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| 1 | Prospective validation of %p2PSA and the Prostate Health Index, in prostate cancer detection in initial prostate biopsies of Asian men, with total PSA 4-10 ng ml-1显示文摘尽管有它为屏蔽的前列腺癌症的普遍使用,低特性使 PSA 成为非最优的 biomarker,特别在 4-10 ng ml 1 的诊断灰色的地区。假积极与伴随的病态导致不必要的活体检视。这在与在 4.0 和 10 ng ml 1 之间的全部的 PSA 介绍的亚洲人是 % p2PSA 和前列腺健康索引(PHI ) 的第一未来的确认研究。我们学习了在 50 和 75 岁之间的 157 个亚洲人,与每直肠的前列腺考试的正常,经历他们的第一前列腺活体检视,用一个标准化活体检视协议,为 4-10 ng ml 1 的 PSA 层次。(19.1%) 三十被发现在活体检视上有前列腺癌症。有或没有前列腺癌症的病人之间的统计上重要的差别被作出对有利的裁决全部的 PSA, p2PSA, % p2PSA,和 PHI。在为全部的 PSA, % fPSA, % p2PSA,和 PHI 操作典型曲线的接收装置的曲线下面的区域分别地是 0.479, 0.420, 0.695,和 0.794。PHI 最好预言 prostatic 活体检视结果。在 90% 的敏感, PHI 的特性(95% CI ) 是 58.3% ,多于在 17.3% 点使全部的 PSA 的特性增加两倍,潜在地避免 77 (49%) 不必要的活体检视。类似于研究在主要白种人人口,我们有希望地证明了 % p2PSA 和 PHI 极大地超过总数并且释放总计 PSA 比率,在前列腺癌症的察觉起初活体检视。更高的 PHI 层次也对应于增加检测 GS 7 癌症的风险。我们验证了 PHI 的使用与在 4 和 10 ng ml 1 之间的浆液 PSA 在亚洲人关于前列腺活体检视帮助决策。 | Lincoln GL Tan Yung Khan Tan Bee Choo Tai Karen ML Tan Vineet Gauhar Ho Yee Tiong Robert CW Hawkins Thomas P Thamboo Felicia SK Hong Edmund Chiong | 2017 | Asian Journal of Andrology2017，19，3： | 13 |
| 2 | Evidence for the involvement of infectious agents in the pathogenesis of Crohn's disease显示文摘Many advances have been made in the understanding of Crohn’s disease (CD) pathogenesis during the last decade. CD is currently seen as a predominantly T-lym-phocyte-driven disease characterized by the presence of a complex cocktail of interacting cytokines, chemokines and other mediators produced by a variety of cell types. Prevailing theories of CD pathogenesis suggest that patients’ T-lymphocytes are inappropriately activated in the setting of an immune imbalance, which is itself caused by an unfortunate confluence of genetic and en- vironmental factors. The T-cell response then leads to the chronic inflammation characteristic for the disease. Various environmental factors may play a role in the development of CD, but microbes are most consistently implied. This theory is based on epidemiological, clinico- pathological, genetic and experimental evidence. Despite the abundance of arguments for the implication of bac-teria in the aetiopathogenesis of CD, the precise role of bacteria in this disease still remains elusive. Three not necessarily mutually exclusive theories have been pro- posed: (1) an unidentified persistent pathogen; (2) an abnormally permeable mucosal barrier leading to exces-sive bacterial translocation; and (3) a breakdown in the balance between putative 'protective' versus 'harmful' intestinal bacteria ('dysbiosis'). At present, one cannot exclude with certainty any of these three proposed hy-potheses; they may all apply to CD to a certain extent. | Gert De Hertogh Jeroen Aerssens Karen P Geboes Karel Geboes | 2008 | World Journal of Gastroenterology2008，14，6： | 11 |
| 3 | Systematic review of nutrition screening and assessment in inflammatory bowel disease显示文摘BACKGROUND Malnutrition is prevalent in inflammatory bowel disease (IBD). Multiple nutrition screening (NST) and assessment tools (NAT) have been developed for general populations, but the evidence in patients with IBD remains unclear. AIM To systematically review the prevalence of abnormalities on NSTs and NATs, whether NSTs are associated with NATs, and whether they predict clinical outcomes in patients with IBD. METHODS Comprehensive searches performed in Medline, CINAHL Plus and PubMed. Included: English language studies correlating NSTs with NATs or NSTs/NATs with clinical outcomes in IBD. Excluded: Review articles/case studies;use of body mass index/laboratory values as sole NST/NAT;age<16. RESULTS Of 16 studies and 1618 patients were included, 72% Crohn’s disease and 28% ulcerative colitis. Four NSTs (the Malnutrition Universal Screening Tool, Malnutrition Inflammation Risk Tool (MIRT), Saskatchewan Inflammatory Bowel Disease Nutrition Risk Tool (SaskIBD-NRT) and Nutrition Risk Screening 2002 (NRS-2002) were significantly associated with nutritional assessment measures of sarcopenia and the Subjective Global Assessment (SGA). Three NSTs (MIRT, NRS-2002 and Nutritional Risk Index) were associated with clinical outcomes including hospitalizations, need for surgery, disease flares, and length of stay (LOS). Sarcopenia was the most commonly evaluated NAT associated with outcomes including the need for surgery and post-operative complications. The SGA was not associated with clinical outcomes aside from LOS. CONCLUSION There is limited evidence correlating NSTs, NATs and clinical outcomes in IBD. Although studies support the association of NSTs/NATs with relevant outcomes, the heterogeneity calls for further studies before an optimal tool can be recommended. The NRS-2002, measures of sarcopenia and developments of novel NSTs/NATs, such as the MIRT, represent key, clinically-relevant areas for future exploration. | Suqing Li Michael Ney Tannaz Eslamparast Ben Vandermeer Kathleen P Ismond Karen Kroeker Brendan Halloran Maitreyi Raman Puneeta Tandon | 2019 | World Journal of Gastroenterology2019，25，28： | 9 |
| 4 | 如何设计高质量针刺临床研究:基于证据的专家共识显示文摘本针刺随机对照试验(Randomised controlled trials, RCT)专家共识是基于目前针刺试验面临的最普遍、最关键问题,由临床医生、研究人员、从事针灸和外科的临床试验专家、统计专家、临床流行病学和方法学专家以及患者组成的国际临床研究小组联合制订。该共识将有助于临床试验资助者、注册者以及期刊编辑等评估针刺RCT方案及研究结果的相关性、重要性和质量。 | 张誉清 焦睿珉 Claudia M Witt 劳力行 刘建平 Lehana Thabane Karen J Sherman Mike Cummings Dawn P Richards Eun-Kyung Anna Kim Tae-Hun Kim Myeong Soo Lee Michael E Wechsler Benno Brinkhaus Jun J Mao Caroline A Smith 岗卫娟 刘保延 刘志顺 刘岩 郑晖 吴佳霓 AloBSO Carrasco-Labra Mohit Bhandari Philip J Devereaux 景向红 Gordon Guyatt | 2022 | 英国医学杂志中文版2022，25，6： | 7 |
| 5 | Acute coronary syndrome in the older adults显示文摘1 Introduction Coronary heart disease remains the leading cause of death in the developed world.Advanced age is the single strongest risk factor for coronary artery disease (CAD) and independent predictor for poor outcomes following an acute coronary syndrome (ACS).ACS refers to a spectrum of conditions compatible with acute myocardial ischemia and/or infarction due to various degrees of reduction in coronary blood flow as a result of plaque rupture/erosion and thrombosis formation or supply and demand mismatch. | Xuming DAI Jan Busby-Whitehead Karen P Alexander | 2016 | Journal of Geriatric Cardiology2016，13，2： | 5 |
| 6 | Stable ischemic heart disease in the older adults显示文摘1 Introduction Ischemic heart disease is caused by atherosclerotic and/or thrombotic obstruction of coronary arteries.Clinical spectrum of ischemic heart disease expands from asymptomatic atherosclerosis of coronary arteries to acute coronary syndromes (ACS) including unstable angina,acute myocardial infarction (non-ST elevation myocardial infarction and ST elevation myocardial infarction). | Xuming DAI Jan Busby-Whitehead Daniel E Forman Karen P Alexander | 2016 | Journal of Geriatric Cardiology2016，13，2： | 5 |
| 7 | Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db / db Mice显示文摘 | Hong Chen Olga Charlat Louis A Tartaglia Elizabeth A Woolf Xun Weng Stephen J Ellis Nathan D Lakey Janice Culpepper Karen J More Roger E Breitbart Geoffrey M Duyk Robert I Tepper Jay P Morgenstern | 1996 | Cell1996，，3： | 2 |
| 8 | Role of computed tomography angiography in detection and staging of small bowel carcinoid tumors显示文摘Small-bowel carcinoid tumors are the most common form(42%) of gastrointestinal carcinoids, which by themselves comprise 70% of neuroendocrine tumors. Although primary small bowel neoplasms are overall rare(3%-6% of all gastrointestinal neoplasms), carcinoids still represent the second most common(20%-30%) primary small-bowel malignancy after small bowel adenocarcinoma. Their imaging evaluation is often challenging. State-of-the-art high-resolution multiphasic computed tomography together with advanced postprocessing methods provides an excellent tool for their depiction. The manifold interactive parameter choices however require knowledge of when to use which technique. Here, we discuss the imaging appearance and evaluation of duodenal, jejunal and ileal carcinoid tumors, including the imaging features of the primary tumor, locoregional mesenteric nodal metastases, and distant metastatic disease. A protocol for optimal lesion detection is presented, including the use of computed tomography enterography, volume acquisition, computed tomography angiography and three-dimensional mapping. Imaging findings are illustrated with a series of challenging cases which illustrate the spectrum of possible disease in the small bowel and mesentery, the range of possible appearances in the bowel itself on multiphase data and extraluminal findings such as the desmoplastic reaction in mesentery and hypervascular liver metastases. Typical imaging pitfalls and pearls are illustrated. | David Bonekamp Siva P Raman Karen M Horton Elliot K Fishman | 2015 | World Journal of Radiology2015，7，9： | 2 |
| 9 | Clinical proof of principle for ChimeriVaxTM:recombi nant live,attenuated vaccines against flavivirus infections 显示文摘 | THOMAS P MONATH KAREN MCCARTHY | 2002 | Vaccine2002，20，： | 1 |
| 10 | Accruals and the Prediction of Future Cash Flows 显示文摘 | MARY E B DONALD P C KAREN K N | 2001 | The Accounting Re- view2001，76，1： | 1 |
| 11 | Flavonol Glycoside Content and Composition of Tea in Fusions Made from Commercially Available Teas and Tea Products 显示文摘 | KEITH R P MICHAEL J R KAREN A B | 1998 | J Agric Food Chem1998，，46： | 1 |
| 12 | Geochemi- cal processes during five years of aquifer storage re- covery显示文摘 | Andrew L H Karen J R Peter P | 2004 | Ground Water2004，42，3： | 1 |
| 13 | CDKN2A gene deletions and loss of p16 expression occur in osteosarcomas that lack RB Alteration显示文摘 | Nielsen Karen L | 1998 | Am J Pathol1998，153，1： | 1 |
| 14 | Morphology of perimembranous ventricular septal defects:implications for transcatheter device closure显示文摘 | Ho SY Path FRC Karen P | 2004 | J Interven Cardiol2004，17，2： | 1 |
| 15 | Single-step purifica- tion/solubilization of recombinant proteins: Application to surfactant protein B显示文摘 | Andreas H Karen S P Timothy E W | 1996 | Bio Tech1996，，20： | 1 |
| 16 | Synthesis and Relative Stereochem- istry of 2 -Monohalo DDT Pyrethroid Structures:2 -halo - 1 - (4' - ethoxypheny) cyclopropane - 1 - methanols and Cyclopropane - 1 - car- boxylic Acid and Esters显示文摘 | Johnson M P Holan G Karen E J | 1986 | Aust J Chem1986，39，： | 1 |
| 17 | Striatal dopaminergic pathways as a target for the insecticides permethrin and chlorpyrifos显示文摘 | Karen D J Li W Harp P R | 2001 | Neurotoxicology2001，22，： | 1 |
| 18 | Target location and laser designation via electrooptic sensors : A three-tiered strategy 显示文摘 | Waiters Karen P | 2004 | FA Journal2004，，3： | 1 |
| 19 | Obesity-related Differential Gene Expression in the Visceral Adipose Tissue显示文摘 | Ancha Baranova Rochelle Collantes Shobha J Gowder Hazem Elariny Karen Schlauch Abraham Younoszai Steve King Manpreet Randhawa Sitapati Pusulury Tariq Alsheddi Janus P Ong Lisa M Martin Vikas Chandhoke Zobair M Younossi | 2005 | Obesity Surgery2005，，6： | 1 |
| 20 | Trace Analysis of Seven Neonicotinoid Insecticides in Bee Pollen by Solid-liquid Extraction and Liquid Chromatography Coupled to Electrospray Ionization Mass Spectrometry显示文摘 | KAREN P Y MARIA T M JOSE L B | 2014 | Food Analytical Methods2014，7，2： | 1 |
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