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| 1 | Role of insulin and insulin resistance in androgen excess disorders显示文摘Insulin has complex effects on cell growth,metabolism and differentiation,and these effects are mediated by a cell-surface bound receptor and eventually a cascade of intracellular signaling events.Among the several metabolic and growth-promoting effects of insulin,insulin resistance is defined as an attenuated effect of insulin on glucose metabolism,primarily the limited export of blood glucose into skeletal muscle and adipose tissue.On the other hand,not all the signaling pathways and insulin-responsive tissues are equally affected,and some effects other than the metabolic actions of insulin are overexpressed.Ovaries and the adrenal glands are two examples of tissues remaining sensitive to insulin actions where insulin may contribute to increased androgen secretion.Polycystic ovary syndrome(PCOS)is the most common form of androgen excess disorder(AED),and its pathogenesis is closely associated with insulin resistance.Patients with idiopathic hirsutism also exhibit insulin resistance,albeit lower than patients with PCOS.Although it is not as evident as in PCOS,patients with congenital adrenal hyperplasia may have insulin resistance,which may be further exacerbated with glucocorticoid overtreatment and obesity.Among patients with severe insulin resistance syndromes,irrespective of the type of disease,hyperinsulinemia promotes ovarian androgen synthesis independently of gonadotropins.It is highly debated in whom and how insulin resistance should be diagnosed and treated among patients with AEDs,including PCOS.It is not suitable to administer an insulin sensitizer relying on only some mathematical models used for estimating insulin resistance.Instead,the treatment decision should be based on the constellation of the signs,symptoms and presence of obesity;acanthosis nigricans;and some laboratory abnormalities such as impaired glucose tolerance and impaired fasting glucose. | Kursad Unluhizarci Zuleyha Karaca Fahrettin Kelestimur | 2021 | World Journal of Diabetes2021，12，5： | 5 |
| 2 | Erythropoietin exerts neuroprotective effect in neonatal rat model of hypoxicischemic brain injury 显示文摘 | Adem Aydin Kursad Genc Mustafa Akhisarogl | 2003 | Brain & Development2003，27，： | 1 |
| 3 | Fabrication of superhydrophobic Cu surfaces with tunable regular micro and random nano-scale structures by hybrid laser texture and chemical etching显示文摘 | Changsheng Dong Yu Gu Minlin Zhong Lin Li Kursad Sezer Mingxing Ma Wenjin Liu | 2011 | Journal of Materials Processing Tech2011，，7： | 1 |
| 4 | A goal programming approach to simple U-line balancing problem显示文摘 | Hadi GOkPen Kursad Agpak | | 0，，171： | 1 |
| 5 | Hepatoprotective effect of l -carnitine against acute acetaminophen toxicity in mice显示文摘 | Kursad Yapar Asim Kart Mahmut Karapehlivan Onur Atakisi Recai Tunca Serpil Erginsoy Mehmet Citil | 2007 | Experimental and Toxicologic Pathology2007，，2： | 1 |
| 6 | The Process of Supervision in the Turkish Educational System: Purpose, Structure, Operation 显示文摘 | Memduhoglu Hasan Basri Aydin Inayet Yilmaz Kursad Gungor Sabri Oguz Ebru | 2007 | Asia Pacific Education Review2007，，4： | 1 |
| 7 | Heavy metals in soil, vegetable and fruits in the epidemic upper gastrointestinal cancer region of Turkey显示文摘 | KURSAD T M FEVZI K KAZIM K | 2002 | Environmental Toxicology Pharmacology2002，，13： | 1 |
| 8 | A goal programming approach to simple U - line balancing problem 显示文摘 | Hadi Gokcen Kursad Agpak | 2006 | European Journal of Operational Research2006，，171： | 1 |
| 9 | Preliminary experi- mental results on the R134a refrigeration system using a two- phase ejector as an expander 显示文摘 | Kursad Ersoy H Nagihan Bilir Sag | 2014 | International Journal of Refrigeration2014，，43： | 1 |
| 10 | The relationship between team- work and organizational trust显示文摘 | TRUSTI MUSAB ISIK M KuRsAD TIMUROgU YUSSUF ALIYEV | 2015 | International Journal of Research in Business and Social Science2015，4，1： | 1 |
| 11 | Ghrelin levels and postnatal growth in health infants 0-3 months of age显示文摘 | Kursad F | 2010 | J Clin Res Ped Endo2010，2，1： | 1 |
| 12 | Increased Levels of 25 Hydroxyvitamin D and 1,25-Dihydroxyvitamin D After Rosuvastatin Treatment: A Novel Pleiotropic Effect of Statins?显示文摘 | Bunyamin Yavuz Derun Taner Ertugrul Hicran Cil Naim Ata Kadir Okhan Akin Ahmet Arif Yalcin Metin Kucukazman Kursad Dal Murat Sevket Hokkaomeroglu Burcu Balam Yavuz Emre Tutal | 2009 | Cardiovascular Drugs and Therapy2009，，4： | 1 |
| 13 | Erythropoietin exerts neuroprotective effect in neonatal rat model of hypoxic-ischemic brain injury 显示文摘 | Adem Aydin Kursad Genc Mustafa Akhisaroglu | 2003 | Brain & Development2003，27，： | 1 |
| 14 | Neutrophil to Lymphocyte Ratio in Evaluation of Inflam- mation in Patients with Chronic Kidney Disease显示文摘 | Gfllay Ulusal Okyay Salih Inal KUrsad OneS | 2013 | Ken Fail2013，35，1： | 1 |
| 15 | Mycophenolate mofetil treatment of crescentic Henoch–Sch?nlein nephritis with IgA depositions显示文摘 | Fatih Dede Birgul Onec Deniz Ayli Ipek Isik Gonul Kursad Onec | 2008 | Scandinavian Journal of Urology and Nephrology2008，，2： | 1 |
| 16 | Erythropoietin exerts neuroprotective effect in neonatal rat model of hypoxic - ischemic brian injury 显示文摘 | Adem Aydin Kursad Gene Mustafa Akhisarouglu | 2003 | brian& De- velopment2003，27，： | 1 |
| 17 | Insights into the Role of the Calcium Sensing Receptor in Epidermal Differentiation in Vivo显示文摘 | Azadeh Arabzadeh Tammy-Claire Troy Kursad Turksen | 2009 | Molecular Biotechnology2009，，3： | 1 |
| 18 | The effect of moisture content in fibre laser cutting of pine wood显示文摘 | Juan Carlos Hernández-Casta?eda Huseyin Kursad Sezer Lin Li | 2011 | Optics and Lasers in Engineering2011，，9： | 1 |
| 19 | High risk of hypopituitarism after traumatic brain injury:a prospective investigation of anterior pituitary function in the acute phase and 12 months after trauma显示文摘 | Hakan S Kursad U | 2006 | J Clin Endocrinol Metab2006，9，6： | 1 |
| 20 | High risk of hypopituitarism after traumatic brain injury: a prospective investigation of anterior pituitary function in the acute phase and 12 months after trauma 显示文摘 | Fatin T Hakan S Kursad U | 2006 | J Clin Endocrinol Metab2006，9，6： | 1 |
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