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| 1 | Hepatitis B virus genotypes:an overview显示文摘BACKGROUND:Hepatitis B virus(HBV)infection is a major cause of mortality and morbidity globally.The quest continues to identify viral factors that influence disease progression and severity as well as responses to treatment of HBV infection.Based on variations in HBV,the virus has been divided into a number of genotypes. DATA SOURCES:Review of published literature on HBV genotypes. RESULTS:HBV genotypes are likely to be important in determining the severity and progression of HBV-induced liver disease as well as responses to different anti-viral agents. CONCLUSION:Although HBV genotyping is not yet recommended for routine use in treating HBV infection, available data suggest that,as in hepatitis C virus infection, HBV genotyping is also likely to become a routine investigation for HBV treatment,perhaps in the not too distant future. | Mamun-Al Mahtab Salimur Rahman Mobin Khan Fazal Karim | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，5： | 25 |
| 2 | A review on promising phytochemical, nutritional and glycemic control studies on Moringa oleifera Lam. in tropical and sub-tropical regions显示文摘Plants have provided sources to find novel compounds. These plants are being used as therapeutic purposes since the birth of mankind. The traditional healers normally utilize medicinal plants as crude drugs while scientists using the folk claim as guides to explore medicinal plants. Moringa oleifera is a famous edible plant having therapeutic and nutritive values. The present study was designed to cumulate the research data regarding to what extent, phytochemical, nutritional and glycemic control studies has been explored using its different extracts. The articles indicated that the powder, aqueous, methanol and ethanol extracts of Moringa oleifera(leaves, pods, seeds, stem and root bark) have significant therapeutic herbal potential to treat diabetes mellitus. Collectively, the mechanism behind is intestinal glucose inhibition, insulin release as well as decrease in insulin resistance probably regeneration of b-cells of pancreas, increase in glutathione and reduction in malondialdehyde. Conclusively, this article give descriptive information about antidiabetic effect, claimed marker compounds and proposed antihyperglycemic mechanism of a single plant. It can be suggested a potential herbal source to treat diabetes mellitus as being widely accepted by major population as nutrition and therapeutic agent. | Hafiz Irfan Muhammad Mohd Zaini Asmawi Nurzalina Abdul Karim Khan | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，10： | 8 |
| 3 | Two-Dimensional Tellurium:Progress,Challenges,and Prospects显示文摘Since the successful fabrication of two-dimensional(2D)tellurium(Te)in 2017,its fascinating properties including a thickness dependence bandgap,environmental stability,piezoelectric effect,high carrier mobility,and photoresponse among others show great potential for various applications.These include photodetectors,field-effect transistors,piezoelectric devices,modulators,and energy harvesting devices.However,as a new member of the 2D material family,much less known is about 2D Te compared to other 2D materials.Motivated by this lack of knowledge,we review the recent progress of research into 2D Te nanoflakes.Firstly,we introduce the background and motivation of this review.Then,the crystal structures and synthesis methods are presented,followed by an introduction to their physical properties and applications.Finally,the challenges and further development directions are summarized.We believe that milestone investigations of 2D Te nanoflakes will emerge soon,which will bring about great industrial revelations in 2D materials-based nanodevice commercialization. | Zhe Shi Rui Cao Karim Khan Ayesha Khan Tareen Xiaosong Liu Weiyuan Liang Ye Zhang Chunyang Ma Zhinan Guo Xiaoling Luo Han Zhang | 2020 | Nano-Micro Letters2020，12，8： | 8 |
| 4 | PI3K signaling pathway targeting by using different molecular approaches to treat cancer显示文摘Recent evidence of research has been proposed that the phosphoinositide 3-kinase(PI3K) pathway is noticeable target for searching novel anticancer agents. The phosphoinositide 3-kinase(PI3K) is accountable for harmonizing a diverse range of cell functions, such as transcription, proliferation, cell survival, cell growth, degranulation, vesicular trafficking and cell migration, which are mostly involved in carcinogenesis. Particularly, PI3K-mediated signaling molecules and its effects on gene expression contribute to tumorigenesis. PI3Ks generally are grouped into three distinct classes: Ⅰ, Ⅱ and Ⅲ according to their structure and function. The class IA of PI3K includes an alpha, beta or delta p110 catalytic subunit(p110α, p110β, or p110γ), which are associated with the activation of RTKs. Mutations in PIK3CA, the gene encoding the p110α catalytic subunit of PI3K, have just been recognized as novel mechanisms of inducing oncogenic PI3K signaling. Therefore, the class IA PI3K is the only one of most evidently implicated in cancer. The PI3K pathway is mostly mutated in more cancer patients compared with normal person, making it an eyecatching molecular target for analyses based on inhibitor molecule. In this article, we highlighted the signaling effects and regulation pathway of PI3K involved in the development and survival of tumor cells. The consequence and intricacy of PI3K pathway made it an essential beneficial target for cancer treatment. | Mohammad Rashid Shahid Karim Babar Ali Shamshir Khan Makhmur Ahmad Asif Husain Ravinesh Mishra | 2017 | Journal of Chinese Pharmaceutical Sciences2017，26，9： | 7 |
| 5 | Hepatitis E virus is a leading cause of acute-on-chronic liver disease:experience from a tertiary centre in Bangladesh显示文摘BACKGROUND:Acute-on-chronic liver failure(ACLF) is common in Bangladesh.Acute viral E hepatitis is sporadically encountered in this country each year,with a rising incidence in the rainy season.This study aimed to identify the etiology of ACLF in Bangladesh. METHODS:In this retrospective study,69 ACLF patients were included.They presented to our department at the Bangabandhu Sheikh Mujib Medical University in Dhaka.History of diseases was recorded and appropriate investigations were conducted in all patients. RESULTS:Acute hepatitis E virus(HEV)infection was positive in 21.7%(15/69)of the patients,while 14.5% (10/69)had septicemia.Upper gastrointestinal tract hemorrhage was seen in 4.3%of the patients(3/69),while another 4.3%(3/69)had a positive history for alcohol or drugs.None of the patients tested positive for hepatitis A virus infection and no evidence of hepatitis B virus flare was found in any patient.No specific cause for ACLF could be identified. CONCLUSIONS:Acute HEV infection is a leading cause of ACLF in Bangladesh.Many patients were thought to have decompensation of cirrhosis,but subsequently were recognized as having ACLF by a retrospective review according to the definition of the Asian Pacific Association for the Study of the Liver Working Party Meeting on ACLF in New Delhi in early 2008. | Mamun-Al Mahtab Salimur Rahman Mobin Khan Md.Fazal Karim | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，1： | 7 |
| 6 | Epidemiology of hepatitis B virus in Bangladeshi general population显示文摘BACKGROUND:Hepatitis B virus(HBV)is encountered sporadically the year round in Bangladesh.It results in a wide range of liver diseases,with asymptomatic acute hepatitis at one end to hepatocellular carcinoma(HCC)at the other end of the spectrum. METHODS:All 1018 individuals of different age groups and sex with varied religious,educational and social backgrounds were tested for HBsAg by ELISA.The positive samples were further tested by ELISA for HBeAg.Before testing,blood samples were preserved at-20℃.The study was conducted in a semi-urban location on the outskirts of Dhaka. RESULTS:Of the 1018 individuals,5.5%tested positive for HBsAg.None were tested positive for anti-HCV.Among the HBsAg-positive population,58.93%were HBeAg- positive and the rest 41.07%HBeAg-negative.There was a male predominance and those who were tested positive were mostly between 16 and 50 years of age.Major risk factors for exposure to HBV appeared to be injudicious use of injectable medications,treatment by unqualified, traditional practitioners,mass-vaccination against cholera and smallpox,barbers and body piercing. CONCLUSION:HBV remains a major cause of morbidity and mortality in Bangladesh and we have a long way to go before we may bid farewell to this deadly menace. | Mamun-Al Mahtab Salimur Rahman Md.Fazal Karim Mobin Khan Graham Foster Susannah Solaiman Shahrin Afroz | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，6： | 4 |
| 7 | Effects of vitamin E on stroke: a systematic review with meta- analysis and trial sequential analysis显示文摘There are several previous studies on the association of vitamin E with prevention of stroke but the findings remain controversial.We have conducted a systematic review,meta-analysis together with trial sequential analysis of randomised controlled trials to evaluate the effect of vitamin E supplementation versus placebo/no vitamin E on the risk reduction of total,fatal,non-fatal,haemorrhagic and ischaemic stroke.Relevant studies were identified by searching online databases through Medline,PubMed and Cochrane Central Register of Controlled Trials.A total of 18 studies with 148016 participants were included in the analysis.There was no significant difference in the prevention of total stroke(RR(relative risk)=0.98,95% CI 0.92-1.04,p=0.57),fatal stroke(RR=0.96,95% CI 0.77-1.20,p=0.73)and non-fatal stroke(RR=0.96,95% CI 0.88-1.05,p=0.35).Subgroup analyses were performed under each category(total stroke,fatal stroke and non-fatal stroke)and included the following subgroups(types of prevention,source and dosage of vitamin E and vitamin E alone vs control).The findings in all subgroup analyses were statistically insignificant.In stroke subtypes analysis,vitamin E showed significant risk reduction in ischaemic stroke(RR=0.92,95% CI 0.85-0.99,p=0.04)but not in haemorrhagic stroke(RR=1.17,95%CI 0.98-1.39,p=0.08).However,the trial sequential analysis demonstrated that more studies were needed to control random errors.Limitations of this study include the following:trials design may not have provided sufficient power to detect a change in stroke outcomes,participants may have had different lifestyles or health issues,there were a limited number of studies available for subgroup analysis,studies were mostly done in developed countries,and the total sample size for all included studies was insufficient to obtain a meaningful result from meta-analysis.In conclusion,there is still a lack of statistically significant evidence of the effects of vitamin E on the risk reduction of stroke.Nevertheless,vitamin E may offer some benefits in the prevention of ischaemic stroke and additional well-designed randomised controlled trials are needed to arrive at a definitive finding.PROSPERO registration number:CRD42020167827. | Hong Chuan Loh Renly Lim Kai Wei Lee Chin Yik Ooi Deik Roy Chuan Irene Looi Yuen Kah Hay Nurzalina Abdul Karim Khan | 2021 | Stroke & Vascular Neurology2021，6，1： | 2 |
| 8 | Recent Progress,Challenges,and Prospects in Two‑Dimensional Photo‑Catalyst Materials and Environmental Remediation显示文摘The successful photo-catalyst library gives significant information on feature that affects photo-catalytic performance and proposes new materials.Competency is considerably significant to form multi-functional photo-catalysts with flexible characteristics.Since recently,two-dimensional materials(2DMs)gained much attention from researchers,due to their unique thickness-dependent uses,mainly for photo-catalytic,outstanding chemical and physical properties.Photo-catalytic water splitting and hydrogen(H2)evolution by plentiful compounds as electron(e−)donors is estimated to participate in constructing clean method for solar H2-formation.Heterogeneous photocatalysis received much research attention caused by their applications to tackle numerous energy and environmental issues.This broad review explains progress regarding 2DMs,significance in structure,and catalytic results.We will discuss in detail current progresses of approaches for adjusting 2DMs-based photo-catalysts to assess their photo-activity including doping,hetero-structure scheme,and functional formation assembly.Suggested plans,e.g.,doping and sensitization of semiconducting 2DMs,increasing electrical conductance,improving catalytic active sites,strengthening interface coupling in semiconductors(SCs)2DMs,forming nano-structures,building multi-junction nano-composites,increasing photo-stability of SCs,and using combined results of adapted approaches,are summed up.Hence,to further improve 2DMs photo-catalyst properties,hetero-structure design-based 2DMs’photo-catalyst basic mechanism is also reviewed. | Karim Khan Ayesha Khan Tareen Muhammad Aslam Rizwan Ur Rehman Sagar Bin Zhang Weichun Huang Asif Mahmood Nasir Mahmood Kishwar Khan Han Zhang Zhongyi Guo | 2020 | Nano-Micro Letters2020，12，12： | 2 |
| 9 | Anti-inflammatory activities of Sieboldogenin from Smilax china Linn.: Experimental and computational studies显示文摘 | Inamullah Khan Muhammad Nisar Farooq Ebad Said Nadeem Muhammad Saeed Haroon Khan Samiullah Fazli Khuda Nasiara Karim Zia Ahmad | 2008 | Journal of Ethnopharmacology2008，，1： | 2 |
| 10 | 孟加拉吉大港动物园恒河猕猴发生具有公共卫生重要性的结核病(英文)显示文摘本调查自2012年7月至2012年9月在孟加拉吉大港动物园进行,确诊猴发生结核病。发病猴共46只,10至21月龄恒河猕猴表现出反应迟钝、明显消瘦的症状,皮内注射结核菌素,隔离检疫3天,仅有7只猴(15.22%)表现阳性结果。结核菌素阳性动物中,5只在一个月内死亡,剖检检查在肺脏发现结核结节。肺脏样品萋尼氏抗酸染色和组织病理学检查,在染片中观察到抗酸染色的结核分枝杆菌,组织病理学观察到淋巴细胞、嗜中性白细胞和实质中高度增生的纤维组织围绕着上皮样巨噬细胞形成结核性肉芽肿,肺脏的肺泡壁增厚。上述检查结果证明猕猴发生结核病。 | Md Shafiqul Islam Khan Farzana Islam Rume Md Mongur Morshed Chowdhury Mussammet Rasheda Begum Md Robiul Karim | 2014 | 中国人兽共患病学报2014，30，9： | 1 |
| 11 | Analysis of Serum Cholesterol Level in Goats Breeds in Gilgit-Baltistan Area of Pakistan显示文摘 | Akbar Khan Shama Rehman Raja Imran Imtiaz Ahmed khan Karim Dad Pitafi | 2013 | Journal of Agricultural Science and Technology(A)2013，3，4： | 1 |
| 12 | Single-dose azithromycin for the treatment of cholera in adults显示文摘 | Saha D Karim MM Khan WA | 2006 | N Engl J Med2006，354，23： | 1 |
| 13 | Viral load speaks little about toll on liver显示文摘BACKGROUND:Bangladesh is situated in the intermediate prevalence region of hepatitis B virus (HBV).The lifetime risk of acquiring HBV infection in Bangladesh is greater than 40%.It has been estimated that this virus is responsible for 10%-35%cases of acute viral hepatitis,35.7%cases of fulminant hepatic failure, 33.3%-40.5%cases of chronic hepatitis and 46.8%cases of hepatocellular carcinoma in Bangladesh.The aim of this study is to compare the correlation between HBV DNA load and grade and stage of liver disease in patients with chronic hepatitis B(CHB). METHODS:Percutaneous liver biopsies done in 159 CHB patients revealed 62.9%(100 patients)had wild type HBV infection and the rest 37.1%(59)had pre-core/core promoter mutant HBV infection.HBV DNA load was measured using PCR in all patients. RESULTS:In the wild type CHB group,97%(97 patients) had moderate to high HBV DNA load and 3%(3)had low to moderate HBV DNA.In the pre-core/core promoter mutant group,74.6%(44 patients)had moderate to high HBV DNA and the rest 25.4%(15)had low to moderate HBV DNA.The patients with moderate to high HBV DNA of the patients with wild type CHB,78.4%(76 patients) had minimal to mild chronic hepatitis(HAI-NI 0-8)and 21.6%(21)had moderate to severe chronic hepatitis(HAI- NI 9-18).66.6%(2 patients)and 33.3%(1)patients with low to moderate HBV DNA load had minimal to mild and moderate to severe chronic hepatitis respectively.In the moderate to high HBV DNA group,77.3%(75 patients) patients had minimal to moderate fibrosis(HAI-F 0-2)and 22.7%(22)(HAI-F 3-4)had severe fibrosis to cirrhosis.These figures were 33.3%(1 patient)and 66.6% (2)respectively in the patients with low to moderate HBV DNA load.On the other hand in case of patients with pre-core/core promoter mutant type CHB,in the moderate to high HBV DNA group,79.5%(35 patients)had minimal to mild chronic hepatitis(HAI-NI 0-8)and 20.5%(9)had moderate to severe chronic hepatitis(HAI-NI 9-18).93.3% (14)and 6.7%(1)patients with low to moderate HBV DNA load had minimal to mild and moderate to severe chronic hepatitis respectively.In the moderate to high HBV DNA group,68.2%(30 patients)had minimal to moderate fibrosis(HAI-F 0-2)and 31.8%(14)(HAI-F 3-4)had severe fibrosis to cirrhosis.These figures were 86.7%(13)and 13.3%(2)respectively in patients with low to moderate HBV DNA load. CONCLUSIONS:The study shows that high HBV DNA load does not correlate with necro-inflammatory activity or extent of fibrosis in the liver in patients with either wild type or pre-core mutant type CHB. | Mamun-Al Mahtab Salimur Rahman Mobin Khan Md Kamal Ayub Al Mamun Md Fazal Karim | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，5： | 1 |
| 14 | Effect of sodium chlo- ride on germination and seedling characters of different types of rice (Oryza sativa I: ) 显示文摘 | Khan M S A Hamid A Karim M A | 1997 | Journal of Agronomy and Crop Science1997，179，3： | 1 |
| 15 | Overuse tendon injuries:where does the pain come from显示文摘 | Karim M Khan JL Cook | 2000 | Sports Med and Arthroscopy Rev2000，8，1： | 1 |
| 16 | A Cretaceous dike swarm provides evidence of a spreading axis in the back-arc basin of the Kohistan paleo-island arc, northwestern Himalaya, Pakistan显示文摘 | Khan T Murata M Karim T | 2007 | Journal of Asian Earth Sciences2007，29，2： | 1 |
| 17 | Removal of heavy metals from sandy soil using CEHIXM process显示文摘 | Karim M A Khan L I | 2001 | J Hazardous Mater B2001，81，： | 1 |
| 18 | Effect of sodium chloride on germination and seeding characters of different types of rice显示文摘 | KHAN M S A HAMID A KARIM M A | 1997 | J Agron & Crop Sci1997，179，： | 1 |
| 19 | Antibacterial activity of different organic extracts of achyranthes aspera and cassia alata显示文摘 | Alam MT Karim MM Khan SN | | 0，，02： | 1 |
| 20 | Removal of heavy metals from sandy soil using CEHIXM process 显示文摘 | M A Karim Lutful I Khan | 2001 | Journal of Hazardous Materials2001，81，2： | 1 |
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