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	题名	作者	年代	出处	被引量
1	Depletion of CD25^+CD4^+T cells (Tregs) enhances the HBV-specific CD8^+ T cell response primed by DNA immunization显示文摘AIM: Persistent hepatitis B virus (HBV) infection is characterized by a weak CD8+ T cell response to HBV. Immunotherapeutic strategies that overcome tolerance and boost these suboptimal responses may facilitate viral clearance in chronically infected individuals. Therefore, we examined whether CD25+CD4+ regulatory T (Treg) cells might be involved in a inhibition of CD8+T cell priming or in the modulation of the magnitude of the'peak' antiviral CD8+ T cell response primed by DNA immunization. METHODS: B10.D2 mice were immunized once with plasmid pCMV-S. Mice received 500 μg of anti-CD25 mAb injected intraperitoneally 3 d before DNA immunization to deplete CD25+ cells. Induction of HBV-specific CD8+ T ceils in peripheral blood mononuclear cells (PBMCs) was measured by S28-39 peptide loaded DimerX staining and their function was analyzed by intracellular IFN-γ staining.RESULTS: DNA immunization induced HBV-specific CD8+ T cells. At the peak T cell response (d 10), 7.1±2.0% of CD8+ T cells were HBV-specific after DNA immunization, whereas 12.7±3.2% of CD8+ T cells were HBV-specific in Treg-depleted mice, suggesting that DNA immunization induced more antigen-specific CD8+ T cells in the absence of CD25+ Treg cells (n = 6, P<0.05). Similarly, fewer HBVspecific memory T cells were detected in the presence of these cells (1.3±0.4%) in comparison to Treg-depleted mice (2.6±0.9%) on d 30 after DNA immunization (n = 6, P<0.01). Both IFN-γ production and the avidity of the HBV-specific CD8+ T cell response to antigen were higher in HBV-specific CD8+ T cells induced in the absence of Treg cells.CONCLUSION: CD25+ Treg cells suppress priming and/or expansion of antigen-specific CD8+ T cells during DNA immunization and the peak CD8+ T cell response is enhanced by depleting this cell population. Furthermore, Treg cells appear to be involved in the contraction phase of the CD8+ T ceil response and may affect the quality of memory T cell pools. The elimination of Treg cells or their inhibition may be important in immunotherapeutic strategies to control HBV infection by inducing virus-specific cytotoxic T lymphocyte responses in chronically infected subjects.	Yoshihiro Furuichi Hirotake Tokuyama Satoshi Ueha Makoto Kurachi Fuminori Moriyasu Kazuhiro Kakimi	2005	World Journal of Gastroenterology2005，11，24：	30
2	Impairment of IFN-a production capacity in patients with hepatitis C virus and the risk of the development of hepatocellular carcinoma显示文摘AIM: To determine the utility of interferon (IFN) -αproduction capacity in patients with hepatitis C virus (HCV) infection for the measurement of immunosurveillance potential and for the early detection of hepatocellular carcinoma (HCC) by investigating the Sendai virus (HVJ) stimulated IFN-α production capacity of patients with HCV infection.METHODS: HVJ stimulated IFN-α production was determined in a large number of patients with HCV infection and the development of HCC was monitored for 3 years in patients with liver cirrhosis (LC).RESULTS: IFN-α production capacity decreases gradually with the progression of liver disease from chronic hepatitis (CH) to HCC. A significant correlation between the duration of HCV infection and impaired IFN-α production capacity was observed. IFN-α production in patients who developed HCC within 3 years was significantly lower than that of patients who remained in LC without developing HCC.CONCLUSION: Measurement of IFN-α production in LC patients may be useful for the early detection of HCC.	Kazuko Uno Yoshiki Suginoshita Kazuhiro Kakimi Fuminori Moriyasu Mayumi Hirosaki Taro Shirakawa Tsunataro Kishida	2005	World Journal of Gastroenterology2005，11，46：	3
3	A phase I study of adoptive immunotherapy for recurrent non-small-cell lung cancer patients with autologous γδ T cells <sup>☆</sup> , <sup>☆☆</sup>显示文摘	Jun Nakajima Tomohiro Murakawa Takeshi Fukami Shigenori Goto Toru Kaneko Yukihiro Yoshida Shinichi Takamoto Kazuhiro Kakimi	2010	European Journal of Cardio-Thoracic Surgery2010，，5：	2
4	Depletion of neutrophils blocks the recruitment of antigen-nonspecific cells into the liver without affecting the antiviral activity of hepatitis B virus-specific cytotoxic T lymphocytes显示文摘	Sitia G Isogawa M Kakimi K	2002	Proc Natl Acad Sci USA2002，99，：	2
5	Interleukin-18 inhibits hepatitis B virus replication in the livers of transgenic mice显示文摘	Kimura K Kakimi K Wieland S	2002	J Virol2002，76，10：	1
6	Natural killer T cell activation inhibits hepatitis B virus replication in vivo显示文摘	Kakimi K Guidotti LG Koezuka Y	2000	J Exp Med2000，192，7：	1
7	Blocking chemokine responsive to gamma-2/interferon (IFN)-gamma inducible protein and monokine induced by IFN-gamma activity in vivo reduces the pathogenetic but not the antiviral potential of hepatitis B virus-specific cytotoxic T lymphocytes显示文摘	Kakimi K Lane TE Wieland S	2001	J Exp Med2001，194，12：	1
8	Natural killer T cell activation inhibits hepatitis B virus replication in vivo显示文摘	Kakimi K Guidotti LG Koezuka Y	2000	J Exp Med2000，192，：	1
9	Investigation of Active-Buffer Pulse Tube Refrigerator 显示文摘	Zhu S W Kakimi Y Matsubara Y	1997	Cryogenics1997，37，：	1
10	Depletion of neutrophils blocks the recruitment of antigen-nonspecific cells into the liver without affecting the antiviral activity of hepatitis B virus-specific cytotoxic T lymphocytes 显示文摘	Sitia G Isogawa M Kakimi K	2002	Proc Natl Acad Sci2002，99，13：	1
11	Natural killer T cell activation inhibits hepatitis B virus replication in vivo显示文摘	Kakimi K Guidotti LG Koezuka Y	2000	J Exp Med2000，192，7：	1
12	Active specific immuno- therapy and cell-transfer therapy for the treat:nent of non- small cell lung cancer显示文摘	Kakimi K Nakajima J Wada H		Lung Cancer0，65，1：	1
13	Extracellular ATP inhibits starvation-induced apoptosis via P2X2 receptors in differentiated rat pheochromocytoma PC12 cells显示文摘	Fujita N Kakimi M Ikeda Y Hiramoto T Suzuki K	2000	Life Sci2000，66，19：	1
14	Interleukin -18 inhib- its hepatitis B virus replication in the livers of transgenic mice 显示文摘	Kimura K Kakimi K Wieland S	2002	J Virol2002，76，10：	1
15	A phase I study of vaccination withNY-ESO-lf peptide mixed with Picibanil OK-432 and MontanideISA-51 in patients with cancers expressing the NY-ESO-1 antigen显示文摘	Kakimi KJsobe M Uenaka A	2011	Int J Cancer2011，129，12：	1
16	Natural killer T cell activation inhits hepatitis B Virus replication in vivo显示文摘	Kakimi K Guidotti LG Koezuka Y	2000	J Exp Med2000，192，7：	1
17	Immunogenicity and tolerogenicity of hepatitis B virus structural and nonstructural proteins:implications for immunotherapy of persistent viral infections显示文摘	Kakimi K Isngawa M Chung J	2002	J Virol2002，76，17：	1
18	Depletion of neutrophils blocks the recruitment of antigen-nonspecific cells into the liver without affecting the antiviral avtivity of hepatitis B virusspecific eytotoxie T lymphoeytes显示文摘	Sitia G Isogawa M Kakimi K	2002	Proc Natl Acad Sci U S A2002，99，13：	1
19	Production Technology of Bar and Wire Rod显示文摘	Kakimi T Saitoh H	2007	Nippon Steel Technical Report2007，，7：	1
20	Interleukin-18 inhibits hepatitis b Virus replication in the livers of transgenic mice显示文摘	KIMURA K KAKIMI K WIELAND S	2002	J Virol2002，76，10：	1

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