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| 1 | OsWRKY03, a rice transcriptional activator that functions in defense signaling pathway upstream of OsNPR1显示文摘WRKY family proteins are a class of plant specific transcription factors that involve in many stress response pathways. It has been shown that one Arabidopsis WRKY protein, AtWRKY29/22, is activated by MAP kinase signaling cascade and confers resistance to both bacterial and fungal pathogens. However, little is known about the biological roles of WRKY proteins in rice. In this study, we investigated the expression patterns of rice AtWRKY29/22 homolog, OsWRKY03, under different conditions, and also its possible role involved in plant defense. Our results showed that OsWRKY03 was up-regulated by several defense signaling molecules or different treatments. Further analysis revealed that the expres- sion of OsWRKY03 was light dependent. Transcriptional activation activity of OsWRKY03 was also demonstrated by yeast functional assay. Transient expression of OsWRKY03-GFP fusion protein in onion epidermis cells showed that OsWRKY03 was a nuclear localized protein. OsNPR1 as well as several other pathogenesis-related genes, such as OsPR1b, phenylalanine ammonia-lyase (ZB8) and peroxidase (POX22.3), were induced in OsWRKY03-overexpressing transgenic plants. These results indicated that OsWRKY03 is located upstream of OsNPR1 as a transcriptional activator in salicylic acid (SA)-dependent or jasmonic acid (JA)-dependent defense signaling cascades. | Xiao Qiang LIU Xian Quan BAI Qian QIAN Xiu Jie WANG Ming Sheng CHEN Cheng Cai CHU | 2005 | Cell Research2005，15，8： | 55 |
| 2 | Traditional Chinese medicine integrated with chemotherapy for stage Ⅳ non-surgical gastric cancer: a retrospective clinical analysis显示文摘OBJECTIVE: Traditional Chinese medicine(TCM) is regarded as an important treatment for gastric cancer patients, especially for those in advanced stage. To evaluate the effects of TCM treatment on gastric cancer patients, the authors performed a retrospective study to report the result of the integrated treatment of TCM with chemotherapy for stage IV non-surgical gastric cancer.METHODS: In this study, 182 patients with stage IV and non-surgical gastric cancer were retrospectively analyzed to evaluate the effects of TCM integrated with chemotherapy. Among the 182 cases, 88 cases received integrated therapy consisting of TCM and chemotherapy, while 94 cases received chemotherapy alone. The overall survival and Karnofsky performance status(KPS) score were measured as the main outcome.RESULTS: The median overall survival of the integrated therapy group and chemotherapy group were 16.9 and 10.5 months, respectively. The 1-, 3-and 5-year survival rates of integrated therapy group vs. chemotherapy group were 70% vs. 32%, 18% vs. 4%, and 11% vs. 0%, respectively. There was a significant difference between the two groups(χ2 = 42.244, P < 0.001). After six-month treatment, KPS scores of the integrated therapy group and the chemotherapy group were 75.00 ± 14.78 and 60.64 ± 21.39, respectively(P < 0.001). The Cox regression analysis showed that TCM treatment is a protective factor for patients' overall survival. CONCLUSION: This study demonstrated that TCM integrated with chemotherapy may prolong overall survival and improve survival rate and life quality of patients with stage IV non-surgical gastric cancer. | xuan liu li-juan xiu jian-peng jiao jing zhao ying zhao ye lu jun shi yong-jin li min ye yu-fang gu xiao-wei wang jing-yu xu ci-an zhang yong-ying liu yun luo xiao-qiang yue | 2017 | Journal of Integrative Medicine2017，15，6： | 18 |
| 3 | A New Approach to Measurement of Regional Inequality in Particular Directions显示文摘Regional inequality is a core issue in geography,and it can be measured by several approaches and indexes.However,the global inequality measures can not reflect regional characteristics in terms of spatiality and non-mobility,as well as correctly explore regional inequality in particular directions.Although conventional between-group inequality indexes can measure the inequality in particular directions,they can not reflect the reversals of regional patterns and changes of within-group patterns.Therefore,we set forth a new approach to measure regional inequality in particular directions,which is applicable to geographic field.Based on grouping,we established a new index to measure regional inequality in particular directions named Particular Direction Inequality index(PDI index),which is comprised of between-group inequality of all data and between-group average gap.It can reflect regional spatiality and non-mobility,judge the main direction of regional inequality,and capture the changes and reversals of regional patterns.We used the PDI index to measure the changes of regional inequality from 1952 to 2009 in China.The results show that:1) the main direction of China's regional inequality was between coastal areas and inland areas;the increasing extent of inequality between coastal areas and inland areas was higher than the global inequality;2) the PDI index can measure the between-region average gap,and is more sensitive to evolution of within-region patterns;3) the inequality between the northern China and the southern China has been decreasing from 1952 to 2009 and was reversed in 1994 and 1995. | WANG Yang FANG Chuanglin XIU Chunliang LIU Daqian | 2012 | Chinese Geographical Science2012，22，6： | 17 |
| 4 | Derivations of the Even Part of the Odd Hamiltonian Superalgebra in Modular Case显示文摘在这篇论文,我们主要为甚至有限维的奇怪的 Hamiltonian 超级代数学的部分学习推导惊讶在主要特征的一块地上。我们首先给平部分的产生集合惊讶。然后,我们从进概括 Witt 超级代数学的平部分计算推导。最后,我们决定推导代数学和 g 和尺寸公式的外部推导代数学。特别地,第一 cohomology 组织 H 1( ;) 并且 H 1( ;) 被决定。 | Wen De LIU Xiu Ying HUA Yu Cai SU | 2009 | Acta Mathematica Sinica,English Series2009，25，3： | 14 |
| 5 | Effects of Low Light on Agronomic and Physiological Characteristics of Rice Including Grain Yield and Quality显示文摘Light intensity is one of the most important environmental factors that determine the basic characteristics of rice development. However, continuously cloudy weather or rainfall, especially during the grain-filling stage, induces a significant loss in yield and results in poor grain quality. Stress caused by low light often creates severe meteorological disasters in some rice-growing regions worldwide. This review was based on our previous research and related research regarding the effects of low light on rice growth, yield and quality as well as the formation of grain, and mainly reviewed the physiological metabolism of rice plants, including characteristics of photosynthesis, activities of antioxidant enzymes in rice leaves and key enzymes involved in starch synthesis in grains, as well as the translocations of carbohydrate and nitrogen. These characteristics include various grain yield and rice quality components(milling and appearance as well as cooking, eating and nutritional qualities) under different rates of shading imposed at the vegetative or reproductive stages of rice plants. Furthermore, we discussed why grain yield and quality are reduced under the low light environment. Next, we summarized the need for future research that emphasizes methods can effectively improve rice grain yield and quality under low light stress. These research findings can provide a beneficial reference for rice cultivation management and breeding program in low light environments. | LIU Qi-hua WU Xiu CHEN Bo-cong MA Jia-qing GAO Jie | 2014 | Rice science2014，21，5： | 14 |
| 6 | Xiaotan Sanjie decoction attenuates tumor angiogenesis by manipulating Notch-1-regulated proliferation of gastric cancer stem-like cells显示文摘AIM: To determine the underlying mechanisms of action and influence of Xiaotan Sanjie(XTSJ) decoction on gastric cancer stem-like cells(GCSCs). METHODS: The gastric cancer cell line MKN-45 line was selected and sorted by FACS using the cancer stem cell marker CD44; the stemness of these cells was checked in our previous study. In an in vitro study, the expression of Notch-1, Hes1, Vascular endothelial growth factor(VEGF), and Ki-67 in both CD44-positive gastric cancer stem-like cells(GCSCs) and CD44-negative cells was measured by Western blot. The effect of XTSJ serum on cell viability and on the above markers was measured by MTT assay and Western blot, respectively. In an in vivo study, the ability to induce angiogenesis and maintenance of GCSCs in CD44-positive-MKN-45- and CD44-negative-engrafted mice were detected by immunohistochemical staining using markers for CD34 and CD44, respectively. The role of XTSJ decoction in regulating the expression of Notch-1, Hes1, VEGF and Ki-67 was measured by Western blot and real-time polymerase chain reaction.RESULTS: CD44+ GCSCs showed more cell proliferation and VEGF secretion than CD44-negative cells in vitro, which were accompanied by the high expression of Notch-1 and Hes1 and positively associated with tumor growth(GCSCs vs CD44-negative cells, 2.72 ± 0.25 vs 1.46 ± 0.16, P < 0.05) and microvessel density(MVD)(GCSCs vs CD44-negative cells, 8.15 ± 0.42 vs 3.83 ± 0.49, P < 0.001) in vivo. XTSJ decoction inhibited the viability of both cell types in a dose-dependent manner in vitro. Specifically, a significant difference in the medium-(82.87% ± 6.53%) and high-dose XTSJ groups(77.43% ± 7.34%) was detected at 24 h in the CD44+ GCSCs group compared with the saline group(95.42% ± 5.76%) and the low-dose XTSJ group(90.74% ± 6.57%)(P < 0.05). However, the efficacy of XTSJ decoction was reduced in the CD44- groups; significant differences were only detected in the high-dose XTSJ group at 48 h(78.57% ± 6.94%) and 72 h(72.12% ± 7.68%) when compared with the other CD44- groups(P < 0.05). Notably, these differences were highly consistent with the Notch-1, Hes1, VEGF and Ki-67 expression in these cells. Similarly, in vivo, XTSJ decoction inhibited tumor growth in a dose-dependent manner. A significant difference was observed in the medium(1.76 ± 0.15) and high-dose XTSJ(1.33 ± 0.081) groups compared with the GCSCs control group(2.72 ± 0.25) and the low-dose XTSJ group(2.51 ± 0.25)(P < 0.05). We also detected a remarkable decrease of MVD in the medium-(7.10 ± 0.60) and high-dose XTSJ(5.99 ± 0.47) groups compared with the GCSC control group(8.15 ± 0.42) and the low-dose XTSJ group(8.14 ± 0.46)(P < 0.05). Additionally, CD44 expression was decreased in these groups [medium-(4.43 ± 0.45) and high-dose XTSJ groups(3.56 ± 0.31) vs the GCSC control(5.96 ± 0.46) and low dose XTSJ groups(5.91 ± 0.38)](P < 0.05). The significant differences in Notch-1, Hes1, VEGF and Ki-67 expression highly mirrored the results of XTSJ decoction in inhibiting tumor growth, MVD and CD44 expression.CONCLUSION: Notch-1 may play an important role in regulating the proliferation of GCSCs; XTSJ decoction could attenuate tumor angiogenesis, at least partially, by inhibiting Notch-1. | Bing Yan Long Liu Ying Zhao Li-Juan Xiu Da-Zhi Sun Xuan Liu Ye Lu Jun Shi Yin-Cheng Zhang Yong-Jin Li Xiao-Wei Wang Yu-Qi Zhou Shou-Han Feng Can Lv Pin-Kang Wei Zhi-Feng Qin | 2014 | World Journal of Gastroenterology2014，20，36： | 14 |
| 7 | Preparation of Boron-coated Expandable Graphite and Its Application in Flame Retardant Rigid Polyurethane Foam显示文摘 | XU Dongmei LIU Xiu FENG Jie HAO Jianwei | 2015 | Chemical Research in Chinese Universities2015，31，2： | 13 |
| 8 | Molecular Typing of Leptospira interrogans Strains Isolated from Rattus tanezumi in Guizhou Province,Southwest of China显示文摘Objective To identify and type three leptospires isolated from Rattus tanezumi in Guizhou Province by using three molecular techniques (PFGE, MLVA, and MLST), reveal the molecular characteristic of causative agents of local leptospirosis and evaluate these three molecular methods based on their detection resolution and efficiency. Methods Three Leptospira strains were isolated from the kidney of Rattus tanezumi and cultured with EMJH medium. PFGE, MLVA, and MLST assays were applied to type the three strains isolated from Rattus tanezumi in Guizhou Province. Results PFGE, MLVA, and MLST typing showed that the three leptospiral isolates matched with leptospiral serogroup Icterohaemorrhagiae serovar Lai. The findings of the genotyping methods were consistent. MLVA and MLST defined genotypes, whereas PFGE allowed the recognition of additional subgroups within the genotypes, and the findings of molecular typing were also consistent with those of traditional techniques. Conclusion Three leptospiral isolates from Guizhou Province matched with leptospiral serogroup Icterohaemorrhagiae serovar Lai, and PFGE, MLVA, and MLST, as reliable molecular techniques for identifying and typing of Leptospira interrogans, would contribute to the active surveillance, outbreak investigation and source tracking for leptospirosis in Guizhou Province. | LI Shi Jun ZHANG Cui Cai LI Xiu Wen TIAN Ke Cheng TANG Guang Peng WANG Ding Ming LIU Ying NIE Yi Xin JIANG Xiu Gao | 2012 | Biomedical and Environmental Sciences2012，25，5： | 12 |
| 9 | Relationship between osmotic stress and polyamines conjugated to the deoxyribonucleic acid-protein in wheat seedling roots显示文摘The contents of covalently conjugated polyamines (CC-PAs) and noncovalently conju- gated polyamines (NCC-PAs) to deoxyribonucleic acid-protein (DNP) isolated from wheat (Triticum aestivum L.) seedling roots under osmotic stress were detected. Results showed that after osmotic stress treatment for 7 d, the levels in NCC-spermine (NCC-Spm) and NCC-spermidine (NCC-Spd) of drought-tolerant Yumai No. 18 cv. increased more markedly than that of drought-sensitive Yangmai No. 9 cv., while the NCC-putrescine (NCC-Put) could not be statistically detected in two cultivars. Exogenous Spm treatment alleviated osmotic stress injury to Yangmai No. 9 cv. seedlings, coupled with marked increases of NCC-Spm and NCC-Spd levels of this cultivar. Under PEG osmotic stress, the concomitant treatment of drought-tolerant Yumai No. 18 cv.seedlings with methylglyoxyl-bis (guanylhydrazone) (MGBG), an inhibitor of S-adenosylmethionine decarboxylase (SAMDC), aggravated osmotic stress injury to this cultivar, coupled with market decreases of the NCC-Spm and NCC- Spd levels. The levels in CC-Put and CC-Spd of drought-tolerant Yumai No. 18 cv. increased more markedly than that of drought-sensitive Yangmai No. 9 cv. Under osmotic stress. The treatment of drought-tolerant Yumai No. 18 cv. seedlings with phenanthrolin (o-Phen), an inhibitor of transglutaminase (TGase), aggravated osmotic stress injury to this cultivar, coupled with a reduction of sum contents of CC-Put+CC-Spd. These results suggested that NCC-Spm and NCC-Spd, together with CC-Put and CC-Spd, in DNP of roots could enhance tolerance of the wheat seedlings to osmotic stress. | LIU Huaipan1,2, JI Xiu’e2, YU Bingjun1 & LIU Youliang1 1. Ministry of Agriculture Key Laboratory of Crop Growth Regulation, College of Life Science, Nanjing Agricultural University, Nanjing 210095, China 2. Key Laboratory of Plant Science, Zhoukou Normal College, Henan 466000, China | 2006 | Science China(Life Sciences)2006，49，1： | 12 |
| 10 | Effects of Fuzhenghuayu decoction on collagen synthesis of cultured hepatic stellate cells,hepatocytes and fibroblasts in rats显示文摘INTRODUCTIONLiverfibrosisisthecommonpathologicalfeatureofchronicliverdiseases,andiscloselyasociatedwithchangesoflivercelfunct... | LIU Cheng 1, LIU Ping 1, LIU Cheng Hai 1, ZHU Xiu Qing 1 and JI Guang 1 | 1998 | World Journal of Gastroenterology1998，4，6： | 11 |
| 11 | Effects of temperature and rare earth content on oxidation resistance of Ni-based superalloy | Xiu SONG Lei WANG Yang LIU Hui-ping MA | 2011 | Progress in Natural Science:Materials International2011，21，3： | 11 |
| 12 | Strategies for diagnosis of xanthogranulomatous cholecystitis masquerading as gallbladder cancer显示文摘有 xanthogranulomatous 胆汁的背景病人有时展出类似于先进胆囊癌症的那些的成像和 intraoperative 调查结果,这样这些病人是容易学习瞄准了胆汁伪装成能潜在地帮助这 condition.Methods 的正确诊断的胆囊癌症调查 xanthogranulomatous 的特征的在场的 misdiagnosed.The 临床,有 obv 的 12 个病人的血清学、放射学。 | ZHANG Ling-fu HOU Chun-sheng LIU Jian-yu XIU Dian-rong XU Zhi WANG Li-xin LING Xiao-feng | 2012 | Chinese Medical Journal2012，，1： | 11 |
| 13 | Effects of Continuous Positive Airway Pressure on Cognitive Deficits in Middle-aged Patients with Obstructive Sleep Apnea Syndrome: A Meta-analysis of Randomized Controlled Trials显示文摘 | Yue-Ying Pan Yan Deng Xiu Xu Ya-Ping Liu Hui-Guo Liu | 2015 | Chinese Medical Journal2015，，17： | 11 |
| 14 | LASER LIFT-OFF OF GaN THIN FILMS FROM SAPPHIRE SUBSTRATES显示文摘Gallium Nitride film was successfully separated from sapphire substrate by laser radiation. The absorption of the 248nm radiation by the GaN at the interface results in rapid thermal decomposition of the interfacial layer, yielding metallic Ga and N2 gas. The substrate can be easily removed by heating above the Ga melting point (29℃). X-ray diffraction, atomic force microscopy and Photoluminescence of CaN before and after lift-off process have been performed, which demonstrated that the separation and transfer process do not alter the structural quality of the GaN films. And further discussions on the threshold energy and crack-free strategies of laser lift-off process have also been presented. | J. Xu, R. Zhang, Y.P. Wang, X.Q. Xiu, S.L. Gu, B. Shen, Y. Shi, Z.G. Liu and Y.D. Zheng (Department of Physics and National Laboratory of Solid State Microstructures, Nanjing University, Nanjing 210093, China) | 2001 | Acta Metallurgica Sinica(English Letters)2001，14，6： | 10 |
| 15 | A heavy mineral viewpoint on sediment provenance and environment in the Qiongdongnan Basin显示文摘Based on heavy mineral data in core samples from eleven drillings, supplemented by paleontological, element geochemical and seismic data, the evolution of sediment provenance and environment in the Qiongdongnan Basin(QDNB) was analysed. The results show that the basement in the QDNB was predominantly composed of terrigenous sediments. Since the Oligocene the QDNB has gradually undergone transgressions and evolution processes in sedimentary environment from terrestrial-marine transitional to littoral-neritic, neritic, and bathyal roughly. The water depth showed a gradually increasing trend and was generally greater in the southern region than that in the northern region in the same time. With changes in sedimentary environment, provenances of the strata(from the Yacheng Formation to the Yinggehai Formation) showed principal characteristics of multisources, evolving from autochthonous source, short source to distant source step by step. During the Early Oligocene, the sediments were mainly proximal basaltic pyroclastic source and adjacent terrigenous clastic source, afterwards were becoming distant terrigenous clastic sources, including Hainan Island on the north,Yongle Uplift on the south, Shenhu Uplift on the northeast, the Red River System on the northwest and Indochina Peninsula on the southwest, or even a wider region. The Hainan Island provenance began to develop during the Early Oligocene and has become a main provenance in the QDNB since the Middle Miocene. The provenances from Yongle Uplift and Shenhu Uplift most developed from the Late Oligocene to the Early Miocene and gradually subsided during the Middle Miocene. During the Late Miocene, as a main source of sediments filled in the central canyon, the Red River System provenance added to the QDNB massively, whose impact terminated at the end of the Pliocene. The western Yinggehai Basin(YGHB) provenance derived from Indochina Peninsula had developed from the Pliocene on to the Pleistocene. In addition, the material contribution of marine authigenous source to the basin(especially to the southern region) could not be ignored. | LIU Xiaofeng ZHANG Daojun ZHAI Shikui LIU Xinyu CHEN Hongyan LUO Wei LI Na XIU Chun | 2015 | Acta Oceanologica Sinica2015，34，4： | 10 |
| 16 | Microvascular protective role of pericytes in melatonin-treated spinal cord injury in the C57BL/6 mice显示文摘 | Jing Yingli Wu Qingbin Yuan Xiaochen Li Bingwei Liu Mingming Zhang Xiaoyan Liu Shuying Li Hongwei Xiu Ruijuan | 2014 | Chinese Medical Journal2014，，15： | 9 |
| 17 | Bartonella Species Detected in the Plateau Pikas(Ochotona curzoiae) from Qinghai Plateau in China显示文摘Bartonella 种类能感染许多哺乳动物的主人并且在人引起许多疾病,但是在那里有不是在 Ochotonidae 的 Bartonella 感染的报告。这是第一研究在 Qinghai 高原在高原一种短耳野兔检测 Bartonella,提供为对在这个区域的人的 Bartonella 感染的风险评价的基线数据。我们与 18.99% 的积极的率在 Qinghai 的 Binggou 和 Maixiu 区域从 79 只一种短耳野兔获得了 15 Bartonella 紧张。基于基因定序的 Bartonella 柠檬酸盐 synthase (gltA ) 的种系发生的分析,大多数紧张是仔细与 B 有关。taylorii (3/15 ) 和 B。grahamii (12/15 ) 。后者是在人的病原的紧张。我们的结果建议相应预防和控制策略应该在 Qinghai 省被考虑。 | RAO Hua Xiang YU Juan GUO Peng MA Yong Cheng LIU Qi Yong JIAO Ming MA Zhong Wen GE Hua WANG Chun Xiang SONG Xiu Ping SHI Yan LI Dong Mei | 2015 | Biomedical and Environmental Sciences2015，28，9： | 8 |
| 18 | Association between Plasma Metal Levels and Diabetes Risk: a Case-control Study in China显示文摘Objective Many metals, some of which have been classified as environmental endocrine disruptors, are used extensively in everyday consumer products and are ubiquitous in our living environment. In the present study, we aimed to explore the associations between the prevalence risk of type 2 diabetes and plasma levels of 20 trace elements as well as those of heavy metals in a Han Chinese population. Methods We conducted a case-control study to investigate the associations between plasma concentrations of 20 metals and diabetes in Jiangsu province. A total of 122 newly diagnosed cases of type 2 diabetes and 429 matched controls were recruited from community physical examinations in Suzhou City of Jiangsu Province. Plasma metal levels were measured by inductively-coupled plasma mass spectrometry. Results After adjusting for confounders, plasma vanadium, chromium, manganese, copper, zinc, arsenic, selenium, strontium, palladium, cadmium, cesium, and barium were associated with diabetes risk(P < 0.05). The adjusted OR increased with increasing concentration of vanadium, manganese, copper, zinc, and cesium. Conclusion Many metals, including manganese, copper, zinc, arsenic, selenium, and cadmium in plasma, are associated with the morbidity of diabetes. Monitoring of environmental metal levels and further studies are urgently needed. | LI Xiu Ting YU Peng Fei GAO Yan GUO Wen Hui WANG Jun LIU Xin GU Ai Hua JI Gui Xiang DONG Qiu WANG Bo Shen CAO Ying ZHU Bao Li XIAO Hang | 2017 | Biomedical and Environmental Sciences2017，30，7： | 8 |
| 19 | Assessment of structural stability in Bohai Sea area based on AHP-GDM model显示文摘The AHP-GDM model is used for the assessment of structural stability, with the Bohai Sea area as an example. In this model, the credit degree of each expert is calculated through the assessment matrix based on the similarity and diversity of vector. The comprehensive opinions of expert panel are quantitatively obtained by considering the effect of credit degree. According to the geological structural setting, the Bohai Sea is divided into twelve assessment zones of structural stability by non-uniform element method. The structural stability grade of each zone is obtained on the basis of the latest geophysical data, earthquake statistical data, and the information of fault activities, current stress field and crustal deformation. The results show that there are one relatively stable area, three relatively sub-stable areas, six relatively sub-unstable areas and two relatively unstable areas. The assessment results of non-uniform element method are very close with those of uniform grid method with size of 0.25° in longitude direction and 0.14° in latitude direction. However the workload of non-uniform element method is only 1/16 of the latter. Compared with traditional assessment methods of structural stability, a more objective and reliable assessment result can be obtained by combining non-uniform element method and AHP-GDM model. | XIU Zongxiang LIU Baohua XIE Qiuhong LI Xishuang LIU Chenguang PEI Yanliang ZHENG Yanpeng | 2013 | Acta Oceanologica Sinica2013，32，4： | 8 |
| 20 | Bezafibrate enhances proliferation and differentiation of osteoblastic MC3T3-E1 cells via AMPK and eNOS activation显示文摘 | Xing ZHONG Ling-ling XIU Guo-hong WEI Yuan-yuan LIU Lei SU Xiao-pei CAO Yan-bing LI Hai-peng XIAO | 2011 | Acta Pharmacologica Sinica2011，32，5： | 8 |
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