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| 1 | Update on the applications and limitations of alpha-fetoprotein for hepatocellular carcinoma显示文摘Alpha-fetoprotein(AFP)is an oncofetal glycoprotein that has been used as a tumor marker for hepatocellular carcinoma(HCC)in combination with ultrasound and other imaging modalities.Its utility is limited because of both low sensitivity and specificity,and discrepancies among the different methods of measurements.Moreover,its accuracy varies according to patient characteristics and the AFP cut-off values used.Combination of AFP with novel biomarkers such as AFP-L3,Golgi specific membrane protein(GP73)and des-gamma-carboxyprothrombin significantly improved its accuracy in detecting HCC.Increased AFP level could also signify severity of hepatic destruction and subsequent regeneration and is commonly observed in patients with acute and chronic liver conditions and cirrhosis.Hereditary and other non-hepatic disorders can also cause AFP elevation. | Hira Hanif Mukarram Jamat Ali Ammu T Susheela Iman Waheed Khan Maria Alejandra Luna-Cuadros Muzammil Muhammad Khan Daryl Tan-Yeung Lau | 2022 | World Journal of Gastroenterology2022，28，2： | 9 |
| 2 | Histone deacetylase inhibitor pre-treatment enhances the efficacy of DNA-interacting chemotherapeutic drugs in gastric cancer显示文摘BACKGROUND The prognosis of gastric cancer continues to remain poor,and epigenetic drugs like histone deacetylase inhibitors(HDACi)have been envisaged as potential therapeutic agents.Nevertheless,clinical trials are facing issues with toxicity and efficacy against solid tumors,which may be partly due to the lack of patient stratification for effective treatments.To study the need of patient stratification before HDACi treatment,and the efficacy of pre-treatment of HDACi as a chemotherapeutic drug sensitizer.METHODS The expression activity of class 1 HDACs and histone acetylation was examined in human gastric cancer cells and tissues.The potential combinatorial regime of HDACi and chemotherapy drugs was defined on the basis of observed drug binding assays,chromatin remodeling and cell death.RESULTS In the present study,the data suggest that the differential increase in HDAC activity and the expression of class 1 HDACs are associated with hypoacetylation of histone proteins in tumors compared to normal adjacent mucosa tissue samples of gastric cancer.The data highlights for the first time that pretreatment of HDACi results in an increased amount of DNA-bound drugs associated with enhanced histone acetylation,chromatin relaxation and cell cycle arrest.Fraction-affected plots and combination index-based analysis show that pre-HDACi chemo drug combinatorial regimes,including valproic acid with cisplatin or oxaliplatin and trichostatin A with epirubicin,exhibit synergism with maximum cytotoxic potential due to higher cell death at low combined doses in gastric cancer cell lines.CONCLUSION Expression or activity of class 1 HDACs among gastric cancer patients present an effective approach for patient stratification.Furthermore,HDACi therapy in pretreatment regimes is more effective with chemotherapy drugs,and may aid in predicting individual patient prognosis. | Ramchandra Vigay Amnekar Shafqat Ali Khan Mudasir Rashid Bharat Khade Rahul Thorat Poonam Gera Shailesh V Shrikhande Duane T Smoot Hassan Ashktorab Sanjay Gupta | 2020 | World Journal of Gastroenterology2020，26，6： | 3 |
| 3 | Positron emission tomography scanning in the evaluation of hepatocellular carcinoma显示文摘 | M.Akram Khan Connie S Combs Elizabeth M Brunt Val J Lowe Michael K Wolverson Harvey Solomon Brian T Collins Adrian M.Di Bisceglie | 2000 | Journal of Hepatology2000，，5： | 2 |
| 4 | Single-Dose Gamma-Irradiation Induces Up-Regulation of Chemokine Gene Expression and Recruitment of Granulocytes into the Portal Area but Not into Other Regions of Rat Hepatic Tissue显示文摘 | Ihtzaz Ahmed Malik Federico Moriconi Nadeem Sheikh Naila Naz Sajjad Khan Jozsef Dudas Tümen Mansuroglu Clemens Friedrich Hess Margret Rave-Fr?nk Hans Christiansen Giuliano Ramadori | 2010 | The American Journal of Pathology2010，，4： | 2 |
| 5 | Dobutamine stress echocardiography predicts myocardial improvement in patients supported by left ventricular assist devices (LVADs) :hemodynamic and histologic evidence of improvement before LVAD explantatian 显示文摘 | Khan T Delgado RM Radovancevic B | 2003 | J Heart Lung Transplant2003，22，2： | 1 |
| 6 | CMV colitis in a patient receiving dasatinib 显示文摘 | Khan MA Walling T Cumpston A | 2007 | Blood2007，110，13： | 1 |
| 7 | Effect of brain e dema on infarct volume in a focal cerebral ischemia model in rats显示文摘 | Lin T N He Y Y Wu G Khan M Hsu C Y | 1993 | Stroke1993，24，： | 1 |
| 8 | Intermittent cyclic process for enhanced biological nutrient removal treating combined chemical laboratory wastewater 显示文摘 | Tanwar P Nandy T Khan R | 2007 | Bioresour Techno12007，98，13： | 1 |
| 9 | Hypereosinophilic syndrome:a case series显示文摘 | Aziz M Khan WS Ammar T el al | 2009 | Biomedica2009，25，3： | 1 |
| 10 | GreenPro-Ⅰ:a risk-based life cycle assessment and decision-making methodology for process plant design显示文摘 | Khan F I Sadiq R Husain T | 2002 | Environmental Modelling & Software2002，17，： | 1 |
| 11 | The human XPC DNA repair gene:arrangement,splice site information content and influence of a single nucleotide polymorphism in a splice acceptor site on alternative splicing and function显示文摘 | Khan SG Muniz-Medina V Shahlavi T | 2002 | Nucleic Acids Res2002，30，16： | 1 |
| 12 | Anemia:an early complication of chronic renal insufficiency显示文摘 | Kazmi W H Kausz A T Khan S | 2001 | Am J Kidney Dis2001，38，4： | 1 |
| 13 | Large volume ' mammotome' biopsy may reduce the need for diagnostic surgery in papillary lesions of the breast显示文摘 | CARDER P J KHAN T BURROWS P | 2008 | J Clin Pathol2008，61，8： | 1 |
| 14 | Seismic risk analysis of modified fan type cable stayed bridges 显示文摘 | Khan R A Datta T K Ahrnad S | 2006 | Engineering Structures2006，28，9： | 1 |
| 15 | An overview and analy- sis of site remediation technologies显示文摘 | Khan F I Husain T Hejazi R | 2004 | Journal of Envi- ronmental Management2004，71，： | 1 |
| 16 | The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements:proposal for a new dosing regimen 显示文摘 | SCONCE E A KHAN T I WYNNE H A | 2005 | Blood2005，106，7： | 1 |
| 17 | Transient liquid phase diffusion bonding A1-6061 using nano-dispersed Ni coatings 显示文摘 | COOKE K O KHAN T I OLIVER G D | 2011 | Materials and Design2011，33，： | 1 |
| 18 | Technical overview of compressed natural gas (CNG) as a transportation fuel显示文摘 | Khan MI Yasmin T Shakoor A | 2015 | Renewable and Sus- tainable Energy Reviews2015，51，： | 1 |
| 19 | Improvement in creep strength in a nickel-base single crystal superalloy by heat treatment 显示文摘 | CARON P KHAN T | 1983 | Mater Sci Eng1983，61，： | 1 |
| 20 | Exact solutions of starting flows for second grade fluid in a porous medium显示文摘 | Khan M Naheed E Fetecau T | 2008 | Int J Nonlinear Mech2008，43，9： | 1 |
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