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| 1 | Minimally invasive surgery alone compared with intensity-modulated radiotherapy for primary stage I nasopharyngeal carcinoma显示文摘Background:The National Comprehensive Cancer Network guidelines recommend intensity-modulated radiotherapy(IMRT)as the primary curative treatment for newly diagnosed nasopharyngeal carcinoma(NPC),but the radiation-related complications and relatively high medical costs remain a consequential burden for the patients.Endoscopic nasopharyngectomy(ENPG)was successfully applied in recurrent NPC with radiation free and relatively low medical costs.In this study,we examined whether ENPG could be an effective treatment for localized stage I NPC.Methods:Ten newly diagnosed localized stage I NPC patients voluntarily received ENPG alone from June 2007 to September 2017 in Sun Yat-sen University Cancer Center.Simultaneously,the data of 329 stage I NPC patients treated with IMRT were collected and used as a reference cohort.The survival outcomes,quality of life(QOL),and medical costs between two groups were compared.Results:After a median follow-up of 59.0 months(95%CI 53.4-64.6),no death,locoregional recurrence,or distant metastasis was observed in the 10 patients treated with ENPG.The 5-year overall survival,local relapse-free survival,regional relapse-free survival,and distant metastasis-free survival among the ENPG-treated patients was similar to that among the IMRT-treated patients(100%vs.99.1%,100%vs.97.7%,100%vs.99.0%,100%vs.97.4%,respectively,P>0.05).In addition,compared with IMRT,ENPG was associated with decreased total medical costs($4090.42±1502.65 vs.$12620.88±4242.65,P<0.001)and improved QOL scores including dry mouth(3.3±10.5 vs.34.4±25.8,P<0.001)and sticky saliva(3.3±10.5 vs.32.6±23.3,P<0.001).Conclusions:ENPG alone was associated with promising long-term survival outcomes,low medical costs,and satisfactory QOL and might therefore be an alternative strategy for treating newly diagnosed localized stage I NPC patients who refused radiotherapy.However,the application of ENPG should be prudent,and prospective clinical tri-als were needed to further verify the results. | You-Ping Liu Xing Lv Xiong Zou Yi-Jun Hua Rui You Qi Yang Le Xia Shao-Yan Guo Wen Hu Meng-Xia Zhang Si-Yuan Chen Mei Lin Yu-Long Xie Li-Zhi Liu Rui Sun Pei-Yu Huang Wei Fan Xiang Guo Ming-Huang Hong Ming-Yuan Chen | 2019 | Cancer Communications2019，39，1： | 17 |
| 2 | Aliskiren ameliorates pressure overload-induced heart hypertrophy and fibrosis in mice显示文摘 | Li-qing WENG Wen-bin ZHANG Yong YE Pei-pei YIN Jie YUAN Xing-xu WANG Le KANG Sha-sha JIANG Jie-yun YOU Jian WU Hui GONG Jun-bo GE Yun-zeng ZOU | 2014 | Acta Pharmacologica Sinica2014，35，8： | 12 |
| 3 | Plant Genome Editing Using FnCpfl and LbCpf Nucleases at Redefined and Altered PAM-Sites显示文摘 | ZhaohuiZhong Yingxiao Zhang Qi You XU Tang Qiurong Ren Shishi Liu Lijia Yang Yan Wang Xiaopei Liu Binglin Liu Tao Zhang Xuelian Zheng Ysa Le Yong Zhang Yiping Qi | 2018 | Molecular Plant2018，11，7： | 10 |
| 4 | Coexpression of MYC and BCL-2 predicts prognosis in primary gastrointestinal diffuse large B-cell lymphoma显示文摘AIM:To investigate whether MYC and BCL-2 coexpression has prognostic significance in primary gastrointestinal diffuse large B-cell lymphoma(PGI-DLBCL)patients,and explore its associations with patients’clinical parameters.METHODS:Fresh and paraffin-embedded tumor tissue samples from 60 PGI-DLBCL patients who had undergone surgery at the Tianjin Medical University Cancer Institute and Hospital from January 2005 to May 2010 were obtained,and 30 lymphoid tissue samples from reactive lymph nodes of age-and sexmatched patients represented control samples.Staging and diagnostic procedures were conducted according to the Lugano staging system.All patients had been treated with three therapeutic modalities:surgery,chemotherapy,or radiotherapy.Expression of MYC and BCL-2 were detected at both protein and m RNA levels by immunohistochemistry and real-time RT-PCR.RESULTS:Positive expression levels of MYC and BCL-2proteins were detected in 35%and 45%of patients,respectively.MYC+/BCL-2+protein was present in30%of patients.MYC and BCL-2 protein levels were correlated with high MYC and BCL-2 m RNA expression,respectively(both P<0.05).We found that advancedstage disease(atⅡE-Ⅳ)was associated with MYC and BCL-2 coexpression levels(P<0.05).In addition,MYC+/BCL-2+patients had more difficulty in achieving complete remission than others(P<0.05).Presenceof MYC protein expression only affected overall survivaland progression-free survival(PFS)when BCL-2 proteinwas coexpressed.The adverse prognostic impact ofMYC+/BCL-2+protein on PFS remained significant(P<0.05)even after adjusting for age,Lugano stage,international prognostic index,and BCL-2 proteinexpression in a multivariable model.CONCLUSION:MYC+/BCL-2+patients have worsechemotherapy response and poorer prognosis thanpatients who only express one of the two proteins,suggesting that assessment of MYC and BCL-2 expressionby immunohistochemistry has clinical significance inpredicting clinical outcomes of PGI-DLBCL patients. | Bing Xia Le Zhang Shan-Qi Guo Xiao-Wu Li Fu-Lian Qu Hai-Feng Zhao Lian-Yu Zhang Bao-Cun Sun James You Yi-Zhuo Zhang | 2015 | World Journal of Gastroenterology2015，21，8： | 7 |
| 5 | A novel approach for one-step forming ε-caprolactam from cyclohexane nitrozation catalyzed by transition metal salt显示文摘The nitrozation reaction of cyclohexane in one-step reaction to form ε-caprolactam has been studied using transition metal salt as catalysts in this work. The results indicated that the catalysts play an especially important role. This method is expected to be a novel way to synthesize other lactam by similar reaction. The possible mechanism was suggested. | Li Qiu Mao Bo Hua Wu Du Lin Yin Kui Yi You Ping Le Liu He An Luo | 2007 | Chinese Chemical Letters2007，18，3： | 6 |
| 6 | Nuclear m^(6)A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos显示文摘N^(6)-methyladenosine(m^(6)A)on chromosome-associated regulatory RNAs(carRNAs),including repeat RNAs,plays important roles in tuning the chromatin state and transcription,but the intrinsic mechanism remains unclear.Here,we report that YTHDC1 plays indispensable roles in the self-renewal and differentiation potency of mouse embryonic stem cells(ESCs),which highly depends on the m^(6)A-binding ability.Ythdcl is required for sufficient rRNA synthesis and repression of the 2-cell(2C)transcriptional program in ESCs,which recapitulates the transcriptome regulation by the LINE1 scaffold.Detailed analyses revealed that YTHDC1 recognizes m^(6)A on LINE1 RNAs in the nucleus and regulates the formation of the LINE1-NCL partnership and the chromatin recruitment of KAP1.Moreover,the establishment of H3K9me3 on 2C-related retrotrans-posons is interrupted in Ythdcl-depleted ESCs and inner cell mass(ICM)cells,which consequently increases the transcriptional activities.Our study reveals a role of m^(6)A in regulating the RNA scaffold,providing a new model for the RNA-chromatin cross-talk. | Chuan Chen Wenqiang Liu Jiayin Guo Yuanyuan Liu Xuelian Liu Jun Liu Xiaoyang Dou Rongrong Le Yixin Huang Chong Li Lingyue Yang Xiaochen Kou Yanhong Zhao You Wu Jiayu Chen Hong Wang Bin Shen Yawei Gao Shaorong Gao | 2021 | Protein & Cell2021，12，6： | 4 |
| 7 | A simple and efficient synthesis of 2-substituted benzothiazoles catalyzed by H_2O_2/HCl显示文摘A simple and efficient procedure for the synthesis of substituted benzothiazoles through condensation of 2-aminothiophenol with aromatic aldehydes in the presence of H_2O_2/HCl system in ethanol at room temperature is described.The target compounds have been characterized by ~1H NMR,^(13)C NMR,IR and MS.Short reaction time,easy and quick isolation of the products,and excellent yields are the main advantages of this procedure. | Hong Yun Guo Ji Chao Li You Le Shang | 2009 | Chinese Chemical Letters2009，20，12： | 4 |
| 8 | Blockchain-enabled wireless communications:a new paradigm towards 6G显示文摘With the deployment of fifth-generation(5 G)wireless networks worldwide,research on sixth-generation(6 G)wireless communications has commenced.It is expected that 6 G networks can accommodate numerous heterogeneous devices and infrastructures with enhanced efficiency and security over diverse,e.g.spectrum,computing and storage,resources.However,this goal is impeded by a number of trust-related issues that are often neglected in network designs.Blockchain,as an innovative and revolutionary technology that has arisen in the recent decade,provides a promising solution.Building on its nature of decentralization,transparency,anonymity,immutability,traceability and resiliency,blockchain can establish cooperative trust among separate network entities and facilitate,e.g.efficient resource sharing,trusted data interaction,secure access control,privacy protection,and tracing,certification and supervision functionalities for wireless networks,thus presenting a new paradigm towards 6 G.This paper is dedicated to blockchain-enabled wireless communication technologies.We first provide a brief introduction to the fundamentals of blockchain,and then we conduct a comprehensive investigation of the most recent efforts in incorporating blockchain into wireless communications from several aspects.Importantly,we further propose a unified framework of the blockchain radio access network(B-RAN)as a trustworthy and secure paradigm for 6 G networking by utilizing blockchain technologies with enhanced efficiency and security.The critical elements of B-RAN,such as consensus mechanisms,smart contract,trustworthy access,mathematical modeling,cross-network sharing,data tracking and auditing and intelligent networking,are elaborated.We also provide the prototype design of B-RAN along with the latest experimental results. | Jiaheng Wang Xintong Ling Yuwei Le Yongming Huang Xiaohu You | 2021 | National Science Review2021，8，9： | 4 |
| 9 | Stress changes of lateral collateral ligament at different knee flexion with or without displaced movements: a 3- dimensional finite element analysis显示文摘目的将创造膝系带并且到压力在不同的膝屈曲侧面的并行的系带(LCL ) 改变与或没有代替的运动的分析的有限元素模型调节的 3-dimensional。four-major-ligament 从一个成年人包含了膝标本的方法死于颅骨损害为与精确预先标记的可检测的系带插入脚印,地点和取向扫描的 CT 作好准备。扫描图象的 CT 与 3-dimensional 重建技术被变换成膝的一个 3-dimensional 模型并且由 ANSYS 的软件转变了成有限元素模型。模型用另外的科学家获得的试验性、数字的结果被验证。在五个不同的膝屈曲角度的 LCL | ZHONG Yan-lin WANG You WANG Hai-peng RONG Ke XIE Le | 2011 | Chinese Journal of Traumatology2011，14，2： | 2 |
| 10 | Artificial intelligence in cancer target identification and drug discovery显示文摘Artificial intelligence is an advanced method to identify novel anticancer targets and discover novel drugs from biology networks because the networks can effectively preserve and quantify the interaction between components of cell systems underlying human diseases such as cancer.Here,we review and discuss how to employ artificial intelligence approaches to identify novel anticancer targets and discover drugs.First,we describe the scope of artificial intelligence biology analysis for novel anticancer target investigations.Second,we review and discuss the basic principles and theory of commonly used network-based and machine learning-based artificial intelligence algorithms.Finally,we showcase the applications of artificial intelligence approaches in cancer target identification and drug discovery.Taken together,the artificial intelligence models have provided us with a quantitative framework to study the relationship between network characteristics and cancer,thereby leading to the identification of potential anticancer targets and the discovery of novel drug candidates. | Yujie You Xin Lai Yi Pan Huiru Zheng Julio Vera Suran Liu Senyi Deng Le Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，6： | 2 |
| 11 | Super-conductive silver nanoparticles functioned three-dimensional CuxO foams as a high-pseudocapacitive electrode for flexible asymmetric supercapacitors显示文摘Copper oxide has aroused great concern in energy storage fields due to its properties of high theoretical capacitance,low cost and mild toxicity.However,its wide application still remains challenges owing to its poor electrical conductivity and unstable cycling life.Binder-free foam electrodes possess abundant porous structures and high specific surface area,which could get good contact with electrolyte.Herein,we demonstrate Ag nanoparticles decorated CuxO nanowires grown spontaneously on copper foam(CF)electrode for asymmetric supercapacitor.The skeleton structure of CF provides large amounts of active sites for the growth of CuxO nanowires.Moreover,Ag nanoparticles further decrease the internal resistance and enhance the electrochemical performance.Ag/CuxO/CF-40 electrode presents a high area specific capacitance of 1192 mF cm^(-2)at 2 mA cm^(-2)and the influence of surface capacitance-dominated process and diffusion-controlled process are discussed in detail.Besides,the energy density of the as-prepared asymmetric supercapacitor(ASC)reaches 46.32 mWh cm^(-2)at a power density of 3.00 mW cm^(-2).A 2V LED is lighted successfully by two ASC in series.This work provides a new strategy to prepare low internal resistance and binder-free flexible Ag/CuxO/CF electrode,which demonstrates a good potential application in flexible supercapacitors or other wearable electronic devices. | Hui Jiang Xuehua Yan Le Wang Xiaonong Cheng Jieyu Miao Mingyu You Yihan Zhu Jianmei Pan | 2021 | Journal of Materiomics2021，7，1： | 2 |
| 12 | A PhaseⅡtrial of erlotinib as maintenance treatment after gemcitabine plus platinum-based chemotherapy in patients with recurrent and/or metastatic nasopharyngeal carcinoma显示文摘 | YOU B LE TOURNEAU C CHEN E X | 2012 | Am J Clin Oncol2012，35，： | 1 |
| 13 | Modeling the protein partitioning in aqueous polymer two-phase systems: influence of polymer concentration and molecular weight 显示文摘 | Dong Qiang Lin You Ting Wu Le He Mei | 2003 | Chemical Engineering Science2003，58，13： | 1 |
| 14 | Pricing a contingent claim with random interval or fuzzy random payoff in one-period setting显示文摘 | YOU S R LE J J DING X D | 2008 | Computers&Mathematics with Applications2008，56，8： | 1 |
| 15 | Pricing a Contingent Claim with Random Interval or Fuzzy Random Payoff in One-Period Setting显示文摘 | You S R Le J J Ding X D | 2008 | Computers &Mathematics with Applications2008，56，8： | 1 |
| 16 | Antiangiogenic Thera py in Patients With HER2-Positive Metastatic Breast Cancer: A Case Series显示文摘 | Le Saux O You B Freyer G | 2013 | Clin Breast Cancer2013，24，7： | 1 |
| 17 | Prototype of single-event effect localization system with CMOS pixel sensor显示文摘The single-event effect(SEE) is a serious threat to electronics in radiation environments. The most important issue in radiation-hardening studies is the localization of the sensitive region in electronics to the SEE. To solve this problem, a prototype based on a complementary metal oxide semiconductor(CMOS) pixel sensor, i.e., TopmetalM, was designed for SEE localization. A beam test was performed on the prototype at the radiation terminal of the Heavy Ion Research Facility in Lanzhou(HIRFL). The results indicated that the inherent deflection angle of the prototype to the beam was 1.7°, and the angular resolution was 0.6°. The prototype localized heavy ions with a position resolution of 3.4 μm. | Jun Liu Zhuo Zhou Dong Wang Shi-Qiang Zhou Xiang-Ming Sun Wei-Ping Ren Bi-Hui You Chao-Song Gao Le Xiao Ping Yang Di Guo Guang-Ming Huang Wei Zhou Cheng-Xin Zhao Min Wang | 2022 | Nuclear Science and Techniques2022，33，11： | 1 |
| 18 | AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function显示文摘 | Dugan Laura L You Young-Hyun Ali Sameh S Diamond-Stanic Maggie Miyamoto Satoshi DeCleves Anne-Emilie Andreyev Aleksander Quach Tammy Ly San Shekhtman Grigory Nguyen William Chepetan Andre Le Thuy P Wang Lin Xu Ming Paik Kacie P Fogo Agnes | 2013 | Journal of Clinical Investigation2013，，11： | 1 |
| 19 | Interconnected graphene scaffolds for functional gas sensors with tunable sensitivity显示文摘In this work,the interconnected graphene scaffolds are prepared by three-dimensional(3 D)printing for multifunctional gas detection with tunable sensitivity.The scaffolds with regularly aligned graphene conductive networks exhibit significant mechanical strength and high electrical stability to multi-direction deformation,which can be attributed to the typical core-shell structure of graphene and PVP.The resistance of the free-standing scaffolds can realize the real-time response to H_(2) O and NO_(2),and the relative resistance change to 100 ppm H_(2) O and 100 ppm NO_(2) can reach 2%and 2.5%,respectively.The charge doping of the oxidizing gases is considered to be the main reason for various response sensitivities of the scaffolds with different orthogonal layers,in which the interconnected conductive network can generate a large specific surface area and significantly improving the adsorption of the target gases and the transfer of charge.The controllable fabrication of regular structure has appropriately great potential for further optimizations and applications in gas detection. | Xiao You Jinshan Yang Mengmeng Wang Hongda Wang Le Gao Shaoming Dong | 2020 | Journal of Materials Science & Technology2020，58，23： | 1 |
| 20 | Pricing a contingent claim with random interval or fuzzy random payoff in one-period setting显示文摘 | YOU Su-rong LE Jia-jin DING Xiao-dong | 2008 | Computers and Mathematics with Applications2008，56，8： | 1 |
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