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| 1 | Bacteriocin from Bacillus subtilis as a novel drug against diabetic foot ulcer bacterial pathogens显示文摘Objective:To isolate and identify Bacillus subtilis(B.subtilis)from soil and to characterize and partially purify the bacteriocin.To evaluate the antimicrobial activity against four diabetic foot ulcer bacterial pathogens.Methods:Genotypic identification was done based on Sergey's manual of systemic bacteriology.Antimicrobial susceptibility test was done by Kirby-Bauer disc diffusion method.Colonies were identified by colony morphology and biochemical characterization and also compared with MTCC 121 strain.Further identification was done by 16S rRNA sequencing.Inhibitory activities of partially purified bacteriocin on all the DFU isolates were done by agar well diffusion method.The strain was identified to produce bacteriocin by stab overlay assay.Bacteriocin was extracted by organic solvent extraction using chloroform,further purified by HPI.C and physical,and chemical characterization was performed.Results:The four isolates showed high level of resistance to amoxyclav and sensitivity to ciprofloxacin.HPLC purification revealed that the extracts are bacteriocin.The phylogenetic tree analysis results showed that the isolate was 99%related to B.subtilis BSF01.The results reveled activity to all the four isolates and high level of activity was seen in case of Klebsiella sp.Conclusions:Partially purified bacteriocin was found to have antimicrobial activity against the four diabetic foot ulcer bacterial pathogens,which can thus be applied as a better drug molecule on further studies.The strain B.subtilis are found to be safe for use and these antimicrobial peptides can be used as an antimicrobial in humans to treat DFU bacterial pathogens. | Baby Joseph Berlina Dhas Vimalin Hena Justin Raj | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，12： | 2 |
| 2 | Growth, Optical, Mechanical, Dielectric and Theoretical Studies on Potassium Pentaborate Tetrahydrate (KB_5O_8·4H_2O) Single Crystal by Modified Sankaranarayanan-Ramasamy Method显示文摘A nonlinear optical single crystal of potassium pentaborate tetrahydrate (KB5O8·4H2O) has been grown from aqueous solution by using unidirectional crystal growth method of Sankaranarayanan-Ramasamy (SR) with a due modification in the growth assembly. Potassium pentaborate crystal of 60 mm length and 10 mm diameter has been grown along (100) plane with a growth rate of 3 mm per day within a period of 20 days. The grown crystal was subjected to single crystal X-ray diffraction analysis to confirm that the crystal belongs to the orthorhombic system. Some fundamental data such as valance electron plasma energy, Penn gap, Fermi energy and electronic polarizability of the grown crystal were calculated. The presence of borate in the grown crystal was confirmed by Fourier transform infrared (FTIR) spectroscopy. The optical transmission property of the grown crystal was analyzed using ultra violet (UV) visible spectral analysis. Surface morphology of the growth plane was observed using scanning electron microscopy (SEM). The mechanical strength of the crystals was found out using Vickers microhardness test along the growth axis. Frequency dependent dielectric constant of the grown crystal was studied for various temperatures along (100) plane. | C. Justin Raj S. Krishnan S. Dinakaran J. Mary Linet R. Uthrakumar R. Robert S. Jerome Das | 2009 | Journal of Materials Science & Technology2009，25，6： | 2 |
| 3 | Synthesis, growth, structural, optical, photoconductivity and dielectric studies on potassium p -nitrophenolate dihydrate: A new semiorganic nonlinear optical material显示文摘 | B. Milton Boaz M. Palanichamy Babu Varghese C. Justin Raj S. Jerome Das | 2008 | Materials Research Bulletin2008，，12： | 1 |
| 4 | Identification of predictive factors for perioperative blood transfusion in colorectal resection patients显示文摘 | Justin Kim Viken Konyalian Richard Huynh Raj Mittal Michael Stamos Ravin Kumar | 2007 | International Journal of Colorectal Disease2007，，12： | 1 |
| 5 | Elec- trochemical capacitor behavior of copper sulfide (CuS) nano- platelets 显示文摘 | Justin Raj C Byung Chul Kim Won -Je Cho | 2014 | Journal of Alloys and Compounds2014，586，： | 1 |
| 6 | Donor age affects fibrosis progression and graft survival after liver transplantation for hepatitis C1显示文摘 | Victor I. Machicao Hugo Bonatti Murli Krishna Bashar A. Aqel Frank J. Lukens Justin H. Nguyen Barry G. Rosser Raj Satyanarayana Hani P. Grewal Winston R. Hewitt Denise M. Harnois Julia E. Crook Jeffery L. Steers Rolland C. Dickson | 2004 | Transplantation2004，，1： | 1 |
| 7 | Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators显示文摘 | Haley Hieronymus Justin Lamb Kenneth N. Ross Xiao P. Peng Cristina Clement Anna Rodina Maria Nieto Jinyan Du Kimberly Stegmaier Srilakshmi M. Raj Katherine N. Maloney Jon Clardy William C. Hahn Gabriela Chiosis Todd R. Golub | 2006 | Cancer Cell2006，，： | 1 |
| 8 | Hydrothermal synthesis of highly crystalline Zn2 SnO4 nanoflowers and their optical properties显示文摘 | M Mary Jaculine C Justin Raj S Jerome Das | 2013 | J Alloys Compd2013，577，： | 1 |
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