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| 1 | Indo-Western Pacific Ocean Capacitor and Coherent Climate Anomalies in Post-ENSO Summer: A Review显示文摘ENSO induces coherent climate anomalies over the Indo-western Pacific, but these anomalies outlast SST anomalies of the equatorial Pacific by a season, with major effects on the Asian summer monsoon. This review provides historical accounts of major milestones and synthesizes recent advances in the endeavor to understand summer variability over the Indo-Northwest Pacific region. Specifically, a large-scale anomalous anticyclone(AAC) is a recurrent pattern in post-El Ni ?no summers, spanning the tropical Northwest Pacific and North Indian oceans. Regarding the ocean memory that anchors the summer AAC, competing hypotheses emphasize either SST cooling in the easterly trade wind regime of the Northwest Pacific or SST warming in the westerly monsoon regime of the North Indian Ocean. Our synthesis reveals a coupled ocean–atmosphere mode that builds on both mechanisms in a two-stage evolution. In spring, when the northeast trades prevail, the AAC and Northwest Pacific cooling are coupled via wind–evaporation–SST feedback. The Northwest Pacific cooling persists to trigger a summer feedback that arises from the interaction of the AAC and North Indian Ocean warming, enabled by the westerly monsoon wind regime. This Indo-western Pacific ocean capacitor(IPOC) effect explains why El Ni ?no stages its last act over the monsoonal Indo-Northwest Pacific and casts the Indian Ocean warming and AAC in leading roles. The IPOC displays interdecadal modulations by the ENSO variance cycle, significantly correlated with ENSO at the turn of the 20 th century and after the 1970 s, but not in between. Outstanding issues, including future climate projections, are also discussed. | Shang-Ping XIE Yu KOSAKA Yan DU Kaiming HU Jasti S.CHOWDARY Gang HUANG | 2016 | Advances in Atmospheric Sciences2016，33，4： | 75 |
| 2 | Precision surgical approach with lymph-node dissection in early gastric cancer显示文摘The gravest prognostic factor in early gastric cancer is lymph-node metastasis,with an incidence of about 10% overall. About two-thirds of early gastric cancer patients can be diagnosed as node-negative prior to treatment based on clinicpathological data. Thus, the tumor can be resected by endoscopic submucosal dissection. In the remaining third, surgical resection is necessary because of the possibility of nodal metastasis. Nevertheless, almost all patients can be cured by gastrectomy with D1+ lymph-node dissection. Laparoscopic or robotic gastrectomy has become widespread in East Asia because perioperative and oncological safety are similar to open surgery. However, after D1+ gastrectomy,functional symptoms may still result. Physicians must strive to minimize postgastrectomy symptoms and optimize long-term quality of life after this operation.Depending on the location and size of the primary lesion, preservation of the pylorus or cardia should be considered. In addition, the extent of lymph-node dissection can be individualized, and significant gastric-volume preservation can be achieved if sentinel node biopsy is used to distinguish node-negative patients.Though the surgical treatment for early gastric cancer may be less radical than in the past, the operative method itself seems to be still in transition. | Shinichi Kinami Naohiko Nakamura Yasuto Tomita Takashi Miyata Hideto Fujita Nobuhiko Ueda Takeo Kosaka | 2019 | World Journal of Gastroenterology2019，25，14： | 21 |
| 3 | A comparative study of natural and experimental nano-sized grinding grain textures in rocks显示文摘In three shallow-level fault systems in eastern China, nano-sized (30―100 nm) grinding grain textures are found in the thin-shelled rheological layer representing frictional-viscous high strain field. The surface layer near slipping plane is composed of stacks of grinding grains with high sphericity and uniform nano-sized diameter, while the underlying layer appears as a mixture of irregular ones with diverse diameters. Rock deformation experiments indicate that the grinding grain texture is a common phenomenon in shearing fractures, suggesting a potential transition from sliding friction to rolling one during the rock deformation process. This transition is crucial for many tribological processes in geo- logical fields. | SUN Yan SHU LiangShu LU XianCai LIU Hao ZHANG XiHui K. KOSAKA LIN AiMing | 2008 | Chinese Science Bulletin2008，53，8： | 13 |
| 4 | Hemi-hepatectomy in pediatric patients using two-surgeon technique and a liver hanging maneuver显示文摘AIM: To evaluate the efficacy of the two-surgeon technique with the liver hanging maneuver (LHM) for hepatectomies in pediatric patients with hepatoblastoma. METHODS: Three pediatric patients with hepatoblastoma were enrolled in this study. Two underwent right hemi-hepatectomies and one underwent a left hemihepatectomy using the two-surgeon technique by means of saline-linked electric cautery (SLC) and the Cavitron Ultrasonic Surgical Aspirator (CUSA; Valleylab, Boulder, CO) and the LHM. RESULTS: The mean operative time during the parenchymal transections was 50 min and the mean blood loss was 235 g. There was no bile leakage from the cut surface after surgery. No macroscopic or microscopic-positive margins were observed in the hepatic transections. CONCLUSION: The two-surgeon technique using SLC and CUSA with the LHM is applicable to even pediatric patients with hepatoblastoma. | Kyoko Mochizuki Susumu Eguchi Ryuichiro Hirose Taiichiro Kosaka Mitsuhisa Takatsuki Takashi Kanematsu | 2011 | World Journal of Gastroenterology2011，17，10： | 9 |
| 5 | Recent progress in studies layer in rock on the nano-sized particle shear planes显示文摘Since the 1990s, an ultramicro-particle texture in nano- or micron-sized scale has been continually found in shear planes of various rocks, and recently further progress was made in generic physical mechanisms. In this article, the characteristics of the nano-sized particle layer in rock shear planes (including widespread distribution, layering texture, non-linear genetic mechanism, and multiple functions) on an ultra micro-scale were briefly introduced and more information was obtained by analyzing cases from home and abroad. Our findings suggest that (1) there is a paragenetic relationship between the development of shear frictional- viscous and the formation of nano-sized particles, and (2) in the shear movement, partitioning, segregating, and layering in rocks are initiated by the sliding motion of the nano-sized particle layer. Moreover, the plastic rheology of rocks is essentially the move- ment of ultra-micro-sized particles (nano-size and micro-size), and the nano-sized particle layer in rock shear planes is characterized by some particular physical and chemical effects. | Yan Sun Liangshu Shu Xiancai Lu Hao Liu Xihui Zhang Aiming Lin Kazuo Kosaka | 2008 | Progress in Natural Science:Materials International2008，18，4： | 7 |
| 6 | Narrow-band imaging observation of colorectal lesions using NICE classification to avoid discarding significant lesions显示文摘AIM: To assess the risk of failing to detect diminutive and small colorectal cancers with the 'resect and discard' policy.METHODS: Patients who received colonoscopy and polypectomy were recruited in the retrospective study. Probable histology of the polyps was predicted by six colonoscopists by the use of NICE classification. The incidence of diminutive and small colorectal cancersand their endoscopic features were assessed. RESULTS: In total, we found 681 cases of diminutive(1-5 mm) lesions in 402 patients and 197 cases of small(6-9 mm) lesions in 151 patients. Based on pathology of the diminutive and small polyps, 105 and 18 were non-neoplastic polyps, 557 and 154 were low-grade adenomas, 18 and 24 were high-grade adenomas or intramucosal/submucosal(SM) scanty invasive carcinomas, 1 and 1 were SM deeply invasive carcinoma, respectively. The endoscopic features of invasive cancer were classified as NICE type 3 endoscopically.CONCLUSION: The risk of failing to detect diminutive and small colorectal invasive cancer with the 'resect and discard' strategy might be avoided through the use of narrow-band imaging observation with the NICE classification scheme and magnifying endoscopy. | Santa Hattori Mineo Iwatate Wataru Sano Noriaki Hasuike Hidekazu Kosaka Taro Ikumoto Masahito Kotaka Akihiro Ichiyanagi Chikara Ebisutani Yasuko Hisano Takahiro Fujimori Yasushi Sano | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，12： | 5 |
| 7 | Diagnostic ability of multi-detector spiral computed tomography for pathological lymph node metastasis of advanced gastric cancer显示文摘BACKGROUND The reliability of preoperative nodal diagnosis of advanced gastric cancer by multi-detector spiral computed tomography(MDCT)is still unclear.AIM To examine the diagnostic ability of MDCT more precisely by using data on intranodal pathological metastatic patterns.METHODS A total of 108 patients with advanced gastric cancer who underwent MDCT and curative gastrectomy at Kanazawa Medical University Hospital were enrolled in this study.The nodal sizes measured on computed tomography(CT)images were compared with the pathology results.A receiver-operating characteristic curve was constructed,from which the critical value(CV)was calculated by using the data of the first 69 patients retrospectively.By using the CV,sensitivity and specificity were calculated with prospectively collected data from 39 consecutive patients.This enabled a more precise one-to-one correspondence of lymph nodes between CT and pathological examination by using the size data of lymph node mapping.The intranodal pathological metastatic patterns were classified into the following four types:Small nodular,peripheral,large nodular,and diffuse.RESULTS Although all the cases were clinically suspected as having metastasis,81 had lymph node metastasis and 27 had no metastasis.The number of dissected,detected on CT,and metastatic nodes were,4241,897,and 801,respectively.The CV obtained from the receiver-operating characteristic was 7.6 mm for the long axis.The sensitivity was 91.4%and the specificity was 47.3%in the prospective phase.The large nodular and diffuse metastases were easy to diagnose becausemetastatic nodes with a large axis often exhibit these forms.CONCLUSION The ability of MDCT to contribute to a nodal diagnosis of advanced gastric cancer was examined prospectively with precise size data from node mapping,using a CV of 7.6 mm for the long axis that was calculated from the retrospectively collected data.The sensitivity was as high as 91%,and would be improved when referring to the enhanced patterns.However,its specificity was as low as 47%,because most of metastatic nodes in gastric cancer being small in size.The small nodular or peripheral type metastatic nodes were often small and considered difficult to diagnose. | Zhi-Yong Jiang Shinichi Kinami Naohiko Nakamura Takashi Miyata Hideto Fujita Hiroyuki Takamura Nobuhiko Ueda Takeo Kosaka | 2020 | World Journal of Gastrointestinal Oncology2020，12，4： | 5 |
| 8 | Risk factors for lymph node metastasis in histologically poorly differentiated type early gastric cancer显示文摘 | C. Kunisaki M. Takahashi Y. Nagahori T. Fukushima H. Makino R. Takagawa T. Kosaka H. Ono H. Akiyama Y. Moriwaki A. Nakano | 2009 | Endoscopy2009，，06： | 4 |
| 9 | Long‐term outcomes of endoscopic submucosal dissection for early gastric cancer: A single‐center retrospective study显示文摘 | Takashi Kosaka Masaki Endo Yosuke Toya Yukito Abiko Norihiko Kudara Masaaki Inomata Toshimi Chiba Yasuhiro Takikawa Kazuyuki Suzuki Tamotsu Sugai | 2014 | Digestive Endoscopy2014，，2： | 4 |
| 10 | Remission of primary low-grade gastric lymphomas of the mucosa-associated lymphoid tissue type in immunocompromised pediatric patients显示文摘我们报导联系 mucosa 的淋巴组织(麦芽) 的主要胃的淋巴瘤的宽恕在二免疫打损害小儿科的病人。病人 1,在免疫的一个 14 岁的男孩损害了未知原因的状态,抱怨了重复腹的疼痛。考试与本地侵略和淋巴节点参与揭示了胃的麦芽。浆液 anti-Helicobacter pylori (H pylori ) 抗体是积极的。H pylori 根除被沉溺于它的不利效果。麦芽损害自发地在没有为淋巴瘤的任何治疗的下一 24 个月的 regressed。病人 2,一个 6 岁的男孩,为 adrenoleukodystrophy 的治疗经历了脐带血移植。他是为在移植以后的 graft-versus-host 疾病的管理抑制免疫力的药。恶心和便血出现了,进一步的考试与 H pylori 胃炎揭示了胃的麦芽。独自为 H pylori 感染由药组成的治疗根除了 H pylori 并且完全也解决了病人的麦芽损害。病人们 1 和 2 被跟随在上面在 10 年和 3 年的经期上,分别地没有恶化的任何症状。在结论, MALT 类型的胃的淋巴瘤能被保守疗法甚至在免疫治好损害小儿科的病人。 | Yasuharu Ohno Taichirou Kosaka Izumi Muraoka Takashi Kanematsu Akira Tsuru Eiichi Kinoshita Hiroyuki Moriuchi | 2006 | World Journal of Gastroenterology2006，12，16： | 4 |
| 11 | Expression of alpha smooth muscle actin in living donor liver transplant recipients显示文摘Recently,there have been reports from liver biopsies that showed the progression of liver fibrosis in liver transplant patients after the cessation of immunosuppression.Herein,we focused on activated hepatic stellate cells expressing alpha smooth muscle actin(α-SMA)to understand the correlation between immunosuppressant medication and liver fibrosis.The study enrolled two pediatric patients who underwent living donor liver transplantation and ceased immunosuppressant therapy.The number ofα-SMA-positive cells in the specimens obtained by liver biopsy from these two patients showed a three-fold increase compared with the number from four transplanted pediatric patients who were continuing immunosuppressant therapy.In addition,theα-SMA-positive area evaluated using the WinRooF image processing software program continued toincrease over time in three adult transplanted patients with liver fibrosis,and theα-SMA-positive area was increasing even during the pre-fibrotic stage in these adult cases,according to a retrospective review.Therefore,α-SMA could be a useful marker for the detection of early stage fibrosis. | Masataka Hirabaru Kyoko Mochizuki Mitsuhisa Takatsuki Akihiko Soyama Taiichiro Kosaka Tamotsu Kuroki Isao Shimokawa Susmu Eguchi | 2014 | World Journal of Gastroenterology2014，20，22： | 3 |
| 12 | Impact of lipoprotein lipase gene polymorphisms on ulcerative colitis显示文摘AIM: To examine the influence of lipoprotein lipase (LPL) gene polymorphism in ulcerative colitis (UC) patients. METHODS: Peripheral blood was obtained from 131 pa- tients with UC and 106 healthy controls for DNA extrac- tion. We determined LPL gene polymorphisms affecting the enzyme at Ser447stop, as well as HindⅢ and Pvu Ⅱ polymorphisms using PCR techniques. PCR products were characterized by PCR-RFLP and direct sequencing. Polymorphisms were examined for association with clini- cal features in UC patients. Genotype frequencies for LPL polymorphisms were also compared between UC patients and controls. RESULTS: In patients with onset at age 20 years or younger, C/G and G/G genotypes for Ser447stop poly- morphism were more prevalent than C/C genotype (OR = 3.13, 95% CI = 0.95-10.33). Patients with H+/- or H-/-genotype for HindⅢ polymorphism also were more nu- merous than those with H+/+ genotype (OR = 2.51, 95% CI = 0.85-7.45). In the group with H+/+ genotype for HindⅢ polymorphism, more patients had serum triglyc- eride concentrations over 150 mg/dL than patients with H+/- or H-/- genotype (P < 0.01, OR = 6.46, 95% CI = 1.39-30.12). Hypertriglycemia was also more prevalent in patients with P+/+ genotypes for PvuⅡ polymorphism (P < 0.05, OR = 3.0, 95% CI = 1.06-8.50). Genotype fre- quency for LPL polymorphism did not differ significantly between UC patients and controls. CONCLUSION: Ser447stop and HindⅢ LPL polymor- phisms may influence age of onset of UC, while HindⅢ and PvuⅡ polymorphisms influence serum triglyceride in UC patients. | Toshihito Kosaka Junji Yoshino Kazuo Inui Takao Wakabayashi Kazumu Okushima Takashi Kobayashi Hironao Miyoshi Yuta Nakamura Shigekazu Hayashi Taizou Shiraishi Masatoshi Watanabe Takayuki Yamamoto Ai Nakahara Takahiko Katoh | 2006 | World Journal of Gastroenterology2006，12，39： | 3 |
| 13 | 覆盖栽培技术的推广对日本冲绳烟草的影响显示文摘 | KOSAKA Y. 徐秋萍(译) | 2005 | 中国烟草学报2005，11，4： | 2 |
| 14 | Aspartate aminotransferase-immunoglobulin complexes in patients with chronic liver disease显示文摘AIM: To determine the complex of AST and immunoglobulin and to investigate its clinical significance in patients with liver disease.METHODS: The complex of AST and immunoglobulin was determined by encounter immunoelectrophoresis and its clinical significance was investigated in 128 patients with liver disease.RESULTS: AST was bound to immunoglobulin of antiimmunoglobulin A (IgA) class, but any binding to antiimmunoglobulin G and anti-immunoglobulin M classes was not observed. Although the incidence of ASTimmunoglobulin complex was 41.8% in chronic hepatitis (CH), the incidences in liver cirrhosis and hepatocellular carcinoma were 62.2 and 90.0%, respectively. In alcoholic liver disease with high level of serum IgA, the incidence of the complex was 66.7%, which was higher than that in CH. The ratio of binding to lambda-chain of IgA was higher than that to kappa-chain of IgA. The serum level of IgA and the ratio of AST/alanine aminotransferase (ALT) were significantly higher in patients with AST-IgA complex than in those without complex.CONCLUSION: These results suggest that AST-IgA complex in patients with progressive liver diseases and alcoholic liver injury can lead to elevation of the ratio of AST/ALT. | Masahiko Tameda Katsuya Shiraki Kinue Ooi Koujirou Takase Yoshitane Kosaka Tsutomu Nobori Yukihiko Tameda | 2005 | World Journal of Gastroenterology2005，11，10： | 2 |
| 15 | Features of early gastric cancer and gastric adenoma by enhanced-magnification endoscopy显示文摘 | Kyosuke Tanaka Hideki Toyoda Shigenori Kadowaki Ryo Kosaka Taizo Shiraishi Ichiro Imoto Hiroshi Shiku Yukihiko Adachi | 2006 | Journal of Gastroenterology2006，，4： | 2 |
| 16 | Impact of lymphovascular invasion in patients with stage I gastric cancer显示文摘 | Chikara Kunisaki Hirochika Makino Jun Kimura Ryo Takagawa Takashi Kosaka Hidetaka A. Ono Hirotoshi Akiyama Tadao Fukushima Yutaka Nagahori Masazumiu Takahashi | 2010 | Surgery2010，，2： | 2 |
| 17 | Role of Ca2+-activated K+ channels in the protective effect of ACE inhibition against ischemic myocardial injury显示文摘 | Node K Kitakaze M Kosaka H | 1998 | Hypertension1998，31，6： | 2 |
| 18 | Angiotensin Ⅱ type 1 receptor antagonist as an angiogenic inhibitor in prostate cancer显示文摘 | Kosaka T Miyajima A Takayama E | 2007 | Prostate2007，67，1： | 1 |
| 19 | Testicular toxicity of thiamphenicol in Sprague-Dawley rats显示文摘 | MAITA K KUWAHARA M KOSAKA T | 1999 | Journal of Toxicologic Pathology1999，12，1： | 1 |
| 20 | Regulation of monocytechemoattractant protein - 1 through angiotensin II type 1 receptor in prostate cancer 显示文摘 | Shirotake S Miyajima A Kosaka T | 2012 | Am J Pathol2012，180，3： | 1 |
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