|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Control of Dis-tributed Uninterrupted Power Supply System显示文摘 | GUERRERO J M LI Junhang JAVIER U | 2008 | IEEE Trans-actions on Industrial Electronics2008，55，8： | 1 |
| 2 | Reverse osmosis of ionic aqueous solutions on a MFI zeolite membrane 显示文摘 | Li Liangxiong Dong Junhang Nenoff T M | 2004 | Desalina- tion2004，170，3： | 1 |
| 3 | Transport of water and alkali metal ions through MFI zeolite membranes during reverse osmosis显示文摘 | Li Liangxing Dong Junhang Nenoff T M | 2007 | Separation and Purification Technology2007，53，1： | 1 |
| 4 | Purification of CVD synthesized single-wall carbon nanotubes by different acid oxidation treatments显示文摘 | Yu Li Xiaobin Zhang Junhang Luo Wanzhen Huang Jipeng Cheng Zhiqiang Luo Ting Li Fu Liu Guoliang Xu Xiaoxing Ke Lin Li and Herman J Geise | 2004 | Nanotechnology2004，15，： | 1 |
| 5 | Preparation of alpha- alumina- supported mesoporous bentonite membranes for reverse osmosis desalination of aqueous solutions 显示文摘 | LI LIANGXIONG DONG JUNHANG LEE ROBERT | 2004 | Journal of Colloid and Interface Science2004，273，： | 1 |
| 6 | A novel multimodal prediction model based on DNA methylation biomarkers and low-dose computed tomography images for identifying early-stage lung cancer显示文摘Objective:DNA methylation alterations are early events in carcinogenesis and immune signalling in lung cancer.This study aimed to develop a model based on short stature homeobox 2 gene (SHOX2)/prostaglandin E receptor 4gene (PTGER4) DNA methylation in plasma,appearance subtype of pulmonary nodules (PNs) and low-dose computed tomography (LDCT) images to distinguish early-stage lung cancers.Methods:We developed a multimodal prediction model with a training set of 257 individuals.The performance of the multimodal prediction model was further validated in an independent validation set of 42 subjects.In addition,we explored the association between SHOX2/PTGER4 DNA methylation and driver gene mutations in lung cancer based on data from The Cancer Genome Atlas (TCGA) portal.Results:There were significant differences between the early-stage lung cancers and benign groups in the methylation levels.The area under a receiver operator characteristic curve (AUC) of SHOX2 in patients with solid nodules,mixed ground-glass opacity nodules and pure ground-glass opacity nodules were 0.693,0.497 and 0.864,respectively,while the AUCs of PTGER4 were 0.559,0.739 and 0.619,respectively.With the highest AUC of0.894,the novel multimodal prediction model outperformed the Mayo Clinic model (0.519) and LDCT-based deep learning model (0.842) in the independent validation set.Database analysis demonstrated that patients with SHOX2/PTGER4 DNA hypermethylation were enriched in TP53 mutations.Conclusions:The present multimodal prediction model could more efficiently distinguish early-stage lung cancer from benign PNs.A prognostic index based on DNA methylation and lung cancer driver gene alterations may separate the patients into groups with good or poor prognosis. | Jing Zhang Haohua Yao Chunliu Lai Xue Sun Xiujuan Yang Shurong Li Yubiao Guo Junhang Luo Zhihua Wen Kejing Tang | 2023 | Chinese Journal of Cancer Research2023，35，5： | 0 |
| 7 | Blue-emitting Sr_(1-x)Ca_(x)Lu_(2)O_(4):Ce^(3+) phosphors for high CRI white LEDs显示文摘A broadband blue-emitting Sr_(1-x)Ca_(x)Lu_(2)O_(4):Ce^(3+)(x=0-0.2) phospho rs were synthesized,which can be used for near-UV pumped white light-emitting diodes(w-LEDs).The crystal structures,photoluminescence pro perties,external quantum efficiency,the rmal stability and application perfo rmance of Sr_(1-x)Ca_(x)Lu_(2)O_(4):Ce^(3+),by partially substituting Sr^(2+) with Ca^(2+)(x=0-0.2),were studied by various analytical techniques.When the Ca/Sr ratio of Sr_(1-x)Ca_(x)Lu_(2)O_(4):Ce^(3+) gradually increases,the emission peak of Sr_(1-x)Ca_(x)Lu_(2)O_(4):Ce^(3+) red-shiftes from 459 to 465 nm,corrected external quantum efficiency increases from 31.8% to 42.9%,and the thermal stability is also improved.The mechanism of the changes of the photoluminescence emission and excitation spectra,external quantum efficiency and thermal stability properties was also investigated in detail.In addition,a w-LED was fabricated by using SrLu_(2)O_(4):Ce^(3+)(blue),β-sialon:Eu^(2+)(green) and(Sr,Ca)AlSiN_(3):Eu^(2+)(red) phosphors combined with a 405 nm near-UV LED chip,and its color rendering index(CRI) reaches 96.0.When Sr_(0.8)Ca_(0.2)Lu_(2)O_(4):Ce^(3+) is applied as blue phosphor to substitute SrLu_(2)O_(4):Ce^(3+),the obtained w-LED devices have high luminous efficiency,and CRI greater than 95.0.These re sults show that the Sr_(1-x)Ca_(x)Lu_(2)O_(4):Ce^(3+) can be potential blue phosphors for n-UV pumped high CRI w-LEDs application. | Yipeng Zhou Yunsheng Hu Ronghui Liu Yuanhong Liu Weidong Zhuang Min Cao Tongyu Gao Junhang Tian Yanfeng Li Guantong Chen | 2021 | Journal of Rare Earths2021，39，6： | 0 |
| 8 | MFN2 suppresses clear cell renal cell carcinoma progression by modulating mitochondria-dependent dephosphorylation of EGFR显示文摘Background:Clear cell renal cell carcinoma(ccRCC)is the most lethal renal cancer.An overwhelming increase of patients experience tumor progression and unfavorable prognosis.However,the molecular events underlying ccRCC tumorigenesis and metastasis remain unclear.Therefore,uncovering the underlying mechanisms will pave the way for developing novel therapeutic targets for ccRCC.In this study,we sought to investigate the role of mitofusin-2(MFN2)in supressing ccRCC tumorigenesis and metastasis.Methods:The expression pattern and clinical significance of MFN2 in ccRCC were analyzed by using the Cancer Genome Atlas datasets and samples from our independent ccRCC cohort.Both in vitro and in vivo experiments,including cell proliferation,xenograft mouse models and transgenic mouse model,were used to determine the role of MFN2 in regulating the malignant behaviors of ccRCC.RNA-sequencing,mass spectrum analysis,co-immunoprecipitation,bio-layer interferometry and immunofluorescence were employed to elucidate the molecular mechanisms for the tumor-supressing role of MFN2.Results:we reported a tumor-suppressing pathway in ccRCC,characterized by mitochondria-dependent inactivation of epidermal growth factor receptor(EGFR)signaling.This process was mediated by the outer mitochondrial membrane(OMM)protein MFN2.MFN2 was down-regulated in ccRCC and associated with favorable prognosis of ccRCC patients.in vivo and in vitro assays demonstrated thatMFN2 inhibited ccRCC tumor growth and metastasis by suppressing the EGFR signaling pathway.In a kidney-specific knockout mouse model,loss of MFN2 led to EGFR pathway activation and malignant lesions in kidney.Mechanistically,MFN2 preferably binded small GTPaseRab21 in its GTPloading form,which was colocalized with endocytosed EGFR in ccRCC cells.Through this EGFR-Rab21-MFN2 interaction,endocytosed EGFR was docked to mitochondria and subsequently dephosphorylated by the OMM-residing tyrosine-protein phosphatase receptor type J(PTPRJ).Conclusions:Our findings uncover an important non-canonicalmitochondriadependent pathway regulating EGFR signaling by the Rab21-MFN2-PTPRJ axis,which contributes to the development of novel therapeutic strategies for ccRCC. | Li Luo Denghui Wei Yihui Pan Qiu-Xia Wang Jian-Xiong Feng Bing Yu Tiebang Kang Junhang Luo Jiefeng Yang Song Gao | 2023 | Cancer Communications2023，43，7： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员