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| 1 | Therapeutic Effects of Traditional Herbal Medicine on Cerebral Ischemia:A Perspective of Vascular Protection显示文摘Although many agents for acute ischemic stroke treatment have been developed from extensive preclinical studies,most have failed in clinical trials.As a result,researchers are seeking other methods or agents based on previous studies.Among the various prospective approaches,vascular protection might be the key for development of therapeutic agents for stroke and for improvements in the efficacy and safety of conventional therapies.Traditional medicines in Asian countries are based on clinical experiences and literature accumulated over thousands of years.To date,many studies have used traditional herbal medicines to prove or develop new agents based on stroke treatments mentioned in traditional medicinal theory or other clinical data.In the current review,we describe the vascular factors related to ischemic brain damage and the herbal medicines that impact these factors,including Prof.Youngmm Bu Salviae Miltiorrhizae Radix,Notoginseng Radix,and Curcumae Rhizoma,based on scientific reports and traditional medical theory.Further,we point out the problems associated with herbal medicines in stroke research and propose better methodologies to address these problems. | Youngmin Bu Kyungjin Lee Hyuk-Sang Jung Sang-Kwan Moon | 2013 | Chinese Journal of Integrative Medicine2013，19，11： | 5 |
| 2 | A Miniaturized Tadpole Robot Using an Electromagnetic Oscillatory Actuator显示文摘 | Bu Hyun Shin Kyung-Min Lee Seung-Yop Lee | 2015 | Journal of Bionic Engineering2015，12，1： | 5 |
| 3 | Emerging Organic Contaminants in Chinese Surface Water:Identification of Priority Pollutants显示文摘The occurrence and impacts of emerging organic contaminants(EOCs)in the aquatic environment have gained widespread attention over the past two decades.Due to large number of potential contaminants,monitoring campaigns,treatment plants,and proposed regulations should preferentially focus on specific pollutants with the highest potential for ecological and human health effects.In the present study,a multi-criteria screening approach based on hazard and exposure potentials was developed for prioritization of 405 unregulated EOCs already present in Chinese surface water.Hazard potential,exposure potential,and risk quotients for ecological and human health effects were quantitatively analyzed and used to screen contaminants.The hazard potential was defined by contaminant persistence,bioaccumulation,ecotoxicity,and human health effects;similarly,the exposure potential was a function of contaminant concentration and detection frequency.In total,123 compounds passed the preselection process,which involved a priority index equal to the normalized hazard potential multiplied by the normalized exposure potential.Based on the prioritization scheme,11 compounds were identified as top-priority,and 37 chemicals were defined as high-priority.The results obtained by the priority index were compared with four other prioritization schemes based on exposure potential,hazard potential,or risk quotients for ecological effects or human health.The priority index effectively captured and integrated the results from the more simplistic prioritization schemes.Based on identified data gaps,four uncertainty categories were classified to recommend:①regular monitoring,derivation of environmental quality standards,and development of control strategies;②increased monitoring;③fortified hazard assessment;and④increased efforts to collect occurrence and toxicity data.Overall,20 pollutants were recommended as priority EOCs.The prioritized list of contaminants provides the necessary information for authoritative regulations to monitor,control,evaluate,and manage the risks of environmentally-relevant EOCs in Chinese surface water. | Mengmeng Zhong Tielong Wang Wenxing Zhao Jun Huang Bin Wang Lee Blaney Qingwei Bu Gang Yu | 2022 | Engineering2022，8，4： | 3 |
| 4 | Review on the characteristics of liver-pacifying medicinal in relation to the treatment of stroke: from scientific evidence to traditional medical theory显示文摘OBJECTIVE: To analyze the characteristics of liver pacifying medicinal in the treatment of brain disease to provide scientific evidence in clinical usage on stroke.METHODS: MEDLINE/Pub Med, Google Scholar,and China National Knowledge Infrastructure Database were used as the literature sources. The Scientific name, Latin pharmaceutical name,Chinese name of 7 kinds of liver pacifying medicinal including Gouteng(Ramulus Uncariae Rhynchophyllae cum Uncis), Tianma(Rhizoma Gastrodiae), Juemingzi(Semen Cassiae Obtusifoliae),Quanxie(Scorpio), Wugong(Scolopendra), Jiangcan(Bombyx Batryticatus), and Dilong(Pheretima Aspergillum) were used as the keywords to search the databases for relevant publications up to July2016. Their major compounds were also used as the keywords. The papers were selected based on the pharmacological activities and mechanisms of action related to brain diseases and subsequently,were analyzed and reviewed. We first described the origin, efficacy, and clinical indications of selected medicines, then brain disease specific activities focusing on stroke after the description of the general pharmacological activities.RESULTS: On the basis of the literature of scientific studies and clinical use in traditional medicine, we found and discussed the characteristics of liver pacifying medicinal in stroke treatment. First, liver-pacifying medicinal,or their components, might pass through the blood-brain barrier and act directly on neurons or on the neural network to provide protective effects against brain disease. Second, although it could be used throughout the disease duration,treatment of stroke might be more effective from the subacute up to the convalescent phase than the acute phase.CONCLUSION: We can suggest that live pacifying medicinal has beneficial pharmacological activities directly or indirectly on neurons in brain disease and is useful for the treatment of stroke from subacute to convalescent phase. | Kyungjin Lee Hyejin Joo Meixiang Sun Minwoo Kim Bumjung Kim Beom-Joon Lee Jae-Heung Cho Jae-Young Jung Jae-Woo Park Youngmin Bu | 2018 | Journal of Traditional Chinese Medicine2018，38，1： | 2 |
| 5 | A-STAR: A mobile Ad Hoc routing strategy for metropolis vehicular communi- cations显示文摘 | Seet Boon Chong Liu Genping Lee Bu Sung et at | 2004 | Lecture Notes in Computer Science2004，，3042： | 1 |
| 6 | 显示文摘 | C. Jang D. Kim S. Bu J. Kim S. Lee J. Kim J. Johnson Y. Seo | 2002 | Plant Cell Reports2002，，10： | 1 |
| 7 | An evaluation of vascular anatomy for minilaparotomic anterior L4-5 procedures显示文摘 | Kang BU Lee SH Jeon SH | 2006 | J Neurosurg Spine2006，5，6： | 1 |
| 8 | Mini transforaminal lumbar interbody fusion versus anterior lumbar interbody fusion augmented by percutaneous pedicle screw fixation: a comparison of surgical outcomes in adult low grade isthmic spondylolisthesis 显示文摘 | IKim JS Kang BU Lee SH | 2009 | J Spinal Disord Tech2009，22，2： | 1 |
| 9 | Surgical site infection in spinal surgery:detection and management based on serial C-reactive protein measurements显示文摘 | Kang BU Lee SH Ahn Y | 2010 | J Neurosurg Spine2010，13，2： | 1 |
| 10 | Isolation and characterization of lipid transfer protein(LTP)genes from a wheat-rye translocation line显示文摘 | Jang C S Kim D S Bu S Y Kim J B Lee S S Kim J Y Seo Y W | 2002 | Plant Cell Rep2002，20，： | 1 |
| 11 | Development of microwave foaming method for phenolic insulation foams显示文摘 | Bu Gi Kim Dai Gil Lee | 2008 | Journal of Materials Processing Technology2008，201，： | 1 |
| 12 | Operative failure of pereu- taneous endoscopic lumbar diseectomy: a radiologic analysis of 55 cases显示文摘 | Lee SH Kang BU Ahn Y | 2006 | Spine2006，31，10： | 1 |
| 13 | Global analyses of transcriptomes and proteomes of a parent strain and an L-threonine-overproducing mutant strain 显示文摘 | Lee JH Lee DE Lee BU | 2003 | J Bacteriol2003，185，18： | 1 |
| 14 | Transcriptional and translation- al dual-regulated oncolytic herpes simplex virus type 1 for targeting prostate tumors 显示文摘 | Lee CY Bu LX DeBenedetti A | 2010 | Mol Ther2010，18，5： | 1 |
| 15 | Operative failure of percu- taneous endoscopic lumbar discectomy: a radiologic analysis of 55 cases显示文摘 | Lee SH Kang BU Ahn Y | 2006 | Spine2006，31，10： | 1 |
| 16 | Tumor suppressor p16INK4a inhibits cancer cell growth by downregulating eEF1A2 through a direct interaction显示文摘 | Mee-Hyun Lee Bu Young Choi Yong-Yeon Cho Sung-Young Lee Zunnan Huang Joydeb Kumar Kundu Myoung Ok Kim Dong Joon Kim Ann M. Bode Young-Joon Surh Zigang Dong | 2013 | Journal of Cell Science2013，，16： | 1 |
| 17 | Development of microwave foaming method for phenolic insulation foams显示文摘 | Bu Gi Kim Dai Gil Lee | 2008 | Journal of Materials Processing Technology2008，201，13： | 1 |
| 18 | Operative failure of percutaneous endoscopic lumbar discectomy:a radiologic analysis of 55 cases显示文摘 | Lee SH Kang BU Ahn Y | | 0，，1976： | 1 |
| 19 | Operative failure of percutaneous endoscopic lumbar discectomy:a radiologic analysis of 55 cases 显示文摘 | Lee SH Kang BU Ahn Y | 2006 | Spine(Phila Pa 1976)2006，，10： | 1 |
| 20 | PIV analysis of flow around a container ship model with a rotating propeller显示文摘 | BU GEUN PAIK CHOUNG MOOK LEE SANG JOON LEE | 2004 | Ezperiments in Fluids2004，36，： | 1 |
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