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| 1 | Towards single-molecule optoelectronic devices显示文摘Benefiting from the development of molecular electronics and molecular plasmonics, the interplay of light and electronic transport in molecular junctions has attracted growing interest among researchers in both fields, leading to a new research direction of 'single-molecule optoelectronics'. Here, we review the latest developments of photo-modulated charge transport,electroluminescence and Raman spectroscopy from single-molecule junctions, and suggest future directions for single-molecule optoelectronics. | Lijue Chen Anni Feng Maoning Wang Junyang Liu Wenjing Hong Xuefeng Guo Dong Xiang | 2018 | Science China Chemistry2018，61，11： | 7 |
| 2 | Protective effects of human umbilical cord mesenchymal stem cell-derived conditioned medium on ovarian damage显示文摘Chemotherapeutic agents are extensively used to treat malignancies.However,chemotherapy-induced ovarian damage and reduced fertility are severe side effects.Recently,stem cell transplantation has been reported to be an effective strategy for premature ovarian insufficiency(POI)treatment,but safety can still be an issue in stem cell-based therapy.Here,we show the protective effects of human umbilical cord mesenchymal stem cell-derived conditioned medium(hUCMSC-CM)on a cisplatin(Cs)-induced ovarian injury model.hUCMSC-CM can relieve Cs-induced depletion of follicles and preserve fertility.In addition,hUCMSC-CM can decrease apoptosis of oocytes and granulosa cells induced by Cs.RNA sequencing analysis reveals the differentially expressed genes of ovaries after Cs and hUCMSC-CM treatments,including genes involved in cell apoptosis.Furthermore,we show that the granulocyte colony-stimulating factor(G-CSF)/phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt)pathway plays an important role in protecting granulosa cells from Cs-induced apoptosis.Together,we confirm the protective effects of hUCMSC-CM on ovarian reserve and fertility in mice treated with Cs,highlighting the remarkable therapeutic effects of hUCMSC-CM. | Liming Hong Long Yan Zhimin Xin Jie Hao Wenjing Liu Shuyu Wang Shujie Liao Hongmei Wang Xiaokui Yang | 2020 | Journal of Molecular Cell Biology2020，12，5： | 7 |
| 3 | Exosomes with low miR-34c-3p expression promote invasion and migration of non-small cell lung cancer by upregulating integrinα2β1显示文摘Exosomes play critical roles in regulating various physiological and pathological processes,including immune stimulation,immune suppression,cardiovascular diseases,and cancers.Recent studies show that exosomes that transport specific microRNAs(miRNAs)are involved in tumor development.However,the molecular mechanism by which tumor invasion and migration are regulated by exosomes from non-small cell lung cancer(NSCLC)is not well understood.Here,we show that exosomes shuttling low levels of miR-34c-3p are involved in NSCLC progression.Our results showed that exosomes derived from NSCLC cells carrying low levels of miR-34c-3p could be transported into the cytoplasm of NSCLC cells and accelerate NSCLC invasion and migration by upregulating integrinα2β1.A luciferase assay revealed that integrinα2β1 was the direct target of miR-34c-3p,and overexpression of integrinα2β1 could promote the invasion and migration of NSCLC cells.The analysis of exosomes derived from clinical serum samples indicated that the expression of miR-34c-3p was significantly downregulated in exosomes from NSCLC patients compared with that of normal controls.A549-derived exosomes promoted NSCLC cells lung metastases in vivo.Exosomes shuttling low levels of miR-34c-3p were associated with the progression of NSCLC in vitro and in vivo.Our data demonstrate that exosomes shuttling low levels of miR-34c-3p can accelerate the invasion and migration of NSCLC by upregulating integrinα2β1.MiR-34c-3p can be a diagnostic and prognostic marker for NSCLC.High expression of integrinα2β1 is positively related to the migration and metastasis of NSCLC cells. | Wenjing Huang Yanyan Yan Yun Liu Minting Lin Jinxiang Ma Wei Zhang Jianwei Dai Jiajun Li Qiaoru Guo Hubiao Chen Bolat Makabel Hong Liu Chaoyue Su Hong Bi Jianye Zhang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 4 | Functional assembly of root-associated microbial consortia improves nutrient efficiency and yield in soybean显示文摘Root-associated microbes are critical for plant growth and nutrient acquisition. However, scant information exists on optimizing communities of beneficial root-associated microbes or the mechanisms underlying their interactions with host plants. In this report, we demonstrate that rootassociated microbes are critical influencers of host plant growth and nutrient acquisition. Three synthetic communities(SynComs) were constructed based on functional screening of 1,893 microbial strains isolated from root-associated compartments of soybean plants. Functional assemblage of SynComs promoted significant plant growth and nutrient acquisition under both N/P nutrient deficiency and sufficiency conditions.Field trials further revealed that application of SynComs stably and significantly promoted plant growth, facilitated N and P acquisition, and subsequently increased soybean yield. Among the tested communities, SynCom1 exhibited the greatest promotion effect, with yield increases of up to 36.1% observed in two field sites. Further RNA-seq implied that SynCom application systemically regulates N and P signaling networks at the transcriptional level, which leads to increased representation of important growth pathways, especially those related to auxin responses. Overall,this study details a promising strategy for constructing SynComs based on functional screening,which are capable of enhancing nutrient acquisition and crop yield through the activities of beneficial root-associated microbes. | Cunhu Wang Yanjun Li Mingjia Li Kefei Zhang Wenjing Ma Lei Zheng Hanyu Xu Baofeng Cui Ran Liu Yongqing Yang Yongjia Zhong Hong Liao | 2021 | Journal of Integrative Plant Biology2021，63，6： | 5 |
| 5 | Numerical simulations of rip currents off arc-shaped coastlines显示文摘The rip currents induced by waves off arc-shaped coastlines are seriously harmful to humans, but understanding of their characteristics is lacking. In this study, the FUNWAVE model was used to calculate the wave-induced currents in the Haller experiment and the ideal arc-shaped coast similar to Sanya Dadonghai, Hainan Province,China. The results showed that the FUNWAVE model has considerable ability to simulate the rip currents, and it was used to further simulate rip currents off arc-shaped coastlines to investigate their characteristics. The rip currents were found to be stronger as the curvature of arc-shaped coastline increased. Coastal beach slope exerts a significant influence on rip currents; in particular, an overly steep or overly mild slope is not conducive to creating rip currents. Furthermore, the rip currents were found to become weaker as the size of arc-shaped coast decreased. When the height and period of waves increase, the strength of rip currents also increases, and, in some cases, wave heights of 0.4 m may produce dangerous rip currents. | WANG Hong ZHU Shouxian LI Xunqiang ZHANG Wenjing NIE Yu | 2018 | Acta Oceanologica Sinica2018，37，3： | 5 |
| 6 | Nano-hydroxyapatite accelerates vascular calcification via lysosome impairment and autophagy dysfunction in smooth muscle cells显示文摘Vascular calcification(VC)is a common characteristic of aging,diabetes,chronic renal failure,and atherosclerosis.The basic component of VC is hydroxyapatite(HAp).Nano-sized HAp(nHAp)has been identified to play an essential role in the development of pathological calcification of vasculature.However,whether nHAp can induce calcification in vivo and the mechanism of nHAp in the progression of VC remains unclear.We discovered that nHAp existed both in vascular smooth muscle cells(VSMCs)and their extracellular matrix(ECM)in the calcified arteries from patients.Synthetic nHAp had similar morphological and chemical properties as natural nHAp recovered from calcified artery.nHAp stimulated osteogenic differentiation and accelerated mineralization of VSMCs in vitro.Synthetic nHAp could also directly induce VC in vivo.Mechanistically,nHAp was internalized into lysosome,which impaired lysosome vacuolar H+-ATPase for its acidification,therefore blocked autophagic flux in VSMCs.Lysosomal re-acidification by cyclic-3′,5′-adenosine monophosphate(cAMP)significantly enhanced autophagic degradation and attenuated nHAp-induced calcification.The accumulated autophagosomes and autolysosomes were converted into calcium-containing exosomes which were secreted into ECM and accelerated vascular calcium deposit.Inhibition of exosome release in VSMCs decreased calcium deposition.Altogether,our results demonstrated a repressive effect of nHAp on lysosomal acidification,which inhibited autophagic degradation and promoted a conversion of the accumulated autophagic vacuoles into exosomes that were loaded with undissolved nHAp,Ca^(2+),Pi and ALP.These exosomes bud off the plasma membrane,deposit within ECM,and form calcium nodules.Vascular calcification was thus accelerated by nHAP through blockage of autophagic flux in VSMCs. | Qi Liu Yi Luo Yun Zhao Pingping Xiang Jinyun Zhu Wangwei Jing Wenjing Jin Mingyao Chen Ruikang Tang Hong Yu | 2022 | Bioactive Materials2022，7，2： | 5 |
| 7 | SNP-based QTL mapping for panicle traits in the japonica super rice cultivar Liaoxing 1显示文摘Panicle traits directly associated with yield are a target of selection in rice breeding.Although abundant QTL for panicle traits have been identified,there is little information about the genetic basis of panicle traits in japonica super rice(JSR)cultivars.In this study,we identified QTL for panicle traits in three environments using a population of recombinant inbred lines(RILs)derived from the JSR cultivar Liaoxing 1.A total of 197 RILs were genotyped with 285 polymorphic SNP markers.Phenotypic data and best linear unbiased prediction(BLUP)value of primary branch number(BNP),secondary branch number(BNS),grain number on primary branch(GNP),grain number on secondary branch(GNS),grain number per panicle(GN),panicle length(PL)and grain density(GD)were used for QTL mapping.A total of 105 QTL for seven panicle traits were detected in single environments using their BLUP values.Individual QTL explained 0.51%–52.22%of the phenotypic variation.Of the 105,49 were also detected by joint multi-environment analyses.Five stable QTL:qGD9,qPL9,qGNP9,qGN6,and qBNS6.2 were identified in multiple environments.qGD9,qGNP9,and qPL9,co-localizing on chromosome 9,likely correspond to the known gene DEP1.Importantly,qGN6 and qBNS6.2 in a co-localization region were identified as novel QTL,and their Liaoxing 1 alleles had a positive effect.Several RILs with the QTL allele combinations qGD9/qPL9/qGNP9 and qGN6/qBNS6.2 showed greater GN.Further investigation of the putative gene underlying qGN6/qBNS6.2 would shed light on the molecular mechanism of JSR. | Mingzhu Zhao Zuobin Ma Lili Wang Zhiqiang Tang Ting Mao Chuanbin Liang Hong Gao Liying Zhang Na He Liang Fu Changhua Wang Guomin Sui Wenjing Zheng | 2020 | The Crop Journal2020，8，5： | 4 |
| 8 | The relationship between light intensity and nutrient uptake kinetics in six freshwater diatoms显示文摘In order to find effective measures to control diatom blooms, a better understanding of the physiological characteristics of nutrient uptake in diatoms is needed. A study of P and Si-uptake kinetics for diatom species from two light regimes was conducted at low(LL),moderate(ML) and high light intensities(HL)(2, 25 and 80 μmol photons/(m2·sec)),respectively. The results showed that P uptake of diatoms was heavily influenced by historic light regimes. P affinity changed with growth and photosynthetic activity. The lowest half saturation constant for P uptake(Km(P)) was under HL for high-light adapted diatoms while the lowest half-saturation constant for low-light adapted diatoms was observed under LL. The Si half-saturation constant(Km(Si)) increased with increasing light intensities for pennate diatoms but decreased for centric diatoms. Diatom volumes were correlated with the maximum Si uptake rates(Vm(Si)) at HL and K m(Si)at ML and HL for six diatom species. Our results imply that when we assess the development of diatom blooms we should consider light intensity and cell volume in addition to ambient Si or P concentration. The relationship between light intensity and P-uptake suggests that we can find suitable methods to control diatom blooms on the basis of reducing phytoplankton activity of P-uptake and photosynthesis simultaneously. | Pengling Shi Hong Shen Wenjing Wang Wenjie Chen Ping Xie | 2015 | Journal of Environmental Sciences2015，27，8： | 3 |
| 9 | ETCM v2.0:An update with comprehensive resource and rich annotations for traditional Chinese medicine显示文摘Existing traditional Chinese medicine(TCM)-related databases are still insufficient in data standardization,integrity and precision,and need to be updated urgently.Herein,an Encyclopedia of Traditional Chinese Medicine version 2.0(ETCM v2.0,http://www.tcmip.cn/ETCM2/front/#/)was constructed as the latest curated database hosting 48,442 TCM formulas recorded by ancient Chinese medical books,9872 Chinese patent drugs,2079 Chinese medicinal materials and 38,298 ingredients.To facilitate the mechanistic research and new drug discovery,we improved the target identification method based on a two-dimensional ligand similarity search module,which provides the confirmed and/or potential targets of each ingredient,as well as their binding activities.Importantly,five TCM formulas/Chinese patent drugs/herbs/ingredients with the highest Jaccard similarity scores to the submitted drugs are offered in ETCM v2.0,which may be of significance to identify prescriptions/herbs/ingredients with similar clinical efficacy,to summarize the rules of prescription use,and to find alternative drugs for endangered Chinese medicinal materials.Moreover,ETCM v2.0 provides an enhanced Java Script-based network visualization tool for creating,modifying and exploring multi-scale biological networks.ETCM v2.0 may be a major data warehouse for the quality marker identification of TCMs,the TCM-derived drug discovery and repurposing,and the pharmacological mechanism investigation of TCMs against various human diseases. | Yanqiong Zhang Xin Li Yulong Shi Tong Chen Zhijian Xu Ping Wang Meng Yu Wenjia Chen Bing Li Zhiwei Jing Hong Jiang Lu Fu Wenjing Gao Yanhua Jiang Xia Du Zipeng Gong Weiliang Zhu Hongjun Yang Haiyu Xu | 2023 | Acta Pharmaceutica Sinica B2023，13，6： | 3 |
| 10 | Multi-interface collaboration of graphene cross-linked NiS-NiS_(2)-Ni_(3)S_(4) polymorph foam towards robust hydrogen evolution in alkaline electrolyte显示文摘Electrocatalytic hydrogen production in alkaline media is extensively adopted in industry. Unfortunately, further performance improvement is severely impeded by the retarded kinetics, which requires the fine regulation of water dissociation, hydrogen recombination, and hydroxyl desorption. Herein, we develop a multi-interface engineering strategy to make an elaborate balance for the alkaline hydrogen evolution reaction (HER) kinetics. The graphene cross-linked three-phase nickel sulfide (NiS-NiS_(2)-Ni_(3)S_(4)) polymorph foam (G-NNNF) was constructed through hydrothermal sulfidation of graphene wrapped nickel foam as a three-dimensional (3D) scaffold template. The G-NNNF exhibits superior catalytic activity toward HER in alkaline electrolyte, which only requires an overpotential of 68 mV to drive 10 mA·cm^(−2) and is better than most of the recently reported metal sulfides catalysts. Density functional theory (DFT) calculations verify the interfaces between nickel sulfides (NiS/NiS_(2)-Ni_(3)S_(4)) and cross-linked graphene can endow the electrocatalyst with preferable hydrogen adsorption as well as metallic nature. In addition, the electron transfer from Ni_(3)S_(4)/NiS_(2) to NiS results in the electron accumulation on NiS and the hole accumulation on Ni_(3)S_(4)/NiS_(2), respectively. The electron accumulation on NiS favors the optimization of the H* adsorption, whereas the hole accumulation on Ni_(3)S_(4) is beneficial for the adsorption of H_(2)O. The work about multi-interface collaboration pushes forward the frontier of excellent polymorph catalysts design. | Haiqing Wang Wenjing Zhang Xiaowei Zhang Shuxian Hu Zhicheng Zhang Weijia Zhou Hong Liu | 2021 | Nano Research2021，14，12： | 3 |
| 11 | 3D metal-organic frameworks based on lanthanide-seamed dimeric pyrogallol[4]arene nanocapsules显示文摘Two novel 3D metal-organic frameworks(MOFs)with cds network,{[Me NH_3]_7[Ln_8(Pg C_2)_2(H_2O)_y(HCOO)_7]}_n·x(Solvent)(FJI-Y4,FJI=Fujian Institute,Ln=Gd,y=12;FJI-Y5,Ln=Dy,y=11;Pg C_2=C-ethylpyrogallol[4]arene),based on unprecedented dimeric pyrogallol[4]arene-based Ln_8metal-organic nanocapsule(MONC)supramolecular building blocks and formate linkers,have been prepared under solvothermal conditions.To our best of knowledge,they present not only the first two examples of 3D hierarchical structures constructed from MONCs in metal-pyrogallol[4]arene system,but also the first two examples of MOFs based on lanthanide MONCs.Remarkably,the inner cavity volume of the Ln_8capsule in FJI-Y4 and FJI-Y5 is approximately151?~3,which is larger than those found in previous transition metal-seamed dimeric Pg C_n-based MONCs.Magnetic investigation on FJI-Y4 suggests a significant magnetocaloric effect(23.97 J kg^(-1)K^(-1),ΔH=7 T,2.5 K),while FJI-Y5 exhibits slow relaxation of the magnetization. | Kongzhao Su Mingyan Wu Wenjing Wang Mi Zhou Daqiang Yuan Maochun Hong | 2018 | Science China Chemistry2018，61，6： | 2 |
| 12 | Effect of sample diameter on primary and secondary dendrite arm spacings during directional solidification of Pb-26wt.%Bi hypo-peritectic alloy显示文摘The microstructure scales of dendrites,such as primary and secondary dendrite arm spacings,control the segregation profiles and the formation of secondary phases within interdendritic regions,which determine the properties of solidified structures.Investigations on primary and secondary dendrite arm spacings of primary α-phase during directionally solidified Pb-26wt%Bi hypo-peritectic alloy were carried out in this research,and systematic studies were conducted using cylindrical samples with different diameters(Φ = 1.8 and 7.0 mm) in order to analyze the effects of sample diameter on the primary and secondary dendrite arm spacings.In this work,the dependence of dendrite arm spacings on growth velocity was established.In addition,the experimental data concerning the primary and secondary dendrite arm spacings were compared with the main predictive dendritic models from the literatures.A comparison between experimental results for dendrite arm spacings of the 1.8-mm-diameter sample and 7.0-mm-diameter sample was also conducted. | HU Xiaowu YAN Hong CHEN Wenjing LI Shuangming FU Hengzhi | 2011 | Rare Metals2011，30，4： | 2 |
| 13 | Promising electroplating solution for facile fabrication of Cu quantum point contacts显示文摘在这篇文章,我们在制造和一个新奇、电气化学地帮助的机械地可控制的裂缝连接(EC-MCBJ ) 准备的 Cu 量点接触的运输大小上报导方法。由采用影印石版术和湿蚀刻的过程,推迟了电极对在 Si 微芯片上成功地有图案、制作。而非采用一个酸 Cu electroplating 答案,一个新奇碱的 electroplating 答案被开发并且利用了建立在电极对之间的 Cu nanocontacts。典型地,同样制作的 Cu nanocontacts 的宽度被发现比 18 nm 小。很多 Cu 量点接触然后被造家的 MCBJ 安装生产并且描绘。除了常规直方图,在山峰趋于与增加传导力在振幅减少的地方,传导力直方图的一种异常类型,展出不同山峰振幅,被观察。通过最大值的统计分析 Si 微芯片,和理论计算的许可的弯曲,我们证明我们的碱的 Cu electroplating 答案负担得起与随后的 MCBJ 操作兼容的 Cu nanocontacts,它为 Cu 量点接触的制造是必要的。当复杂电子横梁平版印刷术没被要求, EC-MCBJ 方法快、简单、划算。而且,它是可能的对从他们的各自的 electroplating 答案的各种各样的金属的量点接触的制造和描述合适。 | Yang Yang Junyang Liu Jueting Zheng Miao Lu Jia Shi Wenjing Hong Fangzu Yang Zhongqun Tian | 2017 | Nano Research2017，10，10： | 2 |
| 14 | Quantum interference effect in the charge transport through single-molecule benzene dithiol junction at room temperature:An experimental investigation显示文摘The quantum interference effect in the charge transport through single-phenyl molecules received intensive interests from theory but remained as an experimental challenge. In this paper, we investigated the charge transport through single-molecule benzene dithiol(BDT) junction with different connectivities using mechanically controllable break junction(MCBJ) technique. By further improving the mechanical stability and the electronic measuring component of the MCBJ set-up, we obtained the conductance histograms of BDT molecules(BDTs) from the statistical analysis of conductance-distance traces without data selection. By tuning the connectivity, the conductance of BDTs is determined to be 10^(-1.2)G_0, 10^(-2.2) G_0 and 10^(-1.0)G_0 for para, meta, and ortho connectivity, following the trend that ortho-BDT >para-BDT >meta-BDT. Furthermore, the displacements of the junctions followed the trend that para > meta > ortho, suggesting the charge transport through the molecules via the gold-thiol bond.The different trends between conductance and displacement for different connectivities suggests the presence of destructive quantum interference effect on meta-BDT, which provides the experimental evidence for the quantum interference effect through single-phenyl molecular junctions. | Guogang Yang Hao Wu Junying Wei Jueting Zheng Zhaobin Chen Junyang Liu Jia Shi Yang Yang Wenjing Hong | 2018 | Chinese Chemical Letters2018，29，1： | 2 |
| 15 | Transparent graphene /PEDOT-PSS composite films as counter electrodes of dye-sen- sitized solar cells 显示文摘 | Hong Wenjing Xu Yuxi Lu Gewu | 2008 | Electrochemistry Communications2008，10，10： | 1 |
| 16 | Towards Responsive Single-Molecule Device显示文摘Single-molecule devices,which are fabricated by the single molecule bridged through electrodes,provide a promising approach to investigate the intrinsic chemical or physical properties of individual molecules.Beyond the studies of single-molecule wires,a large number of responsive single-molecule junctions or devices with unique chemical or physical properties have been designed and fabricated by introducing the external field,which further offers the chance to explore conductive materials at the molecular level.Here,we summarized the latest studies on the behaviors of single-molecule devices based on the photon,thermal,electric,or magnetic responses,and discussed the development of responsive single-molecule devices in prospect. | Yaorong Chen Longfeng Huang Hang Chen Zhixin Chen Hewei Zhang Zongyuan Xiao Wenjing Hong | 2021 | Chinese Journal of Chemistry2021，39，2： | 1 |
| 17 | 显示文摘 | Hong Wenjing Bai Hua Xu Yuxi | 2010 | The Journal of Physical Chemistry C2010，114，4： | 1 |
| 18 | High-loading Pt-alloy catalysts for boosted oxygen reduction reaction performance显示文摘To improve performance of membrane electrode assembly(MEA)at large current density region,efficient mass transfer at the cathode is desired,for which a feasible strategy is to lower catalyst layer thickness by constructing high loading Pt-alloy catalysts on carbon.But the high loading may induce unwanted par-ticle aggregation.In this work,H-PtNi/C with 33%(mass)Pt loading on carbon and monodisperse distri-bution of 3.55 nm PtNi nanoparticles,was prepared by a bimodal-pore route.In electrocatalytic oxygen reduction reaction(ORR),H-PtNi/C displays an activity inferior to the low Pt loading catalyst L-PtNi/C(13.3%(mass))in the half-cell.While in H_(2)-0_(2) MEA,H-PtNi/C delivers the peak power density of 1.51 W·cm^(-2) and the mass transfer limiting current density of 4.4 A·cm^(-2),being 21%and 16%higher than those of L-PtNi/C(1.25 W·cm^(-2),3.8 A·cm^(-2))respectively,which can be ascribed to enhanced mass trans-fer brought by the thinner catalyst layer in the former.In addition,the same method can be used to pre-pare PtFe alloy catalyst with a high-Pt loading of 36%(mass).This work may lead to a range of catalyst materials for the large current density applications,such as fuel cell vehicles. | Wei Hong Xinran Shen Jian Wang Xin Feng Wenjing Zhang Jing Li Zidong Wei | 2022 | Chinese Journal of Chemical Engineering2022，35，8： | 1 |
| 19 | 显示文摘 | Xu Yuxi Hong Wenjing Bai Hua | 2009 | Carbon2009，47，15： | 1 |
| 20 | In vitro and in vivo evaluation of improved EGFR targeting peptide-conjugated phthalocyanine photosensitizers for tumor photodynamic therapy显示文摘Phthalocyanine(Pc) is one of the most promising photosensitizer candidates because of its strong absorption(extinction coefficient ε > 10~5 LmoI ~1 cm^1) at long wavelengths and strong singlet oxygen generation abilities(a singlet oxygen quantum yield of approximately 50%). However, low tumor targeting, low water solubility and a high tendency to aggregate appear to significantly restrict the compound's application in tumor treatment. Conjugating Pc with peptide ligands could be a useful strategy for alleviating these problems. Here, to further optimize the structures of peptide-conjugated zinc Pcs for PDT therapy, we finely tuned the hydrophilicity of the modified Pc aromatic macrocycle with varied length of polyethylene glycol(PEG) and added an extra PEG linker and an extra glutamic acid between the Pc ring and the peptide ligand to reduce the influence of the ligand on the Pc aromatic ring.Among the synthesized conjugates, Pc-3 showed greatly improved targeting towards tumors and abolished inoculated tumors with only a single PDT treatment in a subcutaneous xenograft tumor model,making this approach a promising therapeutic agent for the treatment of cancer. | Qingle Chen Yanhong Ma Jisi Zhao Mei Zhao Wenjing Li Qian Liu Li Xiong Wenjie Wu Zhangyong Hong | 2018 | Chinese Chemical Letters2018，29，7： | 1 |
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