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| 1 | Leukotriene D4 induces brain edema and enhances CysLT2 receptor- mediated aquaporin 4 expression显示文摘 | Wang Meng - Ling Yuan Yu - Mei Huang Xiao - Jia Fang San - Hua Zhang Wei-Ping Lu Yu-Bi Ding Qian Wei Er-Qing | 2006 | 中国药理通讯2006，23，4： | 14 |
| 2 | Human adenovirus(HAdV)infection in children with acute respiratory tract infections in Guangzhou,China,2010–2021:a molecular epidemiology study显示文摘Background Human adenovirus(HAdV)infection can cause a variety of diseases.It is a major pathogen of pediatric acute respiratory tract infections(ARIs)and can be life-threatening in younger children.We described the epidemiology and subtypes shifting of HAdV among children with ARI in Guangzhou,China.Methods We conducted a retrospective study of 161,079 children diagnosed with acute respiratory illness at the Guangzhou Women and Children’s Medical Center between 2010 and 2021.HAdV specimens were detected by real-time PCR and the hexon gene was used for phylogenetic analysis.Results Before the COVID-19 outbreak in Guangzhou,the annual frequency of adenovirus infection detected during this period ranged from 3.92%to 13.58%,with an epidemic peak every four to fve years.HAdV demonstrated a clear seasonal distribution,with the lowest positivity in March and peaking during summer(July or August)every year.A signifcant increase in HAdV cases was recorded for 2018 and 2019,which coincided with a shift in the dominant HAdV subtype from HAdV-3 to HAdV-7.The latter was associated with a more severe disease compared to HAdV-3.The average mortality proportion for children infected with HAdV from 2016 to 2019 was 0.38%but increased to 20%in severe cases.After COVID-19 emerged,HAdV cases dropped to 2.68%,suggesting that non-pharmaceutical interventions probably reduced the transmission of HAdV in the community.Conclusion Our study provides the foundation for the understanding of the epidemiology of HAdV and its associated risks in children in Southern China. | Yi Chen Tao Lin Chang‑Bing Wang Wan‑Li Liang Guang‑Wan Lian Mark Zanin Sook‑San Wong Xin‑Gui Tian Jia‑Yu Zhong Ying‑Ying Zhang Jia‑Hui Xie Ling‑Ling Zheng Fei‑Yan Chen Run Dang Ming‑Qi Zhao Yi‑Yu Yang Rong Zhou Bing Zhu | 2022 | World Journal of Pediatrics2022，18，8： | 5 |
| 3 | Metabolic Factors and Risk of Hepatocellular Carcinoma by Chronic Hepatitis B/C Infection: A Follow-up Study in Taiwan显示文摘 | Chi–Ling Chen Hwai–I. Yang Wei–Shiung Yang Chun–Jen Liu Pei–Jer Chen San–Lin You Li–Yu Wang Chien–An Sun Sheng–Nan Lu Ding–Shin Chen Chien–Jen Chen | 2008 | Gastroenterology2008，，1： | 3 |
| 4 | Clinical Predictors for Diagnosing Pandemic (H1N1) 2009 and Seasonal Influenza (H3N2) in Fever Clinics in Beijing,China显示文摘Objective Symptomatic predictors of influenza could assess risks and improve decisions about isolation and outpatient treatment.To develop such predictors,we undertook a prospective analysis of pandemic (H1N1) 2009 and seasonal influenza (H3N2) in patients attending fever clinics.Methods From 1 May 2009 to 1 January 2010,all adult patients admitted to fever clinics for suspected influenza,confirmed by real time RT-PCR,were enrolled.Predictors of influenza virus infection were selected with logistic regression models.Measures of sensitivity,specificity,positive and negative likelihood ratios (LRs) were calculated to identify the best predictors.Results The clinical features and routine blood test results of influenza (H1N1) 2009 and seasonal influenza were similar.The positive and negative LRs of current US CDC influenza-like illness (ILI) criteria were modest in predicting influenza infection.Our modified clinic predictors improved the ability of the positive and negative LRs to recognize pandemic (H1N1) 2009 and seasonal influenza.The revised criteria are:fever ≥38℃ accompanied by at least one of the following—cough,arthralgia or relative lymphopenia.Conclusion Patients with symptoms and signs that meet the new criteria are likely to have influenza and timely antiviral therapy may be appropriate.In addition,physicians should ascertain if influenza is circulating within the community or if there is a contact history of influenza and combine this information with the newly developed criteria to clinically diagnose influenza. | DAI Xiao Qiu LIU Min ZHANG Tuo Hong YANG Xue Song LI Song Lin LI Xiao Guang LI Yu Ling KADEERBAI Hai San WU Huang | 2012 | Biomedical and Environmental Sciences2012，25，1： | 2 |
| 5 | Kinetic Characteristics of Neutralizing Antibody Responses Vary among Patients with COVID-19显示文摘Objective The coronavirus disease 2019(COVID-19) pandemic continues to present a major challenge to public health. Vaccine development requires an understanding of the kinetics of neutralizing antibody(NAb) responses to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Methods In total, 605 serum samples from 125 COVID-19 patients(from January 1 to March 14, 2020)varying in age, sex, severity of symptoms, and presence of underlying diseases were collected, and antibody titers were measured using a micro-neutralization assay with wild-type SARS-CoV-2.Results NAbs were detectable approximately 10 days post-onset(dpo) of symptoms and peaked at approximately 20 dpo. The NAb levels were slightly higher in young males and severe cases, while no significant difference was observed for the other classifications. In follow-up cases, the NAb titer had increased or stabilized in 18 cases, whereas it had decreased in 26 cases, and in one case NAbs were undetectable at the end of our observation. Although a decreasing trend in NAb titer was observed in many cases, the NAb level was generally still protective.Conclusion We demonstrated that NAb levels vary among all categories of COVID-19 patients. Longterm studies are needed to determine the longevity and protective efficiency of NAbs induced by SARS-CoV-2. | LI Ling Hua TU Hong Wei LIANG Dan WEN Chun Yan LI An An LIN Wei Yin HU Ke Qi HONG Wen Shan LI Yue Ping SU Juan ZHAO San Tao LI Wei YUAN Run Yu ZHOU Ping Ping HU Feng Yu TANG Xiao Ping KE Chang Wen KE Bi Xia CAI Wei Ping | 2021 | Biomedical and Environmental Sciences2021，34，12： | 1 |
| 6 | Metabolic Factors and Risk of Hepatocellular Carcinoma by Chronic Hepatitis B/C Infection: A Follow-up Study in Taiwan显示文摘 | Chi–Ling Chen Hwai–I. Yang Wei–Shiung Yang Chun–Jen Liu Pei–Jer Chen San–Lin You Li–Yu Wang Chien–An Sun Sheng–Nan Lu Ding–Shin Chen Chien–Jen Chen | 2008 | Gastroenterology2008，，1： | 1 |
| 7 | quantum codes from concatenated algebraic geometric codes 显示文摘 | Chen Hao Ling San Xing Chaoping | 2005 | IEEE Trans Inf Theory2005，51，： | 1 |
| 8 | On the constructions of constant-composition codes from perfect nonlinear functions显示文摘A new construction of constant-composition codes based on all known perfect nonlinear functions from Fqm to itself is presented, which provides a kind of unified constructions of constant-composition codes based on all known perfect nonlinear functions from F qm to itself. It is proved that the new constant-composition codes are optimal with respect to the Luo-Fu-Vinck-Chen bound, when m is an odd positive integer greater than 1. Finally, we point out that two constructions of constant-composition codes, proposed by Ding Cunsheng et al. in 2005, are equivalent to two special types of the new constant-composition codes. | LI Chao LI Qiang LING San | 2009 | Science in China(Series F)2009，52，6： | 1 |
| 9 | Zp^k+1-linear codes显示文摘 | Ling San Blackford J T | 2002 | IEEE Trans Inform Theory2002，48，9： | 1 |
| 10 | On the covering structures of two classes of linear codes from perfect nonlinear functions显示文摘 | LI Chao LING San Qu Longjiang | 2009 | IEEE Transactions on Information Theory2009，55，1： | 1 |
| 11 | Zpk+1-linear codes显示文摘 | Ling San Blackford T T | 2002 | IEEE Trans Inform Theory2002，48，9： | 1 |
| 12 | Threshold changeable secret sharing schemes revisited显示文摘 | ZHANG Zhifang CHEE Y M LING San | 2012 | Theoretical Computer Science2012，418，： | 1 |
| 13 | A class of linear codes with good parameters显示文摘 | XING Chao-ping LING San | 2000 | IEEE Trans Inform Theory2000，46，6： | 1 |
| 14 | Proteome database of hepatocellular carcinoma显示文摘 | Rosa C.M.Y Liang Jason C.H Neo Siaw Ling Lo Gek San Tan Teck Keong Seow Maxey C.M Chung | 2002 | Journal of Chromatography B2002，，1： | 1 |
| 15 | Analysis of clinical manifestations,mutant gene and encodedprotein in two Chinese MYH9-related disease families显示文摘 | Yi Y Sen Zhang G Xu M San Ling Z Ru Shao X Zeng Li J | 2006 | ClinChim Acta2006，373，12： | 1 |
| 16 | Quantum Codes Concatenated From Algebraic Geometric Codes 显示文摘 | Hao Chen San Ling Chaoping Xing | 2005 | IEEE Trans Inf Theory2005，51，： | 1 |
| 17 | Type Ⅱcodes over F4+uF4显示文摘 | San Ling Sole P | 2001 | Europ J Combinatorics2001，，22： | 1 |
| 18 | Metabolic Factors and Risk of Hepatocellular Carcinoma by Chronic Hepatitis B/C Infection: A Follow-up Study in Taiwan显示文摘 | Chi–Ling Chen Hwai–I. Yang Wei–Shiung Yang Chun–Jen Liu Pei–Jer Chen San–Lin You Li–Yu Wang Chien–An Sun Sheng–Nan Lu Ding–Shin Chen Chien–Jen Chen | 2008 | Gastroenterology2008，，1： | 1 |
| 19 | A class of linear codes with good parameter from algebraic eurves显示文摘 | Xing Chaoping Ling San | 2000 | IEEE Trans Inform Theory2000，46，4： | 1 |
| 20 | Characterization and expression profiling of cucumber kinesin genes during early fruit development: revealing the roles of kinesins in exponential cell production and enlargement in cucumber fruit显示文摘 | Xue Yong Yang Yan Wang Wei Jie Jiang Xiao Ling Liu Xiao Meng Zhang Hong Jun Yu San Wen Huang Guo Qin Liu | 2013 | Journal of Experimental Botany2013，，14： | 1 |
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