neuropathic pain by remodeling the synaptic structure of the hypothalamic paraventricular nucleus. | Qiuling Xu Tao Liu Shuping Chen Yonghui Gao Junying Wang Lina Qiao Junling Liu | 2013 | Neural Regeneration Research2013，8，3： | 6 |
| 15 | Petroleum Exploration of Craton Basins in China显示文摘Craton basins are a significant petroliferous provenance. Having undergone multiple open- close tectonic cycles and strong reworking of the late Cenozoic tectonic movement, the craton basins in China are highly broken. This has resulted in multi-source and multiphase hydrocarbon generation and later hydrocarbon accumulation so that a complicated spatial assemblage of primary, para- primary and secondary oil-gas pools has been formed. The primary factors controlling hydrocarbon accumulation include hydrocarbon-generating depressions, paleouplifts, paleoslopes, unconformity surfaces, paleo-karst, faults and fissure systems as well as the later conservation conditions. In consequence, the strategy of exploration for China’s craton basins is to identify the effective source rocks, pay attention to the different effects of paleohighs and late reworking, enhance studies of the secondary storage space, attach importance to the exploration of lithologic oil-gas reservoirs and natural gas pools, and approach consciously from the secondary oil pools to the targets near the source rocks. At the same time, a complete system of technologies and techniques must be built up. | ZHANG Kang WANG Junling | 2006 | Acta Geologica Sinica(English Edition)2006，80，1： | 6 |
| 16 | Sequential therapy according to distinct disease progression patterns in advanced ALK-positive non-small-cell lung cancer after crizotinib treatment显示文摘Objective: Crizotinib is recommended as the first-line therapy for advanced anaplastic lymphoma kinase(ALK)-positive non-small-cell lung cancer(NSCLC). Despite its initial efficacy, patients ultimately acquire resistance to crizotinib within 1 year. In such patients, the optimal sequential therapy after crizotinib treatment remains unknown. This study explored which sequential therapy option confers the greatest benefit.Methods: A total of 138 patients with advanced ALK-positive NSCLC resistant to crizotinib were studied. Based on patterns of disease progression of metastases, patients were divided into 3 groups: brain progression, non-liver progression, and liver progression. Sequential therapies included crizotinib continuation plus local therapy, nextgeneration ALK inhibitors(ALKi's), and chemotherapy. The primary endpoint was overall survival(OS) from the time of crizotinib resistance to death or last follow-up.Results: The 138 patients included 64 cases with progression in brain, 57 cases in non-liver sites and 17 cases in liver. A significant difference in OS was observed among the distinct progression pattern(median OS, 25.4 months in brain, 15.8 months in non-liver, and 10.8 months in liver, respectively, P=0.020). The difference in OS among sequential therapies was statistically significant in the non-liver progression group(median OS, 27.6 months with next-generation ALKi's, 13.3 months with crizotinib continuation, and 10.8 months with chemotherapy,respectively, P=0.019). However, crizotinib continuation plus local therapy seems to provide non-inferior median OS compared with next-generation ALKi's for patients with brain progression(median OS, 28.9 months vs.32.8 months, P=0.204). And no significant differences in OS were found in patients with progression in liver(P=0.061).Conclusions: Crizotinib continuation together with local therapy might be a feasible strategy for patients with progression in brain beyond crizotinib resistance, as well as next-generation ALKi's. Next-generation ALKi's tended to provide a survival benefit in patients with non-liver progression. | Haiyan Xu Di Ma Guangjian Yang Junling Li Xuezhi Hao Puyuan Xing Lu Yang Fei Xu Yan Wang | 2019 | Chinese Journal of Cancer Research2019，31，2： | 6 |
| 17 | A Review on Particle Size Effect in Metal-Catalyzed Heterogeneous Reactions显示文摘Size of metal nanoparticles(NPs)plays decisive roles in metal-catalyzed heterogeneous reactions,due to the drastic variation of the geometric and electronic properties of metal NPs with size.Along with the development of controlled catalyst synthesis,tremendous efforts have been devoted to understanding the nature of the particle size effect.In particular,identification of the individual roles of size-dependent geometric and electronic effects on metal-catalyzed reactions is essential,but remains challenging since they are tightly hybridized together with particle size variation.In this review,w e first discuss the fundamentals of the size-dependent geometric and electronic properties of metal NPs and their crucial roles in catalysis in general.Then we summarize the previous representative studies of the particle size effect,metal-by-metal,in heterogeneous catalysis.We highlighted the extension of particle size effect to ultrafine cluster and single-atom catalysts,the new frontiers in heterogeneous catalysis.In the followings,we further introduce the recent advances in disentangling the size-dependent geometric and electronic effects and unveiling their individual contributions to catalysis.Finally,we discuss the challenges and perspectives of investigations on the size effect in metal catalysis for the future studies. | Hengwei Wang Junling Lu | 2020 | Chinese Journal of Chemistry2020，38，11： | 5 |
| 18 | Blockchain-Based Dynamic Group Key Agreement Protocol for Ad Hoc Network显示文摘Group key agreement(GKA)is one of the key technologies for ensuring information exchange security among group members.While GKA is widely used in secure multi-party computation,safety of resources sharing,and distributed collaborative computing.It still has some security flaws and limitations.We proposes a Blockchain-based dynamic Group key agreement(BDGKA)protocol.In contrast to prior works,BDGKA differs in several significant ways:1)anonymous identity authentication-it can prevent privacy leaks;2)traceability-it can track illegal operating entities;3)load balancing-it balances computation and communication to each node,avoiding the breakdown of single-point and network bottlenecks.This protocol is proven secure under the hardness assumption of decision bilinear DiffieHellman.The performance analysis shows that it is more efficient than the referred works. | ZHANG Qikun WANG Bingli ZHANG Xiaosong YUAN Junling WANG Ruifang | 2020 | Chinese Journal of Electronics2020，29，3： | 5 |
| 19 | Inhibition of gasdermin D-dependent pyroptosis attenuates the progression of silica-induced pulmonary inflammation and fibrosis显示文摘Silicosis is a leading cause of occupational disease-related morbidity and mortality worldwide,but the molecular basis underlying its development remains unclear.An accumulating body of evidence supports gasdermin D(GSDMD)-mediated pyroptosis as a key component in the development of various pulmonary diseases.However,there is little experimental evidence connecting silicosis and GSDMD-driven pyroptosis.In this work,we investigated the role of GSDMD-mediated pyroptosis in silicosis.Single-cell RNA sequencing of healthy and silicosis human and murine lung tissues indicated that GSDMD-induced pyroptosis in macrophages was relevant to silicosis progression.Through microscopy we then observed morphological alterations of pyroptosis in macrophages treated with silica.Measurement of interleukin-1βrelease,lactic dehydrogenase activity,and real-time propidium iodide staining further revealed that silica induced pyroptosis of macrophages.Additionally,we verified that both canonical(caspase-1-mediated)and non-canonical(caspase-4/5/11-mediated)signaling pathways mediated silica-induced pyroptosis activation,in vivo and in vitro.Notably,Gsdmd knockout mice exhibited dramatically alleviated silicosis phenotypes,which highlighted the pivotal role of pyroptosis in this disease.Taken together,our results demonstrated that macrophages underwent GSDMD-dependent pyroptosis in silicosis and inhibition of this process could serve as a viable clinical strategy for mitigating silicosis. | Meiyue Song Jiaxin Wang Youliang Sun Junling Pang Xiaona Li Yuan Liu Yitian Zhou Peiran Yang Tianhui Fan Ying Liu Zhaoguo Li Xianmei Qi Baicun Li Xinri Zhang Jing Wang Chen Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 5 |
| 20 | A Self-certified Cross-Cluster Asymmetric Group Key Agreement for Wireless Sensor Networks显示文摘Wireless sensor networks have some obvious characteristics, such as communication range is limited, computing power is limited and energy is limited. Group key agreement in this environment requires a cross-cluster, computation and communication overhead are lightweight and highly safe group key agreement protocol. Aiming at these demands, the paper proposes a Self-certified cross-cluster Asymmetric group key agreement(SC-AGKA). To establish a lightweight and efficient group communication channel among sensor nodes. According to the cluster head as the bridge node to realize the sensor nodes in different cluster have the same group key information, and negotiate a pair of asymmetric group keys to realize the cross cluster secure communication. The group communication adopts asymmetric encryption mechanism. It realizes the group security communication mechanism of message sender unconstraint. The asymmetric group key agreement has the key self-certified, which does not need additional rounds to verify the correctness of group key. Proven and analysis show that the proposed protocol has the advantages of in security and energy consumption. | ZHANG Qikun LI Yongjiao ZHANG Quanxin YUAN Junling WANG Ruifang GAN Yong TAN Yu'an | 2019 | Chinese Journal of Electronics2019，28，2： | 5 |
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