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| 1 | Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes显示文摘This review aims to outline the most up-to-date knowledge of pancreatic adenocarcinoma risk, diagnostics, treatment and outcomes, while identifying gaps that aim to stimulate further research in this understudied malignancy. Pancreatic adenocarcinoma is a lethal condition with a rising incidence, predicted to become the second leading cause of cancer death in some regions. It often presents at an advanced stage, which contributes to poor five-year survival rates of 2%-9%, ranking firmly last amongst all cancer sites in terms of prognostic outcomes for patients. Better understanding of the risk factors and symptoms associated with this disease is essential to inform both health professionals and the general population of potential preventive and/or early detection measures. The identification of high-risk patients who could benefit from screening to detect pre-malignant conditions such as pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasms and mucinous cystic neoplasms is urgently required, however an acceptable screening test has yet to be identified. The management of pancreatic adenocarcinoma is evolving, with the introduction of new surgical techniques and medical therapies such as laparoscopic techniques and neo-adjuvant chemoradiotherapy, however this has only led to modest improvements in outcomes. The identification of novel biomarkers is desirable to move towards a precision medicine era, where pancreatic cancer therapy can be tailored to the individual patient, while unnecessary treatments that have negative consequences on quality of life could be prevented for others. Research efforts must also focus on the development of new agents and delivery systems. Overall, considerable progress is required to reduce the burden associated with pancreatic cancer. Recent, renewed efforts to fund large consortia and research into pancreatic adenocarcinoma are welcomed, but further streams will be necessary to facilitate the momentum needed to bring breakthroughs seen for other cancer sites. | Andrew McGuigan Paul Kelly Richard C Turkington Claire Jones Helen G Coleman R Stephen McCain | 2018 | World Journal of Gastroenterology2018，24，43： | 140 |
| 2 | IPOP:体验偏好理论显示文摘IPOP理论与实践来源自20世纪90年代至今的华盛顿史密森尼博物馆的观众调查,包括基础性的观察以及深入访谈,这些数据构成了一个具有长远意义的数据库。此研究的主要目的在于:能够更好地服务博物馆观众,即给观众带来高于平均水平的独特、有意义以及值得纪念的博物馆体验。在16年间的无数研究和访谈中,观众对于史密森尼博物馆展览的反应按照他们的原始兴趣可以被分为四个类型:I=观点,P=人,O=物,P=身体。事实证明展览若能引起四类观众的强烈共鸣,那么该展览在观众层面上是成功的。 | Andrew J.Pekarik James B.Schreiber Nadine Hanemann Kelly Richmond Barbara Mogel 王思怡 | 2017 | 中国博物馆2017，，2： | 5 |
| 3 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 4 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 5 | Does low volume high-intensity interval training elicit superior benefits to continuous low to moderate-intensity training in cancer survivors?显示文摘AIM To determine the impact ofm low volume high-intensity interval training(LVHIIT) and continuous low to moderate-intensity exercise training(CLMIT) on cardiovascular disease(CVD) risk and health outcomes in cancer survivors.METHODS Sedentary cancer survivors(n=75,aged 51±12year)within 24 months of diagnosis,were randomised into three groups for 12 wk of LVHIIT(n=25),CLMIT(n=25)or control group(n=25).The exercise intervention involved 36 sessions(three sessions per week).The LVHIIT group performed 7 x 30 s intervals(≥85%predicted maximal heart rate)with a 60 s rest between intervals,and the CLMIT group performed continuous aerobic training for 20 min(≤55%predicted maximal heart rate)on a stationary bike.Outcome variables were measured at baseline and at12 weeks and analysed using a 3 x 2(group x time)repeated measures ANCOVA to evaluate main and interaction effects.RESULTS Significant improvements(time)were observed for seven of the 22 variables(ES 0.35-0.97,P≤0.05).There was an interaction effect(P<0.01)after 12 in the LVHIIT group for six-minute walk test(P<0.01;d=0.97;95%CI:0.36,1.56;large),sit to stand test(P<0.01;d=-0.83;95%CI:-1.40,-0.22;large)and waist circumference reduction(P=0.01;d=-0.48;95%CI:-1.10,0.10;medium).An interaction effect(P<0.01)was also observed for quality of life in both the LVHIIT(d=1.11;95CI:0.50,1.72;large)and CLMIT(d=0.57;95%CI:-0.00,1.20;moderate)compared with the control group(d=-0.15;95%CI:-0.95,0.65;trivial).CONCLUSION Low-volume high-intensity training shows promise as an effective exercise prescription within the cancer population,showing greater improvements in cardiorespiratory fitness,lower body strength and waist circumference compared with traditional CLMIT and control groups.Both LVHIIT and CLMIT improved quality of life.A proposed benefit of LVHIIT is the short duration(3 min)of exercise required,which may entice more cancer survivors to participate in exercise,improving health outcomes and lowing the risk of CVD. | Kellie Toohey Kate Pumpa Andrew McKune Julie Cooke Katrina D DuBose Desmond Yip Paul Craft Stuart Semple | 2018 | World Journal of Clinical Oncology2018，9，1： | 3 |
| 6 | Corn growth and nitrogen nutrition after additions of biochars with varying properties to a temperate soil显示文摘 | Shelby Rajkovich Akio Enders Kelly Hanley Charles Hyland Andrew R. Zimmerman Johannes Lehmann | 2012 | Biology and Fertility of Soils2012，，3： | 2 |
| 7 | SLC26A4 mutation testing for hearing loss associated with enlargement of the vestibular aqueduct显示文摘Pendred syndrome(PS) is characterized by autosomal recessive inheritance of goiter associated with a defect of iodide organification, hearing loss, enlargement of the vestibular aqueduct(EVA), and mutations of the SLC26A4 gene. However, not all EVA patients have PSor SLC26A4 mutations. Two mutant alleles of SLC26A4 are detected in 1/4 of North American or European EVA populations, one mutant allele is detected in another 1/4 of patient populations, and no mutations are detected in the other 1/2. The presence of two mutant alleles of SLC26A4 is associated with abnormal iodide organification, increased thyroid gland volume, increased severity of hearing loss, and bilateral EVA. The presence of a single mutant allele of SLC26A4 is associated with normal iodide organification, normal thyroid gland volume, less severe hearing loss and either bilateral or unilateral EVA. When other underlying correlations are accounted for, the presence of a cochlear malformation or the size of EVA does not have an effect on hearing thresholds. This is consistent with observations of an Slc26a4 mutant mouse model of EVA in which hearing loss is independent of endolymphatic hydrops or inner ear malformations. Segregation analyses of EVA in families suggest that the patients carrying one mutant allele of SLC26A4 have a second, undetected mutant allele of SLC26A4, and the probability of a sibling having EVA is consistent with its segregation as an autosomal recessive trait. Patients without any mutations are an etiologically heterogeneous group in which siblings have a lower probability of having EVA. SLC26A4 mutation testing can provide prognostic information to guide clinical surveillance and management, as well as the probability of EVA affecting a sibling. | Taku Ito Julie Muskett Parna Chattaraj Byung Yoon Choi Kyu Yup Lee Christopher K Zalewski Kelly A King Xiangming Li Philine Wangemann Thomas Shawker Carmen C Brewer Seth L Alper Andrew J Griffith | 2013 | World Journal of Otorhinolaryngology2013，3，2： | 2 |
| 8 | Correlates of subjectively and objectively measured physical activity in young adolescents显示文摘背景:很多研究利用自我报告评价青少年个体活动水平,而不是通过客观测量。利用自我报告方式得到的结果与客观测量体力活动相比,可能产生并不存在的关联。本研究旨在探讨与体力活动相关的假设在主客观测量体力活动间的联系。方法:通过加速度计测量对被试青少年(共232人,其中男性101名,平均年龄12.3岁)进行至少4天体力活动检测,同时完成调查评估,包括中高强度体力活动(MVPA)、运动能力、参与度、享受度和自我效能感,并测量身高、体重和BMI。结果:用分层回归模型通过控制性别、种族和BMI的Z值,发现性别、BMI的Z值与客观测量得到的MVPA明显相关:同时,仅性别与客观测量的体力活动总量明显相关。相反,用单一模型衡量主观MVPA关系时发现,仅体力活动的享受度、自我效能感与自我报告的体力活动明显相关。结论:通过自我报告和使用加速度计的客观监测方法测量青少年MVPA,两者所得结果存在较大差异。今后研究若要确定与青少年MVPA相关的因素,应谨慎选择测量方式。 | Kelly Kavanaugh Justin B. Moore Leisha Johnson Hibbett Andrew T. Kaczynski | 2015 | Journal of Sport and Health Science2015，4，3： | 2 |
| 9 | Visible light photocatalytic bismuth oxide coatings are effective at suppressing aquatic cyanobacteria and degrading free-floating genomic DNA显示文摘Access to safe drinking water free from microbial pollution is an issue of global concern. The use of photocatalytic thin films in water treatment has focused on titanium dioxide, which requires UV-activation, proving a potential barrier to upscaling and implementation in the real world. Visible-light-activated photocatalytic thin films, such as bismuth oxide, have recently been shown to have antimicrobial properties. However, more understanding of the photocatalytic effect on the microbial population in water is required. Glass beads coated with bismuth oxide were incubated with either Microcystis aeruginosa, Anabaena sp. or free-floating genomic DNA. The presence of bismuth oxide-coated glass beads was able to rapidly stop a population of cyanobacteria from increasing. The coated beads were also able to degrade genomic DNA. Leachate from the beads showed no increase in toxicity against human liver cells. This data demonstrates the efficacy of bismuth oxide-coated glass beads for controlling potentially dangerous cyanobacterial populations, whilst potentially reducing the amount of free-floating genomic DNA(an essential issue in the face of antimicrobial resistance) – all of which should be essential considerations in emerging water treatment technologies. | James Redfern Marina Ratova Andrew PDean James Pritchett Matthieu Grao Joanna Verran Peter Kelly | 2021 | Journal of Environmental Sciences2021，33，6： | 2 |
| 10 | Progression in Acute Stroke: Value of the Initial NIH Stroke Scale Score on Patient Stratification in Future Trials显示文摘 | Thomas J. DeGraba John M. Hallenbeck Karen D. Pettigrew Andrew J. Dutka Brian J. Kelly | 1999 | Stroke: A Journal of Cerebral Circulation1999，，6： | 2 |
| 11 | Identification and molecular cloning of a novel porcine parvovirus显示文摘 | Andrew K. Cheung Guang Wu David Wang Darrell O. Bayles Kelly M. Lager Amy L. Vincent | 2010 | Archives of Virology2010，，5： | 1 |
| 12 | Influence of Gender, Weight and Hispanic Ethnicity on Physical Activity in Tod- dlers显示文摘 | Marten AS Andrews A Kelly LA | 2015 | Medicine & Science in Sports & Exercise2015，47，5： | 1 |
| 13 | Single event effect induced multiple-cell upsets in a commercial 90 nm CMOS digital technology显示文摘 | Reed K Lawrence Andrew T Kelly | | 0，，06： | 1 |
| 14 | Membrane permeability coefficients of murine primary neural brain cells in the presence of cryoprotectant 显示文摘 | Paynter S J Andrews K J Vinh N N Kelly C M Rosser A E Amso N N Dunnett S B | 2009 | Cryobiology2009，8，3： | 1 |
| 15 | Induction of Influx and Efflux Transporters and Cytochrome P450 3A4 in Primary Human Hepatocytes by Rifampin, Rifabutin, and Rifapentine显示文摘 | Beth Williamson Kelly E. Dooley Yuan Zhang David J. Back Andrew Owen | 2013 | Antimicrobial Agents and Chemotherapy2013，，： | 1 |
| 16 | Effect of high-intensity interval training in adolescents with asthma:The eXercise for Asthma with Commando Joe’s^(■)(X4ACJ)trial显示文摘Background:Higher levels of cardiorespiratory fitness are associated with reduced asthma severity and increased quality of life in those with asthma.Therefore,the purpose of this study was to evaluate the effectiveness of a 6-month high-intensity interval training(HIIT)intervention in adolescents with and without asthma.Methods:A total of 616 adolescents(334 boys;13.0±1.1 years,1.57±0.10 m,52.6±12.9 kg,mean±SD),including 155 with asthma(78 boys),were recruited as part of a randomized controlled trial from 5 schools(4 control and 1 intervention).The 221 intervention participants(116 boys;47 asthma)completed 6 months of school-based HIIT(30 min,3 times per week,10-30 s bouts at>90%age-predicted maximum heart rate with equal rest).At baseline,mid-intervention,post-intervention,and 3-month follow-up,measurements for 20-m shuttle run,body mass index(BMI),lung function,Pediatric Quality of Life Inventory,Paediatric Asthma Quality of Life Questionnaire,and Asthma Control Questionnaire were collected.Additionally,69 adolescents(39 boys(of the 36 with asthma there were 21 boys))also completed an incremental ramp test.For analysis,each group’s data(intervention and control)were divided into those with and without asthma.Results:Participants with asthma did not differ from their peers in any parameter of aerobic fitness,at any time-point,but were characterized by a greater BMI.The intervention elicited a significant improvement in maximal aerobic fitness but no change in sub-maximal parameters of aerobic fitness,lung function,or quality of life irrespective of asthma status.Those in the intervention group maintained their BMI,whereas BMI significantly increased in the control group throughout the 6-month period.Conclusion:HIIT represents an effective tool for improving aerobic fitness and maintaining BMI in adolescents,irrespective of asthma status.HIIT was well-tolerated by those with asthma,who evidenced a similar aerobic fitness to their healthy peers and responded equally well to a HIIT program. | Charles O.N.Winn Kelly A.Mackintosh William T.B.Eddolls Gareth Stratton Andrew M.Wilson Melitta A.McNarry Gwyneth A.Davies | 2021 | Journal of Sport and Health Science2021，10，4： | 1 |
| 17 | Ergodicity and Accuracy of Optimal Particle Filters for Bayesian Data Assimilation显示文摘Data assimilation refers to the methodology of combining dynamical models and observed data with the objective of improving state estimation. Most data assimilation algorithms are viewed as approximations of the Bayesian posterior(filtering distribution)on the signal given the observations. Some of these approximations are controlled, such as particle filters which may be refined to produce the true filtering distribution in the large particle number limit, and some are uncontrolled, such as ensemble Kalman filter methods which do not recover the true filtering distribution in the large ensemble limit. Other data assimilation algorithms, such as cycled 3 DVAR methods, may be thought of as controlled estimators of the state, in the small observational noise scenario, but are also uncontrolled in general in relation to the true filtering distribution. For particle filters and ensemble Kalman filters it is of practical importance to understand how and why data assimilation methods can be effective when used with a fixed small number of particles, since for many large-scale applications it is not practical to deploy algorithms close to the large particle limit asymptotic. In this paper, the authors address this question for particle filters and,in particular, study their accuracy(in the small noise limit) and ergodicity(for noisy signal and observation) without appealing to the large particle number limit. The authors first overview the accuracy and minorization properties for the true filtering distribution,working in the setting of conditional Gaussianity for the dynamics-observation model. They then show that these properties are inherited by optimal particle filters for any fixed number of particles, and use the minorization to establish ergodicity of the filters. For completeness we also prove large particle number consistency results for the optimal particle filters, by writing the update equations for the underlying distributions as recursions. In addition to looking at the optimal particle filter with standard resampling, they derive all the above results for(what they term) the Gaussianized optimal particle filter and show that the theoretical properties are favorable for this method, when compared to the standard optimal particle filter. | David KELLY Andrew M.STUART | 2019 | Chinese Annals of Mathematics,Series B2019，40，5： | 1 |
| 18 | A randomized trial of supine vs. prone positioning in patients undergoing escalated dose conformal radiotherapy for prostate cancer显示文摘 | Andrew John Bayley Charles Nicholas Catton Tara Haycocks Valerie Kelly Hamideh Alasti Robert Bristow Pamela Catton Juanita Crook Mary Krystyna Gospodarowicz Michael McLean Michael Milosevic Pardraig Warde | 2003 | Radiotherapy and Oncology2003，，1： | 1 |
| 19 | Mechanisms of photoluminescent quenching of oxidized porous silicon applications to chemical sensing显示文摘 | Bocarsly Andrew B | 1998 | Coordination Chemistry Reviews1998，171，： | 1 |
| 20 | Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice显示文摘 | Ehud Cohen Johan F. Paulsson Pablo Blinder Tal Burstyn-Cohen Deguo Du Gabriela Estepa Anthony Adame Hang M. Pham Martin Holzenberger Jeffery W. Kelly Eliezer Masliah Andrew Dillin | 2009 | Cell2009，，6： | 1 |
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