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| 1 | Biofunctionalization of metallic implants by calcium phosphate coatings显示文摘Metallic materials have been extensively applied in clinical practice due to their unique mechanical properties and durability.Recent years have witnessed broad interests and advances on surface functionalization of metallic implants for high-performance biofunctions.Calcium phosphates(CaPs)are the major inorganic component of bone tissues,and thus owning inherent biocompatibility and osseointegration properties.As such,they have been widely used in clinical orthopedics and dentistry.The new emergence of surface functionalization on metallic implants with CaP coatings shows promise for a combination of mechanical properties from metals and various biofunctions from CaPs.This review provides a brief summary of state-of-art of surface biofunctionalization on implantable metals by CaP coatings.We first glance over different types of CaPs with their coating methods and in vitro and in vivo performances,and then give insight into the representative biofunctions,i.e.osteointegration,corrosion resistance and biodegradation control,and antibacterial property,provided by CaP coatings for metallic implant materials. | Yingchao Su Irsalan Cockerill Yufeng Zheng Liping Tang Yi-Xian Qin Donghui Zhu | 2019 | Bioactive Materials2019，4，1： | 11 |
| 2 | Calcium phosphate coatings enhance biocompatibility and degradation resistance of magnesium alloy:Correlating in vitro and in vivo studies显示文摘Magnesium(Mg)and its alloys are promising biodegradable materials for orthopedic applications.However,one of the major problems is their rapid degradation rate with quick evolution of hydrogen gas.To overcome this problem,calcium phosphate(CaP)coatings have been used to improve the degradation resistance and the biocompatibility of Mg materials.This study focuses on the comparison and correlation of the in vitro and in vivo degradation and biocompatibility behaviors of these materials.A CaP coating consisting of dicalcium phosphate dihydrate(DCPD)was deposited on an AZ60 Mg alloy by the chemical conversion method.Then,the in vitro degradation testing including electrochemical and immersion tests,and in vivo implantation of the CaP coated Mg alloy were conducted to compare the degradation behaviors.Next,the in vitro cell behavior and in vivo bone tissue response were also compared on both uncoated and CaP-coated Mg samples.Data showed that the CaP coating provided the Mg alloy with significantly better biodegradation behavior and biocompatibility.The in vitro and in vivo biocompatibility tests exhibited good consistency while not the case for biodegradation.Results showed that the in vitro electrochemical test could be a quick screening tool for the biodegradation rate,while the in vitro immersion degradation rate was often 2-4 folds faster than the in vivo degradation rate. | Julia Gao Yingchao Su Yi-Xian Qin | 2021 | Bioactive Materials2021，6，5： | 10 |
| 3 | Strength and deformation behaviors of veined marble specimens after vacuum heat treatment under conventional triaxial compression显示文摘The mechanical behaviors of rocks affected by high temperature and stress are generally believed to be significant for the stability of certain projects involving rocks, such as nuclear waste storage and geothermal resource exploitation. In this paper, veined marble specimens were treated to high temperature treatment and then used in conventional triaxial compression tests to investigate the effect of temperature, confining pressure, and vein angle on strength and deformation behaviors. The results show that the strength and deformation parameters of the veined marble specimens changed with the temperature, presenting a critical temperature of 600℃. The triaxial compression strength of a horizontal vein(β = 90°) is obviously larger than that of a vertical vein(β = 0°). The triaxial compression strength,elasticity modulus, and secant modulus have an approximately linear relation to the confining pressure. Finally,Mohr–Coulomb and Hoek–Brown criteria were respectively used to analyze the effect of confining pressure on triaxial compression strength. | Haijian Su Hongwen Jing Qian Yin Liyuan Yu Yingchao Wang Xingjie Wu | 2017 | Acta Mechanica Sinica2017，33，5： | 5 |
| 4 | Bioactive glass coatings on metallic implants for biomedical applications显示文摘Metallic implant materials possess adequate mechanical properties such as strength,elastic modulus,and ductility for long term support and stability in vivo.Traditional metallic biomaterials,including stainless steels,cobalt-chromium alloys,and titanium and its alloys,have been the gold standards for load-bearing implant materials in hard tissue applications in the past decades.Biodegradable metals including iron,magnesium,and zinc have also emerged as novel biodegradable implant materials with different in vivo degradation rates.However,they do not possess good bioactivity and other biological functions.Bioactive glasses have been widely used as coating materials on the metallic implants to improve their integration with the host tissue and overall biological performances.The present review provides a detailed overview of the benefits and issues of metal alloys when used as biomedical implants and how they are improved by bioactive glass-based coatings for biomedical applications. | Joy-anne N.Oliver Yingchao Su Xiaonan Lu Po-Hsuen Kuo Jincheng Du Donghui Zhu | 2019 | Bioactive Materials2019，4，1： | 4 |
| 5 | Improved mechanical, degradation, and biological performances of Zn–Fe alloys as bioresorbable implants显示文摘Zinc(Zn)is a promising bioresorbable implant material with more moderate degradation rate compared to magnesium(Mg)and iron(Fe).However,the low mechanical strength and localized degradation behavior of pure Zn limit its clinical applications.Alloying is one of the most effective ways to overcome these limitations.After screening the alloying element candidates regarding their potentials for improvement on the degradation and biocompatibility,we proposed Fe as the alloying element for Zn,and investigated the in vitro and in vivo performances of these alloys in both subcutaneous and femoral tissues.Results showed that the uniformly distributed secondary phase in Zn–Fe alloys significantly improved the mechanical property and facilitated uniform degradation,which thus enhanced their biocompatibility,especially the Zn-0.4Fe alloy.Moreover,these Zn–Fe alloys showed outstanding antibacterial property.Taken together,Zn–Fe alloys could be promising can-didates as bioresorbable medical implants for various cardiovascular,wound closure,and orthopedic applications. | Yingchao Su Jiayin Fu Wonsae Lee Shaokang Du Yi-Xian Qin Yufeng Zheng Yadong Wang Donghui Zhu | 2022 | Bioactive Materials2022，7，11： | 3 |
| 6 | A New Type of Nanogel Carrier based on Mixed Pluronic Loaded with Low-Dose Antitumor Drugs显示文摘To design a new type of antitumor nanodrug carrier with good biocompatibility, a drug delivery system with a 2.19% drug-loading rate, measured by high-performance liquid chromatography(HPLC), was prepared by membrane hydration using a mixed polymer: Pluronic■ F-127, which binds folic acid(FA), Pluronic■ F-68 and triptolide(TPL)(FA-F-127/F-68-TPL). As a control, another drug delivery system based on a single polymer(FA-F-127-TPL) with a 1.90% drug-loading rate was prepared by substituting F-68 with F-127. The average particle sizes of FA-F-127/F-68-TPL and FA-F-127-TPL measured by a particle size analyzer were 30.7 nm and 31.6 nm, respectively. Their morphology was observed by atomic force microscopy(AFM). The results showed that FA-F-127-TPL self-assembled into nanomicelles, whereas FA-F-127/F-68-TPL self-assembled into nanogels. An MTT assay showed that a very low concentration of FA-F-127/F-68-TPL or FA-F-127-TPL could significantly inhibit the proliferation of multidrug-resistant(MDR) breast cancer cells(MCF-7/ADR cells) and induce cell death. The effects were significantly different from those of free TPL(P < 0.01). Using the fluorescent probe Nile red(Nr) as the drug model, FA-F-127/F-68-Nr nanogels and FAF-127-Nr nanomicelles were prepared and then incubated with human hepatocarcinoma(HepG2) and MCF-7/ADR cells, and the fluorescence intensity in the cells was measured by a multifunctional microplate reader. The results indicated that both FA-F-127/F-68-Nr and FA-F-127-Nr had sustained release in the cells, but HepG2 and MCF-7/ADR cells exhibited significantly higher endocytosis of FA-F-127/F-68-Nr than that of FA-F-127-Nr(P < 0.01). A nude mice transplanted tumor model was prepared to monitor FA-F-127/F-68-Nr in the tumor tissue and organs by whole-body fluorescent imaging. The results showed that FA-F-127/F-68-Nr targeted tumor tissues. The prepared nanogels had small particle size, were easy to swallow, exhibited slow release property,targeted tumor cells, and could improve the antitumor effects of TPL;hence, they are ideal carriers for low-dose antineoplastic drugs. | 尹美珍 SU Zhenhong CUI Bingcun HAN Yingchao DAI Honglian 喻昕 | 2019 | Journal of Wuhan University of Technology(Materials Science)2019，34，4： | 2 |
| 7 | High-quality genome assembly and pan-genome studies facilitate genetic discovery in mung bean and its improvement显示文摘Mung bean is an economically important legume crop species that is used as a food,consumed as a vegetable,and used as an ingredient and even as a medicine.To explore the genomic diversity of mung bean,we assembled a high-quality reference genome(Vrad_JL7)that was479.35 Mb in size,with a contig N50 length of 10.34 Mb.A total of 40,125 protein-coding genes were annotated,representing96.9%of the genetic region.We also sequenced 217 accessions,mainly landraces and cultivars from China,and identified 2,229,343 high-quality single-nucleotide polymorphisms(SNPs).Population structure revealed that the Chinese accessions diverged into two groups and were distinct from non-Chinese lines.Genetic diversity analysis based on genomic data from 750 accessions in 23 countries supported the hypothesis that mung bean was first domesticated in south Asia and introduced to east Asia probably through the Silk Road.We constructed the first pan-genome of mung bean germplasm and assembled 287.73 Mb of non-reference sequences.Among the genes,83.1%were core genes and 16.9%were variable.Presence/absence variation(PAV)events of nine genes involved in the regulation of the photoperiodic flowering pathway were identified as being under selection during the adaptation process to promote early flowering in the spring.Genomewide association studies(GWASs)revealed 2,912 SNPs and 259 gene PAV events associated with 33 agronomic traits,including a SNP in the coding region of the SWEET10 homolog(jg24043)involved in crude starch content and a PAV event in a large fragment containing 11 genes for color-related traits.This high-quality reference genome and pan-genome will provide insights into mung bean breeding. | Changyou Liu Yan Wang Jianxiang Peng Baojie Fan Dongxu Xu Jing Wu Zhimin Cao Yunqing Gao Xueqing Wang Shutong Li Qiuzhu Su Zhixiao Zhang Shen Wang Xingbo Wu Qibing Shang Huiying Shi Yingchao Shen Bingbing Wang Jing Tian | 2022 | Plant Communications2022，3，6： | 0 |
| 8 | Blending with transition metals improves bioresorbable zinc as better medical implants显示文摘Zinc(Zn)is a new class of bioresorbable metal that has potential for cardiovascular stent material,orthopedic implants,wound closure devices,etc.However,pure Zn is not ideal for these applications due to its low mechanical strength and localized degradation behavior.Alloying is the most common/effective way to overcome this limitation.Still,the choice of alloying element is crucial to ensure the resulting alloy possesses sufficient mechanical strength,suitable degradation rate,and acceptable biocompatibility.Hereby,we proposed to blend selective transition metals(i.e.,vanadium-V,chromium-Cr,and zirconium-Zr)to improve Zn’s properties.These selected transition metals have similar properties to Zn and thus are beneficial for the metallurgy process and mechanical property.Furthermore,the biosafety of these elements is of less concern as they all have been used as regulatory approved medical implants or a component of an implant such as Ti6Al4V,CoCr,or Zr-based dental implants.Our study showed the first evidence that blending with transition metals V,Cr,or Zr can improve Zn’s properties as bioresorbable medical implants.In addition,three in vivo implantation models were explored in rats:subcutaneous,aorta,and femoral implantations,to target the potential clinical applications of bioresorbable Zn implants. | Yingchao Su Jiayin Fu Juncen Zhou Elias Georgas Shaokang Du Yi-Xian Qin Yadong Wang Yufeng Zheng Donghui Zhu | 2023 | Bioactive Materials2023，，2： | 0 |
| 9 | Supplemental mineral ions for bone regeneration and osteoporosis treatment显示文摘Mineral ions play a crucial role in various biological processes in the human body,particularly in bone repair and regeneration.Supplementation with mineral ions offers several advantages over other therapies or treatments for bone repair and regeneration,such as higher biosafety,universal applicability,and compatibility with the immune system.Additionally,supplementation with mineral ions may avoid the need for invasive surgical procedures.The aim of this review is to provide a comprehensive overview of the functions of potentially beneficial mineral ions and their effects on bone regeneration and osteoporosis treatment.By examining previous studies,including in vitro cellular experiments,in vivo animal models,and clinical trials,this review compares the benefits and potential adverse effects of these mineral ions.Moreover,the review provides guidelines for suggested daily supplementation of these mineral ions to assist future preclinical and clinical studies in bone regeneration and osteoporosis treatment. | Yingchao Su Matthew Cappock Stephanie Dobres Allan J.Kucine Wayne C.Waltzer Donghui Zhu | 2023 | Engineered Regeneration2023，4，2： | 0 |
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