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| 1 | 膝关节粘连:治疗和预防研究新进展显示文摘背景:膝关节粘连严重影响了患者术后的日常生活,而传统的治疗方式疗效有限。降低膝关节粘连发生率是提高手术预期疗效的关键,也是临床医学上需要急待解决的重要问题。目的:对膝关节粘连的各类研究文献进行分析,总结近10年的研究成果,为防治膝关节粘连提供新的思路和方法。方法:由第一作者检索Pub Med数据库,查找2006至2016年的文献,英文检索词为'tissue adhesions,arthrofibrosis,joint stiffness,prevent,treatment',共检索到1 500余篇相关文献,59篇符合纳入标准。结果与结论:(1)近年来大量学者研究发现,创伤/手术引起膝关节出血、炎症反应,造成血管内皮细胞生长因子和白细胞介素6高表达,增加了成纤维细胞的活性,导致大量胶原蛋白沉积,发生粘连;(2)改进传统治疗方式和运用微创技术治疗膝关节粘连取得了一定的疗效,但仍存在再粘连风险;(3)关节腔内用药预防膝关节粘连在基础研究方面获得了显著成果,可成为预防膝关节粘连的一种有效方案,但临床可行性存在争议,需进一步深入研究,寻找疗效确切、不良反应小的药物。 | 吴海啸 王鹏 张超 Egiazaryan KA Ratyev AP Melnichenko SY Kuzin VV Skoroglyadov AV | 2017 | 中国组织工程研究2017，21，36： | 12 |
| 2 | β-TCP/α-CSH复合材料骨支架在骨缺损治疗中的应用研究进展显示文摘骨缺损的治疗是骨科面临的世界性难题之一,目前公认的治疗方法是通过骨组织工程支架进行修复填充。理想的骨组织工程支架应具备生物相容性、骨传导性、骨诱导性及降解性,同时具有合适的孔径、孔隙率和机械强度。单一材料由于其理化性质的局限性,无法满足临床需要。β-磷酸三钙(β-TCP)/α-半水硫酸钙(α-CSH)复合材料骨支架由于其在生物相容性、可吸收性及机械强度等方面的优势,在体内和体外试验中都取得了一定的效果,但β-TCP/α-CSH复合材料骨支架的机械强度会随α-CSH的完全降解而消失,因此目前其临床研究主要集中在颌面和口腔领域。β-TCP/α-CSH复合材料骨支架修复骨缺损是目前临床上较有潜力的治疗方案,其联合干细胞移植可能是未来提高临床骨缺损修复率的新方向。 | 吴海啸 张超 Goryaeva GL Kuzin VV Skoroglyadov AV | 2016 | 山东医药2016，56，32： | 3 |
| 3 | Comparison of the prognostic value of frailty assessment tools in patients aged≥65 years hospitalized in a cardiac care unit with acute coronary syndrome显示文摘BACKGROUND Frailty is associated with adverse events in elderly patients with acute coronary syndrome(ACS).Our aim was to compare the prognostic value of four frailty scales in patients aged≥65 years hospitalized with ACS in a cardiac care unit(CCU).METHODS Patients aged≥65 years with ACS were included.Frailty was assessed using the Fried frailty scale(reference standard),the Edmonton Frail Scale(EFS),the FRAIL scale,and the Clinical frailty scale(CFS).The primary end point was all-cause mortality and the secondary end point was unscheduled rehospitalization.RESULTS One hundred and seventy four patients aged≥65 years with ACS were recruited.The median follow-up was 637.5 days.Frailty was identified in 41.4%,40.2%,39.1%and 36.3%patients by the Fried frailty scale,EFS,FRAIL scale and CFS,re-spectively.The agreement coefficients were 0.88,0.86,and 0.79 for the FRAIL scale,EFS and CFS,respectively.In the Cox regres-sion model,frailty was associated with all-cause mortality regardless of the scale used(univariate:hazard ratio[HR]95%CI=10.5,2.4-46.8 Fried frailty scale;12.0,2.7-53.4 FRAIL scale;7.1,2.0-25.2 EFS;8.3,2.4-29.6 CFS.Multivariate:HR=5.1,1.1-23.8 Fried frailty scale;5.7,1.2-26.8 FRAIL scale;3.7,1.0-14.0 EFS;4.2,1.1-15.9 CFS).The FRAIL scale had the highest HR.In the uni-variate analysis,frailty was associated with unscheduled rehospitalization(HR=3.2,1.7-6.0 Fried frailty scale;3.4,1.8-6.3 FRAIL scale;3.5,1.8-6.6 EFS;3.1,1.7-5.8 CFS).In the multivariate analysis,only the EFS independently predicted unscheduled rehospit-alization(HR=2.2,1.1-4.63).CONCLUSIONS Frailty assessed by the Fried frailty scale,FRAIL scale,EFS and CFS is associated with all-cause mortality and unscheduled rehospitalization in elderly patients hospitalized in a CCU with ACS.The adjusted HR of the FRAIL scale for all-cause mortality was the highest among the scales compared,whereas the EFS was an independent predictor of unscheduled re-hospitalization.These data should be taken into consideration when choosing a frailty assessment tool. | Wojciech Nowak Ilona Kowalik Małgorzata Kuzin Agnieszka Krauze Anna Mierzyńska Ewa Sadowy Kamil Marcinkiewicz Janina Stępińska | 2022 | Journal of Geriatric Cardiology2022，19，5： | 2 |
| 4 | Nitric oxide synthase mediates regulation of cell polarity and movement during Drosophila melanogaster morphogenesis 显示文摘 | Slezinger MS Kuzin BA | 2009 | Ontogenez2009，40，1： | 1 |
| 5 | Ocular biometry and open- angle glaucoma: the Los Angeles Latino Eye Study 显示文摘 | Kuzin AA Varma R Reddy HS | 2010 | Ophthalmology2010，117，9： | 1 |
| 6 | Nitric oxide and Drosophila development显示文摘 | Enikolopov G Banerj Kuzin B | 1996 | Cell Death Differ1996，6，10： | 1 |
| 7 | 显示文摘 | Kirillov V A Kuzin N A Mescheryakov V D | 2001 | Chemical Engineering Science2001，56，2： | 1 |
| 8 | Ocular biometry and open-angle glaucoma: the Los Angeles Latino Eye Study显示文摘 | Kuzin AA Varma R Reddy HS Torres M Azen SP Los Angeles Latino Eye Study Group | 2010 | Ophthalmology2010，117，： | 1 |
| 9 | Structure of the SHV-1 beta-lactamase 显示文摘 | Kuzin A Nukaga M Nukaga Y | 1999 | Biochemistry1999，38，18： | 1 |
| 10 | Parent Involvement in Urban Charter Schools:New Strategies for Increasing Participation显示文摘 | Smith Joanna Wohlstetter Priscilla Kuzin Chuan Ally De Pedro Kris | 2011 | School Community Journal2011，21，1： | 1 |
| 11 | Catalytic thermochemical reactor/receiver for solar reforming of natural gas: design and performance显示文摘 | Anikeev V Bobrin A Ortner J Sehmidt S Funken K-H Kuzin N | 1998 | Solar Energy1998，63，2： | 1 |
| 12 | Preoprative and intraoperative topographic diagnosis of insulinomas显示文摘 | Kuzin NM Egorov AV Kondrashin SA | 1998 | World J Surg1998，22，9： | 1 |
| 13 | Hepatitis C virus genotypes in different regions of the former Soviet Union (Russia, Belarus, Moldova, and Uzbekistan) 显示文摘 | Viazov S Kuzin S Paladi N | 1997 | J Med Virol1997，53，： | 1 |
| 14 | Tetracyclines inhibit activated B cell function显示文摘 | Kuzin Ⅱ Jennifer ES Gregory DU | 2001 | Int Immunol2001，13，： | 1 |
| 15 | Nitric oxide interacts with the retinoblastoma pathway to control eye development in Drosophila显示文摘 | KUZIN B REGULSKI M STASIV Y | 2000 | Curr Biol2000，10，8： | 1 |
| 16 | The effect of burn injury on the heart in the whole body and on the extracorporeally perfused isolated heart 显示文摘 | Kuzin M I Portnoy V F Dwortsin G F | 1982 | Burns Incl Therm Inj1982，9，： | 1 |
| 17 | Improving NMR protein structure quality by Rosetta refinement: a molecular replacement study显示文摘 | Ramelot T A Raman S Kuzin A P etal | 2009 | Proteins2009，75，1： | 1 |
| 18 | Cathodes based on (La, Sr)MnOa modified with PrO2-x 显示文摘 | Yaroslavtsev I Y Kuzin B L Bronin D I | 2009 | Russian J Electrochem2009，45，8： | 1 |
| 19 | Observations of solar euv radiation with the CORONAS-F/ SPIRIT and HOHO/EIT instruments 显示文摘 | SLEMZIN V A KUZIN S V ZHITNIK I A | 2005 | Solar System Research2005，39，6： | 1 |
| 20 | TESIS experiment on EUV imaging spectroscopy of the sun显示文摘 | KUZIN S V BOGACHEV S A ZHITNIK I A | | 0，，06： | 1 |
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