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| 1 | Impact of Hepatopulmonary Syndrome on Quality of Life and Survival in Liver Transplant Candidates显示文摘 | Michael B. Fallon Michael J. Krowka Robert S. Brown James F. Trotter Steven Zacks Kari E. Roberts Vijay H. Shah Neil Kaplowitz Lisa Forman Keith Wille Steven M. Kawut | 2008 | Gastroenterology2008，，4： | 4 |
| 2 | Hepatitis B vaccination in patients with inflammatory bowel disease显示文摘AIM:To determine the prevalence for hepatitis B virus(HBV) and HBV screening and vaccination practices for inflammatory bowel disease(IBD).METHODS:This study is a retrospective,cross-sectional observational study.A retrospective chart review was performed in 500 patients who have been consecutively treated for IBD between September 2008 and January 2013 at the Rush University Medical Center Gastroenterology section.The patients were identified through the electronic medical record with the criteria that they attended the gastroenterology clinic,and that they had a diagnosis of IBD at the time of visit discharge.Once identified,each record was analyzed to determine whether the subject had been infected with HBV in the past,already been vaccinated against HBV,or advised to get vaccinated and followed through with the recommended vaccination.RESULTS:About 254 out of 500 patients(51%) had HBV screening ordered.Among those ordered to have screening tests,86% followed through with HBV serology.Gastroenterology physicians had significantly different screening ratios from each other(P < 0.001).There were no significant differences in the ratios of HBV screening when IBD specialists were compared to other gastroenterology physicians(0.505 ± 0.023 vs 0.536 ± 0.066,P = 0.66).Of those 220 patients screened,51% of IBD patients were found not to be immune against HBV.Approximately 50% of gastroenterology physicians recommended HBV vaccinations to their patients in whom serology was negative for antibodies against HBV.IBD specialists recommended vaccinations to a higher percentage of their patients compared to other gastroenterology physicians(0.168 ± 0.019 vs 0.038 ± 0.026,P = 0.015).Present and/or past HBV infection was found in 3.6% of the patients who had serology checked.There was no statistically significant difference in the prevalence of hepatitis B surface antigen(HBsAg) between our study and that reported in previous studies done in Spain(4/220 vs 14/2076 respectively,P = 0.070); and in France(4/220 vs 3/315 respectively,P = 0.159).But,the prevalence of anti-HBcAb in this study was less than that reported in the study in Spain(7/220 vs 155/2076 respectively,P = 0.006); and was not sig-nificantly different from that reported in the study in France(7/220 vs 8/315 respectively,P = 0.313).CONCLUSION:The prevalence of HBsAg in our IBD patients was not higher than previously reported European studies.Most IBD patients are not routinely screened or vaccinated against HBV at a tertiary referral center in the United States. | Ruwaida Ben Musa Anuhya Gampa Sanjib Basu Ali Keshavarzian Garth Swanson Michael Brown Rana Abraham Keith Bruninga John Losurdo Mark DeMeo Sohrab Mobarhan David Shapiro Ece Mutlu | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 3 | Para-aortic lymph node involvement should not be a contraindication to resection of pancreatic ductal adenocarcinoma显示文摘BACKGROUND Para-aortic lymph nodes(PALN)are found in the aortocaval groove and they are staged as metastatic disease if involved by pancreatic ductal adenocarcinoma(PDAC).The data in the literature is conflicting with some studies having associated PALN involvement with poor prognosis,while others not sharing the same results.PALN resection is not included in the standard lymphadenectomy during pancreatic resections as per the International Study Group for Pancreatic Surgery and there is no consensus on the management of these cases.AIM To investigate the prognostic significance of PALN metastases on the oncological outcomes after resection for PDAC.METHODS This is a retrospective cohort study of data retrieved from a prospectively maintained database on consecutive patients undergoing pancreatectomies for PDAC where PALN was sampled between 2011 and 2020.Statistical comparison of the data between PALN+and PALN-subgroups,survival analysis with the Kaplan-Meier method and risk analysis with univariable and multivariable time to event Cox regression analysis were performed,specifically assessing oncological outcomes such as median overall survival(OS)and disease-free survival(DFS).RESULTS 81 cases had PALN sampling and 17(21%)were positive.Pathological N stage was significantly different between PALN+and PALN-patients(P=0.005),while no difference was observed in any of the other characteristics.Preoperative imaging diagnosed PALN positivity in one case.OS and DFS were comparable between PALN+and PALN-patients with lymph node positive disease(OS:13.2 mo vs 18.8 mo,P=0.161;DFS:13 mo vs 16.4 mo,P=0.179).No difference in OS or DFS was identified between PALN positive and negative patients when they received chemotherapy either in the neoadjuvant or in the adjuvant setting(OS:23.4 mo vs 20.6 mo,P=0.192;DFS:23.9 mo vs 20.5 mo,P=0.718).On the contrary,when patients did not receive chemotherapy,PALN disease had substantially shorter OS(5.5 mo vs 14.2 mo;P=0.015)and DFS(4.4 mo vs 9.8 mo;P<0.001).PALN involvement was not identified as an independent predictor for OS after multivariable analysis,while it was for DFS doubling the risk of recurrence.CONCLUSION PALN involvement does not affect OS when patients complete the indicated treatment pathway for PDAC,surgery and chemotherapy,and should not be considered as a contraindication to resection. | Rupaly Pande Shafiq Chughtai Manish Ahuja Rachel Brown David C Bartlett Bobby V Dasari Ravi Marudanayagam Darius Mirza Keith Roberts John Isaac Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastrointestinal Surgery2022，14，5： | 2 |
| 4 | Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases显示文摘 | Sung-Jun Park Faiyaz Ahmad Andrew Philp Keith Baar Tishan Williams Haibin Luo Hengming Ke Holger Rehmann Ronald Taussig Alexandra L. Brown Myung K. Kim Michael A. Beaven Alex B. Burgin Vincent Manganiello Jay H. Chung | 2012 | Cell2012，，3： | 2 |
| 5 | Control of p70 S6 kinase by kinase activity of FRAP in vivo显示文摘 | Brown E J Beal P A Keith C T | 1995 | Nature1995，377，6548： | 1 |
| 6 | Estimating the environmental costs of soil erosion at multiple scales in Kenya using emergy synthesis 显示文摘 | Matthew J Cohen Mark T Brown Keith D Shepherd | 2006 | Agriculture Ecosystems and Environment2006，114，2： | 1 |
| 7 | The roles of the classical and alternative nuclear factor- kappa B pathways:potential implications for autoimmunity and rheumatoid arthritis显示文摘 | Keith D Brown Estefania Claudio Ulrich Siebenlist | 2008 | Arthritis Res Ther2008，10，4： | 1 |
| 8 | Intrinsically disordered protein 显示文摘 | Dunker A Keith Lawson J David Brown Celeste J | 2001 | Journal of Mo- lecular Graphics and Modelling2001，19，1： | 1 |
| 9 | BAI 3, CDX 2 and VIL 1: a panel of three antibodies to distinguish small cell from large cell neuroendocrine lung carcinomas显示文摘 | Muhammad F Bari Helen Brown Andrew G Nicholson Keith M Kerr John R Gosney William A Wallace Irshad Soomro Salli Muller Danielle Peat Jonathan D Moore Lesley A Ward Maxim B Freidin Eric Lim Manu Vatish David R J Snead | 2014 | Histopathology2014，，： | 1 |
| 10 | SUNDIALS:Suite of nonlinear and differential/algebraic equation solvers显示文摘 | Alan C Hindmarsh Peter N Brown Keith E Grant | 2005 | ACM TOMS2005，31，3： | 1 |
| 11 | Comparison between two and five doses a week of recombinant human erythropoietin for anemia of prematurity: a randomized tria显示文摘 | Brown MS Keith JF 3rd | 1999 | Pediatrics1999，104，1： | 1 |
| 12 | Functional and structural diversity of the human Dickkopf gene family显示文摘 | Valery E. Krupnik John D. Sharp Chian Jiang Keith Robison Troy W. Chickering Lakshmi Amaravadi Diane E. Brown Deborah Guyot Gail Mays Kevin Leiby Belle Chang Thao Duong Andrew D.J. Goodearl David P. Gearing Sergei Y. Sokol Sean A. McCarthy | 1999 | Gene1999，，2： | 1 |
| 13 | Proposed triaxial atomic force microscope contact-free tweezers for nanoassembly显示文摘 | Keith A Brown Robert M Westervelt | 2009 | Nanotechnology2009，，38： | 1 |
| 14 | Distinctive Expression Pattern of ErbB Family Receptors Signifies an Aggressive Variant of Bladder Cancer显示文摘 | Wassim Kassouf Peter C. Black Tomasz Tuziak Jolanta Bondaruk Sangkyou Lee Gordon A. Brown Liana Adam Caimiao Wei Keith Baggerly Menashe Bar-Eli David McConkey Bogdan Czerniak Colin P. Dinney | 2008 | The Journal of Urology2008，，1： | 1 |
| 15 | Recombinant human erythropoietin stimulates erythropoiesis and reduces erythrocyte transfusions in very low birth weight preterm infants 显示文摘 | Shannon KM Keith JF Ⅲ Mentzer WC Ehrenkranz RA Brown MS Widness JA | 1995 | Pediatrics1995，95，1： | 1 |
| 16 | Indirectly heated biomass gasification using a latent - heat ballast - 3 : Refinement of the heat transfer model 显示文摘 | Keith Cummer Robert C Brown | 2005 | Biomass and Bioenergy2005，28，3： | 1 |
| 17 | Facility for spectral irradiance and radiance responsivity calibrationsusing uniform souices显示文摘 | Steven W Brown George P Eppeldauer Keith R Lykke | 2006 | Appfied Optics(S0003-6935)2006，45，32： | 1 |
| 18 | NIST facility for Spectral Irradiance and Radiance Responsivity Calibrations with Uniform Sources显示文摘 | 6 Steven W Brown George P Eppeldauer Keith R Lykke | 2000 | Metrologia(S0026-1394)2000，37，： | 1 |
| 19 | Ancillm7 cquilxnent for biommss gasficafion显示文摘 | Keith R Ctmmr Robert C Brown | | Bigness and Biocnergy0，202，23： | 1 |
| 20 | Intrinsic disorder and protein function 显示文摘 | Dunker A Keith Brown Celeste J Lawson J David | 2002 | Bio- chemistry2002，41，21： | 1 |
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