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| 1 | Differential diagnosis of benign and malignant branch duct intraductal papillary mucinous neoplasm using contrastenhanced endoscopic ultrasonography显示文摘AIM: To elucidate the role of contrast-enhanced endoscopic ultrasonography(CE-EUS) in the diagnosis of branch duct intraductal papillary mucinous neoplasm(BD-IPMN).METHODS: A total of 50 patients diagnosed with BDIPMN by computed tomography(CT) and endoscopic ultrasonography(EUS) at our institute were included in this study. CE-EUS was performed when mural lesions were detected by EUS. The diagnostic accuracy for identifying mural nodules(MNs) was evaluated by CT, EUS, and EUS combined with CE-EUS. In the patients who underwent resection, the accuracy of measuring MN height with each imaging modality was compared. The cut-off values to diagnose malignant BD-IPMNs based on MN height for each imaging modality were determined using receiver operating characteristic curve analysis.RESULTS: Fifteen patients were diagnosed with BD-IPMN with MNs and underwent resection. The remaining 35 patients were diagnosed with BD-IPMN without MNs and underwent follow-up monitoring. The pathological findings revealed 14 cases with MNs and one case without. The accuracy for diagnosing MNs was 92% using CT and 72% using EUS; the diagnostic accuracy increased to 98% when EUS and CE-EUS were combined. The accuracy for measuring MN height significantly improved when using CE-EUS compared with using CT or EUS(median measurement error value, CT: 3.3 mm vs CE-EUS: 0.6 mm, P < 0.05; EUS: 2.1 mm vs CE-EUS: 0.6 mm, P < 0.01). A cut-off value of 8.8 mm for MN height as measured by CE-EUS improved the accuracy of diagnosing malignant BDIPMN to 93%. CONCLUSION: Using CE-EUS to measure MN height provides a highly accurate method for differentiating benign from malignant BD-IPMN. | Hirofumi Harima Seiji Kaino Shuhei Shinoda Michitaka Kawano Shigeyuki Suenaga Isao Sakaida | 2015 | World Journal of Gastroenterology2015，21，20： | 12 |
| 2 | Chromoendoscopy of gastric adenoma using an acetic acid indigocarmine mixture显示文摘AIM:To investigate the usefulness of chromoendoscopy,using an acetic acid indigocarmine mixture(AIM),for gastric adenoma diagnosed by forceps biopsy.METHODS:A total of 54 lesions in 45 patients diagnosed as gastric adenoma by forceps biopsy were prospectively enrolled in this study and treated by endoscopic submucosal dissection(ESD)between January 2011 and January 2012.AIM-chromoendoscopy(AIMCE)was performed followed by ESD.AIM solution was sprinkled and images were recorded every 30 s for 3min.Clinical characteristics such as tumor size(<2cm,≥2 cm),surface color in white light endoscopy(WLE)(whitish,normochromic or reddish),macroscopic appearance(flat or elevated,depressed),and reddish change in AIM-CE were selected as valuables.RESULTS:En bloc resection was achieved in all 54 cases,with curative resection of fifty two lesions(96.3%).Twenty three lesions(42.6%)were diagnosed as welldifferentiated adenocarcinoma and the remaining 31lesions(57.4%)were gastric adenoma.All adenocarcinoma lesions were well-differentiated tubular adenocarcinomas and were restricted within the mucosal layer.The sensitivity of reddish color change in AIM-CE is significantly higher than that in WLE(vs tumor size≥2 cm,P=0.016,vs normochromic or reddish surface color,P=0.046,vs depressed macroscopic type,P=0.0030).On the other hand,no significant differences were found in the specificity and accuracy.In univariate analysis,normochromic or reddish surface color in WLE(OR=3.7,95%CI:1.2-12,P=0.022)and reddish change in AIM-CE(OR=14,95%CI:3.8-70,P<0.001)were significantly related to diagnosis of early gastric cancer(EGC).In multivariate analysis,only reddish change in AIM-CE(OR=11,95%CI:2.3-66,P=0.0022)was a significant factor associated with diagnosis of EGC.CONCLUSION:AIM-CE may have potential for screening EGC in patients initially diagnosed as gastric adenoma by forceps biopsy. | Yoshiyasu Kono Ryuta Takenaka Yoshiro Kawahara Hiroyuki Okada Keisuke Hori Seiji Kawano Yasushi Yamasaki Koji Takemoto Takayoshi Miyake Shigeatsu Fujiki Kazuhide Yamamoto | 2014 | World Journal of Gastroenterology2014，20，17： | 12 |
| 3 | study to determine guidelines for pediatric colonoscopy显示文摘AIM To investigated characteristics, diagnosis, bowelcleansing preparation, sedation, and colonoscope length and diameter in Japanese pediatric patients receiving total colonoscopy.METHODS The present study evaluated consecutive patients aged ≤ 15 years who had undergone their first colonoscopy in Kurume University between January 2007 and February 2015. Data were retrospectively analyzed. We identified 110 pediatric patients who had undergone colonoscopy that had reached the cecum, allowing the observation of the total colon.RESULTS Hematochezia, abdominal pain, and diarrhea were the most common symptoms. For bowel-cleansing preparation, pediatric patients aged ≤ 12 years were treated with magnesium citrate, and patients aged 13-15 years were treated with polyethylene glycol 4000. For sedation, thiamylal with pentazocine, which has an analgesic effect, was used in patients aged ≤ 6 years, and midazolam with pentazocine was used in patients aged ≥ 7 years. Regarding the choice of endoscope, short and thin endoscopes were selected for younger patients, particularly patients aged ≤ 3 years. Positive diagnoses were made in 78 patients(70.9%). Inflammatory bowel disease(n = 49, 44.5%), including ulcerative colitis(n = 37, 33.6%) and Crohn's disease(n = 12, 10.9%), was the most common diagnosis. CONCLUSION Colonoscopy offers a high diagnostic capability for pediatric patients with gastrointestinal symptoms. The selection of appropriate management the performance of colonoscopy is important in pediatric patients. | Shinichiro Yoshioka Hidetoshi Takedatsu Shuhei Fukunaga Kotaro Kuwaki Hiroshi Yamasaki RyosukeYamauchi Atsushi Mori Hiroshi Kawano Tadahiro Yanagi Tatsuki Mizuochi Kosuke Ushijima Keiichi Mitsuyama Osamu Tsuruta Takuji Torimura | 2017 | World Journal of Gastroenterology2017，23，31： | 10 |
| 4 | Helicobacter pylori eradication to prevent gastric cancer: underlying molecular and cellular mechanisms显示文摘众多的细胞、分子的事件在胃的癌症的开发被描述了。在这篇文章,我们 Helicobacter pylori (H pylori ) 的 overviewed 角色一些在胃的致癌作用的重要事件上的感染并且讨论了这些细胞、分子的事件是否在感染的痊愈以后是可逆的。有几个细菌的部件,影响胃的致癌作用的胃的上皮的动力学和提升。细菌也增加基因不稳定性和变化的风险由于没有并且另外的反应的氧种类。肿瘤的渐成说 silencing 压制或象 RUNX3 那样的基因可以与肠的组织变形改变那些的胃腺的显型变化的频率。象生长因素, cytokines 和 COX-2 的增加的表示那样的主机因素也在 H pylori 积极的题目在非癌的织物被报导了。大多数上述现象在感染的痊愈以后被颠倒,是引人注目的。然而,他们的一些包括在 COX-2 的表示上继续存在并且可以为致癌作用增加风险在甚至在成功的 H pylori 根除以后遇见了无形或发育异常的的粘膜。因此, H pylori 根除不能完全为胃的致癌作用废除风险。胃的癌症取决于预定和目标人口的在压制的感染的痊愈的效率,和保证推进调查。 | Shingo Tsuji Masahiko Tsujii Hiroaki Murata Tsutomu Nishida Masato Komori Masakazu Yasumaru Shuji Ishii Yoshiaki Sasayama Sunao Kawano Norio Hayashi | 2006 | World Journal of Gastroenterology2006，12，11： | 7 |
| 5 | Analysis of keto-enol tautomers of curcumin by liquid chromatography/mass spectrometry显示文摘curcumin 的 Keto-enol tautomers 被反向阶段的液体证实层析(RPLC )/hybrid 四极离子 trap/time-of-flight 团 spectrometry (QIT/TOFMS ) 。Tautomers 在否定模式给了不同 MS/MS 系列。不同集体系列被氢 / 重氢交换 LC/MS/MS 也在积极模式获得。我们的结果建议那种 enol 形式是在答案(water/acetonitrile ) 的主要形式。 | Shin-ichi Kawano Yusuke Inohana Yuki Hashi Jin-Ming Lin | 2013 | Chinese Chemical Letters2013，24，8： | 6 |
| 6 | Differential effects of physical activity and sleep duration on cognitive function in young adults显示文摘Purpose: Although exercise and sleep duration habits are associated with cognitive function, their beneficial effects on cognitive function remain unclear. We aimed to examine the effect of sleep duration and daily physical activity on cognitive function, elucidating the neural mechanisms using near-infrared spectroscopy(NIRS).Methods: A total of 23 healthy young adults(age 22.0 ± 2.2 years) participated in this study. Exercise amount was assessed using a uniaxial accelerometer. We evaluated total sleep time(TST) and sleep efficiency by actigraphy. Cognitive function was tested using the N-back task, the Wisconsin Card Sorting Test(WCST), and the Continuous Performance Test—Identical Pairs(CPT-IP), and the cortical oxygenated hemoglobin levels during a word fluency task were measured with NIRS.Results: Exercise amount was significantly correlated with reaction time on 0- and 1-back tasks(r = —0.602, p = 0.002; r = —0.446, p = 0.033,respectively), whereas TST was significantly correlated with % corrects on the 2-back task(r = 0.486, p = 0.019). Multiple regression analysis,including exercise amount, TST, and sleep efficiency, revealed that exercise amount was the most significant factor for reaction time on 0- and 1-back tasks(b = —0.634, p = 0.002; b = —0.454, p = 0.031, respectively), and TST was the most significant factor for % corrects on the 2-back task(b = 0.542, p = 0.014). The parameter measured by WCST and CPT-IP was not significantly correlated with TST or exercise amount. Exercise amount, but not TST, was significantly correlated with the mean area under the NIRS curve in the prefrontal area(r = 0.492, p = 0.017).Conclusion: Exercise amount and TST had differential effects on working memory and cortical activation in the prefrontal area. Daily physical activity and appropriate sleep duration may play an important role in working memory. | Kazuko Kato Kunihiro Iwamoto Naoko Kawano Yukihiro Noda Norio Ozaki Akiko Noda | 2018 | Journal of Sport and Health Science2018，7，2： | 5 |
| 7 | Tolerability of magnifying narrow band imaging endoscopy for esophageal cancer screening显示文摘AIM:To compare the tolerability of magnifying narrow band imaging endoscopy for esophageal cancer screening with that of lugol chromoendoscopy.METHODS:We prospectively enrolled and analyzed 51 patients who were at high risk for esophageal cancer.All patients were divided into two groups:a magnifying narrow band imaging group,and a lugol chromoendoscopy group,for comparison of adverse symptoms.Esophageal cancer screening was performed on withdrawal of the endoscope.The primary endpoint was a score on a visual analogue scale for heartburn after the examination.The secondary endpoints were scale scores for retrosternal pain and dyspnea after the examinations,change in vital signs,total procedure time,and esophageal observation time.RESULTS:The scores for heartburn and retrosternal pain in the magnifying narrow band imaging group were significantly better than those in the lugol chromoendoscopy group(P =0.004,0.024,respectively,ANOVA for repeated measures).The increase in heart rate after the procedure was significantly greater in the lugol chromoendoscopy group.There was no significant difference between the two groups with respect to othervital sign.The total procedure time and esophageal observation time in the magnifying narrow band imaging group were significantly shorter than those in the lugol chromoendoscopy group(450 ± 116 vs 565 ± 174,P =0.004,44 ± 26 vs 151 ± 72,P < 0.001,respectively).CONCLUSION:Magnifying narrow band imaging endoscopy reduced the adverse symptoms compared with lugol chromoendoscopy.Narrow band imaging endoscopy is useful and suitable for esophageal cancer screening periodically. | Yasushi Yamasaki Ryuta Takenaka Keisuke Hori Koji Takemoto Seiji Kawano Yoshiro Kawahara Hiroyuki Okada Shigeatsu Fujiki Kazuhide Yamamoto | 2015 | World Journal of Gastroenterology2015，21，9： | 5 |
| 8 | 颈椎压缩性骨折伴脊髓损伤保守治疗后的局部后凸进展显示文摘颈椎屈曲压缩性骨折常伴有小关节面明显移位、颈椎力线偏移以及灾难性的神经功能障碍,因此建议及时施行外科手术。但是,一些患者的小关节面尚能维持平整,颈椎力线可,此外,由于伤后可能同时存在多发性损伤和/或失血性休克,常无法施行手术,因此保守治疗仍是可取的选择。目前鲜有报道评估保守治疗颈椎屈曲压缩性骨折伴脊髓损伤的长期疗效。本研究回顾性分析此类患者的临床特征、影像学表现和远期治疗结果,同时探讨患者损伤后局部后凸进展的潜在危险因素。 | Yokota K Maeda T Kawano 白朝晖 王建华 | 2019 | 中国骨科临床与基础研究杂志2019，11，3： | 4 |
| 9 | Prediction of colorectal tumor grade and invasion depth through narrow-band imaging scoring显示文摘AIM To determine the usefulness of assigning narrow-band imaging(NBI) scores for predicting tumor grade and invasion depth in colorectal tumors.METHODS A total of 161 colorectal lesions were analyzed from138 patients who underwent endoscopic or surgical resection after conventional colonoscopy and magnifying endoscopy with NBI. The relationships between the surface and vascular patterns of the lesions, as visualized with NBI, and the tumor grade and depth of submucosa(SM) invasion were determined histopathologically.Scores were assigned to distinct features of the surface microstructures of tubular and papillary-type lesions.Using a multivariate analysis, a model was developed for predicting the tumor grade and depth of invasion based on NBI-finding scores.RESULTS NBI findings that correlated with a high tumor grade were associated with the 'regular/irregular'(P < 0.0001)surface patterns and the 'avascular area' pattern(P =0.0600). The vascular patterns of 'disrupted vessels'(P = 0.0714) and 'thick vessels'(P = 0.0133) but none of the surface patterns were associated with a depth of invasion of ≥ 1000 μm. In our model, a total NBIfinding score ≥ 1 was indicative of a high tumor grade(sensitivity: 0.97; specificity: 0.24), and a total NBIfinding score ≥ 9(sensitivity: 0.56; specificity: 1.0) was predictive of a SM invasion depth ≥ 1000 μm. Scores less than these cutoff values signified adenomas and a SM invasion depth < 1000 μm, respectively. Associations were also noted between selected NBI findings and tumor tissue architecture and histopathology.CONCLUSION Our multivariate statistical model for predicting tumor grades and invasion depths from NBI-finding scores may help standardize the diagnosis of colorectal lesions and inform therapeutic strategies. | Yasuhiko Maeyama Keiichi Mitsuyama Tetsuhiro Noda Shiuchiro Nagata Tsutomu Nagata Shinichiro Yoshioka Hikaru Yoshida Michita Mukasa Hiroaki Sumie Hiroshi Kawano Jun Akiba Yuko Araki Tatsuyuki Kakuma Osamu Tsuruta Takuji Torimura | 2018 | World Journal of Gastroenterology2018，24，42： | 4 |
| 10 | Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011显示文摘 | Hisanori Umehara Kazuichi Okazaki Yasufumi Masaki Mitsuhiro Kawano Motohisa Yamamoto Takako Saeki Shoko Matsui Tadashi Yoshino Shigeo Nakamura Shigeyuki Kawa Hideaki Hamano Terumi Kamisawa Toru Shimosegawa Akira Shimatsu Seiji Nakamura Tetsuhide Ito Kenji | 2012 | Modern Rheumatology2012，，1： | 4 |
| 11 | Primary intestinal follicular lymphoma:How to identify follicular lymphoma by routine endoscopy显示文摘A 69-year-old Japanese female was diagnosed with primary intestinal follicular lymphoma. Esophagogas-troduodenoscopy with high-definition imaging revealed not only the typical feature of whitish polyps of up to 2 mm in diameter in the duodenal second and third portions, but also more detailed morphology, such as enlarged whitish villi and tiny whitish depositions. These findings appeared to reflect the pathological structures; infiltration of lymphoma cells into the villi were probably seen as enlargement of the villi, and the formation of lymphoid follicles were shown as opaque white spots or tiny white depositions. Thus, the above features might contribute to the distinct diagnosis of intestinal follicular lymphoma. This case indicates that routine esophagogastroduodenoscopy can visualize microsurface structures, which can be pathognomonic and help to diagnose intestinal follicular lymphoma, even without magnifying endoscopy. | Masaya Iwamuro Yoshinari Kawai Katsuyoshi Takata Seiji Kawano Tadashi Yoshino Hiroyuki Okada Kazuhide Yamamoto | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，1： | 4 |
| 12 | A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details显示文摘 | Hisanori Umehara Kazuichi Okazaki Yasufumi Masaki Mitsuhiro Kawano Motohisa Yamamoto Takako Saeki Shoko Matsui Takayuki Sumida Tsuneyo Mimori Yoshiya Tanaka Kazuo Tsubota Tadashi Yoshino Shigeyuki Kawa Ritsuro Suzuki Tsutomu Takegami Naohisa Tomosugi Nozo | 2012 | Modern Rheumatology2012，，1： | 4 |
| 13 | Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential显示文摘 | Tsujii M Kawano S Dubois RN | | 0，，： | 3 |
| 14 | Body mass index correlated with forced expiratory volume in 1 second/forced vital capacity in a population with a relatively low prevalence of obesity显示文摘背景肥胖是在世界上的最普通的新陈代谢的疾病。然而,在肥胖之间的关系和肺功能充分没被理解。尽管几纵的研究证明了那在身体增加,重量能在肺的功能导致减小,这是否并且是否高是有日本人口的盒子身体团索引( BMI )地位独自代表现在的学习的 unclear.The 目的是在日本病人的呼吸量测定法在一般诊所测量的肺功能上估计 BMI 的效果的妨碍的肺机能障碍遗体的一个适当预言者。我们屏蔽请教了一般 clinics.Methods 题目的病人上的测量 BMI 和执行呼吸量测定法包括了 1231 个病人 40 岁(吝啬的年龄(65. | Susumu Fukahori Hiroto Matsuse Nobom Takamura Tomoko Tsuchida Tetsuya Kawano Chizu Fukushima Senjyu Hideaki Shigeru Kohno | 2010 | Chinese Medical Journal2010，，20： | 3 |
| 15 | Magnifying Endoscopy, Stereoscopic Microscopy, and the Microvascular Architecture of Superficial Esophageal Carcinoma显示文摘 | Y. Kumagai H. Inoue K. Nagai T. Kawano T. Iwai | 2002 | Endoscopy2002，，05： | 3 |
| 16 | Analysis of chloramphenicol in honey by on-line pretreatment liquid chromatography-tandem mass spectrometry显示文摘Chloramphenicol is an antibiotic and one of the potential contaminants in honey.Solid-phase extraction is the key pretreatment procedure for analysis of chloramphenicol in honey.In this work,an on-line pretreatment liquid chromatography-tandem mass spectrometer system for sensitive,reliable and higher throughput analysis was developed.With the methylcellulose-immobilized reversed-phase column,sugars in a honey sample were efficiently removed in 1 min.As a result,the limit of quantitation of chloramphenicol was 20 pg/mL(0.2 μg/kg honey). | Shin-ichi Kawano Hong-Yuan Hao Yuki Hashi Jin-Ming Lin | 2015 | Chinese Chemical Letters2015，26，1： | 3 |
| 17 | Surgical resection of a solitary para-aortic lymph node metastasis from hepatocellular carcinoma显示文摘Lymph node (LN) metastases from hepatocellular carcinoma (HCC) are considered uncommon. We describe the surgical resection of a solitary para-aortic LN metastasis from HCC. A 65-year-old Japanese man with B-type liver cirrhosis was admitted for the evaluation of a liver tumor. He had already undergone radiofrequency ablation, transcatheter arterial chemoembolization, and percutaneous ethanol injection therapy for HCC. Despite treatment, viable regions remained in segments 4 and 8. We performed a right paramedian sectionectomy with partial resection of the left paramedian section of the liver. Six months later, serum concentrations of alpha-fetoprotein (189 ng/mL) and PIVKA-2 (507 mAU/mL) increased. Enhanced com- puted tomography of the abdomen revealed a tumor (20 mm in diameter) on the right side of the abdominal aorta. Fluorine-18 fluorodeoxyglucose positron emission tomography revealed an increased standard uptake value. There was no evidence of recurrence in other regions. Esophagogastroduodenoscopy and colonoscopy revealed no malignant tumor in the gastrointestinal tract. Para-aortic LN metastasis from HCC was thus diagnosed. We performed lymphadenectomy. Histopathological examination revealed that the tumor was largely necrotic, with poorly differentiated HCC on its surface, which confirmed the suspected diagnosis. After 6 mo tumor marker levels were normal, with no evidence of recurrence. Our experience suggests that a solitary para-aortic LN metastasis from HCC can be treated surgically. | Junji Ueda Hiroshi Yoshida Yasuhiro Mamada Nobuhiko Taniai Sho Mineta Masato Yoshioka Youichi Kawano Tetsuya Shimizu Etsuko Hara Chiaki Kawamoto Keiko Kaneko Eiji Uchida | 2012 | World Journal of Gastroenterology2012，18，23： | 3 |
| 18 | The Intronic cis Element SE1 Recruits trans-Acting Repressor Complexes to Repress the Expression of ELONGATED UPPERMOST INTERNODE1 in Rice显示文摘 | Yongyao Xie Yaling Zhang Jingluan Han Jikai Luo Gousi Li Jianle Huang Haibin WU Qingwei Tian Qinlong Zhu Yuanling Chen Yoji Kawano Yao-Guang Liu Letian Chen | 2018 | Molecular Plant2018，11，5： | 3 |
| 19 | Novel Radio on Fiber Access Eliminating External Electric Power Supply at Base Station显示文摘A novel Radio On Fiber(ROF) access is proposed and demonstrated which enables the pico-cell Base Station (BS) for high-speed wireless communications to eliminate external electric power supply facilities. We demonstrated 2.4-GHz band radio signal transmission through the BS without external electric power supply. The electrical power used for BS circuit is feeded by optical power over optical fiber from central station. | Tetsuya Miki Katsuyasu Kawano Nobuo Nakajima Naoto Kishi Masaru Miyamoto Tetsu Aoki | 2003 | 光学学报2003，23，S1： | 3 |
| 20 | Randomized study of lafutidine vs lansoprazole in patients with mild gastroesophageal reflux disease显示文摘AIM: To compare the clinical efficacy of the secondgeneration H2 RA lafutidine with that of lansoprazole in Japanese patients with mild gastroesophageal reflux disease(GERD). METHODS: Patients with symptoms of GERD and a diagnosis of grade A reflux esophagitis(according to the Los Angeles classification) were randomized to receive lafutidine(10 mg, twice daily) or lansoprazole(30 mg, once daily) for an initial 8 wk, followed by maintenance treatment comprising half-doses of the assigned drug for 24 wk. The primary endpoint was the frequency and severity of heartburn during initial and maintenance treatment. The secondary endpoints were the sum score of questions 2 and 3 in the Gastrointestinal Symptom Rating Scale(GSRS), and the satisfaction score.RESULTS: Between April 2012 and March 2013, a total of 53 patients were enrolled, of whom 24 and 29 received lafutidine and lansoprazole, respectively. After 8 wk, the frequency and severity of heartburn was significantly reduced in both groups. However, lafutidine was significantly inferior to lansoprazole with regard to the severity of heartburn during initial and maintenance treatment(P = 0.016). The sum score of questions 2 and 3 in the GSRS, and satisfaction scores were also significantly worse in the lafutidine group than the lansoprazole group(P = 0.0068 and P = 0.0048, respectively).CONCLUSION: The clinical efficacy of lafutidine was inferior to that of lansoprazole, even in Japanese patients with mild GERD. | Ryuta Takenaka Hiroyuki Okada Seiji Kawano Yoshinori Komazawa Fumiya Yoshinaga Shinji Nagata Masafumi Inoue Hirohisa Komatsu Seiji Onogawa Yoshinori Kushiyama Shinichi Mukai Hiroko Todo Hideharu Okanobu Noriaki Manabe Shinji Tanaka Ken Haruma Yoshikazu Kinoshita | 2016 | World Journal of Gastroenterology2016，22，23： | 2 |
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