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| 1 | Prognostic value of KRAS and BRAF mutations in curatively resected colorectal cancer显示文摘AIM: To investigate the prognostic role of KRAS and BRAF mutations after adjustment for microsatellite instability(MSI) status in Japanese colorectal cancer(CRC) population.METHODS: We assessed KRAS and BRAF mutations and MSI status in 813 Japanese patients with curatively resected, stage Ⅰ-Ⅲ CRC and examined associations of these mutations with disease-free survival(DFS) and overall survival(OS) using uni- and multivariate Cox proportional hazards models.RESULTS: KRAS and BRAF mutations were detected in 312(38%) of 812 and 40(5%) of 811 tumors, respectively. KRAS mutations occurred more frequently in females than in males(P = 0.02), while the presence of BRAF mutations was significantly associated with the female gender(P = 0.006), proximal tumor location(P < 0.001), mucinous or poorly differentiated histology(P < 0.001), and MSI-high tumors(P < 0.001). After adjusting for relevant variables, including MSI status, KRAS mutations were associated with poorer DFS(HR = 1.35; 95%CI: 1.03-1.75) and OS(HR = 1.46; 95%CI: 1.09-1.97). BRAF mutations were poor prognostic factors for DFS(HR = 2.20; 95%CI: 1.19-4.06) and OS(HR = 2.30; 95%CI: 1.15-4.71). Neither the BRAF by MSI interaction test nor the KRAS by MSI interaction test yielded statistically significant results for DFS and OS.CONCLUSION: KRAS and BRAF mutations are associated with inferior survival, independent of MSI status, inJapanese patients with curatively resected CRC. | Shigenori Kadowaki Miho Kakuta Shuhei Takahashi Akemi Takahashi Yoshiko Arai Yoji Nishimura Toshimasa Yatsuoka Akira Ooki Kensei Yamaguchi Keitaro Matsuo Kei Muro Kiwamu Akagi | 2015 | World Journal of Gastroenterology2015，21，4： | 14 |
| 2 | Combined assessment of myocardial damage and electrical disturbance in chronic heart failure显示文摘AIM To investigate feasibility of combined assessment of biochemical and electrophysiological myocardial impairment markers risk-stratifying patients with chronic heart failure(CHF). METHODS Serum levels of heart-type fatty acid binding protein(H-FABP) as a marker of ongoing myocardial damage and QRS duration on electrocardiogram were measured at admission in 322 consecutive patients with CHF. A prolonged QRS duration was defined as 120 ms or longer. The cut-off value for H-FABP level(4.5 ng/mL) was determined from a previous study. Patients were prospectively followed during a median follow up period of 534 d. The primary endpoint was cardiac deaths and rehospitalization for worsening CHF.RESULTS There were 117 primary events, including 27 cardiac deaths and 90 rehospitalizations. Patients were stratified into four groups according to H-FABP level and QRS duration(≥ 120 ms). Multivariate analysis demonstrated that high H-FABP levels [hazard ratio(HR) = 1.745, P = 0.021] and QRS prolongation(HR1.612, P = 0.0258) were independent predictors of cardiac events. Kaplan-Meier analysis demonstrated that the combination of high H-FABP levels and QRS prolongation could be used to reliably stratify patients at high risk for cardiac events(log rank test P < 0.0001).CONCLUSION Combined assessment of myocardial damage and electrical disturbance can be used to risk-stratify patients with CHF. | Shinpei Kadowaki Tetsu Watanabe Yoichiro Otaki Taro Narumi Yuki Honda Hiroki Takahashi Takanori Arimoto Tetsuro Shishido Takuya Miyamoto Isao Kubota | 2017 | World Journal of Cardiology2017，9，5： | 14 |
| 3 | Adiponectin and Adiponectin Receptors显示文摘 | Takashi Kadowaki Toshimasa Yamauchi | 2005 | Endocrine Reviews2005，，3： | 5 |
| 4 | gastrointestinal symptom prevalence depends on disease duration and gastrointestinal region in type 2 diabetes mellitus显示文摘AIM To unravel relationships between gastrointestinal(GI)symptoms impairing quality of life(QOL)and clinical profiles of diabetes mellitus(DM)patients. METHODS We enrolled 134 outpatients with type 2 DM.Mean age was 64.7 years,mean body mass index was 24.7 RESULTS Lower abdominal symptoms were found to be more frequent than those affecting the upper abdomen.Diabetic duration and medications showed associations with GI symptoms.We identified differences in peak prevalences of the five symptoms.Gastralgia(P=0.02vs 10-14 years)and total GI symptoms(P=0.01 and P=0.02 vs 5-9 years and 10-14 years,respectively)peaked at a diabetes duration of 15-19 years.Heartburn(P=0.004)and postprandial fullness(P=0.03)tended to increase with disease duration.Constipation and diarrhea showed bimodal peaks,with the first early and the second late(e.g.,P=0.03 at 15-19 years vs 10-14years for diarrhea)in the disease course.Finally,GI symptoms showed clustering that reflected the region of the GI tract affected,i.e.,constipation and diarrhea had similar frequencies(P<0.0001). CONCLUSION Our study highlights the importance of questioning patients about QOL impairment due to abdominal symptoms,especially in the early and the late periods of diabetes. | Midori Fujishiro Akifumi Kushiyama Hiroki Yamazaki Sunao Kaneko Yuko Koketsu Takeshi Yamamotoya Takako Kikuchi Hideyuki Sakoda Ryo Suzuki Takashi Kadowaki | 2017 | World Journal of Gastroenterology2017，23，36： | 4 |
| 5 | Distinct cytokine profiles of neonatal natural killer T cells after expansion with subsets of dendritic cells显示文摘 | Kadowaki N Antonenko S Ho s | 2001 | Exp Med2001，193，10： | 3 |
| 6 | Is pancreatectomy with arterial reconstruction a safe and useful procedure for locally advanced pancreatic cancer?显示文摘 | Hodaka Amano Fumihiko Miura Naoyuki Toyota Keita Wada Ken-ichirou Katoh Kouichi Hayano Susumu Kadowaki Makoto Shibuya Sawako Maeno Tomoaki Eguchi Tadahiro Takada Takehide Asano | 2009 | Journal of Hepato - Biliary - Pancreatic Surgery2009，，6： | 2 |
| 7 | Promoter effect ofSm2O3 on Ru/Al2O3 in ammonia synthesis显示文摘 | Kadowaki Y Aika K | 1996 | J Catal1996，161，： | 2 |
| 8 | Features of early gastric cancer and gastric adenoma by enhanced-magnification endoscopy显示文摘 | Kyosuke Tanaka Hideki Toyoda Shigenori Kadowaki Ryo Kosaka Taizo Shiraishi Ichiro Imoto Hiroshi Shiku Yukihiko Adachi | 2006 | Journal of Gastroenterology2006，，4： | 2 |
| 9 | 日粮中添加维生素E对热应激肉鸡肉品质、颜色、持水能力和剪切力的影响显示文摘试验旨在评价饲粮中添加维生素E(VE)对处于慢性热应激(HS)条件下的肉鸡的肉品质尤其是PSE肉(苍白色、柔软、渗水)的影响。将28日龄的雌性罗斯肉鸡分别饲养在24℃(常温:NT)和34℃(高温:HT)条件的独立笼中。NT组肉鸡饲喂基础饲粮。HT组肉鸡分别饲喂基础饲粮(HT)和在基础饲粮中添加VE 200 mg·kg-1(HT+E)。在38日龄时进行屠宰称重。测定胸肌的肉色、pH、持水力(WHC)和剪切力(SFV)。结果表明,与NC组相比,HT和HT+E组的体增重和采食量显著下降,补充VE对生长性能无显著影响,10 d 30℃的慢性热应激会导致PSE肉皮质进一步恶化,对胸肌韧性影响显著。在饲粮中添加VE可有效的抑制慢性热应激条件下PSE肉的产生。 | Hashizawa Y Kubota M Kadowaki M Fujimura S | 2014 | 饲料博览2014，，1： | 2 |
| 10 | Adiponectin Receptor Signaling: A New Layer to the Current Model显示文摘 | Takashi Kadowaki Toshimasa Yamauchi | 2011 | Cell Metabolism2011，，2： | 2 |
| 11 | A novel IKK beta inhibitor stimulates adiponectin levels and ameliorates obesity-linked insulin resistance显示文摘 | Yamauchi T Kadowaki T | 2004 | Biochem Bio phys Res Commun2004，323，1： | 1 |
| 12 | Overexpression of the p21 sdil gene induces senescence-like state in human cancer cells:implication for senescence-directed molecular therapy for cancer显示文摘 | Fujiwara T Kadowaki Y | 1999 | Cell Death Differ1999，6，8： | 1 |
| 13 | Differential organization of mitochondrial genes in rice with normal and male sterile cytoplasm 显示文摘 | Kadowaki K Harada K | 1989 | Jpn J Breed1989，39，： | 1 |
| 14 | Protection against influenza virus infection in mice immunized by administration of hemagglutinin-expressing DNAs with electroporation显示文摘 | Kadowaki S Chen Z Asanuma H | 2000 | Vaccine2000，18，： | 1 |
| 15 | Late malignant transformation of giant cell tumor of bone 41 years after primary surgery显示文摘 | Kadowaki M Yamamoto S Uchio Y | 2012 | Orthopedics2012，35，10： | 1 |
| 16 | Natural inter feron α/β-producing cells link innate and adaptive immunity显示文摘 | Kadowaki N Antonenko S Lau JY | 2000 | J ExpMed2000，192，2： | 1 |
| 17 | Orally administered LPS enhances head kidney macrophage activation with down- regulation of IL-6 in common carp (Cyprinus carpio) 显示文摘 | Kadowaki T Yasui Y Nishimiya O | 2013 | Fish & Shellfish Immunology2013，34，6： | 1 |
| 18 | The physiological and pathophysiological role of adiponectin and adiponectin receptors in the peripheral tissues and CNS显示文摘 | KADOWAKI T YAMAUCHI T KUBOTA N | 2008 | FEBS Lett2008，582，1： | 1 |
| 19 | The nature of the principal type 1 interferon-producing cells in human blood显示文摘 | Siegal FP Kadowaki N Shodell M | | 0，，： | 1 |
| 20 | Features of early gastric cancer and gastric adenoma by enhanced-magnification endoscopy显示文摘 | Kyosuke Tanaka Hideki Toyoda Shigenori Kadowaki Ryo Kosaka Taizo Shiraishi Ichiro Imoto Hiroshi Shiku Yukihiko Adachi | 2006 | Journal of Gastroenterology2006，，4： | 1 |
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