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| 1 | Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction显示文摘Zika 病毒(ZIKV ) 的最近的爆发为治疗学加亮迫切需要。朊酶建筑群 NS2B-NS3 在 flaviviral polyprotein 处理期间起必要作用,并且因此代表一个吸引人的药目标。这里,我们开发了裂口酶识别直接指向 flavivirus NS2B-NS3 相互作用的 orthosteric 禁止者的基于互补的高产量的屏蔽试金。由屏蔽一个总数 2 816 同意了并且 investigational 药,我们识别了三个有势力候选人, temoporfin, niclosamide,和 nitazoxanide,,有 nanomolar 力量的 flavivirus NS2B-NS3 相互作用禁止者。显著地,在老鼠的在人的胎盘、神经的祖先房间的大多数有势力化合物, temoporfin,不是仅仅禁止的 ZIKV 复制,而且阻止的导致 ZIKV 的 viremia 和死亡当模特儿。结构的停靠建议 temoporfin 潜在地绑保持批评 NS2B 残余的 NS3 衣袋,因此禁止以一种非竞争的方式处理的 flaviviral polyprotein。当这些药已经在 USA 或另外的国家在另外的指示任何一个为临床的使用被同意了,他们由 ZIKV 和另外的 flaviviruses 为感染的管理代表有希望、容易开发的治疗。 | Zhong Li Matthew Brecher Yong-Qiang Deng Jing Zhang Srilatha Sakamuru Binbin Liu Ruili Huang Cheri A Koetzner Christina A Allen Susan A Jones Haiying Chen Na-Na Zhang Min Tian Fengshan Gao Qishan Lin Nilesh Banavali Jia Zhou Nathan Boles Menghang Xia Laura D Kramer Cheng-Feng Qin Hongmin Li | 2017 | Cell Research2017，27，8： | 11 |
| 2 | Comparative transcriptomics of Central Asian Vitis vinifera accessions reveals distinct defense strategies against powdery mildew显示文摘Grape powdery mildew(PM),caused by the biotrophic ascomycete Erysiphe necator,is a devastating fungal disease that affects most Vitis vinifera cultivars.We have previously identified a panel of V.vinifera accessions from Central Asia with partial resistance to PM that possess a Ren1-like local haplotype.In this study,we show that in addition to the typical Ren1-associated late post-penetration resistance,these accessions display a range of different levels of disease development suggesting that alternative alleles or additional genes contribute to determining the outcome of the interaction with the pathogen.To identify potential Ren1-dependent transcriptional responses and functions associated with the different levels of resistance,we sequenced and analyzed the transcriptomes of these Central Asian accessions at two time points of PM infection.Transcriptomes were compared to identify constitutive differences and PM-inducible responses that may underlie their disease resistant phenotype.Responses to E.necator in all resistant accessions were characterized by an early up-regulation of 13 genes,most encoding putative defense functions,and a late down-regulation of 32 genes,enriched in transcriptional regulators and protein kinases.Potential Ren1-dependent responses included a hotspot of co-regulated genes on chromosome 18.We also identified 81 genes whose expression levels and dynamics correlated with the phenotypic differences between the most resistant accessions‘Karadzhandahal’,DVIT3351.27,and O34-16 and the other genotypes.This study provides a first exploration of the functions associated with varying levels of partial resistance to PM in V.vinifera accessions that can be exploited as sources of genetic resistance in grape breeding programs. | Katherine C H Amrine Barbara Blanco-Ulate Summaira Riaz Dániel Pap Laura Jones Rosa Figueroa-Balderas M Andrew Walker Dario Cantu | 2015 | Horticulture Research2015，2，1： | 3 |
| 3 | Sepsis in general surgery: a deadly complication显示文摘 | Laura J. Moore Frederick A. Moore Stephen L. Jones Jiaqiong Xu Barbara L. Bass | 2009 | The American Journal of Surgery2009，，6： | 2 |
| 4 | Suppression and recovery of estrous behavior in Syrian hamsters after changes in metabolic fuel availability显示文摘 | Juli E Jones Laura S Lubbers | 2001 | Am J Physiol Regulatory Integrative Comp Physiol2001，280，： | 1 |
| 5 | Endogenous Glucagon-Like Peptide-1 Slows Gastric Emptying in Healthy Subjects, Attenuating Postprandial Glycemia显示文摘 | Adam M. Deane Nam Q. Nguyen Julie E. Stevens Robert J. L. Fraser Richard H. Holloway Laura K. Besanko Carly Burgstad Karen L. Jones Marianne J. Chapman Chris K. Rayner Michael Horowitz | 2010 | The Journal of Clinical Endocrinology & Metabolism2010，，1： | 1 |
| 6 | Exercise Training in Patients With Severe Congestive Heart Failure: Enhancing Peak Aerobic Capacity While Minimizing the Increase in Ventricular Wall Stress显示文摘 | Laura Demopoulos Rachel Bijou Icilma Fergus Margaret Jones Joel Strom Thierry H LeJemtel | 1997 | Journal of the American College of Cardiology1997，，3： | 1 |
| 7 | Emerging Good Practice in Managing Research Data and Research Information within UK Universities 显示文摘 | Joy Davidson Sarah Jones Laura Molloy Ulla Bφgvad Kejser | 2014 | Procedia Computer Science2014，，33： | 1 |
| 8 | A Randomized Trial to Increase Physical Activity in Breast Cancer Survivors显示文摘 | LAURA Q. ROGERS PATRICIA HOPKINS-PRICE SANDY VICARI RICHARD PAMENTER KERRY S. COURNEYA STEPHEN MARKWELL STEVEN VERHULST KAREN HOELZER CATHERINE NARITOKU LINDA JONES GARY DUNNINGTON VICTOR LANZOTTI JAMES WYNSTRA LISA SHAH BILLIE EDSON ASHLEIGH GRAFF MICHEL | 2009 | Medicine & Science in Sports & Exercise2009，，4： | 1 |
| 9 | Differential mobilization of P in the maize rhizosphere by citric acid and potassium citrate 显示文摘 | Laura P Norbert C Jones D L | 2006 | Soil Biology & Biochemistry2006，38，： | 1 |
| 10 | Coping styles in people with chronic fatigue syndrome identified from the general population of Wichita, KS显示文摘 | Urs M. Nater Dieter Wagner Laura Solomon James F. Jones Elizabeth R. Unger Dimitris A. Papanicolaou William C. Reeves Christine Heim | 2006 | Journal of Psychosomatic Research2006，，6： | 1 |
| 11 | The Impact of Abbreviated Progressive Muscle Relaxation on Salivary Cortisol and Salivary Immunoglobulin A (sIgA)显示文摘 | Laura A. Pawlow Gary E. Jones | 2005 | Applied Psychophysiology and Biofeedback2005，，4： | 1 |
| 12 | VPS33B mutation with ichthyosis, cholestasis, and renal dysfunction but without arthrogryposis: Incomplete ARC syndrome phenotype显示文摘 | Laura N. Bull Venus Mahmoodi Alastair J. Baker Rosamond Jones Sandra S. Strautnieks Richard J. Thompson A.S. Knisely | 2006 | The Journal of Pediatrics2006，，2： | 1 |
| 13 | Analyzing the Practice of Life Cycle Assessment显示文摘 | Christi L. Saunders Amy E. Landis Laurel P. Mecca Alex K. Jones Laura A. Schaefer Melissa M. Bilec | 2013 | Journal of Industrial Ecology2013，，5： | 1 |
| 14 | Health related quality of life in people with advanced chronic liver disease显示文摘 | James G. Orr Tara Homer Laura Ternent Julia Newton Calum J. McNeil Mark Hudson David E.J. Jones | 2014 | Journal of Hepatology2014，，5： | 1 |
| 15 | Spitzenkorper, exocyst, and polarisome components in Candida albicans hyphae show differ- ent patterns of localization and have distinct dynamic properties显示文摘 | LAURA A JONE S PETER E | 2010 | Euksryotic Cell2010，9，10： | 1 |
| 16 | Immunohistochemical Loss of Succinate Dehydrogenase Subunit A (SDHA) in Gastrointestinal Stromal Tumors (GISTs) Signals SDHA Germline Mutation显示文摘 | Markku Miettinen Jonathan Keith Killian Zeng-Feng Wang Jerzy Lasota Christopher Lau Laura Jones Robert Walker Marbin Pineda Yuelin Jack Zhu Su Y. Kim Lee Helman Paul Meltzer | 2013 | The American Journal of Surgical Pathology2013，，2： | 1 |
| 17 | 欧洲2017年取消糖配额制度将引发市场巨变显示文摘欧洲的糖生产配额制度限制了它的生产量,并对糖的价格、欧洲以外的进口和甜味剂的使用进行了规定。由于这些规定已不合时宜,超过45年的配额制度将于2017年终结。 | Laura Jones | 2015 | 食品安全导刊2015，，7： | 0 |
| 18 | Notes for genera:Ascomycota显示文摘Knowledge of the relationships and thus the classification of fungi,has developed rapidly with increasingly widespread use of molecular techniques,over the past 10–15 years,and continues to accelerate.Several genera have been found to be polyphyletic,and their generic concepts have subsequently been emended.New names have thus been introduced for species which are phylogenetically distinct from the type species of particular genera.The ending of the separate naming of morphs of the same species in 2011,has also caused changes in fungal generic names.In order to facilitate access to all important changes,it was desirable to compile these in a single document.The present article provides a list of generic names of Ascomycota(approximately 6500 accepted names published to the end of 2016),including those which are lichen-forming.Notes and summaries of the changes since the last edition of‘Ainsworth&Bisby’s Dictionary of the Fungi’in 2008 are provided.The notes include the number of accepted species,classification,type species(with location of the type material),culture availability,life-styles,distribution,and selected publications that have appeared since 2008.This work is intended to provide the foundation for updating the ascomycete component of the'Without prejudice list of generic names of Fungi'published in 2013,which will be developed into a list of protected generic names.This will be subjected to the XIXth International Botanical Congress in Shenzhen in July 2017 agreeing to a modification in the rules relating to protected lists,and scrutiny by procedures determined by the Nomenclature Committee for Fungi(NCF).The previously invalidly published generic names Barriopsis,Collophora(as Collophorina),Cryomyces,Dematiopleospora,Heterospora(as Heterosporicola),Lithophila,Palmomyces(as Palmaria)and Saxomyces are validated,as are two previously invalid family names,Bartaliniaceae and Wiesneriomycetaceae.Four species of Lalaria,which were invalidly published are transferred to Taphrina and validated as new combinations.Catenomycopsis Tibell&Constant.is reduced under Chaenothecopsis Vain.,while Dichomera Cooke is reduced under Botryosphaeria Ces.&De Not.(Art.59). | Nalin N.Wijayawardene Kevin D.Hyde Kunhiraman C.Rajeshkumar David L.Hawksworth Hugo Madrid Paul M.Kirk Uwe Braun Rajshree V.Singh Pedro W.Crous Martin Kukwa Robert Lücking Cletus P.Kurtzman Andrey Yurkov Danny Haelewaters Andre´Aptroot H.Thorsten Lumbsch Einar Timdal Damien Ertz Javier Etayo Alan J.L.Phillips Johannes Z.Groenewald Moslem Papizadeh Laura Selbmann Monika C.Dayarathne Gothamie Weerakoon E.B.Gareth Jones Satinee Suetrong Qing Tian Rafael F.Castanda-Ruiz Ali H.Bahkali Ka-Lai Pang Kazuaki Tanaka Dong Qin Dai Jariya Sakayaroj Martina Hujslová Lorenzo Lombard Belle D.Shenoy Ave Suija Sajeewa S.N.Maharachchikumbura Kasun M.Thambugala Dhanushka N.Wanasinghe Bharati O.Sharma Subhash Gaikwad Gargee Pandit Laura Zucconi Silvano Onofri Eleonora Egidi Huzefa A.Raja Rampai Kodsueb Marcela E.S.Caceres Sergio Perez-Ortega Patrícia O.Fiuza Josiane Santana Monteiro Larissa N.Vasilyeva Roger G.Shivas Maria Prieto Mats Wedin Ibai Olariaga Adebola Azeez Lateef Yamini Agrawal Seyed Abolhassan Shahzadeh Fazeli Mohammad Ali Amoozegar Guo Zhu Zhao Walter P.Pfliegler Gunjan Sharma Magdalena Oset Mohamed A.Abdel-Wahab Susumu Takamatsu Konstanze Bensch Nimali Indeewari de Silva AndréDe Kesel Anuruddha Karunarathna Saranyaphat Boonmee Donald H.Pfister Yong-Zhong Lu Zong-Long Luo Nattawut Boonyuen Dinushani A.Daranagama Indunil C.Senanayake Subashini C.Jayasiri Milan C.Samarakoon Xiang-Yu Zeng Mingkwan Doilom Luis Quijada Sillma Rampadarath Gabriela Heredia Asha J.Dissanayake Ruvishika S.Jayawardana Rekhani H.Perera Li Zhou Tang Chayanard Phukhamsakda Margarita Hernańdez-Restrepo Xiaoya Ma Saowaluck Tibpromma Luis F.P.Gusmao Darshani Weerahewa Samantha C.Karunarathna | 2017 | Fungal Diversity2017，，5： | 0 |
| 19 | 医疗保健提供商须了解的应用、分析及IT方向显示文摘本文从唯一设备标识、医院物联网、纳米医学、实时医疗保健成本计算和危急状况监视系统五个方面介绍了医疗保健行业的发展和动态。 | laura craft vi shaffer barry runyon andrew stevens gregg pessin mike jones | 2017 | 电子产品世界2017，24，12： | 0 |
| 20 | 多成分创新型乳制品的安全与质量挑战显示文摘随着乳制品细分化市场销量的攀升以及各种乳制品广告的风靡,乳品行业已成为近些年金融业的奇迹与广告业所"倾慕"的对象。进入21世纪以来,尽管一路高涨的液态奶价格削弱了其应有的光彩,但乳品行业正努力创新,以迎合消费者的需求,从芒果味牛奶到燕麦精选酸乳,再到液态奶中新元素的添加,乳品行业力求将产品配方提升至一个全新的水平,努力迈向成功巅峰。与此同时,该行业也为不同消费人群提供便捷、 | Laura Jones | 2015 | 食品安全导刊2015，，8： | 0 |
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