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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | A semi range-based iterative localization algorithm for cognitive radio networks显示文摘 | Ma Zhiyao Wei Chen Khaled B | 2010 | IEEE Transactions on Vehicular Technology2010，59，2： | 1 |
| 3 | Combined immuno-magnetic separation-molecular beacon-reverse transcription-PCR assay for detection of hepatitis a virus from environmental samples显示文摘 | Khaled H Abd EI Galil MA | 2004 | Applied and Environmental Microbiology2004，70，7： | 1 |
| 4 | Evaluation of stool antigen test for Helicobacter pylori infection in asymoptomatic children from a developing country using 13 C-urea breath test as a standard显示文摘 | Shaikh S Khaled MA IslamA | 2005 | J Pediatr Gastroenterol Nutr2005，40，5： | 1 |
| 5 | Caesarean scar endometriosis presenting as an acute abdomen:a case report and review of lit- erature显示文摘 | Gajjar KB Mahendru AA Khaled MA | 2008 | Archives of Gynecology and Obstetrics2008，277，2： | 1 |
| 6 | Molecular data suggests the ciliate Mesodinium(Protista: Ciliophora) might represent an undescribed taxon at class level显示文摘The well-known ciliate, Mesodinium Stein, 1863, is of great importance to marine microbial food webs and is related to the 'red tides'. However, it is possibly one of the most confusing ciliate taxa in terms of its systematic position: either the morphological or the molecular data excluded it from all the other known assemblages or groups. In the current work, the sequences of small subunit ribosomal RNA(SSU rR NA) genes for all isolates available are analysed and an examination of the secondary structure patterns of related groups is carried out. The results indicate that(1) Mesodinium invariably represents a completely separated and isolated clade positioned between two subphyla of ciliates with very deep branching, which indicates that they should be a primitive or ancestral group for the subphylum Intramacronucleata;(2) the secondary structure of the SSU r RNA of Mesodinium species is unusual in that, while the secondary structure of V4 in Mesodinium sp. has the deletions common to all litostome ciliates, it has more extensive deletions in helix E23_8 and a longer helix E23_1;(3) combining the phylogenetic and morphological information, we suggest establishing Mesodiniea cl. nov., including the order Mesodiniida Grain, 1994, belonging to the subphylum Intramacronucleata. | Xiao Chen Hong-Gang Ma Khaled A.S. Al-Rasheid Miao Miao | 2015 | Zoological Systematics2015，40，1： | 1 |
| 7 | Wound healing activities of Rafflesia hasseltii extract in rats显示文摘 | Mahmood AA Khaled AA Hapipah MA | 2009 | 1 Clin Biochem Nutr2009，45，3： | 1 |
| 8 | Does the early consideration of the Zavanelli manoeuver in a diff icult case of shoulder dystociare asultin abettero bstetriout come显示文摘 | Jindal S Sharma SS Khaled MA | 2008 | Obstet Gynaecol2008，28，8： | 1 |
| 9 | E-selectin S128R polymorphism and severe coronary artery disease in Arabs显示文摘 | Khaled KA Olayan MA Gamal HM | 2006 | BMC Medical Genetics2006，7，： | 1 |
| 10 | CFD Sensitivity Analysis of a Straight-Blade Vertical Axis Wind Turbine显示文摘 | Khaled M Almohammadi D B Ingham L Ma M Pourkashanian | 2012 | Wind Engineering2012，，5： | 1 |
| 11 | Accuracy of routine magnetic resonance imaging in meniseal and ligamentous injuries of the knee : comparison with arthroscopy显示文摘 | Behairy NH Dorgham MA Khaled SA | 2009 | Int Orthop2009，33，4： | 1 |
| 12 | Efficiency of diagnostic biomarkers among colonic schistosomiasis Egyptian patients 显示文摘 | Hamed MA Ahmed SA Khaled HM | 2011 | Mem Inst Oswaldo Cruz2011，106，3： | 1 |
| 13 | Caesarean scar endometriosis presenting as an acute abdomen:a case report and review of literature显示文摘 | Gajjar KB Mahendru AA Khaled MA | | 0，，02： | 1 |
| 14 | Aeeuracy of routine mag- netic resonance imaging in meniseal and ligamentous injuries of the knee : comparison with arthroseopy 显示文摘 | Behairy NH Dorgham MA Khaled SA | 2009 | Int Orthop2009，33，4： | 1 |
| 15 | Caesarean scar endometriosis presenting as an acute abdomen:a case report and review of literature显示文摘 | Gajjar KB Mahendru AA Khaled MA | 2008 | Arch Gynecol Obstet2008，277，： | 1 |
| 16 | Location-aware downlink and uplink power control and throughput optimization in cellular cognitive radio networks显示文摘In this paper,we consider throughput maximization in cognitive radio systems with proper power control.In particular,we incorporate location-awareness into the power control design and maximize the average throughput of the cognitive system.As we shall show,the proposed approach effectively utilizes the“spatial opportunity”to maximize the system throughput,which clearly outperforms traditional power control methods.Further,the proposed approach still exhibits significant throughput gain even considering imperfect position information,with appropriate robust design modifications. | Zhiyao MA Wei CHEN Zhigang CAO Khaled Ben LETAIEF | 2010 | Frontiers of Electrical and Electronic Engineering in China2010，5，4： | 0 |
| 17 | Nuclear events during conjugation in the poorly studied model ciliate Paramecium jenningsi显示文摘Ciliated protists are highly differentiated unicellular eukaryotes that possess special sexual processes(conjugation and autogamy)that rely on their unique nuclear dimorphism,i.e.,the presence of both a germline micronucleus(MIC)and a somatic macronucleus(MAC)in a single cell.The sexual processes show a high diversity in different ciliates.To better understand the differentiation and evolution of sexual processes in closely related species,we investigated the nuclear events during conjugation in Paramecium jenningsi strain GZ,a poorly studied close relative of the well-known P.aurelia complex.The main results include:(1)the conjugation process takes about 48 h,including three prezygotic divisions(meiosis I,II,and mitosis)and three postzygotic divisions;(2)the MICs are dominated by the“parachute”phase at the prophase of meiosis I;(3)after meiosis II,a variable number of nuclei undergo the third prezygotic division,and the two products near the paroral cone become the genetically identical migratory and stationary pronuclei;(4)the synkaryon divides three times to form the MIC and the MAC anlagen,but only one nuclear product of the first postzygotic division completes the next two divisions;and(5)an extra cell division is required to complete the last step of conjugation,during which two MIC anlagen undergo mitotic division while two MAC anlagen are distributed between the daughter cells without division.The comparison of the nuclear events during conjugation in representatives of the class Oligohymenophorea reveals that usually there are three prezygotic divisions and a variable number of postzygotic divisions.However,the number of selected and differentiated nuclei after each division differs among species.This study provided a new model ciliate for further investigations of nuclear selection and differentiation as well as nuclear morphology during meiosis. | Xue Zhang Ruitao Gong Yaohan Jiang Xiaoteng Lu Chenyin Wu Lihan Wang Hongwei Ma Zhengxiang Zhang Weibo Song Khaled A.S.Al-Rasheid Adriana Vallesi Feng Gao | 2023 | Water Biology and Security2023，2，4： | 0 |
| 18 | Biodiversity of freshwater ciliates(Protista,Ciliophora)in the Lake Weishan Wetland,China:the state of the显示文摘Ciliates are core components of the structure of and function of aquatic microbial food webs.They play an essential role in the energy flow and material circulation within aquatic ecosystems.However,studies on the taxonomy and biodiversity of freshwater ciliates,especially those in wetlands in China are limited.To address this issue,a project to investigate the freshwater ciliates of the Lake Weishan Wetland,Shandong Province,commenced in 2019.Here,we summarize our findings to date on the diversity of ciliates.A total of 187 ciliate species have been found,94 of which are identified to species-level,87 to genus-level,and six to family-level.These species show a high morphological diversity and represent five classes,i.e.,Heterotrichea,Litostomatea,Prostomatea,Oligohymenophorea,and Spirotrichea.The largest number of species documented are oligohymenophoreans.A comprehensive database of these ciliates,including morphological data,gene sequences,microscope slide specimens and a DNA bank,has been established.In the present study,we provide an annotated checklist of retrieved ciliates as well as information on the sequences of published species.Most of these species are recorded in China for the first time and more than 20%are tentatively identified as new to science.Additionally,an investigation of environmental DNA revealed that the ciliate species diversity in Lake Weishan Wetland is higher than previously supposed. | Zhe Wang Yong Chi Tao Li Wenya Song Yunfeng Wang Tong Wu Gongaote Zhang Yujie Liu Honggang Ma Weibo Song Khaled A.S.Al-Rasheid Alan Warren Borong Lu | 2022 | Marine Life Science & Technology2022，4，4： | 0 |
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