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| 1 | Risk factors for bleeding after endoscopic mucosal resection显示文摘AIM: To clarify the risk factors for bleeding after endoscopic mucosal resection (EMR).METHODS: A total of 297 consecutive patients who underwent EMR were enrolled. Some of the patients had multiple lesions. Bleeding requiring endoscopic treatment was defined as bleeding after EMR. Odds ratios (OR) with 95% confidence intervals (CI), calculated by logistic regression with multivariate adjustments for covariates,were the measures of association.RESULTS: Of the 297 patients, 57 (19.2%) patients with bleeding after EMR were confirmed. With multivariate adjustment, the cutting method of ENR, diameter, and endoscopic pattern of the tumor were associated with the risk of bleeding after ENR. The multivariate-adjusted OR for bleeding after EMR using endoscopic aspiration mucosectomy was 3.07 (95%CI, 1.59-5.92) compared with strip biopsy. The multiple-adjusted OR for bleeding after EMR for the highest quartile (16-50 mm) of tumor diameter was 5.63 (95%CI, 1.84-17.23) compared with that for the lowest (4-7 mm). The multiple-adjusted OR for bleeding after EM R for depressed type of tumor was 4.21 (95%CI, 1.75-10.10) compared with elevated type.CONCLUSION: It is important to take tumor characteristics (tumor size and endoscopic pattern) and cutting method of EMR into consideration in predicting bleeding after ENR. | Masatsugu Shiba Kazuhide Higuchi Kaori Kadouchi Ai Montani Kazuki Yamamori Hirotoshi Okazaki Makiko Taguchi Tomoko Wada Atsushi Itani Toshio Watanabe Kazunari Tominaga Yoshihiro Fujiwara Tomoshige Hayashi Kei Tsumura Tetsuo Arakawa | 2005 | World Journal of Gastroenterology2005，11，46： | 25 |
| 2 | Intraductal neoplasm of the intrahepatic bile duct: Clinicopathological study of 24 cases显示文摘AIM: To investigate the clinicopathological features of intraductal neoplasm of the intrahepatic bile duct (INihB). METHODS: Clinicopathological features of 24 cases of INihB, which were previously diagnosed as biliary papillomatosis or intraductal growth of intrahepatic biliary neoplasm, were reviewed. Mucin immunohistochemistry was performed for mucin (MUC)1, MUC2, MUC5AC and MUC6. Ki-67, P53 and β-catenin immunoreactivity were also examined. We categorized each tumor as adenoma (low grade), borderline (intermediate grade), and malignant (carcinoma in situ , high grade including tumors with microinvasion). RESULTS: Among 24 cases of INihB, we identified 24 tumors. Twenty of 24 tumors (83%) were composed of a papillary structure; the same feature observed in intraductal papillary neoplasm of the bile duct (IPNB). In contrast, the remaining four tumors (17%) showed both tubular and papillary structures. In three of the four tumors (75%), macroscopic mucin secretion was limited but microscopic intracellular mucin was evident. Histologically, 16 tumors (67%) were malignant, three (12%) were borderline, and five (21%) were adenoma. Microinvasion was found in four cases (17%). Immunohistochemical analysis revealed that MUC1 was not expressed in the borderline/adenoma group but was expressed only in malignant lesions (P = 0.0095). Ki-67 labeling index (LI) was significantly higher in the malignant group than in the borderline/adenoma group (22.2 ± 15.5 vs 7.5 ± 6.3, P < 0.01). In the 16 malignant cases, expression of MUC5AC showed borderline significant association with high Ki-67 LI (P = 0.0622). Nuclear expression of β-catenin was observed in two (8%) of the 24 tumors, and these two tumors also showed MUC1 expression. P53 was negative in all tumors. CONCLUSION: Some cases of INihB have a tubular structure, and are subcategorized as IPNB with tubular structure. MUC1 expression in INihB correlates positively with degree of malignancy. | Yoshiki Naito Hironori Kusano Osamu Nakashima Eiji Sadashima Satoshi Hattori Tomoki Taira Akihiko Kawahara Yoshinobu Okabe Kazuhide Shimamatsu Jun Taguchi Seiya Momosaki Koji Irie Rin Yamaguchi Hiroshi Yokomizo Michiko Nagamine Seiji Fukuda Shinichi Sugiyama Naoyo Nishida Koichi Higaki Munehiro Yoshitomi Masafumi Yasunaga Koji Okuda Hisafumi Kinoshita Masayoshi Kage Masamichi Nakayama Makiko Yasumoto Jun Akiba Hirohisa Yano | 2012 | World Journal of Gastroenterology2012，18，28： | 16 |
| 3 | Dietary polyphenols and colorectal cancer risk:The Fukuoka colorectal cancer study显示文摘AIM:To investigate the associations between dietary intake of polyphenols and colorectal cancer. METHODS:The study subjects were derived from the Fukuoka colorectal cancer study, a community-based case-control study. The study subjects were 816 cases of colorectal cancer and 815 community-based controls. The consumption of 148 food items was assessed by a computer-assisted interview. We used the consumption of 97 food items to estimate dietary intakes of total, tea and coffee polyphenols. The Phenol-Explorer database was used for 92 food items. Of the 5 foods which were not listed in the Phenol-Explorer Database, polyphenol contents of 3 foods (sweet potatoes, satoimo and daikon) were based on a Japanese study and 2 foods (soybeans and fried potatoes) were estimated by ORAC-based polyphenol contents in the United States Department of Agriculture Database. Odds ratios (OR) and 95%CI of colorectal cancer risk according to quintile categories of intake were obtained by using logistic regression models with adjustment for age, sex, residential area, parental history of colorectal cancer, smoking, alcohol consumption, body mass index 10 years before, type of job, leisure-time physical activity and dietary intakes of calcium and n-3 polyunsaturated fatty acids.RESULTS:There was no measurable difference in total or tea polyphenol intake between cases and controls, but intake of coffee polyphenols was lower in cases than in controls. The multivariate-adjusted OR of colorectal cancer according to quintile categories of coffee polyphenols (from the first to top quintile) were 1.00 (referent), 0.81 (95%CI:0.60-1.10), 0.65 (95%CI:0.47-0.89), 0.65 (95%CI:0.46-0.89) and 0.82 (95%CI:0.60-1.10), respectively (P trend = 0.07). Similar, but less pronounced, decreases in the OR were also noted for the third and fourth quintiles of total polyphenol intake. Tea polyphenols and non-coffee polyphenols showed no association with colorectal cancer risk. The sitespecific analysis, based on 463 colon cancer cases and 340 rectal cancer cases, showed an inverse association between coffee polyphenols and colon cancer. The multivariate-adjusted OR of colon cancer for the first to top quintiles of coffee polyphenols were 1.00 (referent), 0.92 (95%CI:0.64-1.31), 0.75 (95%CI:0.52-1.08), 0.69 (95%CI:0.47-1.01), and 0.68 (95%CI:0.46-1.00), respectively (P trend = 0.02). Distal colon cancer showed a more evident inverse association with coffee polyphenols than proximal colon cancer. The association between coffee polyphenols and rectal cancer risk was U -shaped, with significant decreases in the OR at the second to fourth quintile categories. There was also a tendency that the OR of colon and rectal cancer decreased in the intermediate categories of total polyphenols. The decrease in the OR in the intermediate categories of total polyphenols was most pronounced for distal colon cancer. Intake of tea polyphenols was not associated with either colon or rectal cancer. The associations of coffee consumption with colorectal, colon and rectal cancers were almost the same as observed for coffee polyphenols. The trend of the association between coffee consumption and colorectal cancer was statistically significant. CONCLUSION:The present findings suggest a decreased risk of colorectal cancer associated with coffee consumption. | Zhen-Jie Wang Keizo Ohnaka Makiko Morita Kengo Toyomura Suminori Kono Takashi Ueki Masao Tanaka Yoshihiro Kakeji Yoshihiko Maehara Takeshi Okamura Koji Ikejiri Kitaroh Futami Takafumi Maekawa Yohichi Yasunami Kenji Takenaka Hitoshi Ichimiya Reiji Terasaka | 2013 | World Journal of Gastroenterology2013，19，17： | 12 |
| 4 | Determination of reactive oxygen generated from natural medicines and their antibacterial activity显示文摘Extracts of 16 natural medicine powders {Galla chinensis,Malloti cortex,Cassiae semen,Sophorae radix,Myricae cortex,Crataegi fructus,Gambit,Mume fructus,Geranii herba,Phellodendri cortex,Coptidis rhizoma,Swertiae herba,and Cinnamomi cortex) were assayed for reactive oxygen concentrations using the peroxyoxalate chemiluminescent detection system.High luminescence intensity was observed in Galla chinensis,Geranii herba,Malloti cortex,Myricae cortex,and Cinnamomi cortex.Additional experiments identified the reactive oxygen species as hydrogen peroxide.Galla chinensis generated 2.4 × 10^(-4) mol/L hydrogen peroxide from a 1 mg/mL solution.In bacterial growth tests,Galla chinensis extract had antibacterial activity against Escherichia coli.Staphylococcus aureus,Bacteroides thetaiotaomicron,Campylobacter sputorum biovar sputorum.Streptococcus salivarius thermophilus,Lactobacillus casei,and Bifidobacterium longum infantis.This antibacterial activity was decreased by the addition of catalase.It revealed that hydrogen peroxide which Galla chinensis produced participated in antibacterial activity. | Noriko Tajima Makiko Takasaki Haruka Fukamachi Takeshi Igarashi Yoshijiro Nakajima Hidetoshi Arakawa | 2016 | Journal of Pharmaceutical Analysis2016，6，4： | 7 |
| 5 | Influence of Changes in Solar Radiation on Changes of Surface Temperature in China显示文摘The long-term trends of total surface solar radiation(SSR),surface diffuse radiation,and surface air temperature were analyzed in this study based on updated 48-yr data from 55 observational stations in China,and then the correlation between SSR and the diurnal temperature range(DTR) was studied.The effect of total solar radiation on surface air temperature in China was investigated on the basis of the above analyses.A strong correlation between SSR and DTR was found for the period 1961-2008 in China.The highest correlation and steepest regression line slope occurred in winter,indicating that the solar radiation effect on DTR was the largest in this season.Clouds and water vapor have strong influences on both SSR and DTR,and hence on their relationship.The largest correlations between SSR and DTR occurred in wintertime in northern China,regardless of all-day(including clear days and cloudy days) or clear-day cases.Our results also showed that radiation arriving at the surface in China decreased significantly during 1961-1989(dimming period),but began to increase during 1990-2008(brightening period),in agreement with previous global studies.The reduction of total SSR offset partially the greenhouse warming during 1961-1989.However,with the increase of SSR after 1990,this offsetting effect vanished;on the contrary,it even made a contribution to the accelerated warming.Nonetheless,the greenhouse warming still played a controlling role because of the increasing of minimum and mean surface temperatures in the whole study period of 1961-2008.We estimated that the greenhouse gases alone may have caused surface temperatures to rise by 0.31-0.46℃(10 yr) 1 during 1961-2008,which is higher than previously estimated.Analysis of the corresponding changes in total solar radiation,diffuse radiation,and total cloud cover indicated that the dimming and brightening phenomena in China were likely attributable to increases in absorptive and scattering aerosols in the atmosphere,respectively. | 张华 尹青 Teruyuki NAKAJIMA Nakata Mukai MAKIKO 卢鹏 何金海 | 2013 | Acta meteorologica Sinica2013，27，1： | 6 |
| 6 | Eubacterium limosum ameliorates experimental colitis and metabolite of microbe attenuates colonic inflammatory action with increase of mucosal integrity显示文摘瞄准:为了检验真细菌类高级轿车的效果,加(E。高级轿车和) 在结肠的上皮的房间线在试管内上,并且到评估 E 的效果。试验性的大肠炎上的高级轿车和。方法:E。高级轿车和被接种厌氧的联盟者和它的代谢物被获得。E 的生长 stimulatory 效果。T84 房间上的高级轿车和代谢物被 IL-6 生产被 SUDH 活动,和反煽动性的效果评估。在象受体 4 一样的使用费(TLR4 ) 的 mRNA 的变化被实时 PCR 评估。大肠炎被用 2.0% 葡聚糖硫酸钠喂 BALB/C 老鼠导致。这些老鼠收到了任何一个 5% lyophilized E。高级轿车和(n = 7 ) 或控制节食(n = 7 ) 。在大肠炎正式就职,临床、组织学的分数,冒号长度,和盲肠的有机酸层次以后的七天是坚定的。结果:E。高级轿车和在 0.25, 1.0, 0.025 和 0.07 mmol/L 生产了丁酸盐,醋酸盐,丙酸盐,和 lactate,分别地在里面中等。在这集中,每酸没有生长在 T84 细胞上刺激活动;然而,当这些酸在上述层次一起被混合时,它比控制显示出显著地高的活动。除了 lactate,这些酸显著地在就 0.1 mmol/L 稀释了 IL-6 生产。在 TNF-alpha 刺激下面,另外,丁酸盐稀释了 TLR4 mRNA 的生产。有 E 的处理。高级轿车和显著地随盲肠的丁酸盐层次的增加稀释了大肠炎的临床、组织学的分数,与控制组相比。结论:E。高级轿车和能改善试验性的结肠的发炎。部分地, E 的代谢物。高级轿车和,丁酸盐,增加粘膜正直和表演经由 TLR4 的粘膜防卫系统的反煽动性的行动调整。 | Osamu Kanauchi Masanobu Fukuda Yoshiaki Matsumoto Shino Ishii Toyokazu Ozawa Makiko Shimizu Keiichi Mitsuyama Akira Andoh | 2006 | World Journal of Gastroenterology2006，12，7： | 6 |
| 7 | Cell concentration,viability and culture composition of airborne bacteria during a dust event in Beijing显示文摘Airborne bacteria were measured when a dust storm passed Beijing in spring 2012 with a focus on cell concentration,viability and TSA-and R2A-cultured strain composition.The concentration varied at an order of 10~7 cells/m^3 with dust loading(demonstrated with PM_(10))and they had a very close correlation(R_T^2 = 0.91,p < 0.01).At the time of highest PM_(10) of652 μg/m^3,the bacterial concentration reached 1.4 × 10~8 cells/m^3,which was larger than that before and after the dust event by one order.Bacterial viability,the ratio of number concentration of viable cells to total cells,was 32%-64%and smaller in the dust plume than that before the dust arrival.Bacterial strains from the culture ranged between 2.5 x 104 and4.6×10~5 CFU/m^3 and no correlation with PM_(10) was determined.Their composition was different before and after the dust arrival according to 16SrRNA gene sequences and strains belong to Actinomycetes and Firmicutes were the majority in the dust samples. | Hongli Yuan Daizhou Zhang Yanning Shi Baozhen Li Jinshui Yang Xuejian Yu Nan Chen Makiko Kakikawa | 2017 | Journal of Environmental Sciences2017，29，5： | 5 |
| 8 | A case of asymptomatic intraductal papillary neoplasm of the bile duct without hepatolithiasis显示文摘A 65-year-old woman was found to have dilatation of the intrahepatic bile duct in the right anterior segment during a general health. Laboratory data were within normal ranges and no solid mass was detected in her abdominal computer tomography (CT) or nuclear magnetic resonance imaging (MRI). However, endoscopic retrograde cholangiopancreatography (ERCP) demonstrated an obstruction of the right bile duct. Intraoperative cholangiography showed stenosis of the intrahepatic bile duct in the anterior inferior segment (B5) and narrowness of the intrahepatic bile duct in the anterior superior segment (B8), so that we strongly suspected intrahepatic cholangiocarcinoma (ICC). Histologically, surgically resected liver specimens, without tumor mass by macroscopic observation, showed intraductal papillary proliferation with fibrovascular cores and intraductal spreading of carcinoma in situ throughout a considerable area, especially in bile ductules around the peripheral small portal area. Furthermore, the immunohistochemical profile of the tumor (MUC5AC+/CK7+) was compatible with an intraductal papillary neoplasm of the bile duct (IPN-B). Consequently, this case was diagnosed as IPN-B with spreading CIS, stageⅠ(pT1, pN0, P0, H1, M0). We report a case of IPN-B with interesting histopathologicalfindings and emphasize that cholangiography is especially helpful for the diagnosis of bile duct dilatation due to infiltration of carcinoma cells. | Junpei Hayashi Shyun-ichi Matsuoka Makiko Inami Shu Ohshiro Akiyasu Ishigami Hirotoshi Fujikawa Masahide Miyagawa Kenji Mimatsu Youichi Kuboi Hisao Kanou Takatsugu Oida Makiko Inami Shu Ohshiro Mitsuhiko Moriyama | 2008 | World Journal of Gastroenterology2008，14，10： | 4 |
| 9 | Serum Mac-2 binding protein is a novel biomarker for chronic pancreatitis显示文摘AIM: To determine the efficacy of Mac-2 binding protein(Mac-2bp) for diagnosis of chronic pancreatitis.METHODS: Fifty-nine healthy volunteers(HV), 162 patients with chronic pancreatitis(CP), and 94 patients with pancreatic ductal adenocarcinoma(PDAC) were enrolled in this study. We measured serum Mac-2bp using our developed enzyme-linked immunosorbent assay kit. Additional biochemical variables were measured using an automated analyzer(including aminotransferase, alanine aminotransferase, γ-glutamyltransferase, alkaline phosphatase, triglyceride, C-reactive protein, and amylase levels) or chemiluminescent enzyme immunoassay(carbohydrate antigen 19-9 and carcinoembryonic antigen). The ability of Mac-2bp to predict CP diagnosis accurately was assessed using receiver operating characteristic(ROC) analyses.RESULTS: Serum Mac-2bp levels were significantly increased in CP patients compared to HV(P < 0.0001) and PDAC patients(P < 0.0001). Area under the ROC curve values of Mac-2bp for the discrimination of CP from HV and PDAC were 0.727 and 0.784, respectively. Multivariate analyses demonstrated that serum Mac-2bp levels were independent determinants for CP diagnosis from HV and PDAC patients. Immunohistological staining showed that Mac-2bp was expressed faintly in the pancreas tissues of both CP and PDAC patients. Serum aspartate aminotransferase, alanine aminotransferase, γ-glutamyltransferase, alkaline phosphatase, and triglyceride levels were significantly higher in patients with CP or PDAC. Serum Mac-2bp levels were highly correlated with protein levels of alanine aminotransferase, γ-glutamyltransferase, and C-reactive protein, but not amylase, suggesting that the damaged liver produces Mac-2bp. CONCLUSION: Measurement of serum Mac-2bp may be a novel and useful biomarker for CP diagnosis as well as liver fibrosis in the general population. | Tomohiro Maekawa Yoshihiro Kamada Yusuke Ebisutani Makiko Ueda Tomoki Hata Koichi Kawamoto Shinji Takamatsu Kayo Mizutani Mayuka Shimomura Tomoaki Sobajima Hironobu Fujii Kotarosumitomo Nakayama Kimihiro Nishino Makoto Yamada Takashi Kumada Toshifumi Ito Hidetoshi Eguchi Hiroaki Nagano Eiji Miyoshi | 2016 | World Journal of Gastroenterology2016，22，17： | 3 |
| 10 | Hepatocellular carcinoma in patients with nonalcoholic steatohepatitis显示文摘 | Etsuko Hashimoto Satoru Yatsuji Maki Tobari Makiko Taniai Nobuyuki Torii Katsutoshi Tokushige Keiko Shiratori | 2009 | Journal of Gastroenterology2009，，19： | 3 |
| 11 | Penetration profile of chloride ion in cracked reinforced concrete显示文摘 | Pa Pa Win Makiko Watanabe Atsuhiko Machida | 2003 | Cement and Concrete Research2003，，7： | 3 |
| 12 | Thick vacuum deposited silicon films suitable for the anode of Li-ion battery显示文摘 | Makiko Uehara Junji Suzuki Kohki Tamura Kyoichi Sekine Tsutomu Takamura | 2005 | Journal of Power Sources2005，，1： | 2 |
| 13 | Prospective study of hepatocellular carcinoma in nonalcoholic steatohepatitis in comparison with hepatocellular carcinoma caused by chronic hepatitis C显示文摘 | Katsutoshi Tokushige Etsuko Hashimoto Satoru Yatsuji Maki Tobari Makiko Taniai Nobuyuki Torii Keiko Shiratori | 2010 | Journal of Gastroenterology2010，，9： | 2 |
| 14 | Epidermal growth factor receptor expression in human pancreatic cancer:Significance for liver metastasis显示文摘 | Kosuke Tobita Hiroshi Kijima Shoichi Dowaki Hiroyuki Kashiwagi Yasuo Ohtani Yasuhisa Oida Hitoshi Yamazaki Masato Nakamura Yoshito Ueyama Makiko Tanaka Sadaki Inokuchi Hiroyasu Makuuchi | 2003 | International Journal of Molecular Medicine2003，，3： | 2 |
| 15 | Propagation of Weak Pressure Waves against Two Parallel Subsonic Streams显示文摘在这份报纸,在经常区域的直管对二条平行亚声的溪流宣传的一个压力波浪的特征被一个维的分析,二维的数字模拟,和实验调查。计算被二维的 Euler 方程用 Chakravarthy-Osher-type TVD 计划执行了。由象墙压力大小一样的 schlieren 方法的光观察被执行了澄清结构和压力波浪的繁殖速度。对溪流宣传的压力波浪变成一个区分的压力波浪和分叉的结果表演发生在低速度溪流。分析和计算获得的压力波浪的繁殖速度与现在的试验性的数据同意很好,这也被发现。关键词可压缩的流动 - 流动可视化 - 内部流动 - 化合物飘动 - 复合窒息的 CLC 数字 O354. | Makiko YONAMINE Takanori USHIJIMA Yoshiaki MIYAZATO Mitsuharu MASUDA Hiroshi KATANODA Kazuyasu MATSUO | 2006 | Journal of Thermal Science2006，15，2： | 2 |
| 16 | Penetration profile of chloride ion in cracked reinforced concrete显示文摘 | Pa Pa Win Makiko Watanabe Atsuhiko Machida | 2003 | Cement and Concrete Research2003，，7： | 2 |
| 17 | Overexpression of a 60-kDa heat shock protein enhances cytoprotective function of small intestinal epithelial cells显示文摘 | Makiko Takada Michiro Otaka Taiji Takahashi Yuko Izumi Kumiko Tamaki Tomoyoshi Shibuya Naoto Sakamoto Taro Osada Sou Yamamoto Ryuichi Ishida Masaru Odashima Hideaki Itoh Sumio Watanabe | 2010 | Life Sciences2010，，13： | 2 |
| 18 | Hepatocellular carcinoma in patients with nonalcoholic steatohepatitis显示文摘 | Etsuko Hashimoto Satoru Yatsuji Maki Tobari Makiko Taniai Nobuyuki Torii Katsutoshi Tokushige Keiko Shiratori | 2009 | Journal of Gastroenterology2009，，19： | 2 |
| 19 | Distribution of Halotolerant and/or Fermentative Yeasts in Aquatic Environments 显示文摘 | Naoto Urano Makiko Yamazaki and Ryohei Ueno | 2001 | Journal of Tokyo University of Fisheries2001，87，： | 1 |
| 20 | Recent advances in the generation of human monoclonal antibody 显示文摘 | Makiko Y | 2007 | Cytotechnology2007，55，： | 1 |
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