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| 1 | Stomatocyte structural color-barcode micromotors for multiplex assays显示文摘Artificial micromotors have a demonstrated value in the biomedical area.Attempts to develop this technology tend to impart micromotors with novel functions to improve the values.Herein,we present novel structural color-barcode micromotors for the multiplex assays.We found that,by rapidly extracting solvent and assembling monodispersed nanoparticles in droplets,it could form stomatocyte colloidal crystal clusters,which not only showed striking structural colors and characteristic reflection peaks due to their ordered nanoparticles arrangement,but also provided effective cavities for the integration of functional elements.Thus,the micromotors with catalysts or magnetic elements in their cavities,as well as with the corresponding structural color coding,could be achieved by using the platinum and ferric oxide dispersed pre-gel to fill and duplicate the stomatocyte colloidal crystal clusters.We have demonstrated that the self-movement of these structural color-barcode micromotors could efficiently accelerate the mixing speed of the detection sample and greatly increase the probe-target interactions towards faster and more sensitive single or multiplex detection,and the magnetism of these barcode micromotors enables the flexible collection of the micromotors,which could facilitate the detection processes.These features make the stomatocyte structural color-barcode micromotors ideal for biomedical applications. | Lijun Cai Huan Wang Yunru Yu Feika Bian Yu Wang Keqing Shi Fangfu Ye Yuanjin Zhao | 2020 | National Science Review2020，7，3： | 7 |
| 2 | The role of fibroblast growth factor 21 in the pathogenesis of liver disease: a novel predictor and therapeutic target 显示文摘 | LIU Wenyue HUANG Sha SHI Keqing | 2014 | Expert Opin Ther Targets2014，18，11： | 1 |
| 3 | Porous hydrogel arrays for hepatoma cell spheroid formation and drug resistance investigation显示文摘Drug resistance is one of the major obstacles in the drug therapy of cancers.Efforts in this area in pre-clinical research have focused on developing novel platforms to evaluate and decrease drug resistance.In this paper,inspired by the structure of hives where swarms live and breed,we propose porous hydrogel arrays with a uniform pore structure for the generation of hepatoma cell spheroids and the investigation of drug resistance.The porous hydrogel arrays were fabricated using polyeth-ylene glycol diacrylate(PEGDA)hydrogel to negatively replicate a well-designed template.Benefiting from the elaborate processing of the template,the prepared porous hydrogel arrays possessed a uniform pore structure.Due to their anti-adhesion properties and the excellent biocompatibility of the PEGDA hydrogel,the hepatoma cells could form well-defined and uni-form hepatoma cell spheroids in the porous hydrogel arrays.We found that the resistant hepatoma cell spheroids showed more significant Lenvatinib resistance and a migratory phenotype compared with a two-dimensional(2D)cell culture,which reveals the reason for the failure of most 2D cell-selected drugs for in vivo applications.These features give such porous hydrogel arrays promising application prospects in the investigation of tumor cell spheroid culture and in vitro drug resistance. | Xin Lei Changmin Shao Xin Shou Keqing Shi Liang Shi Yuanjin Zhao | 2021 | Bio-Design and Manufacturing2021，4，4： | 1 |
| 4 | Randomized trial of autologous bone marrow mesenchymal stem cells transplantation for hepatitis B virus cirrhosis: Regulation of T reg/ T h17 cells显示文摘 | Lanman Xu Yuewen Gong Benfu Wang Keqing Shi Yijun Hou Liping Wang Zuo Lin Yixiang Han Lu Lu Dazhi Chen Xiuli Lin Qiqiang Zeng Wenke Feng Yongping Chen | 2014 | J Gastroenterol Hepatol2014，，8： | 1 |
| 5 | A 24-week,parallel-group,open-label,randomized clinical trial comparing the early antiviral efficacy of telbivudine and entecavir in the treatment of hepatitis B e antigen-positive chronic hepatitis B virus infection in adult Chinese patients显示文摘 | Zheng Minghua Shi Keqing Dai Zhijuan | 2010 | Clin Ther2010，32，4： | 1 |
| 6 | Facile preparation of Cu 2 O/carbon sphere heterostructure with high photocatalytic activity显示文摘 | Keqing Zhou Yongqian Shi Saihua Jiang Yuan Hu Zhou Gui | 2013 | Materials Letters2013，，： | 1 |
| 7 | Pollens derived magnetic porous particles for adsorption of low-density lipoprotein from plasma显示文摘Adsorption of low-density lipoprotein from plasma is vital for the treatment of dyslipidemia.Appropriate adsorbent material for efficient and selective adsorption of low-density lipoprotein is highly desired.In this work,we developed pollens-derived magnetic porous particles as adsorbents for this purpose.The natural pollen grains were modified to obtain high surface porosity,a large inner cavity,magnet responsiveness,and specific wettability.The resultant particles exhibited satisfying performance in the adsorption of a series of oils and organic solvents out of water.Besides,the particles were directly utilized to the adsorption of low-density lipoprotein in plasma,which showed high selectivity,and achieved an outstanding adsorption capacity as high as 34.9%within 2 h.Moreover,their salient biocompatibility was demonstrated through simulative hemoperfusion experiments.These features,together with its abundant source and facile fabrication,makes the pollens-derived magnetic porous particles excellent candidate for low-density lipoprotein-apheresis and water treatment applications. | Yuetong Wang Lingyu Sun Jiahui Guo Keqing Shi Luoran Shang Jian Xiao Yuanjin Zhao | 2021 | Bioactive Materials2021，6，6： | 1 |
| 8 | Supramolecular G-quadruplex hydrogels:Bridging fabrication to biomedical application显示文摘G-quadruplex hydrogel is a class of self-assembled supramolecular hydrogel formed by guanine derivatives.As a biomimetic hydrogel,G-quadruplex hydrogels demonstrate wide biomedical applications,such as drug delivery,tissue engineering,and biosensing.The advantages of using G-quadruplex hydrogels include adequate biocompatibility and biodegradability,tunable multifunctionality,and cost-effective and large-scalable fabrication process.In this review,we focus on recent progress in the fabrication and characterization of G-quadruplex hydrogels to help readers understand the principles of G-quadruplex hydrogel formation.Meanwhile,the applications of G-quadruplex hydrogels in the biomedical area are discussed,aiming to pave the way for downward clinical or industry translation.The development of G-quadruplex hydrogel is still in its infancy.We hope this review will boost the development of this area and that more applications of G-quadruplex hydrogel will be developed. | Yuanfeng Li Junjie Chi Pingwei Xu Xing Dong Anh-Tuan Le Keqing Shi Yong Liu Jian Xiao | 2023 | Journal of Materials Science & Technology2023，，24： | 0 |
| 9 | Dynamic covalent nano-networks comprising antibiotics and polyphenols orchestrate bacterial drug resistance reversal and inflammation alleviation显示文摘New antimicrobial strategies are urgently needed to meet the challenges posed by the emergence of drug-resistant bacteria and bacterial biofilms.This work reports the facile synthesis of antimicrobial dynamic covalent nano-networks(aDCNs)composing antibiotics bearing multiple primary amines,polyphenols,and a cross-linker acylphenylboronic acid.Mechanistically,the iminoboronate bond drives the formation of aDCNs,facilitates their stability,and renders them highly responsive to stimuli,such as low pH and high H2O2 levels.Besides,the representative A1B1C1 networks,composed of polymyxin B1(A1),2-formylphenylboronic acid(B1),and quercetin(C1),inhibit biofilm formation of drug-resistant Escherichia coli,eliminate the mature biofilms,alleviate macrophage inflammation,and minimize the side effects of free polymyxins.Excellent bacterial eradication and inflammation amelioration efficiency of A1B1C1 networks are also observed in a peritoneal infection model.The facile synthesis,excellent antimicrobial performance,and biocompatibility of these aDCNs potentiate them as a much-needed alternative in current antimicrobial pipelines. | Yuanfeng Li Yin-Zi Piao Hua Chen Keqing Shi Juqin Dai Siran Wang Tieli Zhou Anh-Tuan Le Yaran Wang Fan Wu Rujiang Ma Linqi Shi Yong Liu | 2023 | Bioactive Materials2023，，9： | 0 |
| 10 | Ellipsoidal porous patch with anisotropic cell inducing ability for inhibiting skin scar formation显示文摘Scar formation has always been a difficult point to overcome in the field of clinical wound care.Here,we present an ellipsoidal porous patch with cell inducing ability for inhibiting scar formation.The patch was prepared by stretching a poly(lactic-co-glycolic acid)(PLGA)inverse opal film at the glass transition temperature to form a neatly arranged three-dimensional ellipsoidal porous structure.Such anisotropic structure showed dramatic capability in directing cell growth and arrangement by reconstructing cell morphology.Besides,the prolifera-tion of cells growing on the stretched patch was significantly suppressed without cell cytotoxicity.In addition,benefitting from the abundant and connected nanopores,the patch could be imparted with a potent ability to promote cell migration by encapsulating fibroblast growth factor 2(FGF2)via the second filling of functional gelatin methacryloyl(GelMA)hydrogel into its scaffold.In a typical scar model,we have demonstrated that the resultant patch performed well in inhibiting scar formation characterized by inhibiting the excessive proliferation of fibroblasts,decreasing the deposition of type I collagen,reducing the scar index and achieved complete tissue reconstruction.These results indicate the anisotropic inverse opal patch has an excellent application prospect in inhibiting scar formation during wound repair. | Wanqing Weng Junjie Chi Xiaocheng Wang Keqing Shi Fangfu Ye Yuanjin Zhao | 2022 | Engineered Regeneration2022，3，3： | 0 |
| 11 | Linearly shifting ferromagnetic resonance response of La_(0.7)Sr_(0.3)MnO_(3) thin film for body temperature sensors显示文摘Human body temperature not only reflects vital signs,but also affects the state of various organs through blood circulation,and even affects lifespan.Here a wireless body temperature detection scheme was presented that the temperature was extracted by investigating the out-of-plane(OP)ferromagnetic resonance(FMR)field of 10.2 nm thick La_(0.7)Sr_(0.3)MnO_(3)(LSMO)film using electron paramagnetic resonance(EPR)technique.Within the range of 34-42℃,the OP FMR field changes linearly with the increasing or decreasing temperature,and this variation comes from the linear responses of magnetization to the fluctuant temperature.Using this method,a tiny temperature change(<0.1℃)of organisms can be detected accurately and sensitively,which shows great potential in body temperature monitoring for humans and mammals. | Weixiao HOU Yufei YAO Yaojin LI Bin PENG Keqing SHI Ziyao ZHOU Jingye PAN Ming LIU Jifan HU | 2022 | Frontiers of Materials Science2022，16，1： | 0 |
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