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| 1 | Meteorin-β/Meteorin like/IL-41 attenuates airway inflammation in house dust mite-induced allergic asthma显示文摘We sought to examine the regulatory effect of Meteorin-β(Metrnβ)/Meteorin like(Metrnl)/IL-41 on lung inflammation in allergic asthma.We found that Metrnβwas elevated significantly in asthmatic patients and in mice with allergic asthma induced by house dust mite(HDM)extract.Upon exposure to HDM,Metrnβwas secreted predominantly by airway epithelial cells and inflammatory cells,including macrophages and eosinophils.The increased Metrnβeffectively blocked the development of airway hyperreactivity(AHR)and decreased inflammatory cell airway infiltration and type 2 cytokine production,which was associated with downregulated DC-mediated adaptive immune responses.Moreover,Metrnβimpaired the maturation and function of bone marrow-derived dendritic cells in vitro.Asthmatic mice adoptively transferred with dendritic cells isolated from Metrnβ-treated allergic mice displayed decreased AHR,airway inflammation,and lung injury.Metrnβalso displayed anti-inflammatory properties in immunodeficient SCID mice with allergic asthma and in in vitro 3D ALI airway models.Moreover,blockade of Metrnβby anti-Metrnβantibody treatment promoted the development of allergic asthma.These results revealed the unappreciated protective roles of Metrnβin alleviating DC-mediated Th2 inflammation in allergic asthma,providing the novel treatment strategy of therapeutic targeting of Metrnβin allergic asthma. | Xun Gao Ting-Fan Leung Gary Wing-Kin Wong Wing-Hung Ko Mengyun Cai Ellie Jiayi He Ida Miu-Ting Chu Miranda Sin-Man Tsang Ben Chung-Lap Chan Jiawei Ling Xiao Fan Liwei Lu Christopher Wai-Kei Lam Chun-Kwok Wong | 2022 | Cellular & Molecular Immunology2022，19，2： | 5 |
| 2 | A Detailed Study on the Equal Arrival Time Surface Effect in Gamma-Ray Burst Afterglows显示文摘Due to the relativistic motion of gamma-ray burst remnant and its deceleration in the circumburst medium, the equal arrival time surfaces at any moment are not spherical, rather, they are distorted ellipsoids. This will leave some imprints in the afterglows. We study the effect of equal arrival time surfaces numerically for various circumstances, i.e., isotropic fireballs, collimated jets, density jumps and energy injection events. For each case, a direct comparison is made between including and not including the effect. For isotropic fireballs and jets viewed on axis, the effect slightly hardens the spectra and postpones the peak time of the afterglows, but does not change the shapes of the spectra and light curves significantly. In the cases of a density jump or an energy injection, the effect smears out the variations in the afterglows markedly. | Yong-Feng Huang Ye Lu Anna Yuen Lam Wong Kwong Sang Cheng | 2007 | Chinese Journal of Astronomy and Astrophysics2007，7，3： | 4 |
| 3 | Characterizations of Sobolev spaces in Euclidean spaces and Heisenberg groups显示文摘Recently,many new features of Sobolev spaces Wk,pRNwere studied in[4–6,32].This paper is devoted to giving a brief review of some known characterizations of Sobolev spaces in Euclidean spaces and describing our recent study of new characterizations of Sobolev spaces on both Heisenberg groups and Euclidean spaces obtained in[12]and[13]and outlining their proofs.Our results extend those characterizations of frst order Sobolev spaces in[32]to the Heisenberg group setting.Moreover,our theorems also provide diferent characterizations for the second order Sobolev spaces in Euclidean spaces from those in[4,5]. | CUI Xiao-yue LAM Nguyen LU Guo-zhen | 2013 | Applied Mathematics(A Journal of Chinese Universities)2013，28，4： | 3 |
| 4 | Novel role of STAT3 in microglia-dependent neuroinflammation after experimental subarachnoid haemorrhage显示文摘Background and purpose Signal transducer and activator of transcription 3(STAT3)may contribute to the proinflammation in the central nervous system diseases by modulating the microglial responses.Thus,this study was intended to investigate the effect of STAT3 on microglia-dependent neuroinflammation and functional outcome after experimental subarachnoid haemorrhage(SAH).Methods The SAH model was established by endovascular perforation in the mouse.Real-time PCR(RtPCR)and western blot were used to examine the dynamic STAT3 signalling pathway responses after SAH.To clarify the role of the STAT3 signalling pathway in the microglia-dependent neuroinflammation after SAH,the microglia-specific STAT3 knockout(KO)mice were generated by the Cre-LoxP system.The neurological functions were assessed by Catwalk and Morris water maze tests.Neuronal loss after SAH was determined by immunohistochemistry staining.Microglial polarisation status after STAT3 KO was then examined by RtPCR and immunofluorescence.Results The STAT3 and Janus kinase-signal transducer 2 activated immediately with the upregulation and phosphorylation after SAH.Downstream factors and related mediators altered dynamically and accordingly.Microglial STAT3 deletion ameliorated the neurological impairment and alleviated the early neuronal loss after SAH.To investigate the underlying mechanism,we examined the microglial reaction after STAT3 KO.STAT3 deletion reversed the increase of microglia after SAH.Loss of STAT3 triggered the early morphological changes of microglia and primed microglia from M1 to M2 polarisation.Functionally,microglial STAT3 deletion suppressed the SAH-induced proinflammation and promoted the anti-inflammation in the early phase.Conclusions STAT3 is closely related to the microglial polarisation transition and modulation of microglia-dependent neuroinflammation.Microglial STAT3 deletion improved neurological function and neuronal survival probably through promoting M2 polarisation and anti-inflammatory responses after SAH.STAT3 may serve as a promising therapeutic target to alleviate early brain injury after SAH. | Zhiyuan Vera Zheng Junfan Chen Hao Lyu Sin Yu Erica Lam Gang Lu Wai Yee Chan George K C Wong | 2022 | Stroke & Vascular Neurology2022，7，1： | 3 |
| 5 | Comprehensive lipidomics in apoM^(-/-) mice reveals an overall state of metabolic distress and attenuated hepatic lipid secretion into the circulation显示文摘Apolipoprotein M(apoM) participates in both high-density lipoprotein and cholesterol metabolism. Little is known about how apo M affects lipid composition of the liver and serum. In this study, we systemically investigated the effects of apo M on liver and plasma lipidomes and how apo M participates in lipid cycling, via apo M knockout in mice and the human SMMC-7721 cell line. We used integrated mass spectrometry-based lipidomics approaches to semiquantify more than 600 lipid species from various lipid classes, which include free fatty acids, glycerolipids, phospholipids, sphingolipids, glycosphingolipids, cholesterol, and cholesteryl esters(CEs), in apo M^(-/-)mouse. Hepatic accumulation of neutral lipids, including CEs, triacylglycerols, and diacylglycerols, was observed in apo M^(-/-)mice;while serum lipidomic analyses showed that, in contrast to the liver, the overall levels of CEs and saturated/monounsaturated fatty acids were markedly diminished. Furthermore, the level of Apo B-100 was dramatically increased in the liver, whereas significant reductions in both Apo B-100 and low-density lipoprotein(LDL) cholesterol were observed in the serum of apo M^(-/-)mice, which indicated attenuated hepatic LDL secretion into the circulation. Lipid profiles and proinflammatory cytokine levels indicated that apo M^(-/-)leads to hepatic steatosis and an overall state of metabolic distress. Taken together, these results revealed that apo M knockout leads to hepatic steatosis, impaired lipid secretion, and an overall state of metabolic distress. | Yuanping Shi Sin Man Lam Hong Liu Guanghua Luo Jun Zhang Shuang Yao Jie Li Lu Zheng Ning Xu Xiaoying Zhang Guanghou Shui | 2020 | Journal of Genetics and Genomics2020，47，9： | 2 |
| 6 | Leptin Signaling Protects NK Cells from Apoptosis During Development in Mouse Bone Marrow显示文摘增加的证据在有免疫力的反应显示 leptin 的一个角色,但是发信号的 leptin 是否涉及在骨头髓(BM ) 调整 NK 房间开发,仍然保持大部分不清楚。在这研究,我们在在 prediabetic 的缺乏的 db/db 老鼠上演的 leptin 受体的 BM 描绘了 NK 房间区别和成熟。尽管 BM 细胞质类似于控制值, NK 房间的全部的数字严重地在变异的鼠标被减少。db/db BM 房间的流动 cytometric 分析揭示了在区别的各种各样的阶段开发 NK 房间的显著地减少的频率。显著地显示的 BM db/db NK 房间增加了 apoptosis,但是维持了正常房间骑车地位和 proliferative 能力。而且, recombinant leptin 能显著地在文化从野类型的老鼠提高 NK 房间的幸存。NK 房间上的进一步的检查功能的活动证明 db/db NK 房间与显著地增加的 IL-10 展出了正常内在的 cytotoxicity 生产。一起拿,我们的调查结果建议发信号的 leptin 经由在老鼠 BM 提高不成熟的 NK 房间的幸存调整 NK 房间开发。 | Cherry Kam Chun Lo Queenie Lai Kwan Lam Min Yang King-Hung Ko Lingyun Sun Rui Ma Shengjun Wang Huaxi Xu Sidney Tam Chang-You Wu Bo-Jiang Zheng Liwei Lu | 2009 | Cellular & Molecular Immunology2009，6，5： | 2 |
| 7 | CFTR mediates bicarbonate-dependent activation of miR-125b in preimplantation embryo development显示文摘尽管 HCO 3− 被知道为早胚胎开发被要求,它的准确角色留下逃犯。这里,我们报导 HCO 3− 在在 preimplantation 胚胎开发期间通过调停 CFTR 的流入调整 miR-125b 表示充当环境暗示。结果证明在 preimplantation 胚胎开发的 HCO 3− 的效果能被介入压制一条 HCO 3−-conducting 隧道的函数, CFTR,由一个特定的禁止者或基因大美人。细胞外的 HCO 3− 的移动或 CFTR 的抑制在 2 个房间阶段老鼠胚胎减少 miR-125b 表示。miR-125b 击倒模仿 HCO 3− 移动和 CFTR 抑制的效果,当 miR-125b 先锋的注射颠倒它时。在人和老鼠胚胎的 miR-125b upregulates p53 串联的 Downregulation。miR-125b 的激活被显示被 sAC/PKA-dependent 调停 NF-κ 的原子 shuttling; B。这些结果在在 preimplantation 胚胎开发期间连接环境 HCO 3− 到 miR-125b 的激活的信号 transduction 揭示了 CFTR 的一个关键角色并且在 miRNAs 的规定显示了离子隧道的重要性。 | Yong Chao Lu Hui Chen Kin Lam Fok Lai Ling Tsang Mei Kuen Yu Xiao Hu Zhang Jing Chen Xiaohua Jiang Yiu Wa Chung Alvin Chun Hang Ma Anskar Yu Hung Leung He Feng Huang Hsiao Chang Chan | 2012 | Cell Research2012，22，10： | 2 |
| 8 | Leptin induces CD40 expression through the activation of AKT in mumne dendritic cells显示文摘 | Queenie Lai Kwan Lam Liwei Lu Bo-Jian Zheng Dong-Yan Jin Xuetao Cao | 2007 | The Journal of Biological Chemistry2007，，： | 1 |
| 9 | Metachronous carcinomas in colorectum and its clinicopathological significance显示文摘 | Alfred Lam Vinod Gopalan Robert Carmichael Petra Buettner Melissa Leung Robert Smith Cu-Tai Lu Yik-Hong Ho Simon Siu | 2012 | International Journal of Colorectal Disease2012，，10： | 1 |
| 10 | A review on the mechanical methods for evaluating coating adhesion显示文摘 | Zhaoxiang Chen Kun Zhou Xuehong Lu Yee Cheong Lam | 2014 | Acta Mechanica2014，，2： | 1 |
| 11 | Thermal andmechanical propertiesof singl -ewallded carbon nan-otube bun -die reinforc -edepoxy nanocomposites: therole of solv-ent for nanotube dispersion显示文摘 | Kin-tak Lau Mei Lu Chunki Lam et al | 2005 | Composites-Science and Technology2005，65，： | 1 |
| 12 | Optic disc coloboma (the morning glory syndrome) and optic nerve coloboma associated with transsphenoidal meningoencephalocele显示文摘 | Sa~lam M Erdem ~ Kocao~lu M | 2003 | Eurl Radiol Extra2003，45，2： | 1 |
| 13 | Role of leptin in immunity显示文摘 | Lam QL Lu L | 2007 | Cell Mol Immunol2007，4，1： | 1 |
| 14 | Thesequence and de novo assembly of the giant panda genome显示文摘 | LI R FAN W TIAN G ZHU H HE L CAI J HUANG Q CAIQ LI B BAI Y ZHANG Z ZHANG Y WANG W LI J WEI F LI H JIAN M LI J ZHANG Z NIELSEN R LI D GU W YANG Z XUAN Z RYDER OA LEUNG FC ZHOU Y CAO J SUN X FU Y FANG X GUO X WANG B HOU R SHEN F MU B NI P LIN R QIAN W WANG G YU C NIE W WANGJ WU Z LIANG H MIN J WU Q CHENG S RUAN J WANGM SHI Z WEN M LIU B REN X ZHENG H DONG D COOKK SHAN G ZHANG H KOSIOL C XIE X LU Z ZHENG H LI Y STEINER CC LAM TT LIN S ZHANG Q LI G TIAN J GONG T LIU H ZHANG D FANG L YE C ZHANG J HU W XU A REN Y ZHANG G BRUFORD MW LI Q MA L GUOY AN N HU Y ZHENG Y SHI Y LI Z LIU Q CHEN Y ZHAO J QU N ZHAO S TIAN F WANG X WANG H XU L LIU X VINAR T WANG Y LAM TW YIU SM LIU S ZHANGH LI D HUANG Y WANG X YANG G JIANG Z WANG J QIN N LI L LI J BOLUND L KRISTIANSEN K WONG GK OLSON M ZHANG X LI S YANG H WANG J WANG J | 2010 | Na-ture2010，463，： | 1 |
| 15 | beta-Amyloid efflux mediated by p-gly- coprotein 显示文摘 | Lam FC Liu R Lu P | 2001 | J Neurochem2001，76，4： | 1 |
| 16 | Leptin and Inflamma tion 显示文摘 | Iikuni NL Lam QL Lu L | 2008 | CurrImmunol Rev2008，4，2： | 1 |
| 17 | A facile design for multifunctional AIEgen based on tetraaniline derivatives显示文摘Aniline oligomers have been widely used in many fields due to their excellent physicochemical properties. Owing to strong intermolecular interactions, their emission is always weakened or quenched when they are in high concentration or aggregated state, which greatly limits their fluorescent applications. Inspired by the concept of aggregation-induced emission(AIE), herein we introduced large steric groups onto the aniline oligomer to prevent the formation of packing structure. In particular, diphenyl vinyl group was bonded with oligomeric tetraaniline by a facile synthetic procedure with high yield. The obtained aniline oligomer derivative exhibited typical AIE features, which was also confirmed by density functional theoretical calculation. More importantly, this AIE oligomer was able to detect Fe^(3+) ions selectively and quantitatively. The fluorescence intensity decreased linearly along with the increment of Fe^(3+) concentration. Moreover, we demonstrated that this AIE oligomer could stain live bacteria, such as E. coli and S. aureus efficiently. All these results suggest that such a readily accessible and multifunctional tetraaniline derivative provides a new platform for the construction of fluorescent materials. | Beibei Liu Wei He Hao Lu Kun Wang Mingming Huang Ryan Tsz Kin Kwok Jacky Wing Yip Lam Longcheng Gao Jiping Yang Benzhong Tang | 2019 | Science China Chemistry2019，62，6： | 1 |
| 18 | Influence of fire on root biomass dynamics and soil respiration rats in young corsican pine (Pinus nigra ) stands in Turkey显示文摘 | Ttifekio lu A Kiik M Sa lam B | 2006 | Forest Ecology and Management2006，15，： | 1 |
| 19 | Construction of efficient solid emitters with conventional and AIE luminogens for blue or- ganic light-emitting diodes显示文摘 | Zhao Z J Chen S M Deng C M Lam J W Y Chan C Y K Lu P Wang Z M Hu B B Chen X P Lu P Kwok H S Ma Y G Qiu H Y Tang B Z | 2011 | Journal of Materials Che- mistry2011，21，10： | 1 |
| 20 | Role of endothelin in diabetic retinopathy 显示文摘 | Lam HC Lee JK Lu CC | 2003 | Curr Vase Pharmaeol2003，1，3： | 1 |
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