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| 1 | Protective effect of Salvia miltiorrhiza and Carthamus tinctorius extract against lipopolysaccharide-induced liver injury显示文摘AIM:To investigate the hepatoprotective effects and mechanisms of an extract of Salvia miltiorrhiza and Carthamus tinctorius in vivo.METHODS:C57BL/6J mice were randomly assigned to five groups and intraperitoneally administered 0.9% saline,Salvia miltiorrhiza and Carthamus tinctorius extract [Danhong injection(DHI),0.75 and 3 g/kg mixed extract] or reduced glutathione for injection(RGI,300 mg/kg) for 30 min before exposure to lipopolysaccharide(LPS,16 mg/kg). After intraperitoneal LPS stimulation for 90 min or 6 h,the mice were sacrificed by ether anaesthesia,and serum and liver samples were collected. Histological analysis(H&E) and terminal deoxynucleotidyl transferase-mediated d UTP nick end-labelling(TUNEL) staining were performed. Alanine transferase(ALT),aspartate transaminase(AST),total bilirubin(TBil),glutathione-S-transferase(GST),malondialdehyde(MDA),tumour necrosis factor(TNF)-α,interleukin(IL)-6,and caspase-3 levels were measured. Bax,Bcl-2,P-IκBα,IκBα,P-NF-κB p65,and NF-κB p65 protein levels were determined by Western blot. TNF-α,IL-6,caspase-3,Bax and Bcl-2 m RNA expression was measured by real-time reverse transcription-polymerase chain reaction(RT-PCR).RESULTS:Hematoxylin-eosin staining and TUNEL results suggested that DHI(3 g/kg) treatment alleviated inflammatory and apoptotic(P < 0.01) injury in the liver of mice. DHI treatment dose-dependently blunted the abnormal changes in biochemical parameters such as ALT(72.53 ± 2.83 for 3 g/kg,P < 0.01),AST(76.97 ± 5.00 for 3 g/kg,P < 0.01),TBil(1.17 ± 0.10 for 3 g/kg,P < 0.01),MDA(0.81 ± 0.36 for 3 g/kg,P < 0.01),and GST(358.86 ± 12.09 for 3 g/kg,P < 0.01). Moreover,DHI(3 g/kg) remarkably decreased LPS-induced protein expression of TNF-α(340.55 ± 10.18 for 3 g/kg,P < 0.01),IL-6(261.34 ± 10.18 for 3 g/kg,P < 0.01),and enzyme activity of caspase-3(0.93 ± 0.029 for 3 g/kg,P < 0.01). The LPS-induced m RNA expression of TNF-α,IL-6 and caspase-3 was also decreased by DHI. Western blot analysis revealed that DHI antagonised LPS-stimulated decrease of Bcl-2 and increase of Bax protein expression. Furthermore,DHI inhibited LPS-induced IκBα and NF-κB p65 phosphorylation.CONCLUSION:DHI may be a multi-function protectant against acute hepatic injury in mice through its antiinflammatory,anti-oxidative and anti-apoptotic activities. | Li-Na Gao Kuo Yan Yuan-Lu Cui Guan-Wei Fan Yue-Fei Wang | 2015 | World Journal of Gastroenterology2015，21，30： | 8 |
| 2 | Biomedical polymers: synthesis, properties, and applications显示文摘Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation. | Wei-Hai Chen Qi-Wen Chen Qian Chen Chunyan Cui Shun Duan Yongyuan Kang Yang Liu Yun Liu Wali Muhammad Shiqun Shao Chengqiang Tang Jinqiang Wang Lei Wang Meng-Hua Xiong Lichen Yin Kuo Zhang Zhanzhan Zhang Xu Zhen Jun Feng Changyou Gao Zhen Gu Chaoliang He Jian Ji Xiqun Jiang Wenguang Liu Zhuang Liu Huisheng Peng Youqing Shen Linqi Shi Xuemei Sun Hao Wang Jun Wang Haihua Xiao Fu-Jian Xu Zhiyuan Zhong Xian-Zheng Zhang Xuesi Chen | 2022 | Science China Chemistry2022，65，6： | 2 |
| 3 | Reliability for sparsely consecutive-k systems显示文摘 | Zhao X Cui L R Kuo W | 2007 | IEEE Transactions on Reliability2007，56，3： | 1 |
| 4 | Study on the Production of Pentachloronitrobenzene Monoclonal Antibody and Its ELISA Kit for Rapid Detection显示文摘[Objectives]This study was conducted to develop an enzyme-linked immunoassay kit that can detect the residual amount of pentachloronitrobenzene in Penaeus vannamei.[Methods]This study was conducted to develop an enzyme-linked immunoassay kit that can detect the residual amount of pentachloronitrobenzene in P.vannamei.[Results]The standard curve range of the kit was 0-8.1μg/L;the detection limit for P.vannamei was 0.912μg/kg;the recovery was 80.6%-103.5%;and the relative standard deviation range within batches was 5.3%-10.1%,and the relative standard deviation range between batches was 6.7%-8.1%.The specificity of the pentachloronitrobenzene monoclonal antibody was relatively good,and the cross-reaction rates with pentachlorophenol,hexachlorobenzene,tetrachlorophthalide,and chlorothalonil were low,all of which did not exceed 30%.The ELISA kit could be stored at 4℃for 12 months,showing good stability.[Conclusions]The detection kit has low cost,short time and small deviation,and is an ideal preliminary screening method. | Yuhua MA Kuo ZHANG Jianxiong ZHANG Fangfang JIA Fangyang HE Yanan CUI Mingyang LI Yuping WAN | 2021 | Agricultural Biotechnology2021，10，5： | 0 |
| 5 | Cloud-Assisted Distributed Edge Brains for Multi-Cell Joint Beamforming Optimization for 6G显示文摘In 5G networks,optimization of antenna beam weights of base stations has become the key application of AI for network optimization.For 6G,higher frequency bands and much denser cells are expected,and the importance of automatic and accurate beamforming assisted by AI will become more prominent.In existing network,servers are“patched”to network equipment to act as a centralized brain for model training and inference leading to high transmission overhead,large inference latency and potential risks of data security.Decentralized architectures have been proposed to achieve flexible parameter configuration and fast local response,but it is inefficient in collecting and sharing global information among base stations.In this paper,we propose a novel solution based on a collaborative cloud edge architecture for multi-cell joint beamforming optimization.We analyze the performance and costs of the proposed solution with two other architectural solutions by simulation.Compared with the centralized solution,our solution improves prediction accuracy by 24.66%,and reduces storage cost by 83.82%.Compared with the decentralized solution,our solution improves prediction accuracy by 68.26%,and improves coverage performance by 0.4 dB.At last,the future research work is prospected. | Juan Deng Kaicong Tian Qingbi Zheng Jielin Bai Kuo Cui Yitong Liu Guangyi Liu | 2022 | China Communications2022，19，3： | 0 |
| 6 | Engineering Fe‑N_(4)Electronic Structure with Adjacent Co‑N_(2)C_(2)and Co Nanoclusters on Carbon Nanotubes for Efficient Oxygen Electrocatalysis显示文摘Regulating the local configuration of atomically dispersed transition-metal atom catalysts is the key to oxygen electrocatalysis performance enhancement.Unlike the previously reported singleatom or dual-atom configurations,we designed a new type of binary-atom catalyst,through engineering Fe-N_(4)electronic structure with adjacent Co-N_(2)C_(2)and nitrogen-coordinated Co nanoclusters,as oxygen electrocatalysts.The resultant optimized electronic structure of the Fe-N_(4)active center favors the binding capability of intermediates and enhances oxygen reduction reaction(ORR)activity in both alkaline and acid conditions.In addition,anchoring M-N-C atomic sites on highly graphitized carbon supports guarantees of efficient charge-and mass-transports,and escorts the high bifunctional catalytic activity of the entire catalyst.Further,through the combination of electrochemical studies and in-situ X-ray absorption spectroscopy analyses,the ORR degradation mechanisms under highly oxidative conditions during oxygen evolution reaction processes were revealed.This work developed a new binary-atom catalyst and systematically investigates the effect of highly oxidative environments on ORR electrochemical behavior.It demonstrates the strategy for facilitating oxygen electrocatalytic activity and stability of the atomically dispersed M-N-C catalysts. | Mingjie Wu Xiaohua Yang Xun Cui Ning Chen Lei Du Mohamed Cherif Fu‑Kuo Chiang Yuren Wen Amir Hassanpour Francois Vidal Sasha Omanovic Yingkui Yang Shuhui Sun Gaixia Zhang | 2023 | Nano-Micro Letters2023，15，12： | 0 |
| 7 | 2D profiling of tumor chemotactic and molecular phenotype at single cell resolution using a SERS-microfluidic chip显示文摘Emerging single-cell technologies create new opportunities for unraveling tumor heterogeneity.However,the development of high-content phenotyping platform is still at its infancy.Here,we develop a microfluidic chip for two-dimensional(2D)profiling of tumor chemotactic and molecular features at single cell resolution.Individual cells were captured by the triangular micropillar arrays in the cell-loading channel,facilitating downstream single-cell analysis.For 2D phenotyping,the chemotactic properties of tumor cells were visualized through cellular migratory behavior in microchannels,while their protein expression was profiled with multiplex surface enhanced Raman scattering(SERS)nanovectors,in which Raman reporter-embedded gold@silver core-shell nanoparticles(Au@Ag REPs)were modified with DNA aptamers targeting cellular surface proteins.As a proof of concept,breast cancer cells with diverse phenotypes were tested on the chip,demonstrating the capability of this platform for simultaneous chemotactic and molecular analysis.The chip is expected to provide a powerful tool for investigating tumor heterogeneity and promoting clinical precision medicine. | Yizhi Zhang Lei Wu Kuo Yang Shenfei Zong Zhuyuan Wang Yiping Cui | 2022 | Nano Research2022，15，5： | 0 |
| 8 | RFID Based Non-Preemptive Random Sleep Scheduling in WSN显示文摘In Wireless Sensor Network(WSN),because battery and energy supply are constraints,sleep scheduling is always needed to save energy while maintaining connectivity for packet delivery.Traditional schemes have to ensure high duty cycling to ensure enough percentage of active nodes and then derogate the energy efficiency.This paper proposes an RFID based non-preemptive random sleep scheduling scheme with stable low duty cycle.It employs delay tolerant network routing protocol to tackle the frequent disconnections.A low-power RFID based non-preemptive wakeup signal is used to confirm the availability of next-hop before sending packet.It eliminates energy consumption of repeated retransmission of the delayed packets.Moreover,the received wakeup signal is postponed to take effect until the sleep period is finished,and the waken node then responds to the sending node to start the packet delivery.The scheme can keep stable duty cycle and then ensure energy saving effect compared with other sleeping scheduling methods. | Tianle Zhang Lihua Yin Xiang Cui Abhishek Behl Fuqiang Dong Ziheng Cheng Kuo Ma | 2020 | Computers, Materials & Continua2020，，10： | 0 |
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