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| 1 | Water and Heavy Metal Transport in Roadside Soils显示文摘Roads with very high traffic loads in regions where soils are low in both pH and sorption capacity might be a source of percolation water loaded with heavy metals. Looking at some 'worst case' scenarios, this study focused on the input of traffic related pollutants and on Pb, Cd, Cu, Zn, Ni and Cr concentrations in the soil matrix and soil solution, respectively. The analysis also included pH and electrical conductivity and at some sites DOC. The investigations were carried out on sandy soils with more or less low pH values at four motorway sites in Germany. The average of daily traffic was about 50 000 up to 90 000 vehicles. Soil pore water was collected in two soil depths and at four distances from the road. The pH in general decreased with increasing distance from the roadside. The elevated pH near the roadside was presumably caused by deposition of dust and weathering residues of the road asphalt, as well as by infiltration of salt that was used during winter time. At these road sites, increased heavy metal concentrations in the soil matrix as well as in the soil solution were found. However, the concentrations seldom exceeded reference values of the German Soil Protection Act. The soil solution concentrations tended to increase from the road edge to 10 m distance, whereas the concentration in the soil matrix decreased. Elevated DOC concentrations corresponded with elevated Cu concentrations but did not substantially change this tendency. High soil water percolation rates were found near the roads. Thus, even low metal concentrations of percolation water could yield high metal loads in a narrow area beside the road. | B. KOCHER G. WESSOLEK H. STOFFREGEN | 2005 | Pedosphere2005，15，6： | 25 |
| 2 | 影响猪的肠道菌群的日粮营养策略显示文摘 | Andreas Kocher | 2006 | 中国畜牧兽医2006，33，4： | 4 |
| 3 | Activated Pancreatic Stellate Cells Sequester CD8+ T-Cells to Reduce Their Infiltration of the Juxtatumoral Compartment of Pancreatic Ductal Adenocarcinoma显示文摘 | Abasi Ene-Obong Andrew J. Clear Jennifer Watt Jun Wang Rewas Fatah John C. Riches John F. Marshall Joanne Chin-Aleong Claude Chelala John G. Gribben Alan G. Ramsa Hemant M. Kocher | 2013 | Gastroenterology2013，，： | 4 |
| 4 | Risk-adjustment in hepatobiliarypancreatic surgery显示文摘AIM: The present study evaluates the performance of the POSSUM, the American Society of Anesthetists (ASA),APACHE and Childs classification in predicting mortality and morbidity in hepatopancreaticobiliary (HPB) surgery.We describe especially the limitations and advantages of risk in stratifying the patients.METHODS: We investigated 177 randomly chosen patients undergoing eledive complex HPB surgery in a single institution with a total of 71 pre-operative and intra-operative risk factors.Primary endpoint was in-hospital mortality and morbidity.Ordered logistic regression analysis was used to identify individual predictors of operative morbidity and mortality.RESULTS: The operative mortality in the series was 3.95% .This compared well with the p-POSSUM and APACHE predicted mortality of 4.31% and 4.29% respectively. Postoperative complications amounted to 45% with 24 (13.6%)patients having a major adverse event. On multivariate analysis the pre-operative POSSUM physiological score (OR = 1.18,P = 0.009) was superior in predicting complications compared to the ASA (P = 0.108), APACHE (P = 0.117)or Childs classification (P = 0.136). In addition, serum sodium, creatinine, international normalized ratio (INR),pulse rate, and intra-operative blood loss were independent risk factors. A combination of the POSSUM variables and INR offered the optimal combination of risk factors for risk prognostication in HPB surgery.CONCLUSION: Morbidity for elective HPB surgery can be accurately predicted and applied in everyday surgical practice as an adjunct in the process of informed consent and for effective allocation of resources for intensive and high-dependency care facilities. | Hemant M Kocher Paris P Tekkis Palepu Gopal Ameet G Patel Simon Cottam Irving S Benjamin | 2005 | World Journal of Gastroenterology2005，11，16： | 3 |
| 5 | Long-term outcomes of breast cancer patients after endoscopic axillary lymph node dissection: a prospective analysis of 52 patients显示文摘 | I. Langer T. Kocher U. Guller J. Torhorst D. Oertli F. Harder M. Zuber | 2005 | Breast Cancer Research and Treatment2005，，1： | 2 |
| 6 | Retinoic Acid–Induced Pancreatic Stellate Cell Quiescence Reduces Paracrine Wnt–β-Catenin Signaling to Slow Tumor Progression显示文摘 | Fieke E.M. Froeling Christine Feig Claude Chelala Richard Dobson Charles E. Mein David A. Tuveson Hans Clevers Ian R. Hart Hemant M. Kocher | 2011 | Gastroenterology2011，，4： | 2 |
| 7 | Organotypic Culture Model of Pancreatic Cancer Demonstrates that Stromal Cells Modulate E-Cadherin, β-Catenin, and Ezrin Expression in Tumor Cells显示文摘 | Fieke E.M. Froeling Tariq A. Mirza Roger M. Feakins Angela Seedhar George Elia Ian R. Hart Hemant M. Kocher | 2009 | The American Journal of Pathology2009，，2： | 2 |
| 8 | Histomorphologic Tumor Regression and Lymph Node Metastases Determine Prognosis Following Neoadjuvant Radiochemotherapy for Esophageal Cancer: Implications for Response Classification显示文摘 | Paul M. Schneider Stephan E. Baldus Ralf Metzger Martin Kocher Rudolf Bongartz Elfriede Bollschweiler Hartmut Schaefer Juergen Thiele Hans P. Dienes Rolf P. Mueller Arnulf H. Hoelscher | 2005 | Annals of Surgery2005，，5： | 2 |
| 9 | Neovascularization of ischemic myocardium by human bone - marrow derived angioblasts prevents cardiomyocyte apoptosis reduces remodeling and improves cardiac function 显示文摘 | Kocher AA Schuster MD Szabolcs ML | 2001 | Nat Med2001，7，4： | 2 |
| 10 | Gallbladder cancer显示文摘 | Stavros Gourgiotis Hemant M. Kocher Leonardo Solaini Arvin Yarollahi Evangelos Tsiambas Nikolaos S. Salemis | 2008 | The American Journal of Surgery2008，，2： | 2 |
| 11 | A comparison of pancreaticoduodenectomy with extended pancreaticoduodenectomy: A meta-analysis of 1909 patients显示文摘 | N. Iqbal R.E. Lovegrove H.S. Tilney A.T. Abraham S. Bhattacharya P.P. Tekkis H.M. Kocher | 2008 | European Journal of Surgical Oncology2008，，1： | 2 |
| 12 | Meniscal disorders:normal, discoid, and cysts 显示文摘 | Kocher MS Klingele K Rassman SO | 2003 | Orthop Clin North Am2003，34，3： | 2 |
| 13 | AIF-regulated oxidative phosphorylation supports lung cancer development显示文摘Cancer is a major and still increasing cause of death in humans. Most cancer cells have a fundamentally different metabolic profile from that of normal tissue. This shift away from mitochondrial ATP synthesis via oxidative phosphorylation towards a high rate of glycolysis, termed Warburg effect, has long been recognized as a paradigmatic hallmark of cancer, supporting the increased biosynthetic demands of tumor cells. Here we show that deletion of apoptosis-inducing factor (AIF) in a Kras^G12D-driven mouse lung cancer model resulted in a marked survival advantage, with delayed tumor onset and decreased malignant progression. Mechanistically, Aif deletion leads to oxidative phosphorylation (OXPHOS) deficiency and a switch in cellular metabolism towards glycolysis in non-transformed pneumocytes and at early stages of tumor development. Paradoxically, although Aif-deficient cells exhibited a metabolic Warburg profile, this bioenergetic change resulted in a growth disadvantage of Kras^G12D-driven as well as Kras wild-type lung cancer cells. Cell-autonomous re-expression of both wild-type and mutant AIF (displaying an intact mitochondrial, but abrogated apoptotic function) in Aif-knockout Kras^G12D mice restored OXPHOS and reduced animal survival to the same level as AIF wild-type mice. In patients with non-small cell lung cancer, high AIF expression was associated with poor prognosis. These data show that AIF-regulated mitochondrial respiration and OXPHOS drive the progression of lung cancer. | Shuan Rao Laura Mondragon Blanka Pranjic Toshikatsu Hanada Gautier Stoll Thomas Kocher Peng Zhang Alexander Jais Alexander Lercher Andreas Bergthaler Daniel Schramek Katharina Haigh Valentina Sica Marion Leduc Nazanine Modjtahedi Tsung-Pin Pai Masahiro Onji Iris Uribesalgo Reiko Hanada Ivona Kozieradzki Rubina Koglgruber Shane J. Cronin Zhigang She Franz Quehenberger Helmut Popper Lukas Kenner Jody J. Haigh Oliver Kepp Malgorzata Rak Kaican Cai Guido Kroemer Josef M. Penninger | 2019 | Cell Research2019，29，7： | 2 |
| 14 | A Systematic Review of Medial and Lateral Entry Pinning Versus Lateral Entry Pinning for Supracondylar Fractures of the Humerus显示文摘 | Carmen Alisa Brauer Ben Minsuk Lee Donald S. Bae Peter M. Waters Mininder S. Kocher | 2007 | Journal of Pediatric Orthopaedics2007，，2： | 2 |
| 15 | Parastomal hernia repair:modifiedthorlakson techniqu],reinforced by polypropylene mesh显示文摘 | Kocher HM Payne JG | 1999 | Dis Colon Rectum1999，42，1： | 1 |
| 16 | A genetic linkage map of a cichlid fish, the tilapia (Oreochromis niloticus) 显示文摘 | Kocher T D Lee W J Sobolewska H etal | 1998 | Genetics1998，148，： | 1 |
| 17 | Granular particle linear flow velocity measurement using an electronic linear image sensor显示文摘 | Chen C Kocher M Jones D | 1994 | Computers and Electronics in Agriculture1994，11，： | 1 |
| 18 | Myocardial hom- ing and neovascularization by human bone marrow angio- blasts is regulated by IL - 8/Gro CXC chemokines 显示文摘 | Kocher AA Schuster MD Bonaros N | 2006 | JMol Cell Cardiol2006，40，4： | 1 |
| 19 | Evolution of the cytochrome b gene of mammals显示文摘 | Irwin D M Kocher T D Wilson A C | 1991 | J Molecular Evolution1991，2，： | 1 |
| 20 | Structure and evolution of teleost mitochondrial control regions显示文摘 | Woo-Jai Lee Janet Conroy W. Huntting Howell Thomas D. Kocher | 1995 | Journal of Molecular Evolution1995，，1： | 1 |
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