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| 1 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 2 | A human ESC model for MLL-AF4 leukemic fusion gene reveals an impaired early hematopoietic-endothelial specification显示文摘MLL-AF4 熔化基因是在在婴儿的高风险的尖锐成淋巴细胞的白血病的一个特点 genomic 错误。尽管 MLL-AF4 在人的开发期间出生前地产生,这很好被建立,它在在 utero 的造血的开发的效果仍然保持未经勘探。我们创造了一个人特定的细胞的系统在 MLL-AF4-expressing 人的胚胎的干细胞(hESCs ) 学习早 hemato-endothelial 开发。介绍的功能的研究,同种细胞的分析和基因表示表明在 hESCs 的 MLL-AF4 的那表情有 phenotypic,功能并且基因表示影响。MLL-AF4 在 hESCs 充当全球 transcriptional 使活跃之物和 homeobox 基因表示的一个积极管理者。机能上地, MLL-AF4 从 hESCs 提高 hemogenic 先锋的说明,但是强烈损害进一步造血的承诺赞成 endothelial 房间命运。MLL-AF4 hESCs transcriptionally 被告知向对 endothelial 成熟敏感的 hemogenic 先锋区分,由联系到 vascular-endothelial 功能和早造血作用的主人基因的显著 upregulation 思考了。而且,我们报导那 MLL-AF4 表情不是足够的转变导出 hESC 的造血的房间。这个工作说明 hESCs 怎么可以提供唯一的卓见进人的开发并且推进我们理解白血病的熔化基因,知道出生前地产生,调整人的胚胎的造血的说明。 | Clara Bueno Rosa Montes Gustavo J Melen Verdnica Ramos-Mejia Pedro J Real Ver6nica Ayllo'n Laura Sanchez Gertmdis Ligero Inmaculada Gutierrez-Aranda Agustin F Femfindez Mario F Fraga Inmaculada Moreno-Gimeno Deborah Btlrks Maria del Carmen Plaza-Calonge Juan C Rodriguez-Manzaneque Pablo Menendez | 2012 | Cell Research2012，22，6： | 2 |
| 3 | R&R blends as refrigerants显示文摘 | Sergio B Roberto C Laura F | 2004 | International Refrigeration and Air Conditioning Conference2004，，： | 1 |
| 4 | Experimental Stady of CFRP-Prestressed high-Strength Concrete Bridge Beams显示文摘 | Saliba J LAURA E C | | Composite Structures0，49，2： | 1 |
| 5 | Recombineering mycobacteria and their phages显示文摘 | Julia C V K Laura J M Graham F H | 2008 | Nat Rev Microbiol2008，6，11： | 1 |
| 6 | Spatially-resolved EELS analysis of antibody distribution on biofunctionalized magnetic nanoparticles显示文摘 | Raul A Laura D M Laura C Alvaro M Marcel T Valeria G Jesus M D L F Clara M Ricardo 1 | 2013 | ACS Nano2013，7，5： | 1 |
| 7 | Degradation of pharmaceuticals in non-Sterile urban wastewater by Trametes versicolor in a fluidized bed bioreactor显示文摘 | Caries C M Laura F C Sara R M | 2013 | Water Research2013，47，14： | 1 |
| 8 | Determination of volatile phenols in red wines by dispersive liquid-liquid microextraction and gas chromatography-mass spectrometry detection显示文摘 | Laura F Eduardo B Francisco C | 2007 | J Chromatogr A2007，1157，： | 1 |
| 9 | Neural stem cells and cholinergic neurons:Regulation by immunolesion and treatment with mitogens,retinoic acid,and nerve growth factor显示文摘 | Laura C Alessandro G Mercedes F | 2003 | Pnas2003，100，12： | 1 |
| 10 | Antimicrobial Activity of Various Cationic Molecules on Foodbome 显示文摘 | Mariachiara C Francesco A Laura F | 2007 | World Journal of Microbiology and Biotechnology2007，23，： | 1 |
| 11 | Journal o{ Inorganic Biochemistry 显示文摘 | Wolfhardt F Loria M Alessandra C Chiara B Keith F T Wolf gang L Laura El C | 2008 | 102 13292008，102，： | 1 |
| 12 | Determination of urinary ortho and meta-cresol in humans by headspace SPME gas chromatographymass spectrometry 显示文摘 | Silvia F Rosa M Laura C | 2005 | Chromatography2005，，2： | 1 |
| 13 | Gluten immunogenic peptide excretion detects dietary transgressions in treated celiac disease patients显示文摘BACKGROUND Life-long removal of gluten from the diet is currently the only way to manage celiac disease(CeD). Until now, no objective test has proven useful to objectively detect ingested gluten in clinical practice. Recently, tests that determine consumption of gluten by assessing excretion of gluten immunogenic peptides(GIP) in stool and urine have been developed. Their utility, in comparison with conventional dietary and analytical follow-up strategies, has not been fully established.AIM To assess the performance of enzyme-linked immunosorbent assay(ELISA) and point-of-care tests(PoCTs) for GIP excretion in CeD patients on gluten-free diet(GFD).METHODS We conducted an observational, prospective, cross-sectional study in patients following a GFD for at least two years. Using the Gastrointestinal Symptom Rating Scale questionnaire, patients were classified at enrollment as asymptomatic or symptomatic. Gluten consumption was assessed twice by 3-d dietary recall and GIP excretion(by ELISA in stool and PoCTs(commercial kits for stool and urine) in two consecutive samples. These samples and dietary reports were obtained 10 day apart one from the other. Patients were encouraged to follow their usual GFD during the study period.RESULTS Forty-four patients were enrolled, of which 19(43.2%) were symptomatic despite being on a GFD. Overall, 83 sets of stool and/or urine samples were collected.Eleven out of 44 patients(25.0%) had at least one positive GIP test. The occurrence of at least one positive test was 32% in asymptomatic patients compared with 15.8% in symptomatic patients. GIP was concordant with dietary reports in 65.9% of cases(Cohen′s kappa: 0.317). PoCT detected dietary indiscretions. Both ELISA and PoCT in stool were concordant(concomitantly positive or negative) in 67 out of 74(90.5%) samples. Excretion of GIP was detected in 7(8.4%) stool and/or urine samples from patients considered to be strictly compliant with the GFD by dietary reports.CONCLUSION GIP detects dietary transgressions in patients on long-term GFD, irrespective of the presence of symptoms. PoCT for GIP detection constitutes a simple homebased method for self-assessment of dietary indiscretions. | Ana Florencia Costa Emilia Sugai María de la Paz Temprano Sonia Isabel Niveloni Horacio Vázquez María Laura Moreno M.Remedios Domínguez-Flores Alba Mu?oz-Suano Edgardo Smecuol Juan Pablo Stefanolo Andrea F González Angel Cebolla-Ramirez Eduardo Mauri?o Elena F Verdú Julio César Bai | 2019 | World Journal of Gastroenterology2019，25，11： | 1 |
| 14 | Neural stem cells and cholinergic neurons:Regulation by immunolesion and treatment with mitogens,retinoic acid,and nerve growth factor显示文摘 | Laura C Alessandro G Mercedes F | 2003 | Pnas2003，100，12： | 1 |
| 15 | Siphonophores off a riverine system in the southern Gulf of Mexico:factors affecting their distribution and spatial niche breadth and overlap 显示文摘 | Laura S A Claudia A Ccbsar F C | 2009 | Aquatic Ecology2009，43，2： | 1 |
| 16 | Identification of sources of Escherichia coli in South Carolina estuaries using antibiotic resistance analysis显示文摘 | Laura F Webster Brian C | 2004 | Journal of Experimental Marine Biology and Ecology2004，298，： | 1 |
| 17 | Glycosylation of individual whey proteins by maillard reaction using dextran of different molecular mass显示文摘 | LAURA J N C VILLAMIEL M ROSINA L P F | 2007 | Food Hydrocolloids2007，21，： | 1 |
| 18 | An intervention to improve secondary prevention of coronary heart disease显示文摘 | Thomas C Bailey F Laura A | 2007 | Areh Intern Med2007，167，6： | 1 |
| 19 | CD1a-binding glycosphingolipids stimulating human autoreactive T-cells:synthesis of a family of sulfatides differing in the acyl chain moiety显示文摘 | FEDERICA C LAURA F GENNARO D L | 2002 | Tetrahedron2002，58，： | 1 |
| 20 | Human amniotic fluid-derived stem cells are rejected after transplantation in the myocardium of normal, ischemic, immuno-suppressed or immuno-deficient rat 显示文摘 | Angela C Sveva B Michela P Saverio S Andrea C Lisa G Jenny T Martina P Elisabetta L Gino G Igor V Emanuele C Annalisa A Laura I Giovanni F Z Anthony A Paolo D C and Saverio S | 2007 | Journal of Molecular and Cellular Cardiology2007，42，4： | 1 |
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