|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Characteristics of distribution of Mycobacterium tuberculosis lineages in China显示文摘The genotyping methods of Mycobacterium tuberculosis would dramatically improve our understanding of the molecular epidemiology of tuberculosis. 3,929 isolates, from a National Survey of Drug-Resistant Tuberculosis in 2007 in China, were successfully genotyped by large sequence polymorphisms and 15 loci variable number tandem repeats. We found that 2,905(2,905/3,929, 73.9%) cases belonged to Lineage 2, dominated in the east and central regions, 975 cases(975/3,929, 24.8%) were Lineage 4, highly prevailed in the west regions, and 36 and 13 cases were Lineage 3 and Lineage 1, respectively. We also explored the associations between lineages(Lineage 2 vs. Lineage 4) and clinical characteristics by logistic regression. For Lineage 2, the risk factors were Han-ethnicity population and fever. However, for Lineage 4, they were occupation(farmer), and degree of education(non-literate). Fully understanding of the distribution of Mycobacterium tuberculosis lineage and its risk factors would play a critical role in tuberculosis prevention, control, and treatment. | Haixia Chen Li He Chao Cai Jingyi Liu Junnan Jia Liang Ma Hairong Huang Lixia Wang Xumin Ni Jimin Gao Weimin Li | 2018 | Science China(Life Sciences)2018，61，6： | 7 |
| 2 | Clinical characteristics and risk factors for mortality in cancer patients with COVID-19显示文摘Patients with cancer are at increased risk of severe infections.From a cohort including 3060 patients with confirmed COVID-19,109(3.4%)cancer patients were included in this study.Among them,23(21.1%)patients died in the hospital.Cancer patients,especially those with hematological malignancies(41.6%),urinary carcinoma(35.7%),malignancies of the digestive system(33.3%),gynecological malignancies(20%),and lung cancer(14.3%),had a much higher mortality than patients without cancer.A total of 19(17.4%)cancer patients were infected in the hospital.The clinical characteristics of deceased cancer patients were compared with those of recovered cancer patients.Multivariate Cox regression analysis indicated that a Nutritional Risk Screening(NRS2002)score≥3(adjusted hazard ratio(HR)11.00;95%confidence interval(CI)4.60–26.32;P<0.001),high-risk type(adjusted HR 18.81;95%CI 4.21–83.93;P<0.001),tumor stage IV(adjusted HR 4.26;95%CI 2.34–7.75;P<0.001),and recent adjuvant therapy(<1 month)(adjusted HR 3.16;95%CI 1.75–5.70;P<0.01)were independent risk factors for in-hospital death after adjusting for age,comorbidities,D-dimer,and lymphocyte count.In conclusion,cancer patients showed a higher risk of COVID-19 infection with a poorer prognosis than patients without cancer.Cancer patients with high-risk tumor,NRS2002 score≥3,advanced tumor stage,and recent adjuvant therapy(<1 month)may have high risk of mortality. | Junnan Liang Guannan Jin Tongtong Liu Jingyuan Wen Ganxun Li Lin Chen Wei Wang Yuwei Wang Wei Liao Jia Song Zeyang Ding Xiao-ping Chen Bixiang Zhang | 2021 | Frontiers of Medicine2021，15，2： | 2 |
| 3 | The Outcome of Laparoscopic Radical Hysterectomy and Lymphadenectomy for Cervical Cancer: A Prospective Analysis of 295 Patients显示文摘 | Yong Chen MD Huichen Xu MD Yuyan Li MD Dan Wang MD Junnan Li MD Jizhao Yuan MD Zhiqing Liang MD | 2008 | Annals of Surgical Oncology2008，，10： | 1 |
| 4 | The Outcome of Laparoscopic Radical Hysterectomy and Lymphadenectomy for Cervical Cancer: A Prospective Analysis of 295 Patients显示文摘 | Yong Chen MD Huichen Xu MD Yuyan Li MD Dan Wang MD Junnan Li MD Jizhao Yuan MD Zhiqing Liang MD | 2008 | Annals of Surgical Oncology2008，，10： | 1 |
| 5 | The Outcome of Laparoscopic Radical Hysterectomy and Lymphadenectomy for Cervical Cancer: A Prospective Analysis of 295 Patients显示文摘 | Yong Chen MD Huichen Xu MD Yuyan Li MD Dan Wang MD Junnan Li MD Jizhao Yuan MD Zhiqing Liang MD | 2008 | Annals of Surgical Oncology2008，，10： | 1 |
| 6 | The Outcome of Laparoscopic Radical Hysterectomy and Lymphadenectomy for Cervical Cancer: A Prospective Analysis of 295 Patients显示文摘 | Yong Chen MD Huichen Xu MD Yuyan Li MD Dan Wang MD Junnan Li MD Jizhao Yuan MD Zhiqing Liang MD | 2008 | Annals of Surgical Oncology2008，，10： | 1 |
| 7 | AICellCounter:A Machine Learning-Based Automated Cell Counting Tool Requiring Only One Image for Training显示文摘Dear Editor,To decipher brain functions,brain cells are generally prelabeled and then imaged using a high-resolution confocal system,and manual or automatic counting methods are widely used in the quantitative and semiquantitative analysis of these confocal images.Therefore,cell counting becomes a bottleneck in efficient analysis because manual counting is laborious and time-consuming.Therefore,an accurate and user-friendly automated cell counting tool is needed for biological researchers. | Junnan Xu Andong Wang Yunfeng Wang Jingting Li Ruxia Xu Hao Shi Xiaowen Li Yu Liang Jianming Yang Tian-Ming Gao | 2023 | Neuroscience Bulletin2023，39，1： | 0 |
| 8 | Bone metastasis of hepatocellular carcinoma:facts and hopes from clinical and translational perspectives显示文摘Patients with hepatocellular carcinoma(HCC)and bone metastasis(BM)suffer from greatly reduced life quality and a dismal prognosis.However,BM in HCC has long been overlooked possibly due to its relatively low prevalence in previous decades.To date,no consensus or guidelines have been reached or formulated for the prevention and management of HCC BM.Our narrative review manifests the increasing incidence of HCC BM to sound the alarm for additional attention.The risk factors,diagnosis,prognosis,and therapeutic approaches of HCC BM are detailed to provide a panoramic view of this disease to clinicians and specialists.We further delineate an informative cancer bone metastatic cascade based on evidence from recent studies and point out the main factors responsible for the tumor-associated disruption of bone homeostasis and the formation of skeletal cancer lesions.We also present the advances in the pathological and molecular mechanisms of HCC BM to shed light on translational opportunities.Dilemmas and challenges in the treatment and investigation of HCC BM are outlined and discussed to encourage further endeavors in the exploration of underlying pathogenic and molecular mechanisms,as well as the development of novel effective therapies for HCC patients with BM. | Zhao Huang Jingyuan Wen Yufei Wang Shenqi Han Zhen Li Xuemei Hu Dongling Zhu Zhenxiong Wang Junnan Liang Huifang Liang Xiao-ping Chen Bixiang Zhang | 2022 | Frontiers of Medicine2022，16，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员