|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Gadoxetic acid-enhanced magnetic resonance imaging can predict the pathologic stage of solitary hepatocellular carcinoma显示文摘BACKGROUND Although important for determining long-term outcome, pathologic stage of hepatocellular carcinoma (HCC) is difficult to predict before surgery. Current state-of-the-art magnetic resonance imaging (MRI) using gadoxetic acid provides many imaging features that could potentially be used to classify single HCC as pT1 or pT2. AIM To determine which gadoxetic acid-enhanced MRI (EOB-MRI) findings predict pathologic stage T2 in patients with solitary HCC (cT1). METHODS Pre-operative EOB-MRI findings were reviewed in a retrospective cohort of patients with solitary HCC. The following imaging features were examined: Hyperintensity in unenhanced T2-weighted images, hypointensity in unenhanced T1-weighted images, arterial enhancement, corona enhancement, washout appearance, capsular appearance, hypointensity in the tumor tissue during the hepatobiliary (HB) phase, peritumoral hypointensity in the HB phase, hypointense rim in the HB phase, intratumoral fat, hyperintensity on diffusionweighted imaging, hypointensity on apparent diffusion coefficient map, mosaic appearance, nodule-in-nodule appearance, and the margin (smooth or irregular). Surgical pathology was used as the reference method for tumor staging. Univariate and multivariate analyses were performed to identify predictors of microvascular invasion or satellite nodules. RESULTS There were 39 (34.2%;39 of 114) and 75 (65.8%;75 of 114) pathological stage T2 and T1 HCCs, respectively. Large tumor size (≥ 2.3 cm) and two MRI findings, i.e., corona enhancement [odds ratio = 2.67;95% confidence interval: 1.101-6.480] and peritumoral hypointensity in HB phase images (odds ratio = 2.203;95% confidence interval: 0.961-5.049) were associated with high risk of pT2 HCC. The positive likelihood ratio was 6.25 (95% confidence interval: 1.788-21.845), and sensitivity of EOB-MRI for detecting pT2 HCC was 86.2% when two or three of these MRI features were present. Small tumor size and hypointense rim in the HB phase were regarded as benign features. Small HCCs with hypointense rim but not associated with aggressive features were mostly pT1 lesions (specificity, 100%). CONCLUSION Imaging features on EOB-MRI could potentially be used to predict the pathologic stage of solitary HCC (cT1) as pT1 or pT2. | Yi-Chen Chou I-Ha Lao Pei-Ling Hsieh Ying-Ying Su Chee-Wai Mak Ding-Ping Sun Ming-Jen Sheu Hsing-Tao Kuo Tzu-Ju Chen Chung-Han Ho Yu-Ting Kuo | 2019 | World Journal of Gastroenterology2019，25，21： | 10 |
| 2 | High Levels of Hepatitis B Surface Antigen Increase Risk of Hepatocellular Carcinoma in Patients With Low HBV Load显示文摘 | Tai–Chung Tseng Chun–Jen Liu Hung–Chih Yang Tung–Hung Su Chia–Chi Wang Chi–Ling Chen Stephanie Fang–Tzu Kuo Chen–Hua Liu Pei–Jer Chen Ding–Shinn Chen Jia–Horng Kao | 2012 | Gastroenterology2012，，5： | 6 |
| 3 | Bioactive glass coatings on metallic implants for biomedical applications显示文摘Metallic implant materials possess adequate mechanical properties such as strength,elastic modulus,and ductility for long term support and stability in vivo.Traditional metallic biomaterials,including stainless steels,cobalt-chromium alloys,and titanium and its alloys,have been the gold standards for load-bearing implant materials in hard tissue applications in the past decades.Biodegradable metals including iron,magnesium,and zinc have also emerged as novel biodegradable implant materials with different in vivo degradation rates.However,they do not possess good bioactivity and other biological functions.Bioactive glasses have been widely used as coating materials on the metallic implants to improve their integration with the host tissue and overall biological performances.The present review provides a detailed overview of the benefits and issues of metal alloys when used as biomedical implants and how they are improved by bioactive glass-based coatings for biomedical applications. | Joy-anne N.Oliver Yingchao Su Xiaonan Lu Po-Hsuen Kuo Jincheng Du Donghui Zhu | 2019 | Bioactive Materials2019，4，1： | 4 |
| 4 | Peginterferon Alfa-2a Plus Ribavirin for the Treatment of Dual Chronic Infection With Hepatitis B and C Viruses显示文摘 | Chun–Jen Liu Wan–Long Chuang Chuan–Mo Lee Ming–Lung Yu Sheng–Nan Lu Shun–Sheng Wu Li–Ying Liao Chi–Ling Chen Hsing–Tao Kuo You–Chen Chao Shui–Yi Tung Sien–Sing Yang Jia–Horng Kao Chen–Hua Liu Wei–Wen Su Chih–Lin Lin Yung–Ming Jeng Pei–Jer Chen Ding–Shinn | 2009 | Gastroenterology2009，，2： | 3 |
| 5 | Overexpression of miR-101 suppresses collagen synthesis by targeting EZH2 in hypertrophic scar fibroblasts显示文摘Background:MicroRNA-101(miR-101)is a tumor suppressor microRNA(miRNA)and its loss is associated with the occurrence and progression of various diseases.However,the biological function and target of miR-101 in the pathogenesis of hypertrophic scars(HS)remains unknown.Methods:We harvested HS and paired normal skin(NS)tissue samples from patients and cultured their fibroblasts(HSF and NSF,respectively).We used quantitative reverse transcriptase polymerase chain reaction(qRT-PCR),fluorescence in situ hybridization(FISH),enzyme-linked immunosorbent assays(ELISA)and Western blot analyses to measure mRNA levels and protein expression of miR-101,enhancer of zeste homolog 2(EZH2),collagen 1 and 3(Col1 and Col3)andα-smooth muscle actin(α-SMA)in different in vitro conditions.We also used RNA sequencing to evaluate the relevant signaling pathways and bioinformatics analysis and dual-luciferase reporter assays to predict miR-101 targets.We utilized a bleomycin-induced fibrosis mouse model in which we injected miR-101 mimics to evaluate collagen deposition in vivo.Results:We found low expression of miR-101 in HS and HSF compared to NS and NSF.Overexpressing miR-101 decreased Col1,Col3 andα-SMA expression in HSF.We detected high expression of EZH2 in HS and HSF.Knockdown of EZH2 decreased Col1,Col3 andα-SMA in HSF.Mechanistically,miR-101 targeted the 3-untranslated region(3UTR)of EZH2,as indicated by the decreased expression of EZH2.Overexpressing EZH2 rescued miR-101-induced collagen repression.MiR-101 mimics effectively suppressed collagen deposition in the bleomycin-induced fibrosis mouse model.Conclusions:Our data reveal that miR-101 targets EZH2 in HS collagen production,providing new insight into the pathological mechanisms underlying HS formation. | Jie Li Yan Li Yunchuan Wang Xiang He Jing Wang Weixia Cai Yanhui Jia Dan Xiao Jian Zhang Ming Zhao Kuo Shen Zichao Li Wenbin Jia Kejia Wang Yue Zhang Linlin Su Huayu Zhu Dahai Hu | 2021 | Burns & Trauma2021，9，1： | 3 |
| 6 | Methylation of IRAK3 is a novel prognostic marker in hepatocellular carcinoma显示文摘AIM: To examine the methylation levels of interleukin-1 receptor-associated kinase 3(IRAK3) and GLOXD1 and their potential clinical applications in hepatocellular carcinoma(HCC).METHODS: m RNA expression and promoter methylation of IRAK3 and GLOXD1 in HCC cells were analyzed by reverse transcription-polymerase chain reaction(RTPCR) and methylation-specific PCR(MSP), respectively. Using pyrosequencing results, we further established a quantitative MSP(Q-MSP) system for the evaluation of IRAK3 and GLOXD1 methylation in 29 normal controls and 160 paired HCC tissues and their adjacent nontumor tissues. We also calculated Kaplan-Meier survival curves to determine the applications of gene methylation in the prognosis of HCC.RESULTS: IRAK3 and GLOXD1 expression was partially restored in several HCC cell lines after treatment with 5-aza-2′-deoxycytidine(DNA methyltransferase inhibitor; 5DAC). A partial decrease in the methylated band was also observed in the HCC cell lines after 5DAC treatment. Using GLOXD1 as an example, we found a significant correlation between the data obtained from the methylation array and from pyrosequencing. The methylation frequency of IRAK3 and GLOXD1 in HCC tissues was 46.9% and 63.8%, respectively. Methylation of IRAK3 was statistically associated with tumor stage. Moreover, HCC patients with IRAK3 methylation had a trend toward poor 3-year disease-free survival(P < 0.05). CONCLUSION: IRAK3 and GLOXD1 were frequently methylated in HCC tissues compared to normal controls and nontumor tissues. IRAK3 methylation was associated with tumor stage and poor prognosis of patients. These data suggest that IRAK3 methylation is a novel prognostic marker in HCC. | Chih-Chi Kuo Yu-Lueng Shih Her-Young Su Ming-De Yan Chung-Bao Hsieh Chin-Yu Liu Wei-Ting Huang Mu-Hsien Yu Ya-Wen Lin | 2015 | World Journal of Gastroenterology2015，21，13： | 2 |
| 7 | The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells显示文摘 | Jen-Liang Su Pan-Chyr Yang Jin-Yuan Shih Ching-Yao Yang Lin-Hung Wei Chang-Yao Hsieh Chia-Hung Chou Yung-Ming Jeng Ming-Yang Wang King-Jen Chang Mien-Chie Hung Min-Liang Kuo | 2006 | Cancer Cell2006，，3： | 2 |
| 8 | Blue emitting CsPbBr3 perovskite quantum dot inks obtained from sustained release tablets显示文摘Blue emitting perovskite ink obtained from cesium lead halide quantum dots bearing chlorine(CsPbClxBr3-x,0 | Hewei Yang Yaqing Feng Zhiyu Tu Kuo Su Xiaozhi Fan Bingjie Liu Zhiping Shi Yuzhe Zhang Chenyang Zhao Bao Zhan | 2019 | Nano Research2019，12，12： | 2 |
| 9 | Serum hepatitis B surface antigen levels help predict disease progression in patients with low hepatitis B virus loads显示文摘 | Tai‐Chung Tseng Chun‐Jen Liu Hung‐Chih Yang Tung‐Hung Su Chia‐Chi Wang Chi‐Ling Chen Cheng‐An Hsu Stephanie Fang‐Tzu Kuo Chen‐Hua Liu Pei‐Jer Chen Ding‐Shinn Chen Jia‐Horng Kao | 2012 | Hepatology2012，，： | 2 |
| 10 | Development of adaptive fuzzy control for electrical servo drive via total sliding mode technique显示文摘 | Rong Jong Wait Shun Lin Yu Q Kuo Ho Su | 2004 | FUZZ-IEEE2004，25，29： | 1 |
| 11 | Dielectric properties of three ceramic/epoxy composites显示文摘 | Kuo D H Chang C C Su T Y | 2004 | Mater Chem Phys2004，85，1： | 1 |
| 12 | A QoS- driven approach for service-oriented device anycasting in ubiquitous environments显示文摘 | Su Wei-tsung Kuo Yau-hwang and Huang Po-cheng | 2008 | Computer Networks2008，52，18： | 1 |
| 13 | Optimization of multiple quality characteristics for polyether ether ketone injection molding process显示文摘 | Kuo C F J Su T L | 2006 | Fibers and Polymers2006，7，4： | 1 |
| 14 | Transforming growth factor-beta induces CD44 cleavage that promotes migration of MDA-MB-435s cells through the up-regulation of membrane type 1-matrix metalloproteinase显示文摘 | Kuo YC Su CH Liu CY | 2009 | Int J Cancer2009，124，11： | 1 |
| 15 | Steganography in JPEG2000 compressed images显示文摘 | SU P C KUO C C J | 2003 | IEEE Trans on Consumer ElectronIcs2003，49，4： | 1 |
| 16 | Low-surface-free-energy Materials Based on Polybenzoxazines显示文摘 | Wang C F Su Y C Kuo S W ef al | 2006 | Angew Chem IntSci2006，45，14： | 1 |
| 17 | Dietary sesame reduces serum cholesterol and enhances antioxidant capacity in hypercholesterolemia显示文摘 | Pey Rong Chen Kuo Liong Chien Ta Chen Su | 2005 | Nutrition Research2005，25，6： | 1 |
| 18 | Syn- theses ,Thermal Properties, and Phase Mor-phologies of Novel Benzoxazines Functionalized with Polyhedral Oli- gomeric Silsesquioxane (POSS) Nanocomposites 显示文摘 | Lee Yuan Jyh Kuo Shiao Wei Su Yi Che | 2004 | Polymer2004，45，18： | 1 |
| 19 | Flavokawain B, a novel chalcone from Alpinia pricei Hayata with potent apoptotic activity: Involvement of ROS and GADD153 upstream of mitochondria-dependent apoptosis in HCT116 cells显示文摘 | Yu-Feng Kuo Ying-Zhen Su Yen-Hsueh Tseng Sheng-Yang Wang Hsi-Ming Wang Pin Ju Chueh | 2010 | Free Radical Biology and Medicine2010，，2： | 1 |
| 20 | Gray relational analysis for recognizing fabric defects显示文摘 | KUO C F J SU T L | 2003 | Textile Res J2003，73，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员