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| 1 | Inhibition of gasdermin D-dependent pyroptosis attenuates the progression of silica-induced pulmonary inflammation and fibrosis显示文摘Silicosis is a leading cause of occupational disease-related morbidity and mortality worldwide,but the molecular basis underlying its development remains unclear.An accumulating body of evidence supports gasdermin D(GSDMD)-mediated pyroptosis as a key component in the development of various pulmonary diseases.However,there is little experimental evidence connecting silicosis and GSDMD-driven pyroptosis.In this work,we investigated the role of GSDMD-mediated pyroptosis in silicosis.Single-cell RNA sequencing of healthy and silicosis human and murine lung tissues indicated that GSDMD-induced pyroptosis in macrophages was relevant to silicosis progression.Through microscopy we then observed morphological alterations of pyroptosis in macrophages treated with silica.Measurement of interleukin-1βrelease,lactic dehydrogenase activity,and real-time propidium iodide staining further revealed that silica induced pyroptosis of macrophages.Additionally,we verified that both canonical(caspase-1-mediated)and non-canonical(caspase-4/5/11-mediated)signaling pathways mediated silica-induced pyroptosis activation,in vivo and in vitro.Notably,Gsdmd knockout mice exhibited dramatically alleviated silicosis phenotypes,which highlighted the pivotal role of pyroptosis in this disease.Taken together,our results demonstrated that macrophages underwent GSDMD-dependent pyroptosis in silicosis and inhibition of this process could serve as a viable clinical strategy for mitigating silicosis. | Meiyue Song Jiaxin Wang Youliang Sun Junling Pang Xiaona Li Yuan Liu Yitian Zhou Peiran Yang Tianhui Fan Ying Liu Zhaoguo Li Xianmei Qi Baicun Li Xinri Zhang Jing Wang Chen Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 5 |
| 2 | Analysis of thermal elastohydrodynamic lubrication of a finite line contact显示文摘 | LIU Xiaoling YANG Peiran | 2002 | Triborlogy International2002，35，3： | 1 |
| 3 | A Generalized Reynolds Equation for Non-Newtonian Thermal Elastohydrodynamic Lubrication显示文摘 | Wen Shizhu | 1990 | Jouranl of Tribology1990，112，： | 1 |
| 4 | On the theory of thermal elastohydrodynamic lubrication at high slide-roll ratios-line contact solution显示文摘 | YANG Peiran QU Shiyue CHANG Qiuying | 2001 | ASME Journal of Tribology2001，123，1： | 1 |
| 5 | A forward iterative numerical method for steadystate elastohydrodynamically lubricated line contacts显示文摘 | Yang Peiran Wen Shizhu | | 0，，01： | 1 |
| 6 | A generalized Reynolds equation for non-Newtonian thermal elastohydrodynamic lubrication显示文摘 | Yang Peiran Wen Shizhu | 1990 | Journal of Tribology1990，112，4： | 1 |
| 7 | Analysis of the thermal elastohydrodynamic lubrication of a finite line contact 显示文摘 | Xiaoling Liu Peiran Yang | 2002 | Tribology International2002，35，： | 1 |
| 8 | A generalized Reynolds equation for non-Newtonian thermal elastohydrodynamic lubrication 显示文摘 | Yang Peiran Wen Shizhu | 1990 | Journal of Tribology1990，112，4： | 1 |
| 9 | Effect of Interfacial Strength on the Flexural Behavior of Glass Fiber Reinforced Polymer(GFRP) Reinforced Concrete Beam显示文摘The reinforcement/matrix interfacial strength has been considered as the key factor when glass fiber reinforced polymer(GFRP) bar is mixed with concrete. In this paper, based on micromechanics, fourpoint bending numerical models with and without glass fiber of different interfacial strength have been set up to simulate the damage process of GFRP reinforced concrete beam. The results show that the higher the interfacial strength is, the higher the ultimate bearing capacity of beams, and the less the opening width and height of cracks will be reached. Furthermore, mixing of glass fibers has less influence on the damage process when the interfacial strength is weak, however, it can help to improve the ultimate bearing capacity of the beams, retard the expansion of cracks and improve the toughness when the interfacial strength is high. | 张亚芳 YANG Wenlong LIU Hao CHEN Peiran LIU Feng | 2015 | Journal of Wuhan University of Technology(Materials Science)2015，30，5： | 1 |
| 10 | Endothelial Notch activation promotes neutrophil transmigration via downregulating endomucin to aggravate hepatic ischemia/reperfusion injury显示文摘Inflammatory leukocytes infiltration is orchestrated by mechanisms involving chemokines,selectins,addressins and other adhesion molecules derived from endothelial cells(ECs),but how they respond to inflammatory cues and coordinate leukocyte transmigration remain elusive.In this study,using hepatic ischemia/reperfusion injury(HIRI)as a model,we identified that endothelial Notch activation was rapidly and dynamically induced in liver sinusoidal endothelial cells(LSECs)in acute inflammation.In mice with EC-specific Notch activation(NICeCA),HIRI induced exacerbated liver damage.Consistently,endothelial Notch activation enhanced neutrophil infiltration and tumor necrosis factor(TNF)-αexpression in HIRI.Transcriptome analysis and further qRT-PCR as well as immunofluorescence indicated that endomucin(EMCN),a negative regulator of leukocyte adhesion,was downregulated in LSECs from NICeCA mice.EMCN was downregulated during HIRI in wild-type mice and in vitro cultured ECs insulted by hypoxia/re-oxygenation injury.Notch activation in ECs led to increased neutrophil adhesion and transendothelial migration,which was abrogated by EMCN overexpression in vitro.In mice deficient of RBPj,the integrative transcription factor of canonical Notch signaling,although overwhelming sinusoidal malformation aggravated HIRI,the expression of EMCN was upregulated;and pharmaceutical Notch blockade in vitro also upregulated EMCN and inhibited transendothelial migration of neutrophils.The Notch activation-exaggerated HIRI was compromised by blocking LFA-1,which mediated leukocyte adherence by associating with EMCN.Therefore,endothelial Notch signaling controls neutrophil transmigration via EMCN to modulate acute inflammation in HIRI. | Peiran Zhang Kangyi Yue Xinli Liu Xianchun Yan Ziyan Yang Juanli Duan Congcong Xia Xinyuan Xu Mei Zhang Liang Liang Lin Wang Hua Han | 2020 | Science China(Life Sciences)2020，63，3： | 1 |
| 11 | Analysis of transient rheological thermal elasto-hydrodynamic lubrication in line contacts显示文摘 | YANG Peiran WEN Shizhu | 1991 | Chinese Journal of Mechanical Engineering1991，4，1： | 1 |
| 12 | Thermoelasto hydrodynamic analysis of the static performance of tilting-pad journal beatings with the Newton-Raphson method显示文摘 | Chang Qiuying Yang Peiran Meng Yonggang | 2002 | Tribology International2002，35，： | 1 |
| 13 | A generalized Reynolds equation for non-Newtonian thermal elastohydrodynamic lubrication 显示文摘 | Yang Peiran Wen Shizhu | 1990 | Journal of Tribology1990，112，4： | 1 |
| 14 | Non-Newtonian thermal analyses of point EHL contacts using the Eyring model 显示文摘 | Liu Xiaoling Jiang Ming Yang Peiran | 2005 | Journal of Tribology Transactions of the ASME2005，127，： | 1 |
| 15 | Analysis of the thermal elastohydrodynamic lubrication of a finite line contact显示文摘 | Liu Xiaoling Yang Peiran | 2002 | Tribology International2002，35，3： | 1 |
| 16 | On the thermal elastohydrodynamic lubrication of tilting roller pairs 显示文摘 | Liu Xiaoling Yang Peiran | 2013 | Tribology International2013，65，： | 1 |
| 17 | Influence of solid body temperature on the thermal EHL behavior in circular contacts显示文摘 | Liu Xiaoling Yang Peiran | 2008 | Tribology2008，130，1： | 1 |
| 18 | Analysis on the thermal elastohydrodynamic lubrication of tapered rollers in opposite orientation 显示文摘 | Yang Ping Yang Peiran | 2007 | Tribology International2007，40，1012： | 1 |
| 19 | H∞control synthesis for lurie networked control systems with multiple delays based on the non-uniform characteristic显示文摘 | Li Peiran Bao Zhejing Yang Qiang | 2013 | Asian Journal of Control2013，15，4： | 1 |
| 20 | Acoustofluidics for simultaneous nanopartide-based drug loading and exosome encapsulation显示文摘Nanocarrier and exosome encapsulation has been found to significantly increase the efficacy of targeted drug delivery while also minimizing unwanted side effects.However,the development of exosome-encapsulated drug nanocarriers is limited by low drug loading efficiencies and/or complex,time-consuming drug loading processes.Herein,we have developed an acoustofluidic device that simultaneously performs both drug loading and exosome encapsulation.By synergistically leveraging the acoustic radiation force,acoustic microstreaming,and shear stresses in a rotating droplet,the concentration,and fusion of exosomes,drugs,and porous silica nanoparticles is achieved.The final product consists of drug-loaded silica nanocarriers that are encased within an exosomal membrane.The drug loading efficiency is significantly improved,with nearly 30%of the free drug(e.g.,doxorubicin)molecules loaded into the nanocarriers.Furthermore,this acoustofluidic drug loading system circumvents the need for complex chemical modification,allowing drug loading and encapsulation to be completed within a matter of minutes.These exosome-encapsulated nanocarriers exhibit excellent efficiency in intracellular transport and are capable of significantly inhibiting tumor cell proliferation.By utilizing physical forces to rapidly generate hybrid nanocarriers,this acoustofluidic drug loading platform wields the potential to significantly impact innovation in both drug delivery research and applications. | Zeyu Wang Joseph Rich Nanjing Hao Yuyang Gu Chuyi Chen Shujie Yang Peiran Zhang Tony Jun Huang | 2022 | Microsystems & Nanoengineering2022，8，2： | 1 |
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