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| 1 | SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade显示文摘Tyrosine phosphatase SHP2 is a promising drug target in cancer immunotherapy due to its bidirectional role in both tumor growth promotion and T-cell inactivation. Its allosteric inhibitor SHP099 is known to inhibit cancer cell growth both in vitro and in vivo. However, whether SHP099-mediated SHP2 inhibition retards tumor growth in vivo via anti-tumor immunity remains elusive. To address this, a CT-26 colon cancer xenograft model was established in mice since this cell line is insensitive to SHP099.Consequently, SHP099 minimally affected CT-26 tumor growth in immuno-deficient nude mice, but significantly decreased the tumor burden in CT-26 tumor-bearing mice with intact immune system.SHP099 augmented anti-tumor immunity, as shown by the elevated proportion of CD8tIFN-γtT cells and the upregulation of cytotoxic T-cell related genes including Granzyme B andPerforin, which decreased the tumor load. In addition, tumor growth in mice with SHP2-deficient T-cells was markedly slowed down because of enhanced anti-tumor responses. Finally, the combination of SHP099 and antiPD-1 antibody showed a higher therapeutic efficacy than either monotherapy in controlling tumor growthin two colon cancer xenograft models, indicating that these agents complement each other. Our study suggests that SHP2 inhibitor SHP099 is a promising candidate drug for cancer immunotherapy. | Mingxia Zhao Wenjie Guo Yuanyuan Wu Chenxi Yang Liang Zhong Guoliang Deng Yuyu Zhu Wen Liu Yanhong Gu Yin Lu Lingdong Kong Xiangbao Meng Qiang Xu Yang Sun | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 18 |
| 2 | Improved innovation-based adaptive Kalman filter for dual-frequency navigation using carrier phase显示文摘A new adaptive Kalman filtering algorithm for dual-frequency navigation using carrier phase is presented.This algorithm gives consideration to both robustness and sensitivity by combining the two main approaches of adaptive Kalman filtering based on innovation-based adaptive estimation(IAE) and fading filtering.Applicable to the navigation using carrier phase measurements typically,this algorithm can balance the weights of observations and predicted states preferably.Applications to both practical static data and kinetic simulations are presented to demonstrate the validity and efficiency of the algorithm. | LU ChenXi,TAN YunHua ,ZHU BoCheng & ZHOU LeZhu School of Electronics Engineering and Computer Science,Peking University,Beijing 100871,China | 2010 | Science China(Information Sciences)2010，53，12： | 5 |
| 3 | Danggui Buxue Tang ameliorates bleomycin-induced pulmonary fibrosis in rats through inhibiting transforming growth factor-β1/Smad3/plasminogen activator inhibitor-1 signaling pathway显示文摘OBJECTIVE: To investigate the effect of Danggui Buxue Tang(DBT), a decoction from Traditional Chinese Medicine, on bleomycin-induced pulmonary fibrosis in rats, and to propose the possible underlying mechanism.METHODS: Forty male Sprague-Dawley rats were randomly divided into sham group, model group,prednisone group and DBT group. Pulmonary fibrosis rat model was established by intratracheal injection with bleomycin. Body weight and lung index were monitored. Histopathologic examination and collagen deposition were determined using Hematoxylin and eosin(HE) and Masson's trichrome staining. Immunohistochemistry staining was applied to observe the expression of alpha-smooth muscle actin(α-SMA). m RNA expression of α-SMA,collagen Ⅰ and collagen Ⅲ were measured by realtime fluorescence quantitative PCR(RT-q PCR). Inflammatory cytokines, including tumor necrosis factor alpha(TNF-α), interleukin-6(IL-6) and IL-1β in serum were detected by Enzyme-linked immunosorbent assay. Alkali hydrolysis method was conducted to investigate the content of hydroxyproline(HYP). Transforming growth factor-β1(TGF-β1),Smad3 and plasminogen activator inhibitor-1(PAI-1) protein level were examined by Western blot assay.RESULTS: DBT significantly reduced the severity of bleomycin-induced pulmonary fibrosis and inflammation as indicated by minimizing the lost of weight, and by lowering the levels of lung index, inflammation score, Ashcroft score, collagen volume fraction(%), HYP, α-SMA, collagen Ⅰ, collagen Ⅲ,TNF-α, IL-6, IL-1β, TGF-β1, Smad3 and PAI-1, consistent with the effect of prednisone.CONCLUSION: Our findings suggest that DBT is able to ameliorate the pulmonary fibrosis, the possible mechanism may involve inhibition of pulmonary inflammation and collagen deposition, possibly via suppressing TGF-β1/Smad3/PAI-1 signaling pathway. | Wang Jiepeng Fang Chaoyi Wang Shaoxian Fang Fang Chu Xinqiao Liu Na Lu Chenxi Wang Shuo Li Wei | 2020 | Journal of Traditional Chinese Medicine2020，40，2： | 5 |
| 4 | Deubiquitinase JOSD2 stabilizes YAP/TAZ to promote cholangiocarcinoma progression显示文摘Cholangiocarcinoma(CCA)has emerged as an intractable cancer with scanty therapeutic regimens.The aberrant activation of Yes-associated protein(YAP)and transcriptional co-activator with PDZ-binding motif(TAZ)are reported to be common in CCA patients.However,the underpinning mechanism remains poorly understood.Deubiquitinase(DUB)is regarded as a main orchestrator in maintaining protein homeostasis.Here,we identified Josephin domain-containing protein 2(JOSD2)as an essential DUB of YAP/TAZ that sustained the protein level through cleavage of polyubiquitin chains in a deubiquitinase activity-dependent manner.The depletion of JOSD2 promoted YAP/TAZ proteasomal degradation and significantly impeded CCA proliferation in vitro and in vivo.Further analysis has highlighted the positive correlation between JOSD2 and YAP abundance in CCA patient samples.Collectively,this study uncovers the regulatory effects of JOSD2 on YAP/TAZ protein stabilities and profiles its contribution in CCA malignant progression,which may provide a potential intervention target for YAP/TAZ-related CCA patients. | Meijia Qian Fangjie Yan Weihua Wang Jiamin Du Tao Yuan Ruilin Wu Chenxi Zhao Jiao Wang Jiabin Lu Bo Zhang Nengming Lin Xin Dong Xiaoyang Dai Xiaowu Dong Bo Yang Hong Zhu Qiaojun He | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 5 |
| 5 | Near-Real-Time Carbon Emission Accounting Technology Toward Carbon Neutrality显示文摘Climate change is the greatest environmental threat to humans and the planet in the 21st century.Global anthropogenic greenhouse gas emissions are one of the main causes of the increasing number of extreme climate events.Cumulative carbon dioxide(CO_(2))emissions showed a linear relationship with cumulative temperature rise since the pre-industrial stage,and this accounts for approximately 80%of the total anthropogenic greenhouse gases.Therefore,accurate and reliable carbon emission data are the foundation and scientific basis for most emission reduction policymaking and target setting.Currently,China has made clear the ambitious goal of achieving the peak of carbon emissions by 2030 and achieving carbon neutrality by 2060.The development of a finer-grained spatiotemporal carbon emission database is urgently needed to achieve more accurate carbon emission monitoring for continuous implementation and the iterative improvement of emission reduction policies.Near-real-time carbon emission monitoring is not only a major national demand but also a scientific question at the frontier of this discipline.This article reviews existing annual-based carbon accounting methods,with a focus on the newly developed real-time carbon emission technology and its current application trends.We also present a framework for the latest near-real-time carbon emission accounting technology that can be widely used.The development of relevant data and methods will provide strong database support to the policymaking for China’s“carbon neutrality”strategy.Finally,this article provides an outlook on the future of real-time carbon emission monitoring technology. | Zhu Liu Taochun Sun Ying Yu Piyu Ke Zhu Deng Chenxi Lu Da Huo Xiang Ding | 2022 | Engineering2022，8，7： | 5 |
| 6 | Software Defect Prediction Using Fuzzy Integral Fusion Based on GA-FM显示文摘The fuzzy measure and fuzzy integral are applied to the classification of software defects in this paper.The fuzzy measure of software attributes and attributes'sets are treated by genetic algorithm,and then software attributes are fused by the Choquet fuzzy integral algorithm.Finally,the class labels of software modules can be output.Experimental results have shown that there are interactions between characteristic attributes of software modules,and also proved that the fuzzy integral fusing method using Fuzzy Measure based on Genetic Algorithm(GA-FM)can significantly improve the accuracy for software defect prediction. | LI Kewen CHEN Chenxi LIU Wenying Fang Xianghua LU Qinghua | 2014 | Wuhan University Journal of Natural Sciences2014，19，5： | 4 |
| 7 | The long-term prognosis and predictors of epilepsy:a retrospective study in 820 patients显示文摘Background:To investigate the prognosis and predictors for seizure control in epileptic patients in China.Methods:Eight hundred and twenty patients with epilepsy who visited Xuanwu Hospital from October 2017 to January 2020,were enrolled.The clinical information of the patients was obtained by retrospectively reviewing medical records.Prognostic measures of seizure control included remission,relapse and occurrence of drug resistance.The relationship of prognosis of seizure control with factors such as demographics,clinical characteristics and initial electroencephalography(EEG)features was investigated.Results:A total of 503(61.3%)patients experienced a 1-year remission and 330(49.3%of 669)had a 2-year remission.Idiopathic type of epilepsy(P<0.001),normal EEG(P<0.05),number of antiepileptic drugs(P<0.05)and seizure frequency of<1/month(P<0.001)at the first arrival predicted a remission independently.Of the 503 patients who achieved a 1-year remission,184(36.6%)experienced a relapse,due to external reversible causes(58 patients)or with unknown reversible triggers(126 patients).No factors were found to be associated with a relapse(P>0.05).At the end of the study,322 patients(39.3%)developed drug resistance.The development of drug resistance was associated with the following factors:symptomatic aetiology of epilepsy,epileptiform abnormality in EEG,number of antiepileptic drugs and seizure frequency of≥1/month at first arrival(P<0.001).For symptomatic epilepsy,patients with meningitis/encephalitis(P=0.007)were more likely to develop drug-resistant epilepsy than these with other causes.Conclusions:Remission is a common process.The type of epilepsy(idiopathic or symptomatic),EEG features,seizure frequency and treatment history at first arrival are related to both remission and terminal drug resistance.Among various causes of symptomatic epilepsy,meningitis/encephalitis is associated with the worst prognosis of epilepsy. | Haoran Yang Jun Zhang Chenxi Yang Dan Wu Xiaoyun Liu Hongjuan Lu Wei Zhou Wei Sun | 2021 | Acta Epileptologica2021，3，1： | 2 |
| 8 | Security in vehicular ad hoc networks 显示文摘 | LIN Xiaodong LU Rongxing ZHANG Chenxi | 2008 | IEEE Communications Magazine2008，46，4： | 1 |
| 9 | Security in vehicular ad hoc networks显示文摘 | LIN Xiaodong LU Rongxing ZHANG Chenxi | | 0，，04： | 1 |
| 10 | 显示文摘 | ZHAO Baohui LI Chenxi LU Yan | 2005 | Polymer2005，46，： | 1 |
| 11 | Xylose fermentation to biofuels (hydrogen and ethanol) by extreme thermophilic (70oC) mixed cuhure 显示文摘 | CHENXI ZHAO DINITAR KARAKASHEV WENJING LU | 2010 | International Journal of Hydrogen Energy2010，35，8： | 1 |
| 12 | Simulation of aggregation effects on co-fired biomass-coal ash in an electrostatic precipitator显示文摘Aggregation of fine ash into larger particles benefits fly ash removal in an electrostatic precipitator.Thermal aggregation,turbulent aggregation,and electrical aggregation of fine ash (derived from co-firing of biomass fuel and anthracite coal) was simulated under different conditions in an electrostatic precipitator.A population balance model and user-defined function in Fluent were assumed to obtain aggregation kernel functions and calculate the aggregation effects on the co-combusted particles.The results show that electrical aggregation had an obvious effect on both micron-and submicron-sized particles.For submicron particles,the effect of thermal aggregation is about ten times greater than turbulent aggregation.Meanwhile,for micron-sized particles,turbulent aggregation is about seven times greater than thermal aggregation.Therefore,particle aggregation in the electrostatic precipitator mainly occurs because of electrical aggregation,supplemented by thermal aggregation and turbulent aggregation.When the flow velocity is 1.0 m/s,particle volume fraction is 1.4%,and biomass co-firing ratio is 10%,the effects of all three aggregation processes on ash particles are optimized. | Jianyi Lu Zhe Yang Bingyi Xu Zhiyong Zhou Chenxi Sun | 2020 | Particuology2020，18，3： | 1 |
| 13 | Security in vehicular ad hoc networks 显示文摘 | Lin Xiaodong Lu Rongxing Zhang Chenxi | 2008 | IEEE Communications Magazine2008，46，4： | 1 |
| 14 | Study on the mechanism of chiral recognition with molecularly imprinted polymers 显示文摘 | LU Yan LI Chenxi ZHANG Hesheng | 2003 | Anal Chim Acta2003，489，： | 1 |
| 15 | Facile fabrication of branched-chain carbohydrate chips for studying carbohydrate-protein interactions by QCM biosensor显示文摘A novel approach for fabricating branched-chain(BC) carbohydrate chips to study carbohydrate-protein interactions using Quartz Crystal Microbalance(QCM) biosensor was developed. This approach utilizes functional alkynyl-branch molecule modified chip surfaces, which through the terminal alkynyl group for covalent linking of unprotected azide-carbohydrates. The unprotected azide-carbohydrates were syhthesized in one-step using 2-azido-1,3-dimethyl-imidazolinium as catalyst, avoiding complex chemical modifications. Additionally, the branch surface modified with the carbohydrates not only supplies more specific binding site but also reveals significant cluster effect. To exemplify the sugar cluster effect on BC carbohydrate chips, BC Galactose and Mannose chips prepared in this work were used to determine carbohydrate-lectin interactions using QCM biosensor. The results clearly showed that BC chip significantly improves the detection sensitivity compared with the straight-chain(SC) chip. More importantly, the BC galactose chip sensitivity was enhanced 40% compared with the SC galactose chip. | Yuchao Lu Siyu Song Chenxi Hou Shuang Pang Xueming Li Xiaowen Wu Chen Shao Yuxin Pei Zhichao Pei | 2018 | Chinese Chemical Letters2018，29，1： | 1 |
| 16 | Adoptive transfer of metabolically reprogrammed macrophages for atherosclerosis treatment in diabetic ApoE^(-/-) mice显示文摘Atherosclerosis is characterized by inflammation in the arterial wall,which is known to be exacerbated by diabetes.Therapeutic repression of inflammation is a promising strategy for treating atherosclerosis.In this study,we showed that diabetes aggravated atherosclerosis in apolipoproteinE knockout(ApoE^(-/-))mice,in which increased expression of long-chain acyl-CoA synthetase 1(Acsl1)in macrophages played an important role.Knockdown of Acsl1 in macrophages(Mφ^(shAcsl1))reprogrammed macrophages to an anti-inflammatory phenotype,especially under hyperglycemic conditions.Injection of Mφ^(shAcsl1) reprogrammed macrophages into streptozotocin(STZ)-induced diabetic ApoE^(-/-) mice(ApoE^(-/-)+STZ)alleviated inflammation locally in the plaque,liver and spleen.Consistent with the reduction in inflammation,plaques became smaller and more stable after the adoptive transfer of reprogrammed macrophages.Taken together,our findings indicate that increased Acsl1 expression in macrophages play a key role in aggravated atherosclerosis of diabetic mice,possibly by promoting inflammation.Adoptive transfer of Acsl1 silenced macrophages may serve as a potential therapeutic strategy for atherosclerosis. | Tingting Wang Yan Dong Li Yao Fan Lu Chenxi Wen Zhuo Wan Li Fan Zhelong Li Te Bu Mengying Wei Xuekang Yang Yi Zhang | 2022 | Bioactive Materials2022，7，10： | 1 |
| 17 | Identification of OsbZIP72 as a positive regulator of ABA response and drought tolerance in rice显示文摘 | Guojun Lu Chenxi Gao Xingnan Zheng Bin Han | 2009 | Planta2009，，3： | 1 |
| 18 | Discrete fourier transformation for seasonal-factor pattern classification and assignment显示文摘 | Luou Shen Chenxi Lu Fang Zhao | 2013 | IEEE Trans on Intelligent Transportation Systems2013，14，2： | 1 |
| 19 | Improved a daptive Karman estimation in dual frequency navigation using carrier phasc显示文摘 | Tan Yunhua Lu Chenxi Zhu P ocheng | 2010 | Compuler Mechatronics control and Electronic Engineering2010，2426，5： | 1 |
| 20 | Targeted inhibition of osteoclastogenesis reveals the pathogenesis and therapeutics of bone loss under sympathetic neurostress显示文摘Sympathetic cues via the adrenergic signaling critically regulate bone homeostasis and contribute to neurostress-induced bone loss,but the mechanisms and therapeutics remain incompletely elucidated.Here,we reveal an osteoclastogenesis-centered functionally important osteopenic pathogenesis under sympatho-adrenergic activation with characterized micro RNA response and efficient therapeutics.We discovered that osteoclastic mi R-21 was tightly regulated by sympatho-adrenergic cues downstream theβ2-adrenergic receptor(β2AR)signaling,critically modulated osteoclastogenesis in vivo by inhibiting programmed cell death 4(Pdcd4),and mediated detrimental effects of both isoproterenol(ISO)and chronic variable stress(CVS)on bone.Intriguingly,without affecting osteoblastic bone formation,bone protection against ISO and CVS was sufficiently achieved by a(D-Asp8)-lipid nanoparticle-mediated targeted inhibition of osteoclastic mi R-21 or by clinically relevant drugs to suppress osteoclastogenesis.Collectively,these results unravel a previously underdetermined molecular and functional paradigm that osteoclastogenesis crucially contributes to sympatho-adrenergic regulation of bone and establish multiple targeted therapeutic strategies to counteract osteopenias under stresses. | Bingdong Sui Jin Liu Chenxi Zheng Lei Dang Ji Chen Yuan Cao Kaichao Zhang Lu Liu Minyan Dang Liqiang Zhang Nan Chen Tao He Kun Xuan Fang Jin Ge Zhang Yan Jin Chenghu Hu | 2022 | International Journal of Oral Science2022，14，4： | 1 |
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