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| 1 | The emerging role of autophagic-lysosomal dysfunction in Gaucher disease and Parkinson's disease显示文摘Gaucher disease(GD),the commonest lysosomal storage disorder,results from the lack or functional deficiency of glucocerebrosidase(GCase) secondary to mutations in the GBA1 gene.There is an established association between GBA1 mutations and Parkinson's disease(PD),and indeed GBA1 mutations are now considered to be the greatest genetic risk factor for PD.Impaired lysosomal-autophagic degradation of cellular proteins,including α-synuclein(α-syn),is implicated in the pathogenesis of PD,and there is increasing evidence for this also in GD and GBA1-PD.Indeed we have recently shown in a Drosophila model lacking neuronal GCase,that there are clear lysosomal-autophagic defects in association with synaptic loss and neurodegeneration.In addition,we demonstrated alterations in mechanistic target of rapamycin complex 1(mTORC1) signaling and functional rescue of the lifespan,locomotor defects and hypersensitivity to oxidative stress on treatment of GCase-deficient flies with the mT OR inhibitor rapamycin.Moreover,a number of other recent studies have shown autophagy-lysosomal system(ALS) dysfunction,with specific defects in both chaperone-mediated autophagy(CMA),as well as macroautophagy,in GD and GBA1-PD model systems.Lastly we discuss the possible therapeutic benefits of inhibiting mT OR using drugs such as rapamycin to reverse the autophagy defects in GD and PD. | Kerri J.Kinghorn Amir M.Asghari Jorge Iván Castillo-Quan | 2017 | Neural Regeneration Research2017，12，3： | 4 |
| 2 | Randomised controlled trial of combined spinal epidural vs. spinal anaesthesia for elective caesarean section: vasopressor requirements and cardiovascular changes显示文摘 | Alan JR Macfarlane Artur Pryn Kerry N Litchfield Fiona Bryden Steven Young Christopher Weir Elizabeth M McGrady | 2009 | European Journal of Anaesthesiology2009，，1： | 2 |
| 3 | The isoflavone genistein inhibits copper and peroxyl mediated low densitylipoprotein oxidation in vitro显示文摘 | Kerry N Abbey M | 1998 | Atherosclerosis1998，140，： | 2 |
| 4 | Seismic waves in a stratified half - space 显示文摘 | KENNETT B L N KERRY N J | 1979 | Geophys J R Astron Soc1979，57，： | 1 |
| 5 | Effect of varying the gas headspace to meat ratio on the quality andshelf life of beef steaks packaged in high oxygen modified atmosphere packs 显示文摘 | MURPHY K M O'GRADY M N KERRY J P | 2013 | Meat Science2013，94，4： | 1 |
| 6 | Seismic waves in a stratified halfspace 显示文摘 | Kennett B L N Kerry N J | 1979 | Geophys J R Astr Soc1979，57，： | 1 |
| 7 | The influence of CYP2D6 polymorphism and quinidine on the disposition and antitussive effect of dextromethorphan in humans显示文摘 | Capon DA Bochner F Kerry N | | 0，，03： | 1 |
| 8 | Role of replication and CpG methylation in fragile X syndrome CGG Deletions in primate cells显示文摘 | Kerrie N E Michelle R L Christopher E P | 2005 | Am Hum Genet2005，76，： | 1 |
| 9 | Past,Current and Potential Utilisation of Active and Intelligent Packaging Systems for Meat and Musele-based Products:A Review 显示文摘 | KERRY J P O'GRADY M N HOGAN S A | 2006 | Meat Science2006，74，1： | 1 |
| 10 | Reference genome sequence of the model plant Setaria显示文摘 | Jeffrey L Bennetzen Jeremy Schmutz Hao Wang RyanPercifield Jennifer Hawkins Ana C Pontaroli Matt Estep Liang Feng Justin N Vaughn Jane Grimwood JerryJenkins Kerrie Barry Erika Lindquist Uffe Hellsten Shweta Deshpande Xuewen Wang Xiaomei Wu ThereseMitros Jimmy Triplett Xiaohan Yang Chu-Yu Ye Margarita Mauro-Her-rera Lin Wang Pinghua Li ManojSharma Rita Sharma Pamela C Ronald Olivier Panaud Elizabeth A Kellogg Thomas P Brutnell Andrew NDoust Gerald A Tuskan Daniel Rokhsar Katrien MDevos | 2012 | Nature Biotechnology2012，，30： | 1 |
| 11 | Addition of tea catechins and vitamin C on sensory evaluation, colour and lipid stability during chilled storage in cooked or raw beef and chicken patties 显示文摘 | Mitsuru Mitsumoto Michael N OGrady Joe P Kerry | 2005 | Meat Science2005，69，4： | 1 |
| 12 | The isoflavone genistein inhibits copper and peroxyl radical mediated low density lipoprotein oxidation in vitro 显示文摘 | Kerry N Abbey M | 1998 | Atherosclerosis1998，140，2： | 1 |
| 13 | The isoflavone genistein inhibits copper and peroxyl radicalmediatedlowdensitylipoprotein oxidation in vitro显示文摘 | Kerry N Abbey M | 1998 | Atherosclerosis1998，140，2： | 1 |
| 14 | Attention bias in adult survi- vors of children maltreatment with and without posttraumatic stress disorder 显示文摘 | FANI N BEKH BD KERRY R | 2011 | Cogn Ther Res2011，35，1： | 1 |
| 15 | Activities of clindamycin,daptomycin,doxycycline,linezolid,trimethoprim-sulfame-thoxazole,and vancomycin against community-associated me-thicillin-resistant Staphylococcus aureus with inducible clin-damycin resistance in murine thigh infection and in vitro pharmacodynamic models显示文摘 | Kerry L Steven N David R | | Antimicrob Agents chemother0，52，6： | 1 |
| 16 | On the extension of CP models to address cathodic protection under a delaminated coating显示文摘 | Kerry N A Mark E O | 2009 | Corrosion Science2009，51，5： | 1 |
| 17 | Combined ef- fects of proteins and polysaccharides on physical properties of whey protein concentrate-based edible films显示文摘 | COUGHLAN K K SHAW N B KERRY J F | 2006 | J Food Sci2006，69，6： | 1 |
| 18 | Members of the Fusarium solani species complex that cause infections in both humans and plants are common in the environment 显示文摘 | Zhang N Kerry O'Donnell Deanna AS | 2006 | J Mi- crobiol2006，44，6： | 1 |
| 19 | Water masses and circulation in the region of Prydz Bay, Antarctica显示文摘 | Smith N R Zhaoqian D Kerry K R | 1984 | Deep-Sea Research I1984，31，11： | 1 |
| 20 | Water masses and circulation in the region of Prydz Bay Antarctica显示文摘 | SMITH N R DONG Z Q KERRY K R | 1984 | Deep-Sea Research 11984，31，： | 1 |
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