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| 1 | Multi-dimension apportionment of clean air “parade blue”phenomenon in Beijing显示文摘The mass concentration and major chemical components of fine particulate matter were measured before,during and after Beijing's massive parade commemorating 70th anniversary of the Chinese Victory in World War II on September 3,2015.Regional emission inventory,positive matrix factorization(PMF),observations from space and backward air mass trajectories were jointly applied to identify the major pollution sources and their temporal and spatial variations.The contributions of emissions variations and the meteorological conditions related to the'parade blue'phenomenon in Beijing and its surrounding areas were investigated in detail.The main cause of the decreased PM_(2.5)mass concentration was attributed to the absolute reduction in emissions of primary air pollutants.The chemical composition of PM_(2.5)varied significantly before,during and after the parade.Fugitive dust particles were well controlled,the secondary formation of PM_(2.5)was reduced along with the controlled gaseous precursors'emissions from vehicles and industrial sources during the temporary intensified control period.During the parade period,the SO_2and NO_2column concentrations in Beijing and the surrounding areas decreased sharply,indicating that the coordinated reduction in primary emissions from the surrounding areas of Beijing played an important role in lowering the ambient concentration of SO_2and NO_2and accordingly lowered PM_(2.5)and improved the regional air quality.A comparison of the temperature,humidity,and wind speed and direction during the same periods in 2014 and 2015 showed that the meteorological conditions positively influenced the achievement of'parade blue'. | Yifeng Xue Yong Wang Xuefeng Li Hezhong Tian Lei Nie Xiaoqing Wu Junrui Zhou Zhen Zhou | 2018 | Journal of Environmental Sciences2018，30，3： | 5 |
| 2 | Multi-perspective digital image correlation method using a single color camera显示文摘A novel 3 D digital image correlation(DIC) system based on a single three charge-couple device(3 CCD) color camera is proposed in this paper. Images from three different perspectives are captured by a 3 CCD camera using a reflective-based pseudo-vision system. These images are then separated by the different CCD channels, and the correlation algorithm for the multi-camera DIC system is adopted to evaluate the images. Compared to the conventional multi-camera DIC system, the proposed system is much more compact. In addition, the proposed system has no loss of spatial resolution, compares to the traditional single camera DIC system. The complex surface measurement ability and the measurement accuracy is significantly improved through the use of the multi-camera DIC algorithm. The principle of the proposed system is described in detail as well as the experimental setup. A series of validation tests are performed, and the results are verified with the commercial 3 D-DIC system. | WANG YongHong DAN XiZuo LI JunRui WU SiJin YANG LianXiang | 2018 | Science China(Technological Sciences)2018，61，1： | 5 |
| 3 | Establishment of an optimized CTC detection model consisting of EpCAM,MUC1 and WT1 in epithelial ovarian cancer and its correlation with clinical characteristics显示文摘Objective:Emerging studies have demonstrated the promising clinical value of circulating tumor cells(CTCs)for diagnosis,disease assessment,treatment monitoring and prognosis in epithelial ovarian cancer.However,the clinical application of CTC remains restricted due to diverse detection techniques with variable sensitivity and specificity and a lack of common standards.Methods:We enrolled 160 patients with epithelial ovarian cancer as the experimental group,and 90 patients including 50 patients with benign ovarian tumor and 40 healthy females as the control group.We enriched CTCs with immunomagnetic beads targeting two epithelial cell surface antigens(EpCAM and MUC1),and used multiple reverse transcription-polymerase chain reaction(RT-PCR)detecting three markers(EpCAM,MUC1 and WT1)for quantification.And then we used a binary logistic regression analysis and focused on EpCAM,MUC1 and WT1 to establish an optimized CTC detection model.Results:The sensitivity and specificity of the optimized model is 79.4%and 92.2%,respectively.The specificity of the CTC detection model is significantly higher than CA125(92.2%vs.82.2%,P=0.044),and the detection rate of CTCs was higher than the positive rate of CA125(74.5%vs.58.2%,P=0.069)in early-stage patients(stage I and II).The detection rate of CTCs was significantly higher in patients with ascitic volume≥500 mL,suboptimal cytoreductive surgery and elevated serum CA125 level after 2 courses of chemotherapy(P<0.05).The detection rate of CTC;and CTC;was significantly higher in chemo-resistant patients(26.3%vs.11.9%;26.4%vs.13.4%,P<0.05).The median progression-free survival time for CTC;patients trended to be longer than CTC;patients,and overall survival was shorter in CTC;patients(P=0.043).Conclusions:Our study presents an optimized detection model for CTCs,which consists of the expression levels of three markers(EpCAM,MUC1 and WT1).In comparison with CA125,our model has high specificity and demonstrates better diagnostic values,especially for early-stage ovarian cancer.Detection of CTC;and CTC;had predictive value for chemotherapy resistance,and the detection of CTC;suggested poor prognosis. | Tongxia Wang Yan Gao Xi Wang Junrui Tian Yuan Li Bo Yu Cuiyu Huang Hui Li Huamao Liang David M.Irwin Huanran Tan Hongyan Guo | 2022 | Chinese Journal of Cancer Research2022，34，2： | 2 |
| 4 | Nonfunctional alleles of long-day suppressor genes independently regulate flowering time显示文摘Due to the remarkable adaptability to various environments, rice varieties with diverse flowering times have abeen domesticated or improved from Oryza rufipogon.Detailed knowledge of the genetic factors controlling flowering time will facilitate understanding the adaptation mechanism in cultivated rice and enable breeders to design appropriate genotypes for distinct preferences. In this study,four genes(Hd1, DTH8, Ghd7 and OsPRR37) in a rice long-day suppression pathway were collected and sequenced in 154, 74,69 and 62 varieties of cultivated rice(Oryza sativa)respectively. Under long-day conditions, varieties with nonfunctional alleles flowered significantly earlier than those with functional alleles. However, the four genes have different genetic effects in the regulation of flowering time: Hd1 and Os PRR37 are major genes that generally regulate rice flowering time for all varieties, while DTH8 and Ghd7 only regulate regional rice varieties. Geographic analysis and network studies suggested that the nonfunctional alleles of these suppression loci with regional adaptability were derived recently and independently. Alleles with regional adaptability should be taken into consideration for genetic improvement. The rich genetic variations in these four genes,which adapt rice to different environments, provide the flexibility needed for breeding rice varieties with diverse flowering times. | Xiao-Ming Zheng Li Feng Junrui Wang Weihua Qiao Lifang Zhang Yunlian Cheng Qingwen Yang | 2016 | Journal of Integrative Plant Biology2016，58，6： | 2 |
| 5 | High-resolution cryo-EM structure of the proteasome in complex with ADP-AIFx显示文摘 | Zhanyu Ding Zhenglin Fu Cong Xu Yifan Wang Yanxing Wang Junrui Li Liangliang Kong Jinhuan Chen Na Li Rongguang Zhang Yao Cong | 2017 | Cell Research2017，27，3： | 1 |
| 6 | LIFU-responsive nanomedicine enables acoustic droplet vaporization-induced apoptosis of macrophages for stabilizing vulnerable atherosclerotic plaques显示文摘Due to the high risk of tearing and rupture,vulnerable atherosclerotic plaques would induce serious cardiovascular and cerebrovascular diseases.Despite the available clinical methods can evaluate the vulnerability of plaques and specifically treat vulnerable plaques before a cardiovascular event,but the efficiency is still low and undesirable.Herein,we rationally design and engineer the low-intensity focused ultrasound(LIFU)-responsive FPD@CD nanomedicine for the highly efficient treatment of vulnerable plaques by facilely loading phase transition agent perfluorohexane(PFH)into biocompatible PLGA-PEG-PLGA nanoparticles(PPP NPs)and then attaching dextran sulphate(DS)onto the surface of PPP NPs for targeting delivery.DS,as a typical macrophages-targeted molecule,can achieve the precise vaporization of NPs and subsequently controllable apoptosis of RAW 264.7 macrophages as induced by acoustic droplet vaporization(ADV)effect.In addition,the introduction of DiR and Fe3O4 endows nanomedicine with near-infrared fluorescence(NIRF)and magnetic resonance(MR)imaging capabilities.The engineered FPD@CD nanomedicine that uses macrophages as therapeutic targets achieve the conspicuous therapeutic effect of shrinking vulnerable plaques based on in vivo and in vitro evaluation outcomes.A reduction of 49.4%of vascular stenosis degree in gross pathology specimens were achieved throughout the treatment period.This specific,efficient and biosafe treatment modality potentiates the biomedical application in patients with cardiovascular and cerebrovascular diseases based on the relief of the plaque rupture concerns. | Jingxin Hou Jun Zhou Meiqi Chang Guangcheng Bao Jie Xu Man Ye Yixin Zhong Shuling Liu Junrui Wang Wei Zhang Haitao Ran Zhigang Wang Yu Chen Dajing Guo | 2022 | Bioactive Materials2022，7，10： | 1 |
| 7 | An evaluation of porosity and permeability based on an un- steady seepage model in a reservoir while underbalanced drill- ing显示文摘 | Fan Xiangyu Wang Junrui Zhang Qiangui Zhou Xin Yu Guo | 2015 | Journal of Petroleum Science and Engineering2015，127，： | 1 |
| 8 | Prediction of the horizontal stress of the tight sand- stone formation in eastern Sulige of China显示文摘 | Fan Xiangyu Gong Ming Zhang Qiangui Wang Junrui Bai Li Chen Yingjie | 2014 | Journal of Petro- leum Science and Engineering2014，113，： | 1 |
| 9 | A Pilot Study on Using Urinary 1-Hydroxypyrene Biomarker for Exposure to PAHs in Beijing显示文摘 | Wenjie Zhang Dongqun Xu Guoshun Zhuang Changming Ding Guifang Wang Junrui Chang Gaiying Ren | 2007 | Environmental Monitoring and Assessment2007，，1： | 1 |
| 10 | Prediction of the horizontal stress of the tight sandstone formation in eastern Sulige of China显示文摘 | Fan Xiangyu Gong Ming Zhang Qiangui Wang Junrui Bai Li Chen Yingjie | 2014 | Journal of Petroleum Science and Engineering2014，，113： | 1 |
| 11 | 3-75 Radiosensitizing Effects of miR-185 on Melanoma Cells显示文摘Melanoma is an aggressive malignancy with high metastasis and low survival rate, of which the incidence rate keeps increasing year by year worldwide while the therapeutic options are still limited up to now[1;2]. Melanoma is considered to be a relatively radioresistant tumor, and radiotherapy has an important role in its treatment, especially in patients with central nervous system metastases[3], so enhancement of cellular radiosensitivity by radiosensitizer is an efficient strategy to improve the outcome of radiotherapy. | He Jinpeng Tian Ning Yang Yanli Jin Liangliang Feng Xiu Hua Junrui Lin Sulan Wang Bing Li He Wang Jufang | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 12 | Encapsulation of docosahexaenoic acid (DHA) using self-assembling food-derived proteins for efficient biological functions显示文摘Docosahexaenoic acid(DHA;22n-6)possesses multiple biological functions, including antioxidant activity and ameliorating hypertriglyceridemia. However, the application of DHA has been limited due to poor aqueous solubility and susceptible to oxidation. Here, ovalbumin(O), myosin(M), 7S soy globulin(S), and β-lactoglobulin(β), hydrolyzed by chymotrypsin, self-assembled into micelles, respectively. Adding incremental DHA to micelles caused endogenous fluorescence quenching of O, M, S, and β micelles, implying successful incorporation of DHA into hydrophobic cores of micelles(O(DHA), M(DHA), S(DHA), and β(DHA)). The results showed that micelles provided spatial stability and improved solubility, and stability against thermal and ultraviolet(UV)light for DHA. The uptake of DHA from M(DHA), β(DHA), O(DHA), and S(DHA)was 3.27-, 3.91-, 2.7-, and 3.95-fold higher, respectively, than that of DHA by Caco-2 cells. Encapsulation in micelles increased DHA aqueous solubility and uptake, which enhanced cellular endogenous antioxidant defense. Meanwhile, increased uptake of DHA was verified by HepG2 cells, and O, M, S, and β micelles were proven to increase DHA uptake to reduce lipid deposition. Our findings strongly support the possibility that O, M, S, and β micelles can be regarded as a carrier for loading DHA. | Yumeng Liu Kaixin Cao Tong Li Delun Mu Naiqi Zhang Ying Wang Rina Wu Junrui Wu | 2023 | Food Science and Human Wellness2023，12，5： | 0 |
| 13 | Effect of normal and strict anaerobic fermentation on physicochemical quality and metabolomics of yogurt显示文摘Generally,yogurts on the market are usually anaerobic fermentation,but oxygen can be still dissolved in the production process,which is actually not strict anaerobic.This study explored the multiple quality indicators and the metabolomic analysis of yogurts fermented by Lactobacillus bulgaricus and Streptococcus thermophilus using two fermentation methods,namely,strict anaerobic and normal fermentation.The changes in flavor substances in yogurts,including 17 free amino acids,17 fatty acids,and 7 response value,were detected using principal component and multi factor analyses.Based on the results of the comparisons between basic physical and chemical indicators,strict anaerobic fermentation increased the growth and acidification of the two bacteria,the response value of sourness,umami and richness.Strict anaerobic fermentation increased the free amino acid(Fold change=1.53)and short chain fatty acid levels(Fold change=1.73),and reduced the polyunsaturated fatty acid(Fold change=0.51)levels.Furthermore,metabolomic analysis based on UPLC-Triple TOF-MS/MS showed that 92 differential metabolites were screened;45 differential metabolites were increased and 47 were decreased.The results revealed that strict anaerobic fermentation was beneficial to metabolic changes and nutritional indicators of yogurt,which may be as indicators of valuable reference to improve dairy fermentation process. | Ruixue Ding Mohan Li Yiting Zou Yiran Wang Chunyue Yan Haibing Zhang Rina Wu Junrui Wu | 2022 | Food Bioscience2022，46，2： | 0 |
| 14 | OsNPF3.1,a member of the NRT1/PTR family,increases nitrogen use efficiency and biomass production in rice显示文摘The overuse of nitrogen(N)fertilizer in fields has increased production costs and raised environmental concerns.Increasing the N use efficiency(NUE)of rice varieties is crucial for sustainable agriculture.Here we report the cloning and characterization of OsNPF3.1,a gene that controls rice NUE.An amino acid mutation in the OsNPF3.1 coding region caused different NUEs in wild and cultivated rice.OsNPF3.1,which is expressed mainly in the aerial parts of rice,also affects rice plant height,heading date,and thousand-grain weight.The OsNPF3.1 protein is located in the plasma membrane.When OsNPF3.1 was subjected to artificial selection,two naturally varying loci were associated with NUE,of which OsNPF3.1Chr6_8741040differed between indica and japonica rice.OsNPF3.1 can be used as a new target gene for breeding rice varieties with high NUE. | Xinghai Yang Baoxuan Nong Can Chen Junrui Wang Xiuzhong Xia Zongqiong Zhang Yu Wei Yu Zeng Rui Feng Yanyan Wu Hui Guo Haifeng Yan Yuntao Liang Shuhui Liang Yong Yan Danting Li Guofu Deng | 2023 | The Crop Journal2023，11，1： | 0 |
| 15 | Air Pollution Health Impact Monitoring and Health Risk Assessment Technology and Its Application-China,2006-2019显示文摘Air pollution is a significant risk factor contributing to the burden of disease in China.Health risk assessment and management are important to reduce the impact of air pollution on public health.To help formulate standardized health risk assessment techniques,a series of studies were conducted from 2006 to 2019.Through systematic review,study of molecular mechanisms,epidemiological investigation,and health effect monitoring,the overall project established a monitoring and evaluation indicator system,a comprehensive information platform,software for automatic data cleaning,and standardized health risk assessment techniques.Technical specifications have been issued by the National Health Commission for promoting health risk assessments across China.This paper introduces the project,the research approach,its main research accomplishments,innovations,and public health significance,and describes directions for further research. | Jingxiu Han Dongqun Xu Donggang Xu Xu Yang Qin Wang Mingqing Chen Wenrong Xia Weiwei Xing Chunyu Xu Yue Liu Junrui Chang Wenliang Fu Shuxin Hao Na Li Xiaoyan Dong Yunpu Li Congshen Meng Jingyi Liu | 2022 | China CDC weekly2022，4，26： | 0 |
| 16 | 重离子辐射引起的衰老人黑色素瘤细胞产生的衰老相关分泌表型显示文摘Senescence is a cell fate that can be induced by intra/extracellular stresses such as DNA damage,oncogenic mutations,telomere shorting,and inflammation[1].Senescent cells develop a characteristic secretion profile including a range of cytokines,chemokines,proteases,and other factors,which is termed the senescence-associated secretory phenotype(SASP)[2].Accumulating evidence indicates that SASP factors provoke multiple chronic diseases,even tumorigenesis and aggressiveness[3].Our recent studies reveal that heavy ion could induce senescence with lower dose than X-ray in various tumor cells[4;5].However,very little is known about the SASP of senescent tumor cells induced by heavy ions.In the present study,human melanoma cell line 92-1 cells were exposed to 10 Gy of carbon ion beams or X-rays,respectively.The cell culture supernatants were harvested 3 days post-irradiation,and the SASP were measured using human antibody arrays including 507 factors. | He Jinpeng Hua Junrui Long Kaiqing Feng Xiu Wei Wenjun Wang Jufang | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 17 | 重离子辐射抑制骨髓间充质干细胞的成脂分化能力显示文摘Heavy ion radiation widely exists in nuclear facilities,space environments and heavy ion radiotherapies.Exposure to heavy ion radiation is a significant threat and a major medical concern[1].In general,hematopoietic system injury is the primary cause of death after accidental or intentional exposure to high dose of irradiation(IR)[2].Protecting hematopoiesis is crucial for medical countermeasures against heavy ion radiation injury.Bone mesenchymal stromal cells(BMSCs)are multipotent,non-hematopoietic adult stem cells,which can differentiate into adipose,osteogenic and neurogenic lineages[3].Moreover,BMSCs can efficiently support proliferations,differentiations and functions of hematopoietic stem cells(HSCs)and multilineage cell types from HSCs[4;5].Such unique properties make BMSCs an invaluable cell type for the repair of tissue damage and a key role in recovery and reconstitution of hematopoiesis and immune system after IR[6]. | Wei Wenjun Wang Jufang Hua Junrui Zhang Yanan | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 18 | 黄芪多糖通过介导碳离子照射BMCSs后MAPK信号通路减轻G1期相关旁观者效应显示文摘Although it has been demonstrated that Astragalus polysaccharide(APS)have various pharmacological effects,there has been no studies concerning the inhibitory effects of APS on the radiation induced bystander effects(RIBE).In this study,A549 cells were irradiated with 2 Gy carbon ions to obtain conditioned medium.BMSCs was incubated with the conditioned medium or APS.The levels of reactive oxygen species(ROS)and TGF-were detected by ELISA.Cell survival,genomic instability,DNA damages and cell cycle were detected by CCK-8 assay,colony formation assay,the micronucleus test,immunofluorescence assay and flow cytometry assay,respectively.The protein and phosphorylation protein expression of p38,c-Jun N-terminal kinase(JNK),extracellular regulated protein kinases(ERK1/2),P65,cyclooxygenase-2(COX-2),cell cycle related proteins and TGF-receptor(TGF-R)in bystander effect cells were detected by western blot.The result showed that APS decreased the colony rate of bystander cells by inducing cell cycle arrest at G1 phase via extrinsic and intrinsic DNA damage. | Zhang Liying Liu Yongqi He Jinpeng Zhang Yiming wang Lei Zhang Lixin Wei Kongxi Zhou Heng Hua Junrui Li Yangyang | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 19 | 蛇床子素通过抑制mir-34c表达防治尾吊大鼠模拟微重力导致的骨质流失显示文摘Bone loss is one of the major barriers for human deep space exploration.To date,there has been less effective measures against bone metabolism derangement during long-term spaceflights[1;2].Traditional Chinese Medicine(TCM)has been used for bone and joint diseases for thousands of years.Osthole(OST),an O-methylated coumarin,is originally extracted from the fruits of Cnidium monnieri which is a main osteoporosis treatment agent in TCM.Studies have demonstrated that OST have multiple pharmacological and biological features including neuroprotective,immunomodulatory,anticancer,hepatoprotective,cardiovascular protective,and antimicrobial activities[3].In addition,numerous studies also suggested that OST has better bone protection effects by enhancing the differentiation and maturation of osteoblasts[4;5].However,the functions of OST in regulation of bone loss induced by microgravity remain unclear. | Feng Xiu He Jinpeng Hua Junrui Long Kaiqin Zhang Yanan Wang Jufang | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 20 | Analysis on Business Organizational Form and Development of Waterfowl Industry显示文摘Waterfowl industry is an essential part of modern agricultural industry system.Enterprises and breeding farmers in waterfowl industry are new agricultural business entities,backbones for development of waterfowl industry,and main undertakers of business risks and major promoters of industry development.From the survey and analysis of several enterprises,farmers and business organizational form of waterfowl industry,it concluded that the business organizational form and the relationship between interested parties exert great influence on the development of waterfowl industry.According to these,it came up recommendations including optimizing business organizational form and reasonably selecting logistics mode according to profits and risks of business entities in the industry chain and main points of input and technological progress,in the hope of helping enterprises to resist risks,conduct scientific management,so as to promote stable development of waterfowl industry. | Junrui LI Yapeng WANG | 2016 | Asian Agricultural Research2016，8，8： | 0 |
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