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| 1 | Injectable peptide hydrogel as intraperitoneal triptolide depot for the treatment of orthotopic hepatocellular carcinoma显示文摘Chemotherapy is among the limited choices approved for the treatment of hepatocellular carcinoma(HCC) at intermediate and advanced stages. Preferential and prolonged drug exposure in diseased sites is required to maximize the therapeutic index of the drug. Here, we report an injectable supramolecular peptide hydrogel as an intraperitoneal depot for localized and sustained release of triptolide for the treatment of orthotopic HCC. We chose peptide amphiphile C16-GNNQQNYKD-OH-based nanofibers as gelators and carriers for triptolide. Sustained triptolide release from the hydrogel was achieved over 14 days in vitro, with higher accumulation in and cytotoxicity against human HCC Bel-7402 in comparison with L-02 fetal hepatocytes. After intraperitoneal injection, the hydrogel showed prolonged retention over 13 days and preferential accumulation in the liver, realizing HCC growth inhibition by99.7 ± 0.1% and animal median survival extension from 19 to 43 days, without causing noticeable pathological changes in the major organs. These results demonstrate that injectable peptide hydrogel can be a potential carrier for localized chemotherapy of HCC. | Xiyue Zhao Xiaoyu Liu Pengcheng Zhang Yiran Liu Wei Ran Ying Cai Junyang Wang Yihui Zhai Guanru Wang Yaping Ding Yaping Li | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 7 |
| 2 | Kiwifruit Genome Database(KGD):a comprehensive resource for kiwifruit genomics显示文摘Kiwifruit(Actinidia spp.)plants produce economically important fruits containing abundant,balanced phytonutrients with extraordinarily high vitamin C contents.Since the release of the first kiwifruit reference genome sequence in 2013,large volumes of genome and transcriptome data have been rapidly accumulated for a handful of kiwifruit species.To efficiently store,analyze,integrate,and disseminate these large-scale datasets to the research community,we constructed the Kiwifruit Genome Database(KGD;http://kiwifruitgenome.org/).The database currently contains all publicly available genome and gene sequences,gene annotations,biochemical pathways,transcriptome profiles derived from public RNA-Seq datasets,and comparative genomic analysis results such as syntenic blocks and homologous gene pairs between different kiwifruit genome assemblies.A set of user-friendly query interfaces,analysis tools and visualization modules have been implemented in KGD to facilitate translational and applied research in kiwifruit,which include JBrowse,a popular genome browser,and the NCBI BLAST sequence search tool.Other notable tools developed within KGD include a genome synteny viewer and tools for differential gene expression analysis as well as gene ontology(GO)term and pathway enrichment analysis. | Junyang Yue Jiacheng Liu Wei Tang Ya Qing Wu Xiaofeng Tang Wei Li Ying Yang Lihuan Wang Shengxiong Huang Congbing Fang Kun Zhao Zhangjun Fei Yongsheng Liu Yi Zheng | 2020 | Horticulture Research2020，7，1： | 6 |
| 3 | Analysis of genotypes and phenotypes in Chinese children with tuberous sclerosis complex显示文摘Tuberous sclerosis complex(TSC) is a neurocutaneous syndrome with serious clinical presentations, an autosomal dominant genetic disorder involving multiple organs and systems. We retrospectively investigated the clinical manifestations and genotypes of 20 Chinese children with TSC to enable informed diagnostic and surveillance recommendations in China. A retrospective analysis of clinical manifestations in 20 children(7.00±5.30 years old) with TSC was conducted. A genetic testing of the genes TSC1 and TSC2 was performed in 14 children.The earliest manifestations of TSC were skin lesions(80% of patients) and seizures(75%). Fourteen of the children presented with retinal hamartomas, and 2 of these underwent eye enucleation at other hospitals through misdiagnosis. On magnetic resonance imaging, 18 children exhibited subependymal nodules, and 16 ones showed cortical nodules. 5 cases of non-renal hamartomas, 5 cases of multiple renal cysts, and 5 cases of cardiac rhabdomyomas were observed.The genotyping of TSC1 and TSC2 in 14 children revealed 11 with mutations in TSC2, 2 with mutations in TSC1, and no mutations of either gene in one patient. Eight of these observed mutations are reported here in for the first time. The illness presentations of the TSC2-mutated patients were more severe than that of patients carrying TSC1 mutations.There were differences in the mutations of TSC genes in Chinese children from those reported in other countries. The described clinical characteristics and genotyping will help pediatric neurologists to understand, diagnosis, and treat TSC. | Dayong Bai Junyang Zhao Li Li Jun Gao Xu Wang | 2017 | Science China(Life Sciences)2017，60，7： | 5 |
| 4 | Diagnosis and treatment of infantile malignant solid tumors in Beijing,China:A multicenter 10-year retrospective study显示文摘Importance:Cancer is the main cause of death by disease in children.Children experience the highest incidence of cancer in the first year of life.However,there is no comprehensive registration system for children with tumors in China.Objective:To summarize the diagnosis and treatment of infant cancer and analyze the status of standardized diagnosis and management among several treatment centers in Beijing,China,thereby providing evidence to guide further clinical research.Methods:From January 1,2010 to December 31,2019,patients with newly diagnosed infantile malignant solid tumors were admitted to six large tertiary pediatric solid tumor diagnosis and treatment centers in Beijing.The epidemiology,clinical features,and therapeutic effects of tumors in these patients were analyzed retrospectively.All patients were followed up until March 31,2020.Results:In total,938 patients were enrolled in this study.There were 530 boys(56.5%)and 408 girls(43.5%);the median age was 6.0 months(range,0-12.0 months).The three most common tumors were retinoblastoma in 366 patients(39.0%),neuroblastoma in 266 patients(28.4%),hepatoblastoma in 133 patients(14.2%),and central nervous system tumors in 52 patients(5.5%).The estimated 5-year overall survival rate was 81.3%±1.8%,and the 5-year event-free survival rate was 71.8%±2.9%.The 5-year overall survival rates of non-rhabdomyosarcoma soft tissue sarcoma,neuroblastoma,and retinoblastoma were 100%,88%±2.2%,and 86.9%±2.1%,respectively.The 5-year event-free survival rates were 81.1%±2.7%for neuroblastoma,81.6%±9.8%for non-rhabdomyosarcoma soft tissue sarcoma,and 72.7%±14.1%for extracranial malignant germ cell tumors.Interpretation:The three most common infantile malignant solid tumors were retinoblastoma,neuroblastoma,and hepatoblastoma.Multidisciplinary combined diagnosis and treatment is needed for infantile tumors. | Mei Jin Zhi Tian Yao Xie Zhaoxia Zhang Miao Li YaxiongYu Weiling Zhang Junyang Zhao Huanmin Wang Qi Zeng Long Li Ming Ge Ning Sun Xiaolun Zhang Jian Gong Wanshui Wu Rong Liu Weihong Zhao Dongsheng Huang Xiaoli Ma | 2020 | Pediatric Investigation2020，4，3： | 3 |
| 5 | Dissolution-precipitation growth of uniform and clean two dimensional transition metal dichalcogenides显示文摘Two dimensional transition metal dichalcogenides(TMDCs)have attracted much interest and shown promise in many applications.However,it is challenging to obtain uniform TMDCs with clean surfaces,because of the difficulties in controlling the way the reactants are supplied to the reaction in the current chemical vapor deposition growth process.Here,we report a new growth approach called’dissolution-precipitation’(DP)growth,where the metal sources are sealed inside glass substrates to control their feeding to the reaction.Noteworthy,the diffusion of metal source inside glass to its surface provides a uniform metal source on the glass surface,and restricts the TMDC growth to only a surface reaction while eliminating unwanted gas-phase reaction.This feature gives rise to highly uniform monolayer TMDCs with a clean surface on centimeter-scale substrates.The DP growth works well for a large variety of TMDCs and their alloys,providing a solid foundation for the controlled growth of clean TMDCs by the fine control of the metal source. | Zhengyang Cai Yongjue Lai Shilong Zhao Rongjie Zhang Junyang Tan Simin Feng Jingyun Zou Lei Tang Junhao Lin Bilu Liu Hui-Ming Cheng | 2021 | National Science Review2021，8，3： | 2 |
| 6 | A review of data mining technologies in building energy systems:Load prediction,pattern identification,fault detection and diagnosis显示文摘With the advent of the era of big data,buildings have become not only energy-intensive but also data-intensive.Data mining technologies have been widely utilized to release the values of massive amounts of building operation data with an aim of improving the operation performance of building energy systems.This paper aims at making a comprehensive literature review of the applications of data mining technologies in this domain.In general,data mining technologies can be classified into two categories,i.e.,supervised data mining technologies and unsupervised data mining technologies.In this field,supervised data mining technologies are usually utilized for building energy load prediction and fault detection/diagnosis.And unsupervised data mining technologies are usually utilized for building operation pattern identification and fault detection/diagnosis.Comprehensive discussions are made about the strengths and shortcomings of the data mining-based methods.Based on this review,suggestions for future researches are proposed towards effective and efficient data mining solutions for building energy systems. | Yang Zhao Chaobo Zhang Yiwen Zhang Zihao Wang Junyang Li | 2020 | Energy and Built Environment2020，1，2： | 1 |
| 7 | Locally maximal idempotent- generated subsemigroups of singular order- preserving transformation semigroups 显示文摘 | Xu Bo Zhao Ping and Li Junyang | 2006 | Semigroup Fo- rum2006，72，3： | 1 |
| 8 | Global issue and Opportunities for Optimized Retinoblastoma Care显示文摘 | Brenda Gallie Junyang Zhao Kirk Vandezande | 2007 | Pediatr Blood Caneer2007，49，： | 1 |
| 9 | Locally Maximal Idempotent-generated Subsemigr-oups of Singular Or-der-preserving Transformation Semigroups显示文摘 | XU Bo ZHAO Ping LI Junyang | 2006 | Semigroup Forum2006，72，： | 1 |
| 10 | Federated learning-based short-term building energy consumption prediction method for solving the data silos problem显示文摘Transfer learning is an effective method to predict the energy consumption of information-poor buildings by learning transferable knowledge from operational data of information-rich buildings.However,it is not recommended to directly use the operational data without protection due to the risk of leaking occupants’privacy.To address this problem,this study proposes a federated learning-based method to learn transferable knowledge from building operational data without privacy leaking.It trains a transferable federated model based on the operational data from the buildings similar to the target building with limited data.An advanced secure aggregation algorithm is adopted in the training process to ensure that no one can infer private information from the training data.The federated model obtained is evaluated by comparing it with the standalone model without federated learning based on 13 similar office buildings from the Building Data Genome Project.The results show that the federated model outperforms the standalone model concerning the prediction accuracy and training time.On average,the federated model achieves a 25.4%decrease in CV-RMSE when the target building has limited operational data.Even if the target building has no operational data,the federated model still achieves acceptable accuracy(CV-RMSE is 22.2%).Meanwhile,the training time of the federated model is 90%less than that of the standalone model.The research insights can help develop federated learning-based methods for solving the data silos problem in building energy management.The methodology and analysis procedures are reproducible and all codes and data sets are available on Github. | Junyang Li Chaobo Zhang Yang Zhao Weikang Qiu Qi Chen Xuejun Zhang | 2022 | Building Simulation2022，15，6： | 1 |
| 11 | Global issue and Opportunities for Optimized Retinoblastoma Care 显示文摘 | BRENDA GALLIE JUNYANG ZHAO KIRK VANDEZANDE | 2007 | Pediatr Blood Caneer2007，49，： | 1 |
| 12 | Locally maximal idempotent - generated subsemigroups of singular order - preserving transformation semigroup 显示文摘 | Xu Bo Zhao Ping Li Junyang | 2006 | Semigroup forum2006，72，3： | 1 |
| 13 | Locally maximal idempotent-generated subsemigroups of singular order-preserving transformation semigroups显示文摘 | Xu Bo Zhao Ping and Li Junyang | 2006 | Semigroup Forum2006，72，： | 1 |
| 14 | Thiol Ligand-Modified Au for Highly Efficient Electroreduction of Nitrate to Ammonia显示文摘Electroreduction of nitrate(NO_(3)-)to ammonia(NH_(3))is an environmentally friendly route for NH_(3)production,serving as an appealing alternative to the Haber-Bosch process.Recently,various noble metal-based electrocatalysts have been reported for electroreduction of NO_(3)-.However,the application of pure metal electrocatalysts is still limited by unsatisfactory performance,owing to the weak adsorption of nitrogen-containing intermediates on the surface of pure metal electrocatalysts.In this work,we report thiol ligand-modified Au nanoparticles as the effective electrocatalysts toward electroreduction of NO_(3)-.Specifically,three mercaptobenzoic acid(MBA)isomers,thiosalicylic acid(ortho-MBA),3-mercaptobenzoic acid(meta-MBA),and 4-mercaptobenzoic acid(para-MBA),were employed to modify the surface of the Au nanocatalyst.During the NO_(3)-electroreduction,para-MBA modified Au(denoted as para-Au/C)displayed the highest catalytic activity among these Au-based catalysts.At-1.0 V versus reversible hydrogen electrode(vs RHE),para-Au/C exhibited a partial current density for NH_(3)of 472.2 mA cm^(-2),which was 1.7 times that of the pristine Au catalyst.Meanwhile,the Faradaic efficiency(FE)for NH_(3)reached 98.7%at-1.0 V vs RHE for para-Au/C.The modification of para-MBA significantly improved the intrinsic activity of the Au/C catalyst,thus accelerating the kinetics of NO_(3)-reduction and giving rise to a high NH_(3)yield rate of para-Au/C. | Yuheng Wu Xiangdong Kong Yechao Su Jiankang Zhao Yiling Ma Tongzheng Ji Di Wu Junyang Meng Yan Liu Zhigang Geng Jie Zeng | 2024 | Precision Chemistry2024，2，3： | 0 |
| 15 | Clinical treatment and prognostic observation for different pathological infiltrations in 537 patients with unilateral retinoblastoma显示文摘 | Wang Yizhuo Huang Dongsheng Shi Jitong Ma Jianmin Zhao Junyang Li Bin Xu Xiaolin Hu Huimin Zhou Yan Sun Yongchang | 2014 | Chinese Medical Journal2014，，20： | 0 |
| 16 | Research on automatic spraying of single-walled carbon nanotubes and detection of spraying effects显示文摘Single-walled carbon nanotubes(SWNTs)have been introduced as compliant electrodes for dielectric elastomers(DEs)due to fault tolerance.To acquire a better electrostrictive strain and longer lifetime,it is essential to obtain a certain and uniform width of the SWNT electrode.To ensure uniform width manually,a small flux and longer time are necessary.Moreover,it is difficult to control the width of the electrode for the randomness of manual spraying.Therefore,a new type of automatic spraying process is presented in this paper.The width and homogeneity of the electrode can be easily controlled by certain parameters of the process.Two methods for detecting the homogeneity of the electrode are introduced in this paper:Measurement of surface resistance and luminosity.The coefficient of variation(CV)values detected by the two methods are virtually equal and less than 8%,which shows the feasibility of the detection method and homogeneity of automatic spraying.The speed of automatic spraying is 102 mm^(2)/s,which is higher than that of manual spraying.The spraying process and the method used to detect homogeneity in this paper provide a reference for the relevant processes. | Jianwen Zhao Jiangcheng Yu Junyang Niu Yong Ge Liwu Liu | 2014 | International Journal of Smart and Nano Materials2014，5，2： | 0 |
| 17 | Iodine-assisted ultrafast growth of high-quality monolayer MoS_(2) with sulfur-terminated edges显示文摘Two-dimensional(2D)semiconductors have attracted great attention to extend Moore’s law,which motivates the quest for fast growth of high-quality materials.However,taking MoS_(2) as an example,current methods yield 2D MoS_(2) with a low growth rate and poor quality with vacancy concentrations three to five orders of magnitude higher than silicon and other commercial semiconductors.Here,we develop a strategy of using an intermediate product of iodine as a transport agent to carry metal precursors efficiently for ultrafast growth of high-quality MoS_(2).The grown MoS_(2) has the lowest density of sulfur vacancies(~1.41×10^(12) cm^(−2))reported so far and excellent electrical properties with high on/off current ratios of 108 and carrier mobility of 175 cm^(2) V^(−1) s^(−1).Theoretical calculations show that by incorporating iodine,the nucleation barrier of MoS_(2) growth with sulfur-terminated edges reduces dramatically.The sufficient supply of precursor and low nucleation energy together boost the ultrafast growth of sub-millimeter MoS_(2) domains within seconds.This work provides an effective method for the ultrafast growth of 2D semiconductors with high quality,which will promote their applications. | Qinke Wu Jialiang Zhang Lei Tang Usman Khan Huiyu Nong Shilong Zhao Yujie Sun Rongxu Zheng Rongjie Zhang Jingwei Wang Junyang Tan Qiangmin Yu Liqiong He Shisheng Li Xiaolong Zou Hui-Ming Cheng Bilu Liu | 2023 | National Science Open2023，2，4： | 0 |
| 18 | Gold mineralization in Jiaodong Peninsula and destruction of North China Craton:Insights from Mesozoic granite显示文摘Large-scale tectonic magmatism and extensive gold mineralization have occurred in the eastern North China Craton(NCC)(Jiaodong and Liaodong peninsulas)since Mesozoic,which indicated that the region experienced decratonization process.The genesis type of granites evolved from S-type to I-type and A-type during Late Jurassic to Early Cretaceous,and thus reflects the evolution of geodynamics in the Late Mesozoic,indicating the varied subduction process of the Paleo-Pacific Plate(PPP)and the craton destruction.The evolution of geochemical features shows that the mantle beneath the Jiaodong Peninsula evolved from EM-II in Jurassic to EM-I in Early Cretaceous,demonstrating that the mantle switched from enriched to depleted.The gold of decratonic gold deposits in Jiaodong Peninsula mainly comes from the lithospheric mantle domains metasomatized by fluids derived from the metamorphism and dehydration of the subducted slab in the mantle transition zone.The rapid decomposition of minerals leads to the concentrated release of ore-forming fluids,and this process leads to the explosive gold mineralization during the craton destruction.Extensive magmatic uplift and extensional structures,triggered by the craton destruction in Early Cretaceous formed the extensional tectonic system,providing space for the decratonic gold deposits in Jiaodong Peninsula. | WANG Bin ZHOU Jianbo DING Zhengjiang ZHAO Tiqun SONG Mingchun BAO Zhongyi LYU Junyang XU Shaohui YAN Chunming LIU Xiangdong LIU Jialiang | 2023 | Global Geology2023，26，2： | 0 |
| 19 | Intermolecular coupling enhanced thermopower in single-molecule diketopyrrolopyrrole junctions显示文摘Sorting out organic molecules with high thermopower is essential for understanding molecular thermoelectrics.The intermolecular coupling offers a unique chance to enhance the thermopower by tuning the bandgap structure of molecular devices,but the investigation of intermolecular coupling in bulk materials remains challenging.Herein,we investigated the thermopower of diketopyrrolopyrrole(DPP)cored single-molecule junctions with different coupling strengths by varying the packing density of the self-assembled monolayers(SAM)using a customized scanning tunneling microscope break junction(STM-BJ)technique.We found that the thermopower of DPP molecules could be enhanced up to one order of magnitude with increasing packing density,suggesting that the thermopower increases with larger neighboring intermolecular interactions.The combined density functional theory(DFT)calculations revealed that the closely-packed configuration brings stronger intermolecular coupling and then reduces the highest occupied molecular orbital(HOMO)-lowest unoccupied molecular orbital(LUMO)gap,leading to an enhanced thermopower.Our findings offer a new strategy for developing organic thermoelectric devices with high thermopower. | Chao Fang Renad Almughathawi Qingqing Wu Wenqiang Cao Hang Chen Songjun Hou Yu Gu Hewei Zhang Yi Zhao Jueting Zheng Guopeng Li Jia Shi Junyang Liu Bing-Wei Mao Zitong Liu Colin J.Lambert Wenjing Hong | 2023 | National Science Open2023，2，1： | 0 |
| 20 | The fabrication,characterization and functionalization in molecular electronics显示文摘Developments in advanced manufacturing have promoted the miniaturization of semiconductor electronic devices to a near-atomic scale,which continuously follows the‘top-down’construction method.However,huge challenges have been encountered with the exponentially increased cost and inevitably prominent quantum effects.Molecular electronics is a highly interdisciplinary subject that studies the quantum behavior of electrons tunneling in molecules.It aims to assemble electronic devices in a‘bottom-up’manner on this scale through a single molecule,thereby shedding light on the future design of logic circuits with new operating principles.The core technologies in this field are based on the rapid development of precise fabrication at a molecular scale,regulation at a quantum scale,and related applications of the basic electronic component of the‘electrode-molecule-electrode junction’.Therefore,the quantum charge transport properties of the molecule can be controlled to pave the way for the bottom-up construction of single-molecule devices.The review firstly focuses on the collection and classification of the construction methods for molecular junctions.Thereafter,various characterization and regulation methods for molecular junctions are discussed,followed by the properties based on tunneling theory at the quantum scale of the corresponding molecular electronic devices.Finally,a summary and perspective are given to discuss further challenges and opportunities for the future design of electronic devices. | Yi Zhao Wenqing Liu Jiaoyang Zhao Yasi Wang Jueting Zheng Junyang Liu Wenjing Hong Zhong-Qun Tian | 2022 | International Journal of Extreme Manufacturing2022，4，2： | 0 |
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