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| 1 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 2 | Topically effective acetazolamide eye-solution in man 显示文摘 | Thorsteinn Loftsson Stefànsson E Kristinsson JK | 1996 | Pharm Sci1996，6，： | 2 |
| 3 | Fish protein hydrolysates:production,biochemical,and functional properties显示文摘 | KRISTINSSON H G RASCO B A | 2000 | Critical Reviewsin Food Science and Nutrition2000，40，1： | 1 |
| 4 | Kinetics of the hydrolysis of Atlantic salmon (salmo salar) muscle proteins by alkaline proteases and a visceral serine protease mixture显示文摘 | Kristinsson H G Rasco B A | 2000 | Process Biochem2000，36，： | 1 |
| 5 | Comparison of Minolta colorimeter and machine vision system in measuring colour of irradiated Atlantic salmon显示文摘 | Yagiz Yavuz Balaban Murat O Kristinsson Hordur G | | 0，，04： | 1 |
| 6 | Faecal calprotectin: a novel test for the diagnosis of colorectal cancer 显示文摘 | Roseth AG Kristinsson J Fagerhol MK | 1993 | Scand J Gastroenterol1993，28，12： | 1 |
| 7 | Evaluation of Color Parameters in a Machine Vision Analysis of Carbon Monoxide-Treated Fish-Part Ⅰ显示文摘 | Balaban Murat O Kristinsson Hordur G Otwell W.Steven | | 0，，02： | 1 |
| 8 | Biochemical and functional properties of Atlantic salmon (Salmo salar) muscle proteins hydrolyzed with various alkaline proteases显示文摘 | KRISTINSSON H G RASCO B A | 2000 | Journal of Agricultural and Food Chemistry2000，48，3： | 1 |
| 9 | System identification and control using genetic algorithms 显示文摘 | Kristinsson K | 1992 | System Man and Cybernetics1992，22，5： | 1 |
| 10 | Radical scavenging and reducing ability of tilapia ( Oreochromis niloticus ) protein hydrolysates 显示文摘 | Raghavan S Kristinsson H G Leeuwenburgh C | 2008 | Journal of Agricultural and Food Chemistry2008，56，10： | 1 |
| 11 | Risk factorsand outcome in ICU-acquired infection 显示文摘 | Magnason S Kristinsson KG Stefansson T | 2008 | Acta AnaesthesiolScand2008，52，9： | 1 |
| 12 | Lean mass and physical activity as predictors of bone mineral density in 16-20 years old women显示文摘 | Valdimarsson O Kristinsson JO Stefansson SO | 1999 | J Intern Med1999，245，5： | 1 |
| 13 | ACE-inhibitory activity of tilapia protein hydrolysates显示文摘 | Raghavan S Kristinsson HG | 2009 | Food them2009，17，： | 1 |
| 14 | Fish protein hydrolysates: production,biochemical,and functional properties显示文摘 | KRISTINSSON H G RASCO B A | 2000 | Critical Reviews in Food Science and Nutrition2000，40，1： | 1 |
| 15 | Kinetics of the hydrolysis of Atlantic salmon muscle proteins by alkaline protease and a visceral serine protease mixture显示文摘 | Hordur G Kristinsson Barbara A Rasco | 2000 | Process biochemistry2000，36，： | 1 |
| 16 | Risk of plasma cell and lymphoproliferative disorders among 14621 first-degree rela- tives of 4458 patients with monodonal gammopathy of undeter- mined significance m Sweden显示文摘 | Landgren O Kristinsson SY Goldin LR | 2009 | Blood2009，114，4： | 1 |
| 17 | Use of carbon monoxide for color retention in fish显示文摘 | Balaban M Kristinsson H G | 2003 | Innovation handing and processing2003，，： | 1 |
| 18 | Do antiml crobials increase the carriage rate of penicillin resistant pneumo2cocci in children Cross sectional prevalence study显示文摘 | A rason V A Kristinsson K G Sigurdsson J A etal | 1996 | BrM ed J1996，313，： | 1 |
| 19 | System identification and control using genetic algorithms 显示文摘 | | 1992 | IEEE Trans Sys Man Cybernetics1992，22，5： | 1 |
| 20 | Deep vein thrombosis following monoclonal gammopathy of undetermined significance and multiple myeloma显示文摘 | Kristinsson SY Fears TR Gridley G | 2008 | Blood2008，112，9： | 1 |
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