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| 1 | Neoadjuvant and Adjuvant Therapy in Intrahepatic Cholangiocarcinoma显示文摘Intrahepatic cholangiocarcinoma(ICC)is the second most common primary liver cancer and causes major economic and health burdens throughout the world.Although the incidence of ICC is relatively low,an upward trend has been seen over the past few decades.Owing to the lack of specific manifestations and tools for early diagnosis,most ICC patients have relatively advanced disease at diagnosis.Thus,neoadjuvant therapy is necessary to evaluate tumor biology and downstage these patients so that appropriate candidates can be selected for radical liver resection.However,even after radical resection,the recurrence rate is relatively high and is a main cause leading to death after surgery,which makes adjuvant therapy necessary.Because of its low incidence,studies in both neoadjuvant and adjuvant settings of ICC are lagging compared with other types of malignancy.While standard neoadjuvant and adjuvant regimens are not available in the current guidelines due to a lack of high-level evidence,some progress has been achieved in recent years.In this review,the available literature on advances in neoadjuvant and adjuvant strategies in ICC are evaluated,and possible challenges and opportunities for clinical and translational investigations in the near future are discussed. | Xing Chen Jinpeng Du Jiwei Huang Yong Zeng Kefei Yuan | 2022 | Journal of Clinical and Translational Hepatology2022，10，3： | 4 |
| 2 | Efficacy and Safety of Second-line Treatments in Patients with Advanced Hepatocellular Carcinoma after Sorafenib Failure:A Meta-analysis显示文摘Background and Aims:In the last decade,several second-line therapies followed by sorafenib in patients with advanced hepatocellular carcinoma(HCC)have been reported.But the outcomes were different from each other.This meta-analysis aimed to evaluate the efficacy and safety of the second-line therapies followed by sorafenib in patients with advanced HCC.Methods:Embase(1974 to October 2019)and Ovid MEDLINE(1946 to October 2019)were searched for randomized clinical trials on second-line therapies followed by sorafenib in patients with advanced HCC.The quality of each study was assessed by the modified Jadad scale.Statistical analysis was carried out by RevMan5.3 software.Efficacy and safety were analyzed.Efficacy included overall survival(OS),disease control rate,time to progression,and progression-free survival.Results:Eight studies involving 3,173 patients were eligible.No difference in OS was found between the second-line treatment group and the control group(HR=0.87,95%CI:0.74-1.01,p=0.06).Disease control rate(relative risk(RR)=1.36,95%CI:1.16-1.60,p=0.0002),time to progression(HR=0.64,95%CI:0.51-0.81,p=0.0002)and progression-free survival(HR=0.60,95%CI:0.46-0.77,p<0.0001)were significantly improved by the second-line therapies.There was a slight difference in adverse events of any grade(RR=1.07,95%CI:1.00-1.14,p=0.03)between the two groups.Conclusions:These second-line therapies followed by sorafenib may potentially improve the prognosis in patients with advanced HCC.Compared with other second-line therapies,regorafenib seemed to be more effective. | Limin An Haotian Liao Kefei Yuan | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 2 |
| 3 | Effect of arotinolol on right ventricular function in patients with dilated cardiomyopathy显示文摘Objective Dilated cardiomyopathy(DCM) is generally considered to be accompanied by both left and right ventricular dysfunction,but most studies only analyze the left ventricular function. In this study,we evaluated the effect of arotinolol on right ventricular function in patients with DCM. Methods Right ventricular ejection fraction(RVEF) and right ventricular diameter(RVD) were measured by two-dimensional echocardiography(2-DE) in 33 DCM patients;RVEF measured by first-pass radionuclide angiography(FPRA) was compared with that by 2-DE. Results The treatment with arotinolol for one year resulted in a reduction in the right ventricular diameter(baseline,23.0 ± 8.3 mm vs after one-year treatment,20.7 ± 5.4 mm;P=0.004 ) and an associated increase in ejection fraction(baseline,36.9 ± 10.3% vs after one-year treatment,45.8 ± 9.6%;P < 0.001 ) ;there is a high correlation between the 2-DE method and radionuclide ventriculographic method. The correlation coefficient is 0.933(P<0.001) . Conclusion Arotinolol therapy could not only improve left ventricular function,but also improve right ventricular function in DCM patients. | Hong Yang Li Xu Yongkang Tao Zhimin Xu Xiuqing Du Naqiang Lu Kefei Dou Jinglin Zhao Xianqi Yuan Yanfen Zhao Rongfang Shi Chaomei Fan | 2007 | Journal of Geriatric Cardiology2007，4，3： | 1 |
| 4 | MDIG-mediated H3K9me3 demethylation upregulates Myc by activating OTX2 and facilitates liver regeneration显示文摘The mineral dust-induced gene(MDIG)comprises a conserved JmjC domain and has the ability to demethylate histone H3 lysine 9 trimethylation(H3K9me3),Previous studies have indicated the significance of MDIG in promoting cell proliferation by modulating cell-cycle transition.However,its involvement in liver regeneration has not been extensively investigated.In this study,we generated mice with liver-specific knockout of MDIG and applied partial hepatectomy or carbon tetrachloride mouse models to investigate the biological contribution of MDIG in liver regeneration. | Jinpeng Du Wenwei Liao Haichuan Wang Guimin Hou Min Liao Lin Xu Jiwei Huang Kefei Yuan Xiangzheng Chen Yong Zeng | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 1 |
| 5 | Three-dimensional ionospheric tomography by an improved algebraic reconstruction technique显示文摘 | Debao Wen Yunbin Yuan Jikun Ou Xingliang Huo Kefei Zhang | 2007 | GPS Solutions2007，，4： | 1 |
| 6 | An efficient iO-based data integrity verification scheme for cloud storage显示文摘Dear editor,With the advent of big data,an increasing number of people are storing their data on remote cloud servers.Cloud storage services enable users to flexibly maintain and access their data via mobile or wireless networks.However,despite these benefits,cloud storage deprives users of physical control over their data,which poses new challenges in data security(1–4)Data integrity protection is one of the most important of these security chal-lenges. | Lixue SUN Chunxiang XU Yuan ZHANG Kefei CHEN | 2019 | Science China(Information Sciences)2019，62，5： | 1 |
| 7 | Spatiotemporal characteristics of the ionospheric TEC variation for GPS net-based real-time positioning in Victoria 显示文摘 | Wu Suqin Zhang Kefei Yuan Yunbin | 2006 | Journal of Global Postioning System2006，5，12： | 1 |
| 8 | New insights in the metabolic function related to gut microbiota in the process of liver regeneration显示文摘Liver disease is a prominent cause of premature mortality globally(1).Many patients with liver diseases require therapeutic liver surgery,usually through hepatectomy(2).Due to the clinical demand for such practice,the study of liver regeneration following hepatectomy holds significant value.The gut microbiota,considered as a“new organ”due to its substantial influence on various physiological functions,has gained increasing attention from the scientific community,particularly in relation to the gut-liver axis. | Nan Jiang Zhen Wang Kefei Yuan | 2023 | Hepatobiliary Surgery and Nutrition2023，12，6： | 0 |
| 9 | Epigenome-wide development and validation of a prognostic methylation score in intrahepatic cholangiocarcinoma based on machine learning strategies显示文摘Background:Clinical parameter-based nomograms and staging systems provide limited information for the prediction of survival in intrahepatic cholangiocarcinoma(ICC)patients.In this study,we developed a methylation signature that precisely predicts overall survival(OS)after surgery.Methods:An epigenome-wide study of DNA methylation based on whole-genome bisulfite sequencing(WGBS)was conducted for two independent cohorts(discovery cohort,n=164;validation cohort,n=170)from three hepatobiliary centers in China.By referring to differentially methylated regions(DMRs),we proposed the concept of prognostically methylated regions(PMRs),which were composed of consecutive prognostically methylated CpGs(PMCs).Using machine learning strategies(Random Forest and the least absolute shrinkage and selector regression),a prognostic methylation score(PMS)was constructed based on 14 PMRs in the discovery cohort and confirmed in the validation cohort.Results:The C-indices of the PMS for predicting OS in the discovery and validation cohorts were 0.79 and 0.74,respectively.In the whole cohort,the PMS was an independent predictor of OS[hazard ratio(HR)=8.12;95% confidence interval(CI):5.48-12.04;P<0.001],and the C-index(0.78)of the PMS was significantly higher than that of the Johns Hopkins University School of Medicine(JHUSM)nomogram(0.69,P<0.001),the Eastern Hepatobiliary Surgery Hospital(EHBSH)nomogram(0.67,P<0.001),American Joint Committee on Cancer(AJCC)tumor-node-metastasis(TNM)staging system(0.61,P<0.001),and MEGNA prognostic score(0.60,P<0.001).The patients in quartile 4 of PMS could benefit from adjuvant therapy(AT)(HR=0.54;95%CI:0.32-0.91;log-rank P=0.043),whereas those in the quartiles 1-3 could not.However,other nomograms and staging system failed to do so.Further analyses of potential mechanisms showed that the PMS was associated with tumor biological behaviors,pathway activation,and immune microenvironment.Conclusions:The PMS could improve the prognostic accuracy and identify patients who would benefit from AT for ICC patients,and might facilitate decisions in treatment of ICC patients. | Xing Chen Liangqing Dong Lu Chen Yuan Wang Jinpeng Du Lijie Ma Xiaokai Yan Jiwei Huang Mingheng Liao Xiangzheng Chen Dongming Liu Jin Li Bo Zhang Wen Teng Kefei Yuan Deqiang Sun Qiang Gao Yong Zeng | 2023 | Hepatobiliary Surgery and Nutrition2023，12，4： | 0 |
| 10 | Role of Noncoding RNAs in the Tumor Immune Microenvironment of Hepatocellular Carcinoma显示文摘Hepatocellular carcinoma (HCC) is one of the most preva-lent malignancies. It has high mortality and poor clinical out-comes, but the molecular mechanisms in the pathogenesis of HCC are not understood. The tumor immune microenviron-ment (TIME) is a highly intricate system with distinct popula-tions of innate and adaptive immune cells, as well as other stromal cells. They interact and evolve with tumor cells to influence tumor growth, migration, invasion, immune eva-sion, and response to therapy. Emerging evidence has shown noncoding RNAs (ncRNAs) are prominent regulators of TIME in HCC. In this review, we elaborate on the functions and molecular mechanisms of ncRNAs in remodeling TIME of HCC and discuss their diagnostic and therapeutic potential for HCC treatment. | Yue Lv Zhen Wang Kefei Yuan | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 0 |
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