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| 1 | MLKL regulates necrotic plasma membrane permeabilization显示文摘 | Lorenzo Galluzzi | 2014 | Cell Research2014，24，2： | 12 |
| 2 | Immunogenic Cell Death in Cancer Therapy显示文摘 | Guido Kroemer Lorenzo Galluzzi Oliver Kepp Laurence Zitvogel | 2013 | Annual Review of Immunology2013，，： | 2 |
| 3 | FADD: an endogenous inhibitor of RIP3-driven regulated necrosis显示文摘 | Lorenzo Galluzzi Oliver Kepp Guido Kroemei | 2011 | Cell Research2011，21，10： | 2 |
| 4 | AIF-regulated oxidative phosphorylation supports lung cancer development显示文摘Cancer is a major and still increasing cause of death in humans. Most cancer cells have a fundamentally different metabolic profile from that of normal tissue. This shift away from mitochondrial ATP synthesis via oxidative phosphorylation towards a high rate of glycolysis, termed Warburg effect, has long been recognized as a paradigmatic hallmark of cancer, supporting the increased biosynthetic demands of tumor cells. Here we show that deletion of apoptosis-inducing factor (AIF) in a Kras^G12D-driven mouse lung cancer model resulted in a marked survival advantage, with delayed tumor onset and decreased malignant progression. Mechanistically, Aif deletion leads to oxidative phosphorylation (OXPHOS) deficiency and a switch in cellular metabolism towards glycolysis in non-transformed pneumocytes and at early stages of tumor development. Paradoxically, although Aif-deficient cells exhibited a metabolic Warburg profile, this bioenergetic change resulted in a growth disadvantage of Kras^G12D-driven as well as Kras wild-type lung cancer cells. Cell-autonomous re-expression of both wild-type and mutant AIF (displaying an intact mitochondrial, but abrogated apoptotic function) in Aif-knockout Kras^G12D mice restored OXPHOS and reduced animal survival to the same level as AIF wild-type mice. In patients with non-small cell lung cancer, high AIF expression was associated with poor prognosis. These data show that AIF-regulated mitochondrial respiration and OXPHOS drive the progression of lung cancer. | Shuan Rao Laura Mondragon Blanka Pranjic Toshikatsu Hanada Gautier Stoll Thomas Kocher Peng Zhang Alexander Jais Alexander Lercher Andreas Bergthaler Daniel Schramek Katharina Haigh Valentina Sica Marion Leduc Nazanine Modjtahedi Tsung-Pin Pai Masahiro Onji Iris Uribesalgo Reiko Hanada Ivona Kozieradzki Rubina Koglgruber Shane J. Cronin Zhigang She Franz Quehenberger Helmut Popper Lukas Kenner Jody J. Haigh Oliver Kepp Malgorzata Rak Kaican Cai Guido Kroemer Josef M. Penninger | 2019 | Cell Research2019，29，7： | 2 |
| 5 | Anti-and pro-tumor functions of autophagy显示文摘 | Eugenia Morselli Lorenzo Galluzzi Oliver Kepp | 2009 | Biochim Biophys Acta2009，10，： | 1 |
| 6 | Chemotherapy induces ATP release from tumor cells显示文摘 | Isabelle Martins Antoine Tesniere Oliver Kepp Mickael Michaud Frederic Schlemmer Laura Senovilla Claire Séror Didier Métivier Jean-Luc Perfettini Laurence Zitvogel Guido Kroemer | 2009 | Cell Cycle2009，，： | 1 |
| 7 | Mitochondrial Control of Cellular Life, Stress, and Death显示文摘 | Lorenzo Galluzzi Oliver Kepp Christina Trojel-Hansen Guido Kroemer | 2012 | Circulation Research2012，，9： | 1 |
| 8 | Immunogenic cell death modalities and their impact on cancer treatment显示文摘 | Oliver Kepp Antoine Tesniere Frederic Schlemmer Mickael Michaud Laura Senovilla Laurence Zitvogel Guido Kroemer | 2009 | Apoptosis2009，，4： | 1 |
| 9 | Immunogenic Tumor Cell Death for Optimal Anticancer Therapy: The Calreticulin Exposure Pathway 显示文摘 | Laurence Zitvogel Oliver Kepp Laura Senovilla | 2010 | Clin Cancer Res2010，16，12： | 1 |
| 10 | Decoding cell death signals in liver inflammation<.-- Doctopic: Review -->显示文摘 | Catherine Brenner Lorenzo Galluzzi Oliver Kepp Guido Kroemer | 2013 | Journal of Hepatology2013，，： | 1 |
| 11 | Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells显示文摘 | Yuting Ma Sandy Adjemian Stephen R. Mattarollo Takahiro Yamazaki Laetitia Aymeric Heng Yang Jo?o Paulo Portela Catani Dalil Hannani Helene Duret Kim Steegh Isabelle Martins Frederic Schlemmer Micka?l Michaud Oliver Kepp Abdul Qader Sukkurwala Laurie Menge | 2013 | Immunity2013，，4： | 1 |
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