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| 1 | Clinical implications of hepatitis B virus mutations:Recent advances显示文摘Hepatitis B virus(HBV)infection is a major cause of acute and chronic hepatitis,and of its long-term complications.It is the most variable among DNA viruses,mostly because of its unique life cycle which includes the activity of error-prone enzyme,reverse transcriptase,and the very high virion production per day.In last two decades,numerous research studies have shown that the speed of disease progression,reliability of diagnostic methods and the success of antiviral therapy and immunization are all influenced by genetic variability of this virus.It was shown that mutations in specific regions of HBV genome could be responsible for unwanted clinical outcomes or evasion of detection by diagnostic tools,thus making the monitoring for these mutations a necessity in proper evaluation of patients.The success of the vaccination programs has now been challenged by the discovery of mutant viruses showing amino acid substitutions in hepatitis B surface antigen(HBsAg),which may lead to evasion of vaccine-induced immunity.However,the emergence of these mutations has not yet raised concern since it was shown that they develop slowly.Investigations of HBV genetic variability and clinical implications of specific mutations have resulted in significant advances over the past decade,particularly in regard to management of resistance to antiviral drugs.In the era of drugs with high genetic barrier for resistance,on-going monitoring for possible resistance is still essential since prolonged therapy is often necessary.Understanding the frequencies and clinical implications of viral mutations may contribute to improvement of diagnostic procedures,more proper planning of immunization programs and creating the most efficient therapeutic protocols. | Ivana Lazarevic | 2014 | World Journal of Gastroenterology2014，20，24： | 12 |
| 2 | Colonic ulcerations may predict steroid-refractory course in patients with ipilimumab-mediated enterocolitis显示文摘AIM To investigate management of patients who develop ipilimumab-mediated enterocolitis, including association of endoscopic findings with steroid-refractory symptoms and utility of infliximab as second-line therapy.METHODS We retrospectively reviewed all patients at our centerwith metastatic melanoma who were treated with ipilimumab between March 2011 and May 2014. All patients received a standard regimen of intravenous ipilimumab 3 mg/kg every 3 wk for four doses or until therapy was stopped due to toxicity or disease progression. Basic demographic and clinical data were collected on all patients. For patients who developed grade 2 or worse diarrhea(increase of 4 bowel movements per day), additional data were collected regarding details of gastrointestinal symptoms, endoscopic findings and treatment course. Descriptive statistics were used.RESULTS A total of 114 patients were treated with ipilimumab during the study period and all were included. Sixteen patients(14%) developed ≥ grade 2 diarrhea. All patients were treated with high-dose corticosteroids(1-2 mg/kg prednisone daily or equivalent). Nine of 16 patients(56%) had ongoing diarrhea despite highdose steroids. Steroid-refractory patients received one dose of intravenous infliximab at 5 mg/kg, and all but one had brisk resolution of diarrhea. Fourteen of the patients underwent either colonoscopy or sigmoidoscopy with variable endoscopic findings, ranging from mild erythema to colonic ulcers. Among 8 patients with ulcers demonstrated by sigmoidoscopy or colonoscopy, 7 patients(88%) developed steroidrefractory symptoms requiring infliximab. With a median follow-up of 264 d, no major adverse events associated with prednisone or infliximab were reported.CONCLUSION In patients with ipilimumab-mediated enterocolitis, the presence of colonic ulcers on endoscopy was associated with a steroid-refractory course. | Animesh Jain Evan J Lipson William H Sharfman Steven R Brant Mark G Lazarev | 2017 | World Journal of Gastroenterology2017，23，11： | 8 |
| 3 | Development of dynamic-mathematical model of hydraulic excavator显示文摘This work deals with analysis of dynamic behaviour of hydraulic excavator on the basis of developed dynamic-mathematical model.The mathematical model with maximum five degrees of freedom is extended by new generalized coordinate which represents rotation around transversal main central axis of inertia of undercarriage.The excavator is described by a system of six nonlinear,nonhomogenous differential equations of the second kind.Numerical analysis of the differential equations has been done for BTH-600 hydraulic excavator with moving mechanism with pneumatic wheels. | Vujic Dragoljub Lazarevic Olgica Batinic Vojislav | 2017 | Journal of Central South University2017，24，9： | 5 |
| 4 | Left ventricular false tendons and electrocardiogram repolarization abnormalities in healthy young subjects显示文摘AIM To describe echocardiographically left ventricular false tendon characteristics and the correlation with ventricular repolarization abnormalities in young athletes.METHODS Three hundred and sixteen healthy young athletes from different sport disciplines were evaluated from 2009 to 2011 during routine screening for agonistic sports eligibility. All subjects, as part of standard preparticipation screening medical evaluation, underwent a basal and post step test 12-lead electrocardiogram(ECG). The athletes with abnormal T-wave flattening and/or inversion were considered for an echocardiogram evaluation and an incremental maximal exercise test on a cycle ergometer. Arterial blood pressure and heart rate, during and after exercise, were also measured.RESULTS Twenty-one of the 316 subjects(6.9%) showed false tendons in the left ventricle. The majority of false tendons(52.38%) were localized between the middle segments of the inferior septum and the lateral wall, 19.06% between the distal segments of the septum and the lateral wall, in 5 subjects between the middle segments of the anterior and inferior walls, and in one subject between the middle segments of the anterior septum and the posterior wall. ECG abnormalities, represented by alterations of ventricular repolarization, were found in 11 subjects(52.38%), 90% of these anomalies were T wave abnormalities from V1 to V3. These anomalies disappeared with an increasing heart rate following the three minute step test as well as during the execution of the maximal exercise.CONCLUSION Left ventricular false tendons are frequently localized between the middle segments of the inferior septum and the lateral wall and are statistically associated with ventricular repolarization abnormalities. | Zlatan Lazarevic Emanuela Ciminelli Federico Quaranta Fabio Sperandii Emanuele Guerra Fabio Pigozzi Paolo Borrione | 2016 | World Journal of Cardiology2016，8，10： | 4 |
| 5 | Inflammatory bowel disease associated neoplasia:Asurgeon's perspective显示文摘Inflammatory bowel disease(IBD) is associated with increased risk of colorectal cancer(CRC). The risk is known to increase with longer duration of the disease, family history of CRC, and history of primary sclerosing cholangitis. The diagnosis of the neoplastic changes associated with IBD is difficult owing to the heterogeneous endoscopic appearance and interobserver variability of the pathological diagnosis. Screening and surveillance guidelines have been established which aim for early detection of neoplasia. Several surgical options are available for the treatment of IBD-associated neoplasia. Patients' morbidities, risk factors for CRC, degree and the extent of neoplasia must be considered in choosing the surgical treatment. A multidisciplinary team including the surgeon, gastroenterologist, pathologist, and the patient who has a clear understanding of the nature of their disease is needed to optimize outcomes. | Azah A Althumairi Mark G Lazarev Susan L Gearhart | 2016 | World Journal of Gastroenterology2016，22，3： | 4 |
| 6 | Co-expression of the proteinase inhibitors oryzacystatin I and oryzacystatin II in transgenic potato alters Colorado potato beetle larval development显示文摘科罗拉多土豆甲壳虫(CPB;Leptinotarsa decemlineata 说,翘目:Chrysomelidae ) 显示出显著适应性到许多控制措施。尽管 oryzacystatin 我和 II (OCI 和 OCII ) 在控制为食物消化使用半胱氨酸朊酶的害虫有潜力,在土豆的单个 OC 基因的表示展出了一最小或 CPB 健康特点上的没有效果。这研究的目的是在土豆(茄属 tuberosum L.) 检验 coexpressed OCI 和 OCII 的效果 CPB 幼虫上的栽培变种 Desiree, Dragaevka 和 Jelica。CPB 幼虫的朊酶的生长参数,消费率和食物利用,以及活动是 assayed。第二和第三个中间形态幼虫在更高相对的生长和消费比在 nontransformed 叶子喂的幼虫评估的更早、有的转变叶子 molted 上喂了,当食物利用的效率是未受影响的时。相反,消费的叶子的第四中间形态最大值重量获得和数量是大约 20% 为在转基因的土豆上喂的幼虫更低。第三个中间形态幼虫的全部的朊酶活动的分析在 azocasein 水解作用测量的全面解朊的活动揭示了减小,在土豆的摄取离开以后,与半胱氨酸朊酶活动 24 h 的抑制伴随了表示 OCI 和 OCII。然而,在在转变叶子的长期的喂以后,幼虫的解朊的活动变得类似于控制。尽管在 OCI/OCII 叶子喂没影响幼虫的幸存, OC 基因的 coexpression 减少了发展时间并且显著地因此减少了 CPB 幼虫引起的植物损坏。 | Aleksandar Cingel Jelena Savic Jelica Lazarevic Tatjana Cosic Martin Raspor Ann Smigocki Slavica Ninkovic | 2017 | Insect Science2017，24，5： | 3 |
| 7 | The influence of single and combined IL28B polymorphisms on response to treatment of chronic hepatitis C显示文摘 | Ivana Lazarevic Jelena Djordjevic Maja Cupic Danijela Karalic Dragan Delic Neda Svirtlih Jasmina Simonovic Petar Svorcan Natasa Milic Tanja Jovanovic | 2013 | Journal of Clinical Virology2013，，： | 2 |
| 8 | IRRITABLE BOWEL SYNDROME, ANXIETY, DEPRESSION AND PERSONALITY CHARACTERISTICS显示文摘 | Suzana Tosic-Golubovic Srbobran Miljkovic Aleksandar Nagorni Dusan Lazarevic Gordana Nikolic | 2010 | Psychiatria Danubina2010，，3： | 2 |
| 9 | Family history and disease outcomes in patients with Crohn's disease:A comparison between China and the United States显示文摘AIM To investigate the differences in family history of inflammatory bowel disease(IBD) and clinical outcomes among individuals with Crohn's disease(CD) residing in China and the United States.METHODS We performed a survey-based cross-sectional study of participants with CD recruited from China and the United States.We compared the prevalence of IBD family history and history of ileal involvement,CD-related surgeries and IBD medications in China and the United States,adjusting for potential confounders.RESULTS We recruited 49 participants from China and 145 from the United States.The prevalence of family history of IBD was significantly lower in China compared with the United States(China:4.1%,United States:39.3%).The three most commonly affected types of relatives were cousin,sibling,and parent in the United States compared with child and sibling in China.Ileal involvement(China:63.3%,United States:63.5%) and surgery for CD(China:51.0%,United States:49.7%) were nearly equivalent in the two countries.CONCLUSION The lower prevalence of familial clustering of IBD in China may suggest that the etiology of CD is less attributed to genetic background or a family-shared environment compared with the United States.Despite the potential difference in etiology,surgery and ileal involvement were similar in the two countries.Examining the changes in family history during the continuing rise in IBD may provide further insight into the etiology of CD. | Pei-Qi Wang Jun Hu Elie S Al Kazzi Eboselume Akhuemonkhan Min Zhi Xiang Gao Raquel Holand de Paula Pessoa Sami Ghazaleh Tuhina Cornelius Suhel Abbas Sabunwala Shadi Ghadermarzi Kartikeya Tripathi Mark Lazarev Pin-Jin Hu Susan Hutfless | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 2 |
| 10 | Formation of fine near field scanning optical microscopy tips-part Ⅰ:by static and dynamic chemical etching显示文摘 | LAZAREV A FANG N LUO Q | 2003 | Rev Sci Instrum2003，74，8： | 1 |
| 11 | Long-term control of Myeobacterium tuberculosis infection is mediated by dynamic immune response显示文摘 | Lazarevic V Nolt D Flynn JL | 2005 | Immunol2005，175，5： | 1 |
| 12 | Forced vibrations of plates and cylindrical shells with regular orthogonal system of stiffeners显示文摘 | B.M. Efimtsov L.A. Lazarev | 2009 | Journal of Sound and Vibration2009，，1： | 1 |
| 13 | Myeloablative allogeneic stem cell transplantation for lymphoblastic lymphoma in Sweden : a retrospective study 显示文摘 | Lazarevic VLj Remberger M Hagglund H | 2011 | Am J Hematol2011，86，8： | 1 |
| 14 | Oxidative stress parameters as possible urine markers in patients with diabetic nephropathy 显示文摘 | Cvetkovic T Mitic B Lazarevic G Vlahovic P Antic S Stefanovic V | 2009 | J Diabetes Complications2009，23，： | 1 |
| 15 | Long-term control of Mycobacterium tuberculosis infection is mediated by dynamic immune responses显示文摘 | Lazarevic V Nolt D Flynn JL | 2005 | J Immunol2005，175，2： | 1 |
| 16 | A physical ac-tivity programme and its effects on insulin resistance andoxidative defense in obese male patients with type 2 diabe-tes mellitus 显示文摘 | Lazarevic G Antic S Cvetkovic T | 2006 | Diabetes Metab2006，32，6： | 1 |
| 17 | T-bet in disease显示文摘 | Lazarevic V Glimcher LH | 2011 | Nat Immunol2011，12，7： | 1 |
| 18 | GIS Based Multi-criteria Analysis for Industrial Site Selection 显示文摘 | Aleksandar Rikalovic Ilija Cosic Djordje Lazarevic | 2014 | Procedia Engineering2014，69，： | 1 |
| 19 | Poly(glucosyl-N-acetylgalactosamine 1-phosphate), a wall teiehoic acid of Bacillus subtilis 168: its biosynthetie pathway and mode of attachment to peptidoglycan显示文摘 | Freyrnond PP Lazarevic V Soldo B | 2006 | Microbiology2006，152，6： | 1 |
| 20 | Amide i band of ir spectrum and structure of collagen and related polypeptides显示文摘 | Yu A Lazarev Bagtbk | 1985 | Biopolymers1985，24，8： | 1 |
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