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| 1 | Fractional partial differential equation denoising models for texture image显示文摘In this paper,a set of fractional partial differential equations based on fractional total variation and fractional steepest descent approach are proposed to address the problem of traditional drawbacks of PM and ROF multi-scale denoising for texture image.By extending Green,Gauss,Stokes and Euler-Lagrange formulas to fractional field,we can find that the integer formulas are just their special case of fractional ones.In order to improve the denoising capability,we proposed 4 fractional partial differential equation based multiscale denoising models,and then discussed their stabilities and convergence rate.Theoretic deduction and experimental evaluation demonstrate the stability and astringency of fractional steepest descent approach,and fractional nonlinearly multi-scale denoising capability and best value of parameters are discussed also.The experiments results prove that the ability for preserving high-frequency edge and complex texture information of the proposed denoising models are obviously superior to traditional integral based algorithms,especially for texture detail rich images. | PU YiFei SIARRY Patrick ZHOU JiLiu LIU YiGuang ZHANG Ni HUANG Guo LIU YiZhi | 2014 | Science China(Information Sciences)2014，57，7： | 13 |
| 2 | Significance of Axial Length Monitoring in Children with Congenital Cataract and Update of Measurement Methods显示文摘Congenital cataract is the main cause of blindness in children, with significantly varying treatment effects. The development of axial length is an important factor that affects the prognosis of these children.However,when compared with the eyes of normal children,the mechanism of growth of the axial length is so complicated that the reported findings differ significantly in terms of the measuring apparatus,assessment methods,and statistical outcome,making the rule of axial length development still unclear. In this paper, we first review the process of axial length development in normal healthy children and compare different hypotheses about certain factors that could affect the development of axial length. The results of some current research about the characteristics of axial length development in congenital cataract children are then reviewed. Lastly, the advantages and disadvantages of current axial length measurements methods are compared and analyzed.The purpose of this review is to improve our understanding of the complexity and importance of axial length development and to suggest better use of axial length monitoring measurements in congenital cataract children for pediatric ophthalmologists,with the hope of offering assistance that will enhance long-term therapeutic effects for these children. | Jiao Zhan Haotian Lin Xinyu Zhang Weirong Chen Yizhi Liu | 2013 | Eye Science2013，28，2： | 11 |
| 3 | Satellite UV-Vis spectroscopy:implications for air quality trends and their driving forces in China during 2005-2017显示文摘Abundances of a range of air pollutants can be inferred from satellite UV-Vis spectroscopy measurements by using the unique absorption signatures of gas species.Here,we implemented several spectral fitting methods to retrieve tropospheric NO_(2),SO_(2),and HCHO from the ozone monitoring instrument(OMI),with radiative simulations providing necessary information on the interactions of scattered solar light within the atmosphere.We analyzed the spatial distribution and temporal trends of satellite-observed air pollutants over eastern China during 2005-2017,especially in heavily polluted regions.We found significant decreasing trends in NO_(2) and SO_(2) since 2011 over most regions,despite varying temporal features and turning points.In contrast,an overall increasing trend was identified for tropospheric HCHO over these regions in recent years.Furthermore,generalized additive models were implemented to understand the driving forces of air quality trends in China and assess the effectiveness of emission controls.Our results indicated that although meteorological parameters,such as wind,water vapor,solar radiation and temperature,mainly dominated the day-to-day and seasonal fluctuations in air pollutants,anthropogenic emissions played a unique role in the long-term variation in the ambient concentrations of NO_(2),SO_(2),and HCHO in the past 13 years.Generally,recent declines in NO_(2) and SO_(2) could be attributed to emission reductions due to effective air quality policies,and the opposite trends in HCHO may urge the need to control anthropogenic volatile organic compound(VOC)emissions. | Chengxin Zhang Cheng Liu Qihou Hu Zhaonan Cai Wenjing Su Congzi Xia Yizhi Zhu Siwen Wang Jianguo Liu | 2019 | Light(Science & Applications)2019，8，1： | 11 |
| 4 | A Robust Fault Detection Algorithm for the GNSS/INS Integrated Navigation Systems显示文摘Integrity is an important index for GNSS-based navigation and positioning, and the receiver autonomous integrity monitoring (RAIM) algorithm has been presented for integrity applications. In the integrated navigation systems of a global navigation satellite system (GNSS) and inertial navigation system (INS),the conventional RAIM algorithm has been developed to extended receiver autonomous integrity monitoring (ERAIM). However, the ERAIM algorithm may fail and a false alarm may generate once the measurements are contaminated by significant outliers, and this problem is rarely discussed in the existing literatures. In this paper, a robust fault detection and the corresponding data processing algorithm are proposed based on the ERAIM algorithm and the robust estimation. In the proposed algorithm, weights of the measurements are adjusted with the equivalent weight function, and the efficiency of the outlier detection and identification is improved, therefore, the estimates become more reliable, and the probability of the false alarm is decreased. Experiments with the data collected under actual environments are implemented, and results indicate that the proposed algorithm is more efficient than the conventional ERAIM algorithm for multiple outliers and a better filtering performance is achieved. | Chen JIANG Shubi ZHANG Yizhi CAO Hui LI Hui ZHENG | 2020 | Journal of Geodesy and Geoinformation Science2020，3，1： | 10 |
| 5 | Reliability Evaluation of IEEE 802.11p-Based Vehicle-to-Vehicle Communication in an Urban Expressway显示文摘IEEE 802.11p/DSRC(Dedicated Short Range Communication) is considered to be a promising wireless communication standard for enhancing transportation safety and efficiency. However, IEEE 802.11p-based Vehicleto-Vehicle(V2V) communication is still unreliable because of the complicating factors of high vehicle speed and complex radio environments. In this paper, we performed a data-based evaluation of V2 V communication reliability,using real-world measurements in a typical urban expressway in Beijing. With respect to the characteristics of the urban expressway and our experimental data, we found road slope and traffic density to be the major environmental factors having a significant impact on the V2 V communication's Line-Of-Sight(LOS) conditions. On the basis of these two factors, we propose a fuzzy classification method for the LOS conditions, and separate the realtime communication environments into different LOS cases. For each LOS case, we quantify the metrics as received signal strength indication, packet delivery rate, and communication latency. The results reveal that the communication reliability in urban expressways is very unstable because of the changing LOS conditions. This study provides a useful reference for the IEEE 802.11p-based cooperative systems in urban expressways. | Yizhi Wang Jianming Hu Yi Zhang Chao Xu | 2015 | Tsinghua Science and Technology2015，20，4： | 5 |
| 6 | Ephedrine hydrochloride inhibits PGN-induced inflammatory responses by promoting IL-10 production and decreasing proinflammatory cytokine secretion via the PI3K/Akt/GSK3β pathway显示文摘 | Yuejuan Zheng Yang Yang Yuhu Li Limin Xu Yi Wang Ziyi Guo Haiyan Song Muyi Yang Beier Luo Aoxiang Zheng Ping Li Yan Zhang Guang Ji Yizhi Yu | 2013 | Cellular & Molecular Immunology2013，10，4： | 4 |
| 7 | Impact of diabetes on promoting the growth of breast cancer显示文摘Background:Type Ⅱ diabetes mellitus(DM2)is a significant risk factor for cancers,including breast cancer.However,a proper diabetic breast cancer mouse model is notwell-established for treatment strategy design.Additionally,the precise diabetic signaling pathways that regulate cancer growth remain unresolved.In the present study,we established a suitable mouse model and demonstrated the pathogenic role of diabetes on breast cancer progression.Methods:We successfully generated a transgenic mouse model of human epidermal growth factor receptor 2 positive(Her2^(+) or ERBB2)breast cancer with DM2 by crossing leptin receptor mutant(Lepr^(db/+))mice with (MMTV-ErbB2/neu)mice.Themousemodelswere administrated with antidiabetic drugs to assess the impacts of controlling DM2 in affecting tumor growth.Magnetic resonance spectroscopic imaging was employed to analyze the tumor metabolism.Results:Treatment with metformin/rosiglitazone in MMTV-ErbB2/Lepr^(db/db) mousemodel reduced serum insulin levels,prolonged overall survival,decreased cumulative tumor incidence,and inhibited tumor progression.Anti-insulin resistance medications also inhibited glycolytic metabolism in tumors in vivo as indicated by the reduced metabolic flux of hyperpolarized ^(13)C pyruvate-to-lactate reaction.The tumor cells from MMTV-ErbB2/Lepr^(db/db) transgenic mice treated with metformin had reprogrammed metabolism by reducing levels of both oxygen consumption and lactate production.Metformin decreased the expression of Myc and pyruvate kinase isozyme 2(PKM2),leading to metabolism reprogramming.Moreover,metformin attenuated the mTOR/AKT signaling pathway and altered adipokine profiles.Conclusions:MMTV-ErbB2/Lepr^(db/db) mouse model was able to recapitulate diabetic HER2^(+) human breast cancer.Additionally,our results defined the signaling pathways deregulated in HER2^(+) breast cancer under diabetic condition,which can be intervened by anti-insulin resistance therapy. | Ping-Chieh Chou Hyun Ho Choi Yizhi Huang Enrique Fuentes-Mattei Guermarie Velazquez-Torres Fanmao Zhang Liem Phan Jaehyuk Lee Yanxia Shi James A.Bankson Yun Wu Huamin Wang Ruiying Zhao Sai-Ching Jim Yeung Mong-Hong Lee | 2021 | Cancer Communications2021，41，5： | 4 |
| 8 | A compact design of four-degree-of-freedom transmission electron microscope holder for quasi-four-dimensional characterization显示文摘Electron tomography(ET) has been demonstrated to be a powerful tool in addressing challenging problems, such as understanding 3 D interactions among various microstructures. Advancing ET to broader applications requires novel instrumentation design to break the bottlenecks both in theory and in practice. In this work, we built a compact four-degree-of-freedom(threedirectional positionings plus self-rotation) nano-manipulator dedicated to ET applications, which is called X-Nano transmission electron microscope(TEM) holder. All the movements of the four degrees of freedom are precisely driven by built-in piezoelectric actuators, minimizing the artefacts due to vibration and drifting of the TEM stage. Full 360° rotation is realized with an accuracy of 0.05° in the whole range, which solves the missing wedge problem. Meanwhile, the specimen can move to the rotation axis with an integrated 3D nano-manipulator, greatly reducing the effort in tracking sample locations during tilting.Meanwhile, in-situ stimulation function can be seamlessly integrated into the X-Nano TEM holder so that dynamic information can be uncovered. We expect that more delicate researches, such as those about 3D microstructural evolution, can be carried out extensively by means of this holder in the near future. | ZHANG YiZhi BU YeQiang FANG XiaoYang WANG HongTao | 2020 | Science China(Technological Sciences)2020，63，7： | 3 |
| 9 | Fast approximate matching of binary codes with distinctive bits显示文摘 | Chenggang Clarence YAN Hongtao XIE Bing ZHANG Yanping MA Qiong DAI Yizhi LIU | 2015 | Frontiers of Computer Science2015，9，5： | 3 |
| 10 | A hybrid deep neural network based prediction of 300 MW coalfired boiler combustion operation condition显示文摘In power generation industries,boilers are required to be operated under a range of different conditions to accommodate demands for fuel randomness and energy fluctuation.Reliable prediction of the combustion operation condition is crucial for an in-depth understanding of boiler performance and maintaining high combustion efficiency.However,it is difficult to establish an accurate prediction model based on traditional data-driven methods,which requires prior expert knowledge and a large number of labeled data.To overcome these limitations,a novel prediction method for the combustion operation condition based on flame imaging and a hybrid deep neural network is proposed.The proposed hybrid model is a combination of convolutional sparse autoencoder(CSAE)and least support vector machine(LSSVM),i.e.,CSAE-LSSVM,where the convolutional sparse autoencoder with deep architectures is utilized to extract the essential features of flame image,and then essential features are input into the least support vector machine for operation condition prediction.A comprehensive investigation of optimal hyper-parameter and dropout technique is carried out to improve the performance of the CSAE-LSSVM.The effectiveness of the proposed model is evaluated by 300 MW tangential coal-fired boiler flame images.The prediction accuracy of the proposed hybrid model reaches 98.06%,and its prediction time is 3.06 ms/image.It is observed that the proposed model could present a superior performance in comparison to other existing neural network models. | HAN ZheZhe HUANG YiZhi LI Jian ZHANG Biao HOSSAIN Md.Moinul XU ChuanLong | 2021 | Science China(Technological Sciences)2021，64，10： | 3 |
| 11 | In situ probing of cell-cell communications with surface- enhanced Raman scattering (SERS) nanoprobes and microfluidic networks for screening of immunotherapeutic drugs显示文摘为癌症免疫疗法发现新奇的药要求一在屏蔽允许的站台的 vitro 药柔韧房间房间通讯的直接探查。这里,我们联合了散布的提高表面的拉曼(重量的单位) 有 microfluidic 的 nanoprobes 联网在 situ 监视癌症免疫者系统细胞间的通讯。microfluidic 站台与癌症房间在有免疫力的房间上面连接,在癌症房间分泌物充当表明调停人的地方。首先, gold@silver 核心壳 nanorods 被采用为发信号的分子的分析制作重量的单位 immunoprobes。在肿瘤微型环境的多重癌症分泌物是分析由的份量上一帮助重量的单位三维(3D ) 有高敏感(1 ng/mL ) 的 barcode 免疫分析。在在薄片上房间增长试金,第二,多重抑制免疫力的蛋白质由房间被发现禁止有免疫力的房间的激活的癌症藏匿了,显示站台模仿癌症免疫者系统通讯的生理的过程。而且,潜在的药候选人在这个平台上被测试。量的重量的单位免疫分析被执行在调整癌症房间和有免疫力的房间的活动的分泌物行为评估药功效。这试金显示出这个平台的适用性为在 vitro 药屏蔽。充分综合、高度自动化的 SERS-microfluidic 站台将为探查细胞间的通讯成为一个强大的分析工具并且应该加速发现和新奇的药的临床的确认,这被期望。 | Lei Wu Zhuyuan Wang Yizhi Zhang Jiayuan Fei Hui Chen Shenfei Zong Yiping Cui | 2017 | Nano Research2017，10，2： | 3 |
| 12 | A resource recycling technique of hydrogen production from the catalytic degradation of organics in wastewater显示文摘A resource recycling technique of hydrogen production from the catalytic degradation of organics in wastewater by aqueous phase reforming (APR) has been proposed. It is worthy of noting that this technique may be a potential way for the purification of refractory and highly toxic organics in water for hydrogen production. Hazardous organics (such as phenol, aniline, nitrobenzene, tetrahydrofuran (THF), toluene, N,N-dimethylformamide (DMF) and cyclohexanol) in water could be completely de-graded into H2 and CO2 with high selectivity over Raney Ni, and Sn-modified Raney Ni (Sn-Raney-Ni) or Pd/C catalyst under mild conditions. The experimental results operated in tubular and autoclave reactors, indicated that the degradation degree of organics and H2 selectivity could reach 100% under the optimal reaction conditions. The Sn-Raney-Ni (Sn/Ni=0.06) and Pd/C catalysts show better catalytic performances than the Raney Ni catalyst for the degradation of organics in water into H2 and CO2 by the aqueous phase reforming process. | LI XiaoNian KONG LingNiao XIANG YiZhi JU YaoMing WU XiaoQiong FENG Feng YUAN JunFeng MA Lei LU ChunShan ZHANG QunFeng | 2008 | Science China Chemistry2008，51，11： | 2 |
| 13 | A critical review of mineral–microbe interaction and co-evolution:mechanisms and applications显示文摘Mineral–microbe interactions play important roles in environmental change,biogeochemical cycling of elements and formation of ore deposits.Minerals provide both beneficial(physical and chemical protection,nutrients,and energy)and detrimental(toxic substances and oxidative pressure)effects to microbes,resulting in mineral-specific microbial colonization.Microbes impact dissolution,transformation and precipitation of minerals through their activity,resulting in either genetically controlled or metabolism-induced biomineralization.Through these interactions,minerals and microbes co-evolve through Earth history.Mineral–microbe interactions typically occur at microscopic scale but the effect is often manifested at global scale.Despite advances achieved through decades of research,major questions remain.Four areas are identified for future research:integrating mineral and microbial ecology,establishing mineral biosignatures,linking laboratory mechanistic investigation to field observation,and manipulating mineral–microbe interactions for the benefit of humankind. | Hailiang Dong Liuqin Huang Linduo Zhao Qiang Zeng Xiaolei Liu Yizhi Sheng Liang Shi Geng Wu Hongchen Jiang Fangru Li Li Zhang Dongyi Guo Gaoyuan Li Weiguo Hou Hongyu Chen | 2022 | National Science Review2022，9，10： | 2 |
| 14 | Sphingosine kinase 1 promotes growth of glioblastoma by increasing inflammation mediated by the NF-κB/IL-6/STAT3 and JNK/PTX3 pathways显示文摘Glioblastoma(GBM)is the most challenging malignant tumor of the central nervous system because of its high morbidity,mortality,and recurrence rate.Currently,mechanisms of GBM are still unclear and there is no effective drug for GBM in the clinic.Therefore,it is urgent to identify new drug targets and corresponding drugs for GBM.In this study,in silico analyses and experimental data show that sphingosine kinase 1(SPHK1)is up-regulated in GBM patients,and is strongly correlated with poor prognosis and reduced overall survival.Overexpression of SPHK1 promoted the proliferation,invasion,metastasis,and clonogenicity of GBM cells,while silencing SPHK1 had the opposite effect.SPHK1 promoted inflammation through the NF-κB/IL-6/STAT3 signaling pathway and led to the phosphorylation of JNK,activating the JNK-JUN and JNK-ATF3 pathways and promoting inflammation and proliferation of GBM cells by transcriptional activation of PTX3.SPHK1 interacted with PTX3 and formed a positive feedback loop to reciprocally increase expression,promote inflammation and GBM growth.Inhibition of SPHK1 by the inhibitor,PF543,also decreased tumorigenesis in the U87-MG and U251-MG SPHK1 orthotopic mouse models.In summary,we have characterized the role and molecular mechanisms by which SPHK1 promotes GBM,which may provide opportunities for SPHK1-targeted therapy. | Wan Li Hongqing Cai Liwen Ren Yihui Yang Hong Yang Jinyi Liu Sha Li Yizhi Zhang Xiangjin Zheng Wei Tan Guanhua Du Jinhua Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，12： | 2 |
| 15 | Collision of the North China and Yangtse Blocks and formation of coesite-bearing eclogites: Timing and processes显示文摘 | Li Shuguang Xiao Yilin Lion Deliang Chert Yizhi Ge Ningjie Zhang Zongqing Sun Shen-su Cong Bolin Zhang Ruyuan Hart S R Wang Songshan | 1993 | Chem Geol1993，109，14： | 1 |
| 16 | Fish Density Estimation with Multi-Scale Context Enhanced Convolutional Neural Network显示文摘With the development of fishery industry,accurate estimation of the number of fish in aquaculture waters is of great importance to fish behavior analysis,bait feeding and fishery resource investigation.In this paper,we propose a method for fish density estimation based on the multi-scale context enhanced convolutional network,which could map a fish school image taken at any angle to a density map,and calculate the number of fish in the image finally.In order to eliminate the influence of camera perspective effect and image resolution on density estimation,multi-scale filters are utilized in a convolutional neural network to process fish image in parallel.And then,the context enhancement module is merged in the network structure to help the network understand the global context information of the image.Finally,different feature maps are merged together to construct the density map of fish school images,and finally get the number of fish in the image.In order to make the effectiveness of our method valid,we test the proposed method on DlouDataset.The results show that the proposed method has lower mean square error and mean absolute error,which is helpful to improve the accuracy of the fish counting in dense fish school images. | Yizhi Zhou Hong Yu Junfeng Wu Zhen Cui Hongshuai Pang Fangyan Zhang | 2019 | Journal of Communications and Information Networks2019，4，3： | 1 |
| 17 | Progress on diagnostic and prognostic markers of pancreatic cancer显示文摘Pancreatic cancer is a malignant disease characterized by low survival and high recurrence rate,whose patients are mostly at the stage of locally advanced or metastatic disease when first diagnosed.Early diagnosis is particularly important because prognostic/predictive markers help guide optimal individualized treatment regimens.So far,CA19-9 is the only biomarker for pancreatic cancer approved by the FDA,but its effectiveness is limited by low sensitivity and specificity.With recent advances in genomics,proteomics,metabolomics,and other analytical and sequencing technologies,the rapid acquisition and screening of biomarkers is now possible.Liquid biopsy also occupies a significant place due to its unique advantages.In this review,we systematically describe and evaluate the available biomarkers that have the greatest potential as vital tools in diagnosing and treating pancreatic cancer. | HONG YANG WAN LI LIWEN REN YIHUI YANG YIZHI ZHANG BINBIN GE SHA LI XIANGJIN ZHENG JINYI LIU SEN ZHANG GUANHUA DU BO TANG HONGQUAN WANG JINHUA WANG | 2023 | Oncology Research2023，31，2： | 1 |
| 18 | Chemoattractive effect on the effector cells of the supernatants from melanoma cells transfected with the interleukin-2 (IL-2), IL-4 or IL-6 gene显示文摘 | Xuetao Cao Guoyou Chen Long He Weiping Zhang Yizhi Yu TianXing Ye | 1998 | Journal of Cancer Research and Clinical Oncology1998，，2： | 1 |
| 19 | Ultrafast Nonlinear Optical Excitation Behaviors of Mono-and Few-Layer Two Dimensional MoS2显示文摘The layered MoS2 has recently attracted significant attention for its excellent nonlinear optical properties.Here,the ultrafast nonlinear optical (NLO)absorption and excited carrier dynamics of layered MoS2(monolayer,3-4 layers,and 6-8 layers)are investigated via Z-scan and transient absorption spectra.Our experimental results reveal that NLO absorption coefficients of these MoS2 increase from-27×10^3cm/GW to -11×10^3cm/GW with more layers at 400-nm laser excitation,while the values decrease from 2.0×10^3cm/GW to 0.8×10^3cm/GW at 800nm.In addition, at high pump fluence,when the NLO response occurs,the results show that not only the reformation of the excitonic bands,but also the recovery time of NLO response decreases from 150ps to lOOps with an increasing number of layers,while the reductive energy of A excitonic band decreases from 191.TmeV to 51.1meV.The intriguing NLO response of MoS2 provides excellent potentials for the next-generation optoelectronic and photonic devices. | Yizhi WANG Zhongyuan GUO Jie YOU Zhen ZHANG Xin ZHENG Xiangai CHENG | 2019 | Photonic Sensors2019，9，1： | 1 |
| 20 | Linkage analysis suggests a locus of ichthyosis vulgaris on 1q22显示文摘 | Wei Zhong Bin Cui Yizhi Zhang Haisong Jiang Shengcai Wei Lei Bu Guoping Zhao Landian Hu Xiangyin Kong | 2003 | Journal of Human Genetics2003，，7： | 1 |
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