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| 1 | Vasculogenic mimicry is a prognostic factor for postoperative survival in patients with glioblastoma显示文摘A previous report has confirmed the existence and clinical significance of vasculogenic mimicry(VM)in glioma.However,its conclusions about the negative clinical significance of VM in glioblastoma are based on a small group of patients and,thus,might be unconvincing.The aim of the present study was to reevaluate the clinical significance of VM in glioblastoma.Patients were classified as VM-positive or | Wang SY Ke YQ Lu GH Song ZH Yu L Xiao S Sun XL Jiang XD Yang ZL Hu CC | 2013 | 中国神经肿瘤杂志2013，11，3： | 22 |
| 2 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 3 | STUDY ON HARVESTED POPULATION WITH DIFFUSIONAL MIGRATION显示文摘This paper is devoted to the study of the dynamical behavior and harvesting problem of an exploited population with diffusional migration, for which a protective patch is established. We examine the effects of protective patch and harvest on the population resources and conclude that the protective patch is effective for the conservation of population resources and ecological environment, though in some cases the extinction can not be eliminated. The dangerous region, the parameters domains and the typical bifurcation curves of stability of steady states for the considered system are determined. The optimal harvest policy for the considered population is made also. The explicit expressions are obtained for the optimal harvesting effort, the maximum sustainable yield and the corre- sponding population density. Our results provide a theoretical evidence for the practical management of biological resources. | FAN Meng WANG Ke (Deportment of Mathematics, Northeast Normal University, Changchun 130024, China) ZHANG Yujuan ZHANG Shuwen LIU Huimin (Department of Mathematics, Anshan Teacher’s College, Anshan 114005, China) | 2001 | Journal of Systems Science & Complexity2001，14，2： | 7 |
| 4 | Monitoring Greenhouses Gases over China Using Space-Based Observations Monitoring Greenhouses Gases over China Using Space-Based Observations显示文摘The atmospheric carbon dioxide(CO 2)concentration has increased to more than 405 parts per million(ppm.1 ppm=10-6 m/s 2)in 2017 due to human activities such as deforestation,land-use change and burning of fossil fuels.Although there is broad scientific consensus on the damaging consequences of the change in climate associated with increasing concentrations of greenhouse gases,fossil CO 2 emissions have continued to increase in recent years mainly from rapidly developing economies and China is now the largest emitter of CO 2 generating about 30%of all emissions globally.To allow more reliable forecast of the future state of the carbon cycle and to support the efforts for mitigation greenhouse gas emissions,a better understanding of the global and regional carbon budget is needed.Space-based measurements of CO 2 can provide the necessary observations with dense coverage and sampling to provide improved constrains on of carbon fluxes and emissions.The Chinese Global Carbon Dioxide Monitoring Scientific Experimental Satellite(TanSat)was established by the National High Technology Research and Development Program of China with the main objective of monitoring atmospheric CO 2 and CO 2 fluxes at the regional and global scale.TanSat has been successfully launched in December 2016 and as part of the Dragon programme of ESA and the Ministry of Science and Technology(MOST),a team of researchers from Europe(UK and Finland)and China has evaluated early TanSat data and contrast it against data from the GOSAT mission and models.In this manuscript,we report on retrieval intercomparisons of TanSat data using two different retrieval algorithms,on validation efforts for the Eastern Asia region using GOSAT CO 2 data and first assessments of TanSat and GOSAT CO 2 data against model calculations using the GEOS-Chem model. | Hartmut BOESCH Yi LIU Paul I PALMER Johanna TAMMINEN Jasdeep S ANAND Zhaonan CAI Ke CHE Huilin CHEN Xi CHEN Liang FENG Janne HAKKARAINEN Pauli HEIKKINEN Nikoleta KALAITZI Rigel KIVI Robert PARKER Peter SOMKUTI Jing WANG Alex WEBB Dongxu YANG Lu YAO You YI | 2020 | Journal of Geodesy and Geoinformation Science2020，3，4： | 2 |
| 5 | Tetrapod -shaped ZnO whisker and its composites 显示文摘 | ZHOU Z PENG W KE S | 1999 | J Materials Processing Technology1999，8990，： | 2 |
| 6 | Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12显示文摘 | Birgit Oppmann Robin Lesley Bianca Blom Jackie C Timans Yuming Xu Brisdell Hunte Felix Vega Nancy Yu Jing Wang Komal Singh Francesca Zonin Elena Vaisberg Tatyana Churakova Man-ru Liu Daniel Gorman Janet Wagner Sandra Zurawski Yong-Jun Liu John S Abrams Ke | 2000 | Immunity2000，，5： | 2 |
| 7 | 王红阳院士发现肝癌患者中红细胞增多症的分子机制显示文摘近日国际著名肝脏疾病杂志Hepatology在线发表了第二军医大学附属东方肝胆外科医院王红阳院士研究成果,癌细胞来源的促红细胞生成素在肝细胞癌的进展中发挥一定的作用,并且EPO/EPOR可被视为具有红细胞增多症的肝癌患者的一个治疗靶标。红细胞增多症(Erythrocytosis)与许多类型的肿瘤相关,包括肾细胞癌、脑膜瘤以及肝细胞癌(HCC)。 | Ke S Chen S Dong Z | 2016 | 胃肠病学和肝病学杂志2016，25，12： | 2 |
| 8 | Zero tillage furrow opener effects on seed environment and wheat emergence显示文摘 | Tessier S Saxton Ke Papendick Ri | 1991 | Soil and Tillage Research1991，3，21： | 1 |
| 9 | High levels of Bcell activating factor in patients with active chronic graft-versushost disease 显示文摘 | Sarantopoulos S Stevenson KE Kim HT | 2007 | Clin Cancer Res2007，13，： | 1 |
| 10 | The BODE index after lung volume reduction surgery correlates with survival 显示文摘 | Imfeld S Bloch KE Weder W | 2006 | Chest2006，129，4： | 1 |
| 11 | Photocatalytic degradation of a cationic azo dye by TiO2/bentonite nanocomposite 显示文摘 | Sun Z S Chen Y X Ke Q | 2002 | J Photochem Photobiol A2002，149，13： | 1 |
| 12 | The effect of active oxygen on the activity of ACC synthase induced by exogenous IAA显示文摘 | Ke D S Wang A G Sun G C | 2002 | Acta Botany Sinica2002，44，： | 1 |
| 13 | Adaptations in response selection processes used during sport competition with increasing age and expertise显示文摘 | French KE McPherson S | 1999 | International Journal of Sport Psychology1999，30，： | 1 |
| 14 | Induction chemotherapy plus three-dimensional conformal radiation therapy in the definitive treatment of locally advanced non-cell lung cancer显示文摘 | Sim S Rosenzweig KE Schindeheim R | 2002 | Int J Radiat Oncol Biol Phys2002，53，2： | 1 |
| 15 | Guidelines tor the management of incicatrical pemphigus vulgaris 显示文摘 | Harman KE Albert S | 2003 | Br J Derm Atol2003，149，5： | 1 |
| 16 | Correlation between dark spot growth and pinhole size in organic light - emitting diodes显示文摘 | Lim S F Ke L Wang W | 2001 | Appl Phys Lett2001，78，15： | 1 |
| 17 | Continence after colorectal reconstruction following resection:impact of level of anastomosis显示文摘 | Matzel KE Stadelmaier U Muehldorfer S | 1997 | Int J Colorectal Dis1997，12，： | 1 |
| 18 | TAXUS I:Six and twelve-month results from a randomized,double-blind trial on a slow-release paclitaxel-eluting stent for de novo coronary lesions 显示文摘 | Grube E Silber S Hauptmann KE | 2003 | Circulation2003，107，1： | 1 |
| 19 | Regulation of osteogenic proteins by chondrocytes显示文摘 | Chubinskaya S Kuettner KE | 2003 | Int J Biochem Cell Biol2003，35，： | 1 |
| 20 | Retroper-itoneal laparoscopic dismembered Anderson-Hynes py-eloplasty in treatment of ureteropelvic junction obstruc-tion (report of 150 cases) 显示文摘 | CHUANYU S GUOWEI X KE X | 2009 | Urology2009，74，： | 1 |
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