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| 1 | Late Pleistocene glaciation of the Changbai Mountains in northeastern China显示文摘The Changbai Mountains (2749 m a.s.l.) in northeastern China are one of the typical mountain regions with glaciation since late Pleistocene as evidenced by well-preserved erosive and accumulative landforms at elevations above 2000 m a.s.l. formed by glaciers around the crater lake, Tianchi Lake. Cirque glaciers developed on both the inner and outer sides of the volcanic cone. Well-preserved cirques, glacial trough valleys, glacial threholds, polished surfaces of the glacial erratics and the moraine ridges indicate that several glaciation processes took place during the last glacial period in this region. Results of optically stimulated luminescence (OSL) dating on the moraine sediments, and the K/Ar, ther- mal ionization mass spectrometry (TIMS), electronic spinning resonance (ESR) dating on the volcanic rocks suggest two periods of glacier advances. One is named the Black Wind Mouth glacier advance taking place on the west and north slopes of the volcanic cone at an elevation of 2000―2100 m a.s.l., which is dated to about 20 ka, being the result of the Last Glacial Maximum (LGM). The other is named the Meteorological Station glacier advance at the elevation of 2400―2600 m a.s.l., dated to 11 ka during the late glacial period, and is tentatively correlated to the Younger Dryas stage. The scope of the former glacier advance is larger than that of the latter. Regional comparisons showed that the glacial sequences in the Changbai Mountains are similar to other glaciated areas in eastern Asia during the later part of the last glacial cycle. | ZHANG Wei NIU YunBo YAN Ling CUI ZhiJiu LI ChuanChuan MU KeHua | 2008 | Chinese Science Bulletin2008，53，17： | 18 |
| 2 | 北高丛越桔芽器官离体培养与快繁体系的建立显示文摘The rapid propagation of plantlets of Vaccinium corymbosum in vitro was studied by using the stem-segment with buds as the explant.The optimal culture conditions were set as follows:1)for the initial culture,the explants were sterilized with alcohol,sap nation of cresol and HgCl2,and then cultured on WPM medium containing ZT 3.0 mg·L-1 and 3% sucrose;2)the medium for clump bud induction was WPM + ZT 2.0 mg·L-1 + 3% sugar;3)the medium for robust shoot was WPM + ZT 0~1.0 mg·L-1 + 3% sugar;4)for adventitious root induction from shoots,the medium was 1/2 WPM liquid nutritions containing IBA 1.0~5.0 mg·L-1 and 2% sugar,in which either vermiculite,filter paper or sterilized cotton were added,and shoots were cultured under a photoperiod of 12 h illumination and 12 h darkness alternatively after 14 days in darkness;5)the medium for transplanting was turfy-soil and mosses(V∶V= 1∶1). | 赵建萍 柏新富 蒋小满 张萍 Bi Kehua | 2007 | 林业科学2007，43，5： | 13 |
| 3 | Efficient generation of transgenic chickens using the spermatogonial stem cells in vivo and ex vivo transfection显示文摘The highly efficient novel methods to produce transgenic chickens were established by directly in-jecting the recombinant plasmid containing green fluorescent protein (GFP) gene into the cock's testis termed as testis-medianted gene transfer (TMGT), and transplanting transfected spermatogonial stem cells (TTSSCs). For the TMGT approach,four dosages of pEGFP-N1 DNA/cationic polymer complex were injected intratesticularly. The results showed: (1) 48 h after the injection,the percentages of testis cells expressing GFP were 4.0%, 8.7%, 10.2% and 13.6% in the 50, 100, 150 and 200 μg/mL group, re-spectively. The difference from the four dosage groups was significant (P<0.05). On day 25 after the injection, a dosage-dependent and time-dependent increase in the number of transgenic sperm was observed. The percentages of gene expression reached the summit and became stable from day 70 to 160, being 12.7%, 12.8%, 15.9% and 19.1%, respectively. The difference from the four dosage groups was also significant (P<0.05). (2) 70 d after the injection, strong green fluorescent could be observed in the seminiferous tubules by whole-mount in-situ hybridization. (3) 70 d after the injection, the semen was collected and used to artificially inseminate wild-type females. The blastoderms of F1 and F2 transgenic chicken expressed GFP were 56.2% (254/452) and 53.2% (275/517), respectively. The detec-tion of polymerase chain reaction (PCR) of F1 and F2 transgenic chicken blood genomic DNA showed that 56.5% (3/23) of F1 and 52.9% (9/17) of F2 were positive. Southern blot showed GFP DNA was in-serted in their genomic DNAs. (4) Frozen whole mount tissue sections of F1 and F2 transgenic chicken liver, heart, kidney and muscle showed that the rates of green fluorescent positive were between 50.0% and 66.7%. (5) With the TTSSCs method, SSCs ex vivo transfected with GFP were transplanted into recipient roosters whose endogenic SSCs had been resoluted. The donor SSCs settled and GFP ex-pression became readily detectable in the frozen whole mount tissue sections of recepient testes. Moreover, sperms carrying GFP could be produced normally. The results of artificially inseminating wild-type females with these sperms showed 12.5% (8/64) of offspring embryo expressed GFP and 11.1% (2/18) hatched chicks were tested transgenic. Our data therefore suggest TMGT and TTSSCs are the feasible methods for the generation of transgenic chickens. | LI BiChun SUN GuoBo SUN HuaiChang XU Qi GAO Bo ZHOU GuanYue ZHAO WenMing WU XinSheng BAO WenBin YU Fei WANG KeHua CHEN GuoHong | 2008 | Science China(Life Sciences)2008，51，8： | 13 |
| 4 | A Geometric Understanding of Deep Learning显示文摘This work introduces an optimal transportation(OT)view of generative adversarial networks(GANs).Natural datasets have intrinsic patterns,which can be summarized as the manifold distribution principle:the distribution of a class of data is close to a low-dimensional manifold.GANs mainly accomplish two tasks:manifold learning and probability distribution transformation.The latter can be carried out using the classical OT method.From the OT perspective,the generator computes the OT map,while the discriminator computes the Wasserstein distance between the generated data distribution and the real data distribution;both can be reduced to a convex geometric optimization process.Furthermore,OT theory discovers the intrinsic collaborative-instead of competitive-relation between the generator and the discriminator,and the fundamental reason for mode collapse.We also propose a novel generative model,which uses an autoencoder(AE)for manifold learning and OT map for probability distribution transformation.This AE–OT model improves the theoretical rigor and transparency,as well as the computational stability and efficiency;in particular,it eliminates the mode collapse.The experimental results validate our hypothesis,and demonstrate the advantages of our proposed model. | Na Lei Dongsheng An Yang Guo Kehua Su Shixia Liu Zhongxuan Luo Shing-Tung Yau Xianfeng Gu | 2020 | Engineering2020，6，3： | 10 |
| 5 | Traditional Chinese medicine: potential approaches from modern dynamical complexity theories显示文摘尽管有在临床的背景的繁体中文药(TCM ) 的普遍使用,经由科学审判证明它的有效性仍然是挑战。TCM 把人的身体看作一个复杂动态系统,并且集中于人的身体的平衡,内部并且与它的外部环境。如此的基本概念用系统级的 quantification 途径要求调查,它在常规简化论以外。仅仅确定的方法动态复杂性能把新卓见带进 TCM 的评估。在一篇以前的文章,我们简短在 TCM 介绍了多尺度的熵(MSE ) 分析的潜在的价值。这篇文章试图在 TCM quantification 解释存在挑战,以介绍动态复杂性理论和 TCM 理论的一致性,并且启发未来关于健康和疾病的系统级的研究。 | Yan Ma Kehua Zhou Jing Fan Shuchen Sun | 2016 | Frontiers of Medicine2016，10，1： | 9 |
| 6 | Burn image segmentation based on Mask Regions with Convolutional Neural Network deep learning framework:more accurate and more convenient显示文摘Background:Burns are life-threatening with high morbidity and mortality.Reliable diagnosis supported by accurate burn area and depth assessment is critical to the success of the treatment decision and,in some cases,can save the patient’s life.Current techniques such as straight-ruler method,aseptic film trimming method,and digital camera photography method are not repeatable and comparable,which lead to a great difference in the judgment of burn wounds and impede the establishment of the same evaluation criteria.Hence,in order to semi-automate the burn diagnosis process,reduce the impact of human error,and improve the accuracy of burn diagnosis,we include the deep learning technology into the diagnosis of burns.Method:This article proposes a novel method employing a state-of-the-art deep learning technique to segment the burn wounds in the images.We designed this deep learning segmentation framework based on the Mask Regions with Convolutional Neural Network(Mask R-CNN).For training our framework,we labeled 1150 pictures with the format of the Common Objects in Context(COCO)data set and trained our model on 1000 pictures.In the evaluation,we compared the different backbone networks in our framework.These backbone networks are Residual Network-101 with Atrous Convolution in Feature Pyramid Network(R101FA),Residual Network-101 with Atrous Convolution(R101A),and InceptionV2-Residual Network with Atrous Convolution(IV2RA).Finally,we used the Dice coefficient(DC)value to assess the model accuracy.Result:The R101FA backbone network gains the highest accuracy 84.51%in 150 pictures.Moreover,we chose different burn depth pictures to evaluate these three backbone networks.The R101FA backbone network gains the best segmentation effect in superficial,superficial thickness,and deep partial thickness.The R101A backbone network gains the best segmentation effect in full-thickness burn.Conclusion:This deep learning framework shows excellent segmentation in burn wound and extremely robust in different burn wound depths.Moreover,this framework just needs a suitable burn wound image when analyzing the burn wound.It is more convenient and more suitable when using in clinics compared with the traditional methods.And it also contributes more to the calculation of total body surface area(TBSA)burned. | Chong Jiao Kehua Su Weiguo Xie Ziqing Ye | 2019 | Burns & Trauma2019，7，1： | 4 |
| 7 | A near-infrared fluorescent probe for fluorine ions and its application in the imaging of HepG2 cells显示文摘In this study, we have designed and synthesized a new near-infrared (NIR) fluorescent probe (BODIPY-Se) to detect fluorine ions (F-) using a B-Se bond to connect the fluorescent dye BODIPY and benzotrifluoride. The probe exhibited a highly selective fluorescence response to F- with a detection limit of 7.4×108 mol/L. The excitation and emission spectra of the probe in the NIR region avoid background fluorescence interference present in biological systems. The fluorescent imaging of HepG2 cells demonstrated that the newly developed probe should be broadly applicable to detect F- in living cells. | GONG Wei SU RuiXian LI Lu XU KeHua TANG Bo | 2011 | Chinese Science Bulletin2011，56，31： | 4 |
| 8 | Carbon decorated Li_(3)V_(2)(PO_(4))_(3) for high-rate lithium-ion batteries:Electrochemical performance and charge compensation mechanism显示文摘Fast charging and high-power delivering batteries are highly demanded in mobile electronics,electric vehicles and grid energy storage,but there are full of challenges.The star-material Li_(3)V_(2)(PO_(4))_(3) is demonstrated as a promising high-rate cathode material meeting the above requirements.Herein,we report the carbon decorated Li_(3)V_(2)(PO_(4))_(3) (LVP/C) cathode prepared via a facile method,which displays a remarkable high-rate capability and long-term cycling performance.Briefly,the prepared LVP/C delivers a high discharge capacity of 122 mAh g^(-1)(-93% of the theoretical capacity) at a high rate up to 20 C and a superior capacity retention of 87.1% after 1000 cycles.Importantly,by applying a combination of X-ray absorption spectroscopy and full-range mapping of resonant inelastic X-ray scattering,we clearly elucidate the structural and chemical evolutions of LVP upon various potentials and cycle numbers.We show unambiguous spectroscopic evidences that the evolution of the hybridization strength between V and O in LVP/C as a consequence of lithiation/delithiation is highly reversible both in the bulk and on the surface during the discharge-charge processes even over extended cycles,which should be responsible for the remarkable electrochemical performance of LVP/C.Our present study provides not only an effective synthesis strategy but also deeper insights into the surface and bulk electrochemical reaction mechanism of LVP,which should be beneficial for the further design of high-performance LVP electrode materials. | Manling Ding Chen Cheng Qiulong Wei Yue Hu Yingying Yan Kehua Dai Jing Mao Jinghua Guo Liang Zhang Liqiang Maig | 2021 | Journal of Energy Chemistry2021，30，2： | 3 |
| 9 | Effect of 'Yang-warming and kidney essence-replenishing' herbal paste on cold-related asthma exacerbation显示文摘OBJECTIVE: To observe the effect of 'Yang-warming and kidney essence-replenishing' herbal paste on cold-related asthma exacerbation. METHODS: One hundred and fifty one patients with moderate to severe persistent asthma were randomly divided into a treatment group (n=74) and a control group (n=69). Both groups were given basic treatment according to the Global Initiative for Asthma scheme. The treatment group was also treated with herbal paste in the winter. The frequency of asthma exacerbation, cold and cold-re-lated asthma exacerbation, scores of the asthma control test (ACT), and kidney-deficiency syndrome during the one-year follow-up in each group were recorded. RESULTS: Compared with the control group, the onset frequencies of catching cold, asthma exacerbation, cold-related asthma exacerbation, and kidney-deficiency syndrome score were significantly reduced. There was no significant difference in scores of ACT between the two groups. CONCLUSION: 'Yang-warming and kidney essence-replenishing' herbal paste could reduce cold-related asthma exacerbation. | Binqing Tang Kehua Shi Xiaoqi Li Hongchang Wang Hong Fang Bidan Xiong Yingen Wu | 2013 | Journal of Traditional Chinese Medicine2013，33，4： | 3 |
| 10 | Boosting polysulfide redox conversion of Li-S batteries by one-step-synthesized Co-Mo bimetallic nitride显示文摘Lithium-sulfur(Li-S)batteries are considered as one of the most promising next generation energy storage systems due to the high theoretical specific capacity,low cost,and environmental benignity.However,the notorious shuttle effect of polysulfides hinders the practical application of Li-S batteries.Herein,we have rationally designed and synthesized sea urchin-like Co-Mo bimetallic nitride(Co_(3) MO_(3) N)in the absence of additional nitrogen sources with only one step,which was applied as the sulfur host materials for Li-S batteries.The results indicate that Co_(3) Mo_(3) N can efficiently anchor and catalyze the conversion of polysulfides,thus accelerating the electrochemical reaction kinetics and enabling prominent electrochemical properties.As a consequence,the S@Co_(3) Mo_(3) N cathode exhibits a high rate performance of 705 mAh g^(-1) at 3 C rate and an excellent cycling stability with a low capacity fading rate of 0.08%per cycle at 1 C over 600 cycles.Even at a high sulfur loading of 5.4 cmg cm^(-2),it delivers a high initial areal capacity of 4.50 mAh cm^(-2) which is still retained at 3.64 mAh cm^(-2) after 120 cycles.Furthermore,the catalytic mechanism and structural stability of Co_(3) Mo_(3) N during cycling were elucidated by a combination of X-ray photoelectron spectroscopy and X-ray absorption fine structure.This work highlights the strategy of structure-catalysis engineering of bimetallic nitride,which is expected to have a wide application in Li-S batteries. | Yingying Yan Hongtai Li Chen Cheng Tianran Yan Wenping Gao Jing Mao Kehua Dai Liang Zhang | 2021 | Journal of Energy Chemistry2021，30，10： | 3 |
| 11 | Experimental investigation of methane hydrate decomposition by depressurizing in porous media with 3-Dimension device显示文摘In order to simulate the behavior of gas hydrate formation and decomposition,a 3-Dimension experimental device was built,consisting of a high-pressure reactor with an inner diameter of 300 mm,effective height of 100 mm,and operation pressure of 16 MPa.Eight thermal resistances were mounted in the porous media at different depthes and radiuses to detect the temperature distribution during the hydrate formation/decomposition.To collect the pressure,temperature,and flux of gas production data,the Monitor and Control Generated System(MCGS) was used.Using this device,the formation and decomposition behavior of methane hydrate in the 20 ~ 40 mesh natural sand with salinity of 3.35 wt% was examined.It was found that the front of formation or decomposition of hydrate can be judged by the temperature distribution.The amount of hydrate formation can also be evaluated by the temperature change.During the hydrate decomposition process,the temperature curves indicated that the hydrate in the top and bottom of reactor dissociated earlier than in the inner.The hydrate decomposition front gradually moved from porous media surface to inner and kept a shape of column form,with different moving speed at different surface position.The proper decomposition pressure was also determined. | Kehua Su Changyu Sun Xin Yang Guangjin Chen Shuanshi Fan | 2010 | Journal of Natural Gas Chemistry2010，19，3： | 3 |
| 12 | Cortactin is involved in transforming growth factor-β1-induced epithelial-mesenchymal transition in AML-12 cells显示文摘Cortactin 是 F 肌动朊有约束力的蛋白质,调整房间运动和粘合剂连接汇编。然而,在上皮间充质的转变(EMT ) 的 cortactin 的功能留下逃犯。这里,我们发现在转变生长期间, factor-1 (TGF-1 ) 在 AML-12 鼠科的 hepatocytes 导致了 EMT, cortactin 经历了酷氨酸 dephosphorylation。由钠 vanadate 的 cortactin 的 dephosphorylation 的抑制堵住了 TGF-1-induced EMT。由导致的 RNAi 的 cortactin 击倒细胞间的连接蛋白质 E-cadherin 和 Zonula occludens-1 和间充质的蛋白质 fibronectin 的导致的表示的减少。另外, cortactin 击倒进一步在 AML-12 房间支持了 TGF-1-induced EMT,由 EMT 标记和房间决定了词法变化。而且,迁居试金显示出那 cortactin 击倒支持了 AML-12 房间的迁居,并且也提高了 TGF-1-induced 移植。我们的学习在 TGF-1-induced EMT 显示出 cortactin 的参与。 | Kehua Zhang Dongmei Wang Jianguo Song | 2009 | Acta Biochimica et Biophysica Sinica2009，41，10： | 2 |
| 13 | Autoantibody against angiotensin AT1 receptor from preeclamptic patients enhances collagen-induced human platelet aggregation显示文摘Hypercoagulability,血小板激活,和 thrombocytopenia 是 preeclampsia 的主要特征,但是他们的负责的内在的分子的机制仍然保持阴暗。最近的研究证明了对血管收缩素 II 类型 1 受体(AT1-AA ) 的自身抗体为 preeclampsia 组成一个新奇风险因素。然而,在血小板激活的 AT1-AA 和在 preeclampsia 的 hypercoagulability 的角色从来没被调查过。在现在的学习,我们决定了 AT1-AA 是否在 vitro 支持血小板聚集,并且把潜在的位于 \O 下面机制。AT1-AA 被连接酶的 immunosorbent 试金检测。在从 preeclamptic 病人净化的免疫球蛋白 G 部分以后,积极 sera 被加到从健康志愿者,血小板聚集和细胞内部的 Ca2+ 孤立的血小板层次被检测。AT1-AA 显著地在 vitro 提高了导致骨胶原的血小板聚集,效果由 AT1 受体对手 losartan 堵住了。另外, AT1-AA 在整个实验增加了并且维持导致骨胶原的 cytosolic 钙集中。我们第一次证明 AT1-AA 显著地在 vitro 通过血管收缩素类型 1 受体激活支持导致骨胶原的血小板聚集,潜在地经由增加的细胞内部的 Ca2+ 集中,作为一个潜在的贡献者支持 AT1-AA 到 preeclampsia 的 hypercoagulable 状态。 | Kehua Bai Ke Wang Xiaoyu Li Jie Wang Jie Zhang LiSong Jin Wang Suli Zhang Wayne Bond Lau Xinliang Ma Huirong Liu | 2013 | Acta Biochimica et Biophysica Sinica2013，45，9： | 2 |
| 14 | Simultaneous Localization and Mapping Technology Based on Project Tango显示文摘Aiming at the problem of system error and noise in simultaneous localization and mapping(SLAM) technology, we propose a calibration model based on Project Tango device and a loop closure detection algorithm based on visual vocabulary with memory management. The graph optimization is also combined to achieve a running application. First, the color image and depth information of the environment are collected to establish the calibration model of system error and noise. Second, with constraint condition provided by loop closure detection algorithm, speed up robust feature is calculated and matched. Finally, the motion pose model is solved, and the optimal scene model is determined by graph optimization method. This method is compared with Open Constructor for reconstruction on several experimental scenarios. The results show the number of model's points and faces are larger than Open Constructor's, and the scanning time is less than Open Constructor's. The experimental results show the feasibility and efficiency of the proposed algorithm. | XU Pei SU Kehua HONG Cheng ZHANG Dengyi | 2019 | Wuhan University Journal of Natural Sciences2019，24，2： | 2 |
| 15 | Jump Type Cahn-Hilliard Equations with Fractional Noises显示文摘The authors explore a class of jump type Cahn-Hilliard equations with fractional noises. The jump component is described by a (pure jump) Lévy space-time white noise. A fixed point scheme is used to investigate the existence of a unique local mild solution under some appropriate assumptions on coefficients. | Lijun BO Kehua SHI Yongjin WANG | 2008 | Chinese Annals of Mathematics,Series B2008，29，6： | 2 |
| 16 | Growth,physiological and anatomical responses of creeping bentgrass cultivars to different depths of waterlogging显示文摘 | Yiwei Jiang Kehua Wang | 2006 | Crop Science2006，46，： | 1 |
| 17 | Study on the effect of ultrasonic surface rolling processing parameters on the surface roughness of Q345 hydraulic prop显示文摘 | Mei Guangyi Zhang Kehua Ding Jinfu | 2010 | Advanced Materials Research2010，，102104： | 1 |
| 18 | An im- proved synthesis of disulfides linked β - cyclodextrin dim- mer and its analytical application for dequalinium chloride determination by spectrofluorimetry显示文摘 | TANG Bo LIANG Hulling XU Kehua | 2005 | Analytica Chimi- ca Acta2005，554，： | 1 |
| 19 | New solutions for solute transport in a finite column with distance-dependent dispersivities and time-dependent solute sources显示文摘 | You Kehua Zhan Hongbin | 2013 | Journal of Hydrology2013，487，： | 1 |
| 20 | A new nanobio sensor for glucose with high sensitivity and selectivity in serum based on fluorescence resonance energy transfer (FRET) between CdTe quantum dots and Au nanopar- ticles 显示文摘 | Tang Bo Cao Lihua Xu Kehua | 2008 | Chem Eur J2008，14，2： | 1 |
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