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| 1 | AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells显示文摘The current coronavirus disease 2019(COVID-19)pandemic presents a global public health challenge.The viral pathogen responsible,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),binds to the host receptor ACE2 through its spike(S)glycoprotein,which mediates membrane fusion and viral entry.Although the role of ACE2 as a receptor for SARS-CoV-2 is clear,studies have shown that ACE2 expression is extremely low in various human tissues,especially in the respiratory tract.Thus,other host receptors and/or co-receptors that promote the entry of SARS-CoV-2 into cells of the respiratory system may exist.In this study,we found that the tyrosine-protein kinase receptor UFO(AXL)specifically interacts with the N-terminal domain of SARS-CoV-2 S.Using both a SARS-CoV-2 virus pseudotype and authentic SARS-CoV-2,we found that overexpression of AXL in HEK293T cells promotes SARS-CoV-2 entry as efficiently as overexpression of ACE2,while knocking out AXL significantly reduces SARS-CoV-2 infection in HI 299 pulmonary cells and in human primary lung epithelial cells.Soluble human recombinant AXL blocks SARS-CoV-2 infection in cells expressing high levels of AXL.The AXL expression level is well correlated with SARS-CoV-2 S level in bronchoalveolar lavage fluid cells from COVID-19 patients.Taken together,our findings suggest that AXL is a novel candidate receptor for SARS-CoV-2 which may play an important role in promoting viral infection of the human respiratory system and indicate that it is a potential target for future clinical intervention strategies. | Shuai Wang Zongyang Qiu Yingnan Hou Xiya Deng Wei Xu Tingting Zheng Peihan Wu Shaofang Xie Weixiang Bian Chong Zhang Zewei Sun Kunpeng Liu Chao Shan Aifu Lin Shibo Jiang Youhua Xie Qiang Zhou Lu Lu Jing Huang Xu Li | 2021 | Cell Research2021，31，2： | 39 |
| 2 | Stimulated Brillouin scattering evolution and suppression in an integrated stimulated thermal Rayleigh scattering-based fiber laser显示文摘The spectral purity of fiber lasers has become a critical issue in both optical sensing and communication fields.As a result of ultra-narrow intrinsic linewidth, stimulated thermal Rayleigh scattering(STRS) has presented special potential to compress the linewidth of fiber lasers. To suppress stimulated Brillouin scattering(SBS), the most dominant disturbance for STRS in optical fibers, a semi-quantitative estimation has been established to illuminate the mechanism of suppressing SBS in a periodic tapered fiber, and it agrees with experimental results. Finally, a linewidth compression device based on STRS is integrated into a single-longitudinal-mode ring-cavity fiber laser with secondary cavities, and its linewidth is verified to be 200 Hz through a self-heterodyne detecting and Voigt fitting method. | JIWEN CUI HONG DANG KUNPENG FENG WENLEI YANG TAO GENG YANG HU YUANHANG ZHANG DONG JIANG XUDONG CHEN JIUBIN TAN | 2017 | Photonics Research2017，5，3： | 2 |
| 3 | Short body length phenotype is compensated by the upregulation of nidogen family members in a deleterious nid1a mutation of zebrafish显示文摘To decode biological processes,interfering with gene functions is a widely used strategy.There are a number of ways to interfere with gene functions.For instance,small interfering RNAs(siRNAs)are used to induce mRNA degradation;morpholinos are used to block protein translation(Nasevicius and Ekker,2000);CRISPR interference/inactive CRISPR-associated 9 nuclease(CRISPR-i/dCas9)is used to block mRNA transcription(Qi et al.,2013); | Peipei Zhu Zhipeng Ma Liwei Guo Wei Zhang Qinghe Zhang Ting Zhao Kunpeng Jiang Jinrong Peng Jun Chen | 2017 | Journal of Genetics and Genomics2017，44，11： | 2 |
| 4 | A chromosome-scale reference genome of Aquilegia oxysepala var.kansuensis显示文摘The genus Aquilegia(Ranunculaceae)has been cultivated as ornamental and medicinal plants for centuries.With petal spurs of strikingly diverse size and shape,Aquilegia has also been recognized as an excellent system for evolutionary studies.Pollinator‐mediated selection for longer spurs is believed to have shaped the evolution of this genus,especially the North American taxa.Recently,however,an opposite evolutionary trend was reported in an Asian lineage,where multiple origins of mini-or even nonspurred morphs have occurred.Interesting as it is,the lack of genomic resources has limited our ability to decipher the molecular and evolutionary mechanisms underlying spur reduction in this special lineage.Using long-read sequencing(PacBio Sequel),in combination with optical maps(BioNano DLS)and Hi–C,we assembled a high-quality reference genome of A.oxysepala var.kansuensis,a sister species to the nonspurred taxon.The final assembly is approximately 293.2 Mb,94.6%(277.4 Mb)of which has been anchored to 7 pseudochromosomes.A total of 25,571 protein-coding genes were predicted,with 97.2%being functionally annotated.When comparing this genome with that of A.coerulea,we detected a large rearrangement between Chr1 and Chr4,which might have caused the Chr4 of A.oxysepala var.kansuensis to partly deviate from the“decaying”path that was taken before the split of Aquilegia and Semiaquilegia.This high-quality reference genome is fundamental to further investigations on the development and evolution of petal spurs and provides a strong foundation for the breeding of new horticultural Aquilegia cultivars. | Jinghe Xie Haifeng Zhao Kunpeng Li Rui Zhang Yongchao Jiang Meimei Wang Xuelian Guo Ben Yu Hongzhi Kong Yuannian Jiao Guixia Xu | 2020 | Horticulture Research2020，7，1： | 1 |
| 5 | Changes of glacial lakes and implications in Tian Shan, central Asia, based on remote sensing data from 1990 to 2010显示文摘 | Xin Wang Yongjian Ding Shiyin Liu Lianghong Jiang Kunpeng Wu Zongli Jiang Wanqin Guo | 2013 | Environmental Research Letters2013，，4： | 1 |
| 6 | CdTe-paper-based Visual Sensor for Detecting Methyl Viologen显示文摘This study developed a method on detecting methyl viologen(paraquat)using a CdTe-paper-based visual sensor.The CdTe Qdots were immobilized on the paper using glycerin.The volume percentages of CdTe in glycerin were optimized to be 50%.The sensing principle is that the methyl viologen quenches the fluorescence intensity of CdTe Qdots in a concentration dependent manner.The sensor is linearly response to the logarithm concentration of the methyl viologen in the range from 0.39μmol/L to 3.89 mmol/L with a detection limit of 0.16μmol/L and the corre-lation coefficient R^(2) of 0.99.Three parallel experiments at the methyl viologen concentration of 38.89μmol/L give a relative error of 2.45%,which indicates a good reproducibility.The sensor is not disturbed by other pestisides in-cluding omethoate,anilofos,machete and glyphosate isopropylamine salt.The advantages of this sensor are dis-posable,stable,convenient,and easy to operate. | Yingchun Su Shenghua Ma Kunpeng Jiang Xiaojun Han | 2015 | Chinese Journal of Chemistry2015，33，4： | 0 |
| 7 | 1D Bi_(2)S_(3) nanorods modified 2D BiOI nanoplates for highly efficient photocatalytic activity:Pivotal roles of oxygen vacancies and Z-scheme heterojunction显示文摘In this study,a novel Bi_(2)S_(3)/BiOI Z-scheme photocatalyst with 3D porous hierarchical network-like heterostructure(BSBI NHs)and rich oxygen vacancies(OVs)was fabricated by a facile ion exchange method followed by the in-situ growth process.A possible formation mechanism of BSBI NHs was studied,showing the self-assembled process of in-situ interwoven growth of 1D Bi_(2)S_(3) nanorods(NRs)on the surface of 2D BiOI disk-like nanoplates(NPs),which followed the Ostwald ripening and epitaxial growth.The modification of BiOI NPs by Bi_(2)S_(3) NRs brought about the formation of Z-scheme heterojunction and massive OVs,which improved the visible-light response property and promoted the separation of photoexcited charge carriers of BSBI NHs.BSBI NHs exhibited a significantly enhanced photocatalytic activity compared with Bi_(2)S_(3) and BiOI,and BSBI-1 can remove almost all bacteria and Rhodamine B(RhB)after 60 min visible light illumination.In addition,the photocatalytic mechanism was studied and speculated based on the tests of active species capture,electron spin resonance(ESR),and density functional theory(DFT)simulation calculation,proving the primary roles of·OH,·O_(2)^(-)and h^(+)during the photocatalytic reaction.This work provides new insights into the design and exploitation of novel heterojunctions with highly efficient photocatalytic performances for environmental remediation applications. | Peng Ju Yu Zhang Lei Hao Jiazhen Cao Xiaofan Zhai Kunpeng Dou Fenghua Jiang Chengjun Sun | 2023 | Journal of Materials Science & Technology2023，，11： | 0 |
| 8 | Decoratable hybrid-film-patch stabilized Pickering emulsions and their catalytic applications显示文摘我们表明了一个方法制作被用来形成皮克林乳剂(足) 的功能的混合电影补丁。混合补丁用碳 nanotubes 做的, Fe 3 O 4 nanoparticles, octadecyltrimethoxysilane,并且 poly (diallyldimethylammonium 氯化物) 。混合补丁的稳定的足的水的阶段能被使用一个磁场容易分开。hybrid-film-patch 稳定了足为在房间温度的八个月极其稳定、持续。而且,他们被增加乙醇容易破裂,并且在 aqueous/oil 混合物由 vortexing 改革了补丁,启用容易与金属 nanoparticles 要修改的补丁的内部吸水的方面。作为一个例子,钯 nanoparticles 被嵌进混合补丁的表面用一在里面 situ 减小方法。Pd functionalized 补丁形成了显示出的足为有 99.5% 的收益的丙酮的加氢的优秀催化表演。没有催化活动的损失, Pd functionalized 补丁的一样的批被再循环 13 次。混合补丁的形成的足在催化的域里有一个大潜力。 | Shenghua Ma Yinan Wang Kunpeng Jiang Xiaojun Han | 2015 | Nano Research2015，8，8： | 0 |
| 9 | The mortise and tenon structure enabling lamellar carbon composites of ultra-high bending strength显示文摘Carbon materials are important but find little application in bending components due to their unsatisfy-ing bending strength(300-500 MPa).To fabricate carbon composites of high bending strength is a tough task,even using carbon fibers(CFs)structures as reinforcements.Here we report lamellar carbon com-posites of ultra-high bending strength(>1.2 GPa)produced from CFs cloths coated with nano-diamond(ND)particles by spark plasma sintering(SPS).When NDs are sandwiched between CFs cloths,some ND particles penetrate into interstices between CFs.During the sintering,the ND particles are transformed into graphite onions;this transformation is associated with an active state of carbon atoms participating in the change.As a result,the carbon onions strongly bond the CFs together,helping consolidate the com-pacts into strong lamellar carbon composite bulks.The produced graphite onions from the NDs located at crossings of CFs tows form a robust mortise and tenon structure,which helps the bending strength of the lamellar composite from the compact of 40 wt.%NDs exceed 1.2 GPa.The as-prepared compos-ite possesses the highest specific bending strength of all current high temperature structural materials reported so far.This work may pave a new way for high performance carbon materials. | Zhaojun Li Kunpeng Lin Hailiang Fang Hui Yu Junzhuo Wang Yimin Miao Lianjun Wang Jianlin Li Wan Jiang | 2023 | Journal of Materials Science & Technology2023，，2： | 0 |
| 10 | A Temporal–Spatial Atlas of Peripheral Nerve Evoked Cortex Potential in Rat:A Novel Testbed to Explore the Responding Patterns of the Brain to Peripheral Nerves显示文摘Observing the dynamic progress of the brain in response to peripheral nerve stimulation as a whole is the basis for a deeper understanding of overall brain function;however,it remains a great challenge.In this work,a novel mini-invasive orthogonal recording method is developed to observe the overall evoked cortex potential(ECP)in rat brain.A typical ECP atlas with recognizable waveforms in the rat cortex corresponding to the median,ulnar,and radial nerve trunks and subdivided branches is acquired.Reproducible exciting temporal–spatial progress in the rat brain is obtained and visualized for the first time.Changes in the ECPs and exciting sequences in the cortex four months after median nerve transection are also observed.The results suggest that the brain’s response to peripheral stimulation has precise and reproducible temporal–spatial properties.This resource can serve as a testbed to explore the overall functional interaction and dynamic remodeling mechanisms between the peripheral and central nervous systems over time. | Xiaofeng Yin Jiuxu Deng Bo Chen Bo Jin Xinyi Gu Zhidan Qi Kunpeng Leng Baoguo Jiang | 2022 | Engineering2022，8，7： | 0 |
| 11 | Preparation, structure and properties of fluorescent nano- CdTe/poly (1, 4-butanediol-citrate) bioelastomer nanocomposite in-situ dispersion technique显示文摘吸水的 photoluminescent CdTe/poly (1, 4-butanediol-citrate )(PBC ) bioelastomer nanocomposite 被一个二拍子的圆舞方法成功地综合并且由 X 光检查衍射(XRD ) 描绘了, Fourier 变换红外线(英尺红外) 光谱学,Uv力光谱学,光致发光( PL )光谱学和扫描电子显微镜( SEM )。微分扫描热量测定分析证明有 CdTe 的不同集体部分的 bioelastomer nanocomposites 有低眼镜转变温度。 | Li JIANG Aimiao QIN Kunpeng JIANG Lei LIAO Xiulan WU Chaojian WU | 2013 | Frontiers of Optoelectronics2013，6，4： | 0 |
| 12 | Morphogenesis of Chinese Water Chestnut Pistil and Pollen Tube during Germination显示文摘With the forms of pistil stigma of ' Guiti 2' Chinese water chestnut cultivar during the pollination as the object of observation,we reveal the pollination process of Chinese water chestnut from the microscopic point of view,to provide reference for Chinese water chestnut crossbreeding. The results show that the Chinese water chestnut pistil has 2- 4 stigmas which present white filament and vascular bundle forms,and the vessels on epidermis are thick with long translucent branched hairs; after pollination,pollen grains are tightly bound on branched hairs,and after identification,the pollen tube can penetrate branched hairs,continue to grow,and transfer the genetic material in pollen to vascular bundle. | Kunpeng OU Fanglian HE Yan WANG Wen JIANG Meiping GAO Zhiqiang BI Lijuan CHEN Weiqing DONG Jie GUI | 2016 | Asian Agricultural Research2016，8，5： | 0 |
| 13 | Lipid metabolism analysis in esophageal cancer and associated drug discovery显示文摘Esophageal cancer is an upper gastrointestinal malignancy with a bleak prognosis.It is still being explored in depth due to its complex molecular mechanisms of occurrence and development.Lipids play a crucial role in cells by participating in energy supply,biofilm formation,and signal transduction processes,and lipid metabolic reprogramming also constitutes a significant characteristic of malignant tumors.More and more studies have found esophageal cancer has obvious lipid metabolism abnormalities throughout its beginning,progress,and treatment resistance.The inhibition of tumor growth and the enhancement of antitumor therapy efficacy can be achieved through the regulation of lipid metabolism.Therefore,we reviewed and analyzed the research results and latest findings for lipid metabolism and associated analysis techniques in esophageal cancer,and comprehensively proved the value of lipid metabolic reprogramming in the evolution and treatment resistance of esophageal cancer,as well as its significance in exploring potential therapeutic targets and biomarkers. | Ruidi Jiao Wei Jiang Kunpeng Xu Qian Luo Luhua Wang Chao Zhao | 2024 | Journal of Pharmaceutical Analysis2024，14，1： | 0 |
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