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| 1 | The Tea Tree Genome Provides Insights into Tea Flavor and Independent Evolution of Caffeine Biosynthesis显示文摘茶是世界有巨大的经济、药用、文化的重要性的最旧、很流行的包含咖啡因的饮料。这里,我们在场第一个高质量的核苷酸序列充满重复(80.9%) ,栽培的茶树山茶 sinensis 的 3.02-Gb 染色体。我们证明茶树的一种非常地大的染色体尺寸从一些 LTR retrotransposon 家庭的慢、稳定、长期的扩大被结果。除了一个最近的整个染色体的复制事件,基因的系特定的扩大把新陈代谢的生合成与 flavonoid 联系了被发现,它提高 catechin 生产,萜烯酶激活,和应力公差,为茶风味和改编的重要特征。我们相对可可子和咖啡表明一个独立人士和茶咖啡因合成小径的快速的进化。在 25 山茶种类之中的比较研究表明那更高的表情大多数 flavonoid- 和咖啡因铺平 -- 然而并非 theanine 相关的基因贡献 catechins 和咖啡因的增加的生产并且因此提高处理茶的适用性和茶质量。这些新奇调查结果为进一步的 metabolomic 和典型生合成小径的功能的 genomic 精炼铺平道路并且将帮助开发将最后满足并且吸引世界范围的更多的茶喝酒者的茶风味的一个更多样化的集合。 | En-Hua Xia Hai-Bin Zhang Jun Sheng Kui Li Qun-Jie Zhang Changhoon Kim Yun Zhang Yuan Liu Ting Zhu Wei Li Hui Huang Yan Tong Hong Nan Cong Shi Chao Shi Jian-Jun Jiang Shu-Yan Mao Jun-Ying Jiao Dan Zhang Yuan Zhao You-Jie Zhao Li-Ping Zhang Yun-Long Liu Ben-Ying Liu Yue Yu Sheng-Fu Shao De-Jiang Ni Evan E. Eichler Li-Zhi Gao | 2017 | Molecular Plant2017，10，6： | 113 |
| 2 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 3 | Electromagnetic chirality:from fundamentals to nontraditional chiroptical phenomena显示文摘Chirality arises universally across many different fields.Recent advancements in artificial nanomaterials have demonstrated chiroptical responses that far exceed those found in natural materials.Chiroptical phenomena are complicated processes that involve transitions between states with opposite parities,and solid interpretations of these observations are yet to be clearly provided.In this review,we present a comprehensive overview of the theoretical aspects of chirality in light,nanostructures,and nanosystems and their chiroptical interactions.Descriptions of observed chiroptical phenomena based on these fundamentals are intensively discussed.We start with the strong intrinsic and extrinsic chirality in plasmonic nanoparticle systems,followed by enantioselective sensing and optical manipulation,and then conclude with orbital angular momentum-dependent responses.This review will be helpful for understanding the mechanisms behind chiroptical phenomena based on underlying chiral properties and useful for interpreting chiroptical systems for further studies. | Jungho Mun Minkyung Kim Younghwan Yang Trevon Badloe Jincheng Ni Yang Chen Cheng-Wei Qiu Junsuk Rho | 2020 | Light(Science & Applications)2020，9，1： | 13 |
| 4 | 限制卡路里摄入可抑制大鼠促进动脉衰老的炎症反应,保持年轻的表型显示文摘老化呈指数性增加典型心血管病的发病率和死亡率,这主要是由于动脉壁内分子、细胞和组织水平的动脉促炎变化。动物实验中,大鼠的卡路里限制(calorie restriction,CR)改善了动脉功能并延长了健康跨度和寿命。然而,CR如何影响大鼠动脉壁内分子,细胞和组织表型促炎变化仍有待阐明。该文选取随意喂食的344只年轻(6个月大)和老(24个月大)的Fischer大鼠,获取主动脉;另外选取1组在1个月大时开始只维持40%CR。 | 刘青 叶鹏 Wang MY Zhang L Zhu WQ Zhang J Kim SH Wang YS Ni L Telljohann R Monticone RE McGraw K Liu LJ Rafael de Cabo Lakatta EG | 2018 | 中华高血压杂志2018，26，11： | 3 |
| 5 | Integrated Network Pharmacology and Antioxidant Activity?Guided Screen System to Exploring Antioxidants and Quality Markers of Shunaoxin Pills against Chronic Cerebral Ischemia显示文摘Objective: The main objective of the study is to screen the quality markers(Q-markers) for relieving oxidative stress damage and against chronic cerebral ischemia in Shunaoxin pills(SNX). Methods: The benefit effect of SNX was evaluated by a rat chronic cerebral ischemia model. The main ingredients of SNX were identified by ultra-performance liquid chromatography-quadrupole time-of-flight, whereas its core targets and pathways around antioxidative stress were predicted by Pharm Mapper and kyoto encyclopedia of genes and genomes(KEGG) analysis. Moreover, the antioxidants were screened by high-performance liquid chromatography with postcolumn derivatization system and then representative ingredients were verified by cell experiments. Results: SNX could increase expression of catalase and superoxide dismutase(SOD) as well as antagonize oxidative damage in the brain. The effects may be related to three types of antioxidant pathways, including nitrogen metabolism, arachidonic acid metabolism, and the cyclic guanosine monophosphate-dependent protein kinase(c GMP-PKG) signaling pathway by multiple active components regulate targets. Among them, ferulic acid and ligustilide were shown the key scavenging ability for reactive oxygen free radicals and significantly increased the contents of nitric oxide(NO), NO synthase, and SOD as well as decreased malonaldehyde. Conclusion: The oxidation resistances of biological and chemical processes in SNX to protect against cerebral oxidative stress injury were preliminary revealed by an integrated network pharmacology and antioxidant activity-guided screen system. Ferulic acid and ligustilide played a major antioxidant role that could be used as Q-markers to control the quality of SNX. | Nian-Wei Chang Dan-Dan Cheng Jia-Nan Ni Ying-Ying Guo Guang-Cui Chu Unchol Kim Min Jiang Gang Bai | 2019 | World Journal of Traditional Chinese Medicine2019，5，1： | 3 |
| 6 | High Incidence of Mortality and Recurrent Bleeding in Patients With Helicobacter pylori –Negative Idiopathic Bleeding Ulcers显示文摘 | Grace Lai–Hung Wong Vincent Wai–Sun Wong Yawen Chan Jessica Yuet–Ling Ching Kim Au Aric Josun Hui Larry Hin Lai Dorothy Kai–Lai Chow Danny Ka–Fai Siu Yan–Ni Lui Justin Che–Yuen Wu Ka–Fai To Lawrence Cheung–Tsui Hung Henry Lik–Yuen Chan Joseph Jao–Yiu Sung | 2009 | Gastroenterology2009，，2： | 2 |
| 7 | Modeling of the size effects on the behavior of metals in mieroscale deformation proeesses显示文摘 | Kim G Y Ni J Koc M | 2007 | Journal of Manufacturing Science and Engineering Transactions of the ASME2007，129，3： | 1 |
| 8 | A numerical study on propagation of premixed flames in small tubes 显示文摘 | Kim NI Maruta K | 2006 | Combustion and Flame2006，146，1： | 1 |
| 9 | The dynamics of vitello- genin gene expression differs between intact and eyestalk ablated kuruma prawn Penaeus (Marsupenaeus) japonicus 显示文摘 | TsuTsuI NI KIM YK JASMANI S etal | 2005 | Fish Sci2005，71，： | 1 |
| 10 | Nonablative fractional laser as a tool to facilitate skin penetration of 5-amino- laevulinic acid with minimal skin disruption:a preliminary study显示文摘 | Lira HK Jeong KH Kim NI | 2014 | Br J Dermatol2014，170，6： | 1 |
| 11 | A static model of chip formation in microscale milling 显示文摘 | Kim C J Mayor J R Ni J | 2004 | Journal of Manufacturing Science and Engineering2004，126，4： | 1 |
| 12 | Active components from artemisia iwayomogi displaying ONOO-scavenging activity显示文摘 | Ae Ra Kim Ya Ni Zou Tae Hyun Park | 2004 | Phytotherapy Research2004，18，： | 1 |
| 13 | A static model of chip tormation in microscale milling 显示文摘 | Kim C J Mayor J R Ni J | 2004 | Journal of Manufacturing Science and Engineering2004，126，4： | 1 |
| 14 | Mast cells play a key role in the development of lateairway hyperresponsiveness through TNF-alpha in a murine model of asthma显示文摘 | Kim YS Ko HM Kang NI | 2007 | Eur J Immunol2007，37，： | 1 |
| 15 | The genome of the cucumber显示文摘 | HUANG S LI R ZHANG Z LI L GU X FAN W LUCAS W J WANG X XIE B NI P REN Y ZHU H LI J LIN K JIN W FEI Z LI G STAUB J KILIAN A VAN DER VOSSEN EA WUY GUO J HE J JIA Z REN Y TIAN G LU Y RUAN J QIANW WANG M HUANG Q LI B XUAN Z CAO J ASAN WUZ ZHANG J CAI Q BAI Y ZHAO B HAN Y LI Y LI X WANG S SHI Q LIU S CHO WK KIM JY XU Y HELLER-USZYNSKA K MIAO H CHENG Z ZHANG S WU J YANG Y KANG H LI M LIANG H REN X SHI Z WEN M JIAN M YANG H ZHANG G YANG Z CHEN R LIU S LI J MA L LIU H ZHOU Y ZHAO J FANG X LI G FANG L LI Y LIUD ZHENG H ZHANG Y QIN N LI Z YANG G YANG S BOLUND L KRISTIANSEN K ZHENG H LI S ZHANG X YANG H WANG J SUN R ZHANG B JIANG S WANG J DUY LI S | 2009 | Cucumis Sativus L NatureGenetics2009，41，： | 1 |
| 16 | Modeling of the size effects on the behavior of metals in microscale deformation显示文摘 | Kim G Y Ni J Koc M | 2007 | Transactions of the ASME2007，129，： | 1 |
| 17 | An experimental investigation on semi-solid forming of micro/meso-scale features显示文摘 | KIM G Y NI J MAYOR R KIM H | | 0，，02： | 1 |
| 18 | Modeling of the semi-Solid material behavior and analysis of micro-/mesoscale feature forming显示文摘 | KIM G Y KOC M MAYOR R NI J | | 0，，02： | 1 |
| 19 | Modeling of the size effects on the behavior of metals in microscale deformation processes 显示文摘 | KIM G Y NI J | 2007 | Journal of Manufacturing Science and Engineering2007，129，3： | 1 |
| 20 | A static model of chip formation in mieroscale milling显示文摘 | KIM C J MAYOR J R NI J | 2004 | ASME Journal of Manufacturing Science and Engineering2004，126，4： | 1 |
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